Research Topics
| MAYTHEM M SAEEDSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
MR fluoroscopy in vascular and cardiac interventions (review)Maythem Saeed
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107 1701, USA
Int J Cardiovasc Imaging 28:117-37. 2012..MR fluoroscopy has the potential to form the basis for minimally invasive image-guided surgeries that offer improved patient management and cost effectiveness...
Left ventricular remodeling after infarction: sequential MR imaging with oral nicorandil therapy in rat modelMaythem Saeed
Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Rm L 308, 94143 0628, USA
Radiology 224:830-7. 2002..To use magnetic resonance (MR) imaging in quantification of the short- and long-term effects of therapy with orally administered nicorandil on left ventricular (LV) geometry and function independent of infarction size...
Cardiovascular magnetic resonance imaging in delivering and evaluating the efficacy of hepatocyte growth factor gene in chronic infarct scarMaythem Saeed
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107 1701, USA
Cardiovasc Revasc Med 12:111-22. 2011....
MR assessment of myocardial perfusion, viability, and function after intramyocardial transfer of VM202, a new plasmid human hepatocyte growth factor in ischemic swine myocardiumMaythem Saeed
Department of Radiology and Biomedical Imaging, University of California San Francisco, 513 Parnassus Ave, HSW 207B, San Francisco, CA 94134 0628, USA
Radiology 249:107-18. 2008....
Discrimination of myocardial acute and chronic (scar) infarctions on delayed contrast enhanced magnetic resonance imaging with intravascular magnetic resonance contrast mediaMaythem Saeed
Department of Radiology, University of California San Francisco, San Francisco, California 94134 0628, USA
J Am Coll Cardiol 48:1961-8. 2006..The purpose of this study was to examine the potential of intravascular gadolinium (Gd)-chelates in discriminating acute from chronic myocardial infarctions (MIs)...
Reperfused myocardial infarction as seen with use of necrosis-specific versus standard extracellular MR contrast media in ratsM Saeed
Department of Radiology, University of California San Francisco 94143 0628, USA
Radiology 213:247-57. 1999....
Delivery and assessment of endovascular stents to repair aortic coarctation using MR and X-ray imagingMaythem Saeed
Department of Radiology, University of California San Francisco, California 94143 0628, USA
J Magn Reson Imaging 24:371-8. 2006..To investigate the utility of MR and X-ray imaging for characterizing aortic coarctation and flow, and guiding the endovascular catheter to place a stent to repair the coarctation...
Scarred myocardium imposes additional burden on remote viable myocardium despite a reduction in the extent of area with late contrast MR enhancementMaythem Saeed
Department of Radiology, University of California, San Francisco, 94143 0628, USA
Eur Radiol 16:827-36. 2006..The integration of late enhancement and cine MRI incorporates anatomical and functional evaluation of remodeled hearts...
MRI in guiding and assessing intramyocardial therapyM Saeed
Department of Radiology, School of Medicine, University of California San Francisco, 94143 0628, USA
Eur Radiol 15:851-63. 2005..MRI represents a highly attractive discipline whose systematic development will foster the implementation of new cardiac and vascular therapies...
Transendocardial delivery of extracellular myocardial markers by using combination X-ray/MR fluoroscopic guidance: feasibility study in dogsMaythem Saeed
Department of Radiology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
Radiology 231:689-96. 2004....
Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine modelMaythem Saeed
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94134 0628, USA
Radiology 249:560-71. 2008..To provide evidence that vascular endothelial growth factor (VEGF) genes delivered transendocardially with magnetic resonance (MR) imaging guidance may neovascularize or improve vascular recruitment in occlusive infarction...
MR guidance of targeted injections into border and core of scarred myocardium in pigsMaythem Saeed
Department of Radiology, University of California San Francisco, 513 Parnassus Ave, Room HSW 207 B, San Francisco, CA 94143 0628, USA
Radiology 240:419-26. 2006....
MR contrast media for myocardial viability, microvascular integrity and perfusionM Saeed
Department of Radiology, University of California, Box 0628, 505 Parnassus Ave, San Francisco, CA 94143, USA
Eur J Radiol 34:179-95. 2000..MR imaging may emerge as one-stop-shop for evaluating the heart and coronary system. This capability will make MR imaging cost-effective in the first decade of this millennium...
Blood pool MR contrast agents for cardiovascular imagingM Saeed
Department of Radiology, University of California, San Francisco, California 94143, USA
J Magn Reson Imaging 12:890-8. 2000..This review discusses the applications of MR blood pool agents in the cardiovascular system. J. Magn. Reson. Imaging 2000;12:890-898...
Magnetic resonance characterization of the peri-infarction zone of reperfused myocardial infarction with necrosis-specific and extracellular nonspecific contrast mediaM Saeed
Department of Radiology, University of California, San Francisco, Calif, USA
Circulation 103:871-6. 2001..Because ischemically injured myocardium is frequently composed of viable and nonviable portions, a method to discriminate the two is useful for clinical management...
New concepts in characterization of ischemically injured myocardium by MRIM Saeed
Department of Radiology, School of Medicine, University of California, San Francisco 94143 0628, USA
Exp Biol Med (Maywood) 226:367-76. 2001..MR techniques will have great future in the drug discovery process and in testing the effects of drugs on myocardial biochemistry, physiology, and morphology. Molecular imaging is going to bloom in this decade...
Quantitative and qualitative characterization of the acute changes in myocardial structure and function after distal coronary microembolization using MDCTMaythem Saeed
Department of Radiology and Biomedical Imaging, University of California, San Francisco, 94107 5705, USA
Acad Radiol 18:479-87. 2011..To determine the potential of multidetector computed tomography (MDCT) in assessing, at 72 hours, the effects of distal coronary microembolization on myocardial structure and function...
Noninvasive MR characterization of structural and functional components of reperfused infarctMaythem Saeed
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107 5705, USA
Acta Radiol 51:1093-102. 2010..left ventricular (LV) remodeling is a highly complex phenomenon that starts soon after infarction and progresses to extensive regional and global architectural changes over time...
Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imagingDemetrius L Dicks
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94143 2205, USA
J Magn Reson Imaging 30:69-76. 2009..To use velocity-encoded phase contrast (PC) MRI in assessing the effect of coronary microembolization on longitudinal and radial myocardial strain...
Percutaneous transendocardial VEGF gene therapy: MRI guided delivery and characterization of 3D myocardial strainDemetrius Dicks
Department of Radiology and Biomedical Imaging, 513 Parnassus Avenue, HSW207B, University of California, San Francisco, CA, USA
Int J Cardiol 143:255-63. 2010....
Quantitative MR measurements of regional and global left ventricular function and strain after intramyocardial transfer of VM202 into infarcted swine myocardiumMarcus Carlsson
Dept of Radiology and Biomedical Imaging, UCSF, 513 Parnassus Ave, HSW207B, San Francisco, CA 94134 0628, USA
Am J Physiol Heart Circ Physiol 295:H522-32. 2008..The combined use of cine and tagging MR imaging provides valuable information on the efficacy of gene therapy...
The potential of contrast-enhanced magnetic resonance imaging for predicting left ventricular remodelingNorbert Watzinger
Department of Radiology, University of California San Francisco, San Francisco, California 94143-0628, USA
J Magn Reson Imaging 16:633-40. 2002..The complementary use of functional and contrast-enhanced MRI may provide reliable assessment of therapeutic interventions to reduce IS and LV remodeling...
Intracoronary injection of contrast media maps the territory of the coronary artery: an MRI technique for assessing the effects of locally delivered angiogenic therapiesMarcus Carlsson
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94134 0628, USA
Acad Radiol 15:1354-9. 2008..Therefore, the aim of this study was to determine the ability of the selective injection of magnetic resonance contrast media (MR-CM) to map and quantify the territories of the major coronary arteries...
Accentuation of high susceptibility of hypertrophied myocardium to ischemia: complementary assessment of Gadophrin-enhancement and left ventricular function with MRISimon Schalla
Department of Radiology, University of California San Francisco, California 94143-0628, USA
Magn Reson Med 51:552-8. 2004..Hypertrophied hearts are more sensitive to ischemia than nonhypertrophied hearts. The complementary assessment of Gadophrin-enhancement and LV function with MRI provides unique information about myocardium sensitivity to ischemia...
Injection of adeno-associated viral vector encoding vascular endothelial growth factor gene in infarcted swine myocardium: MR measurements of left ventricular function and strainAlexis Jacquier
Department of Radiology, University of California San Francisco, 513 Parnassus Ave, HSW 207 B, San Francisco, CA 94134 0628, USA
Radiology 245:196-205. 2007....
Endovascular stents in pulmonary valve and artery in swine: feasibility study of MR imaging-guided deployment and postinterventional assessmentTitus Kuehne
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, L308, San Francisco, CA 94143-0628, USA
Radiology 226:475-81. 2003..CONCLUSION: MR imaging has the potential to guide stent placement in the pulmonary valve or artery and to evaluate flow volume within the stent lumen after the intervention...
Influence of blood-pool contrast media on MR imaging and flow measurements in the presence of pulmonary arterial stents in swineTitus Kuehne
Department of Radiology, Division of Pediatric Cardiology, University of California San Francisco, 505 Parnassus Ave, L308, San Francisco, CA 94143-0628, USA
Radiology 223:439-45. 2002..Blood-pool contrast media provide persistent signal enhancement in the pulmonary artery and, to a lesser extent, in the lumina of nitinol and platinum stents...
MR imaging assessment of the kinetics of P846, a new gadolinium-based MR contrast medium, in ischemically injured myocardiumAlexis Jacquier
Department of Radiology, University of California San Francisco, CA 94134 0628, USA
Contrast Media Mol Imaging 3:112-9. 2008..Despite lower gadolinium dose, P846 permits differentiation of viable and nonviable myocardium owing to a high contrast and a long imaging window with conventional t1-weighted SE sequence...
Noninvasive assessment of the effects of nicorandil on left ventricular volumes and function in reperfused myocardial infarctionNorbert Watzinger
Department of Radiology, University of California, San Francisco, 505 Parnassus Avenue, Room L-308, 94143-0628, USA
Cardiovasc Res 54:77-84. 2002..01). CONCLUSION: These results demonstrate that the long-term oral treatment with nicorandil started 2 days after MI attenuates left ventricular dilatation and improves cardiac function in rats with reperfused MI...
Effects of pulmonary insufficiency on biventricular function in the developing heart of growing swineTitus Kuehne
Division of Pediatric Cardiology and Department of Radiology, University of California San Francisco, San Francisco, Calif 94143, USA
Circulation 108:2007-13. 2003..CONCLUSIONS: In the young developing heart, chronic PI alters biventricular systolic function, RV myocardial contractility, and LV diastolic performance...
Balloon sizing and transcatheter closure of acute atrial septal defects guided by magnetic resonance fluoroscopy: assessment and validation in a large animal modelSimon Schalla
Department of Radiology, University of California-San Francisco, San Francisco, California 94143-0628, USA
J Magn Reson Imaging 21:204-11. 2005..CONCLUSION: Assessment and closure of small shunts with MR fluoroscopy is feasible. A barrier to the rapid implementation of transcatheter closure in patients is uncertainty about the MR safety of guidewires and device delivery systems...
Assessment of myocardial viability using standard extracellular and necrosis specific MR contrast mediaMaythem Saeed
University of California San Francisco, Department of Radiology, 94143-0628, USA
Acad Radiol 9:S84-7. 2002
Blood pool contrast-enhanced MRI detects suppression of microvascular permeability in early postinfarction reperfusion after nicorandil therapyGabriele A Krombach
Department of Radiology, University of California, San Francisco 94143-0628, USA
Magn Reson Med 47:896-902. 2002..Nicorandil suppressed microvascular permeability, reduced infarction size, and improved LV function in early postinfarction reperfusion...
Identification of residual ischemia, infarction, and microvascular impairment in revascularized myocardial infarction using 64-slice MDCTAndre D Furtado
Department of Radiology and Biomedical Imaging, University of California San Francisco, California 94134 0628, USA
Contrast Media Mol Imaging 3:198-206. 2008..In conclusion, modern MDCT has the potential to identify residual ischemia on FPP and microvascular impairment and infarction on DE images...
Steady-state imaging for visualization of endovascular interventionsAlastair J Martin
Department of Radiology, University of California San Francisco, San Francisco, California 94143, USA
Magn Reson Med 50:434-8. 2003..The addition of a blood pool agent in an in vivo model was found to be necessary for adequate visualization of a dysprosium-marked catheter...
Myocardial microinfarction after coronary microembolization in swine: MR imaging characterizationMarcus Carlsson
Department of Radiology and Biomedical Imaging, University of California San Francisco, 513 Parnassus Ave, HSW 207B, San Francisco, CA 94134, USA
Radiology 250:703-13. 2009..To use first-pass perfusion and delayed-enhanced (DE) magnetic resonance (MR) imaging for the detection of the early effects of coronary microembolization on myocardial perfusion and viability...
Experimental renal artery embolization in a combined MR imaging/angiographic unitMark W Wilson
Department of Radiology, University of California, San Francisco, 505 Parnassus Avenue, Room M 361, San Francisco, CA 94143, USA
J Vasc Interv Radiol 14:1169-75. 2003....
Distribution of intramyocardially injected extracellular MR contrast medium: effects of concentration and volumeGabriele A Krombach
Department of Radiology, University of California San Francisco, 505 Parnassus Avenue, L308, San Francisco, CA 94143-0628, USA
Eur Radiol 14:334-40. 2004..Intramyocardial injection of extracellular MR contrast media may be useful as a marker for the extent of distribution of intramyocardially delivered therapeutic solutions...
Magnetic resonance imaging quantification of left ventricular dysfunction following coronary microembolizationMarcus Carlsson
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94134, USA
Magn Reson Med 61:595-602. 2009..It also changed LV geometry and decreased radial and circumferential strain over the course of 1 week...
MR imaging of spatial extent of microvascular injury in reperfused ischemically injured rat myocardium: value of blood pool ultrasmall superparamagnetic particles of iron oxideGabriele A Krombach
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, L308, San Francisco, CA 94143-0628, USA
Radiology 225:479-86. 2002..CONCLUSION: Clariscan has potential for estimating the spatial extent of microvascular injury in ischemically injured myocardium and may be useful as a marker of microvascular injury after thrombolytic therapy...
Heterogeneous microinfarcts caused by coronary microemboli: evaluation with multidetector CT and MR imaging in a swine modelMarcus Carlsson
Department of Radiology and Biomedical Imaging and Department of Pathology, University of California, San Francisco, 185 Berry St, Suite 350, Campus Box 0946, San Francisco, CA 94107 5705, USA
Radiology 254:718-28. 2010..Conclusion: Modern multidetector CT and MR imaging are sensitive modalities with which to depict heterogeneous microinfarcts and determine regional LV dysfunction and decreased perfusion in the territory of intervention. (c) RSNA, 2010...
Contrast agents for cardiovascular magnetic resonance imaging. Current status and future directionsSimon Schalla
Department of Radiology, University of California, San Francisco, San Francisco, California, USA
Drugs R D 3:285-302. 2002..The research and development of MR contrast agents will continue at the cellular and molecular levels in the next decade...
P846, a new gadolinium based low diffusion magnetic resonance contrast agent, in characterizing occlusive infarcts, reperfused ischemic myocardium and reperfused infarcts in ratsAlexis Jacquier
Department of Radiology, University of California San Francisco, 513 Parnassus Ave, HSW 207B, San Francisco, CA 94134 0628, USA
MAGMA 21:207-18. 2008....
Adeno-associated viral vector-encoding vascular endothelial growth factor gene: effect on cardiovascular MR perfusion and infarct resorption measurements in swineMaythem Saeed
Department of Radiology, University of California San Francisco, San Francisco, CA 94134 0628, USA
Radiology 243:451-60. 2007....
Magnetic resonance--guided cardiac catheterization in a swine model of atrial septal defectSimon Schalla
Department of Radiology, University of California San Francisco, San Francisco, CA 94143-0628, USA
Circulation 108:1865-70. 2003..The combination of hemodynamic catheterization data with anatomic and functional MRI may significantly improve the evaluation of patients with congenital heart disease while avoiding radiation exposure...
Gadomer-enhanced MR imaging in the detection of microvascular obstruction: alleviation with nicorandil therapyGabriele A Krombach
Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, HSW 207B, San Francisco, CA 94143-0628, USA
Radiology 236:510-8. 2005..CONCLUSION: Gadomer-enhanced MR imaging can be used to quantify small microvascular obstruction regions 24 hours after reperfusion. Intravenous therapy with nicorandil reduces formation of microvascular obstruction regions...
Interventional cardiac magnetic resonance imagingOliver M Weber
Departments of Radiology, Electrophysiology, Medicine, and Pediatric Cardiology, University of California at San Francisco, 505 Parnassus Ave, L310 Box 0628, San Francisco, CA 94143-0628, USA
Semin Roentgenol 38:352-7. 2003
Long-term oral treatment with nicorandil prevents the progression of left ventricular hypertrophy and preserves viabilitySimon Schalla
Department of Radiology, University of California San Francisco, San Francisco, CA 94143-0628, USA
J Cardiovasc Pharmacol 45:333-40. 2005..001) than treated and control animals. MR and postmortem data showed close agreement. Nicorandil therapy prevented the development of cardiac hypertrophy and protected myocardium against ischemia...
A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysmKay Sun
Department of Surgery, University of California, San Francisco, USA
J Biomech Eng 131:111001. 2009..The computation time of less than 5 hours associated with our proposed method for estimating regional myocardial contractility in vivo makes it a potentially very useful clinical tool...
Myocardial blood flow in patients with dilated cardiomyopathy: quantitative assessment with velocity-encoded cine magnetic resonance imaging of the coronary sinusNorbert Watzinger
Department of Radiology, University of California, San Francisco, California 94143-0628, USA
J Magn Reson Imaging 21:347-53. 2005..This integrated MRI approach allows quantitative measurement of global MBF in humans and may have the potential to study the effects of pharmacological interventions on myocardial perfusion...
Thallium-like test for myocardial viability with MnDPDP-enhanced MRIMichael F Wendland
University of California San Francisco, Department of Radiology, 94143-0628, USA
Acad Radiol 9:S82-3. 2002
Chronic heart failure: global left ventricular perfusion and coronary flow reserve with velocity-encoded cine MR imaging: initial resultsGunnar K Lund
Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Rm L-308, San Francisco, CA 94143-0628, USA
Radiology 227:209-15. 2003..Impaired CFR may contribute to progressive decline in LV function in patients with chronic heart failure...
Magnetic resonance imaging as a potential gold standard for infarct quantificationMarcus Carlsson
Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA
J Electrocardiol 41:614-20. 2008..The biological rationale and technical background for detecting MI by DE-MR imaging were reviewed as well as the different approaches for quantification of the DE-MR images, exemplified by patient cases...
Endovascular interventional MRIChristine B Henk
Department of Radiology, University of California-San Francisco, San Francisco, California 94143-0628, USA
J Magn Reson Imaging 22:451-60. 2005..In this article we review the current state of the art and address the topic partly by referring to our own experiments and presenting our recent illustrations...
MR imaging in assessing cardiovascular interventions and myocardial injuryAlexis Jacquier
Department of Radiology, University of California San Francisco, CA 94134 0628, USA
Contrast Media Mol Imaging 2:1-15. 2007....
Combined pulmonary stenosis and insufficiency preserves myocardial contractility in the developing heart of growing swine at midterm follow-upTitus Kuehne
Department of Pediatrics and Radiology, University of California, San Francisco, 94143, USA
J Appl Physiol 99:1422-7. 2005..05) compared with control animals at 3-mo follow-up. In the young, developing heart, chronic combined PSPI impairs biventricular systolic pump function and diastolic compliance but preserves RV myocardial contractility...
Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporineClaus U Niemann
Department of Anesthesia and Perioperative Care, University of California-San Francisco, San Francisco, CA, USA
J Pharmacol Exp Ther 302:1123-8. 2002..97; NAD(+): r = 0.82, P < 0.01). The reduction in cardiac energy metabolism before occlusion may be the cause of myocardial preservation during ischemia/reperfusion...
[New therapies for interventional cardiovascular magnetic resonance imaging]Olaf Saborowski
Department of Radiology, and Biomedical Imaging, University of California, San Francisco, CA, USA
Herz 33:323-33. 2008....
Contrast enhanced MRI of stunned myocardium using Mn-based MRI contrast mediaMichael F Wendland
Department of Radiology, University of California, San Francisco, USA
Acad Radiol 9:S341-2. 2002
Effect of potassium-channel opener therapy on reperfused infarction in hypertrophied hearts: demonstration of preconditioning by using functional and contrast-enhanced magnetic resonance imagingSimon Schalla
Department of Radiology, University of California San Francisco, San Francisco, CA 94143-0628, USA
J Cardiovasc Pharmacol Ther 9:193-202. 2004..Brief ischemia caused severe injury in hypertrophied hearts. Infusing nicorandil increased the tolerance of hypertrophied hearts to ischemia. MRI is a suitable technique for the evaluation of new therapies in LV hypertrophy...
Contrast-enhanced MR delineation of stunned myocardium with administration of MnCl(2) in ratsGabriele A Krombach
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
Radiology 230:183-90. 2004..CONCLUSION: Stunned myocardium was delineated with MnCl2-enhanced MR imaging as a hypoenhanced zone. This finding suggests that Ca2+ channel activity is diminished in stunned myocardium...
Research Grants
- MR Guided Transendocardial Angiogenic AgentsMaythem Saeed; Fiscal Year: 2007..abstract_text> ..
- MR Guided Transendocardial Angiogenic AgentsMaythem Saeed; Fiscal Year: 2007..abstract_text> ..
