Research Topics
Species | Alfredo A SadunSummaryAffiliation: University of Southern California Country: USA Publications
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Publications
Abnormalities of the optic discAlfredo A Sadun
Departments of Ophthalmology and Neurosurgery, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
Handb Clin Neurol 102:117-57. 2011..OCT can therefore be used to quantitate pathology or the response to therapy in various generalized CNS conditions, such as multiple sclerosis...- Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathyAlfredo A Sadun
Doheny Eye Institute, Department of Ophthalmology, USC Keck School of Medicine, 1450 San Pablo St, Los Angeles, CA 90089 0228, USA
Arch Neurol 69:331-8. 2012..To evaluate the safety and efficacy of a new therapeutic agent, EPI-743, in Leber hereditary optic neuropathy (LHON) using standard clinical, anatomic, and functional visual outcome measures... 
Extensive investigation of a large Brazilian pedigree of 11778/haplogroup J Leber hereditary optic neuropathyAlfredo A Sadun
Keck University of Southern California School of Medicine Doheny Eye Institute, Los Angeles, CA 90033, USA
Am J Ophthalmol 136:231-8. 2003..To conduct systematic epidemiologic, neuro-ophthalmologic, psychophysical, and mitochondrial DNA (mtDNA) genetic examinations on a newly identified pedigree with Leber hereditary optic neuropathy (LHON)...
A very large Brazilian pedigree with 11778 Leber's hereditary optic neuropathyAlfredo A Sadun
University of Southern California Keck School of Medicine Doheny Eye Institute, Los Angeles, USA
Trans Am Ophthalmol Soc 100:169-78; discussion 178-9. 2002..We conducted extensive epidemiological, neuro-ophthalmological, psychophysical, and blood examinations on a newly discovered, very large pedigree with molecular analysis showing mtDNA mutation for Leber's hereditary optic neuropathy (LHON)...- Subclinical carriers and conversions in Leber hereditary optic neuropathy: a prospective psychophysical studyAlfredo A Sadun
Keck USC School of Medicine Doheny Eye Institute, Los Angeles, California, USA
Trans Am Ophthalmol Soc 104:51-61. 2006.... - TNF-alpha-induced optic nerve degeneration and nuclear factor-kappaB p65Yasushi Kitaoka
Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Invest Ophthalmol Vis Sci 47:1448-57. 2006..To characterize a model of optic nerve axonal degeneration induced by tumor necrosis factor (TNF)-alpha and to determine the role of nuclear factor (NF)-kappaB p65 in axonal degeneration... - Association between retinal nerve fiber layer thickness and abnormalities of vision in people with human immunodeficiency virus infectionPartho S Kalyani
Ocular Inflammatory Disease Center, Jules Stein Eye Institute and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7003, USA
Am J Ophthalmol 153:734-42, 742.e1. 2012.... - Nuclear factor-kappaB p65 and upregulation of interleukin-6 in retinal ischemia/reperfusion injury in ratsJiantao Wang
Department of Ophthalmology, Doheny Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Brain Res 1081:211-8. 2006..These findings support the hypothesis that upregulation of endogenous retinal IL-6 in retinal I/R injury in microglial/phagocytic cells is controlled predominantly by NF-kappaB p65... - Mathematically modeling the involvement of axons in Leber's hereditary optic neuropathyBilly X Pan
Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Invest Ophthalmol Vis Sci 53:7608-17. 2012..The present study seeks to predict the order of axonal loss in LHON optic nerves using the Nerve Fiber Layer Stress Index (NFL-S(I)), which is a novel mathematical model... - Multifocal electroretinography in HIV-positive patients without infectious retinitisIryna A Falkenstein
Joan and Irwin Jacobs Retina Center, Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, La Jolla, California 92093, USA
Am J Ophthalmol 146:579-88. 2008..To evaluate early changes in the central retinal response in human immunodeficiency virus (HIV)-positive patients without infectious retinitis using multifocal electroretinography (mfERG)... - Patterns of ganglion cell complex and nerve fiber layer loss in nonarteritic ischemic optic neuropathy by Fourier-domain optical coherence tomographyDivya Aggarwal
Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA
Invest Ophthalmol Vis Sci 53:4539-45. 2012..To characterize by Fourier-domain optical coherence tomography (FD-OCT) the loss of nerve fiber layer (NFL) and ganglion cell complex (GCC) in nonarteritic ischemic optic neuropathy (NAION)... - Novel 3D computer-automated threshold Amsler grid visual field testing of scotomas in patients with glaucomaDieuthu T Nguyen
Doheny Eye Institute and Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USA
Eur J Ophthalmol 19:776-82. 2009..Three-dimensional (3D) computer-automated threshold Amsler grid testing was used to identify and characterize scotomas typical of glaucoma... - Leber hereditary optic neuropathy possibly triggered by exposure to tire fireRuben N Sanchez
Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
J Neuroophthalmol 26:268-72. 2006..All three had been exposed to smoke from two large rubber tire fires within the previous 24 months, suggesting the possibility of an epigenetic triggering factor... - Morphometric analysis of optic nerves and retina from an end-stage retinitis pigmentosa patient with an implanted active epiretinal arrayJeffrey G Eng
Doheny Eye Institute, Los Angeles, California 90033, USA
Invest Ophthalmol Vis Sci 52:4610-6. 2011..To characterize optic nerve and retinal changes in a patient with end-stage retinitis pigmentosa (RP) with an implanted active epiretinal array... - Neuron-specific enolase is elevated in asymptomatic carriers of Leber's hereditary optic neuropathyKenneth M Yee
Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Invest Ophthalmol Vis Sci 53:6389-92. 2012..We hypothesize that increased levels of blood NSE may characterize LHON carriers as a biomarker of ongoing RGC stress... - Vision function in HIV-infected individuals without retinitis: report of the Studies of Ocular Complications of AIDS Research GroupWilliam R Freeman
Joan and Irwin Jacobs Retina Center, Department of Ophthalmology, University of California, San Diego, La Jolla, California 92037, USA
Am J Ophthalmol 145:453-462. 2008..To evaluate the prevalence and risk factors for vision loss in patients with clinical or immunologic AIDS without infectious retinitis... - Low-density lipoprotein receptor-related protein is decreased in optic neuropathy of Alzheimer diseaseLloyd M Cuzzo
Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 0228, USA
J Neuroophthalmol 31:139-46. 2011..As a key player in the reaction to central nervous system injury, astrocytes associate with LRP in AD. This study investigates the role of LRP and astrocytes in the pathogenesis of AD optic neuropathy... - Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseasesYimin Wang
Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Invest Ophthalmol Vis Sci 52:840-5. 2011..To investigate blood flow changes in retinal and optic nerve diseases with Doppler Fourier domain optical coherence tomography (OCT)... - Receptor for advanced glycation end products is upregulated in optic neuropathy of Alzheimer's diseaseMichelle Y Wang
Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Acta Neuropathol 118:381-9. 2009..The up-regulation of RAGE in the AD optic nerves indicates that RAGE may play a role in the pathophysiology of AD optic neuropathy... - Early detection of glaucoma by means of a novel 3D computer-automated visual field testPaul P Nazemi
Doheny Eye Institute and Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA
Br J Ophthalmol 91:1331-6. 2007..Further, the location, shape and depth of these field defects were characterised. Finally, the visual fields were compared with those obtained by standard automated perimetry... - Mitochondrial dysfunction as a cause of optic neuropathiesValerio Carelli
Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
Prog Retin Eye Res 23:53-89. 2004.... - Risk factors for ethambutol optic toxicityKatherine Anne Talbert Estlin
Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Int Ophthalmol 30:63-72. 2010..Optic neuropathy is a well-known complication of ethambutol therapy and usually manifests as a decrease in visual acuity, cecocentral scotomas, and deficits in color vision... - Correlation of Fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathyTarek Alasil
Department of Ophthalmology, University of Southern California, Los Angeles, California, USA
Ophthalmic Surg Lasers Imaging 39:S71-9. 2008..To correlate peripapillary retinal nerve fiber layer (NFL) loss and visual field defects in nonarteritic ischemic optic neuropathy (NAION)... - Optical coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathyChristopher I Zoumalan
Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1355 San Pablo St, DVRC 311, Los Angeles, CA 90033, USA
Graefes Arch Clin Exp Ophthalmol 243:410-6. 2005..However, early on, when the toxic optic neuropathy is mild and partly reversible, the funduscopic findings are often subtle and easy to miss... - Devastating complications from alcohol cauterization of recurrent Rathke cleft cyst. Case reportHugo Y Hsu
Department of Ophthalmology, Doheny Eye Institute, University of Southern California/Keck School of Medicine, Los Angeles, California 90033, USA
J Neurosurg 100:1087-90. 2004..The authors therefore advocate caution when attempting alcohol cauterization and advise that meticulous care be taken to ensure the patency of the cyst... - First application of extremely high-resolution magnetic resonance imaging to study microscopic features of normal and LHON human optic nerveAlfredo A Sadun
Department of Ophthalmology, Doheny Eye Institute, Keck/USC School of Medicine, Los Angeles, California 90033, USA
Ophthalmology 109:1085-91. 2002..Several atrophic lesions, normally visible only by histopathologic examination, were visualized in the Leber's optic nerve. microMRI may eventually permit the in vivo visualization of lesions in or about the optic nerve... - Review: orbital amyloidosisMehryar Taban
Doheny Eye Institute, USC School of Medicine, Los Angeles, California 90033, USA
Ophthal Plast Reconstr Surg 20:162-5. 2004 - Axonal degeneration in peripheral nerves in a case of Leber hereditary optic neuropathyLilit Mnatsakanyan
Doheny Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, California 90033, USA
J Neuroophthalmol 31:6-11. 2011..We investigated possible qualitative and quantitative histological changes in the peripheral nerve of a patient with LHON as compared to normal controls... - Hertel curve: orbital volume increment and proptosis in a cadaver modelTimothy B Neuschwander
Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Ophthal Plast Reconstr Surg 21:431-4. 2005..The predictable relation between proptosis and volume increment (Hertel curve) may be a useful tool for surgeons in planning the size of an implant required to surgically correct enophthalmos... - Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathiesValerio Carelli
Doheny Eye Institute, USC Keck School of Medicine, DVRC 311, 1355 San Pablo Street, Los Angeles, CA 90033, USA
Neurochem Int 40:573-84. 2002..Histological evidence of myelin pathology in LHON also suggests a role for oxidative stress, possibly affecting the oligodendrocytes of the optic nerves... - Death associated with an indwelling orbital catheterSumit Garg
Doheny Eye Institute, Department of Ophthalmology, Keck/USC School of Medicine, Los Angeles, California 90033, USA
Ophthal Plast Reconstr Surg 19:398-400. 2003..This may be the first report of this type of outcome when using indwelling catheters for ophthalmic surgery. We recommend that placement of orbital indwelling catheters be performed in a controlled hospital setting... - Scotomas of age-related macular degeneration detected and characterized by means of a novel three-dimensional computer-automated visual field testPaul P Nazemi
Doheny Eye Institute and Keck School of Medicine at the University of Southern California, Los Angeles, California 90033-4671, USA
Retina 25:446-53. 2005..The test shows promise as an effective tool in accurately evaluating, characterizing, and monitoring scotomas in patients with AMD. It may have the potential as a screening tool for the early diagnosis of AMD... - Metabolic optic neuropathiesAlfredo A Sadun
Department of Ophthalmology, Doheny Eye Institute, University of Southern California, 1450 San Pablo Street, Los Angeles, CA 90033, USA
Semin Ophthalmol 17:29-32. 2002.... - Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia veraKelly S Rue
Department of Neuro Ophthalmology, Doheny Eye Institute and Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Clin Ophthalmol 6:1763-5. 2012..Thus, further study is warranted to elucidate the treatment of both polycythemia vera and interferon-induced impending AION... - Mitochondrial dysfunction in optic neuropathies: animal models and therapeutic optionsValerio Carelli
aDepartment of Biomedical and NeuroMotor Sciences DiBiNeM, University of Bologna bIRCCS Istituto di Scienze Neurologiche, Bologna, Italy cDoheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Curr Opin Neurol 26:52-8. 2013..We review the recent advances in animal models generated to study the complexities of mitochondrial optic neuropathies and the therapeutic strategies proposed for these disorders... - Is Leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative caseEsfandiar J Sabet-Peyman
Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Neuroophthalmol 32:54-7. 2012..Our case report is in agreement with 2 large published series of patients with LHON treated with idebenone, raising hope for treatment of this visually devastating mitochondrial disorder... - Interleukin-6 in retinal ischemia reperfusion injury in ratsRuben N Sanchez
Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
Invest Ophthalmol Vis Sci 44:4006-11. 2003..CONCLUSIONS: IL-6 is upregulated after retinal I/R injury, and its expression by microglia/phagocytic cells may protect RGC layer neurons from I/R injury. Exogenously added IL-6 protects the inner retina after I/R injury... - Lymphoepithelial carcinoma of the lacrimal glandNarsing A Rao
Doheny Eye Institute, 1450 San Pablo St, DVR-211, Los Angeles, CA 90033, USA
Arch Ophthalmol 120:1745-8. 2002 - Leber's Hereditary Optic NeuropathyAlfredo A Sadun
Thornton Professor of Vision, Departments of Ophthalmology and Neurosurgery, Doheny Eye Institute and Keck USC School of Medicine, Los Angeles, CA, 90033, USA
Curr Treat Options Neurol 13:109-17. 2011..Other therapeutic options are under scrutiny, including gene therapy, agents increasing mitochondrial biogenesis, and anti-apoptotic drugs...