Alfredo A Sadun

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. doi request reprint Abnormalities of the optic disc
    Alfredo A Sadun
    Departments of Ophthalmology and Neurosurgery, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Handb Clin Neurol 102:117-57. 2011
  2. doi request reprint Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy
    Alfredo A Sadun
    Doheny Eye Institute, Department of Ophthalmology, USC Keck School of Medicine, 1450 San Pablo St, Los Angeles, CA 90089 0228, USA
    Arch Neurol 69:331-8. 2012
  3. ncbi request reprint Extensive investigation of a large Brazilian pedigree of 11778/haplogroup J Leber hereditary optic neuropathy
    Alfredo A Sadun
    Keck University of Southern California School of Medicine Doheny Eye Institute, Los Angeles, CA 90033, USA
    Am J Ophthalmol 136:231-8. 2003
  4. pmc A very large Brazilian pedigree with 11778 Leber's hereditary optic neuropathy
    Alfredo A Sadun
    University of Southern California Keck School of Medicine Doheny Eye Institute, Los Angeles, USA
    Trans Am Ophthalmol Soc 100:169-78; discussion 178-9. 2002
  5. pmc Subclinical carriers and conversions in Leber hereditary optic neuropathy: a prospective psychophysical study
    Alfredo A Sadun
    Keck USC School of Medicine Doheny Eye Institute, Los Angeles, California, USA
    Trans Am Ophthalmol Soc 104:51-61. 2006
  6. ncbi request reprint TNF-alpha-induced optic nerve degeneration and nuclear factor-kappaB p65
    Yasushi Kitaoka
    Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 47:1448-57. 2006
  7. doi request reprint Association between retinal nerve fiber layer thickness and abnormalities of vision in people with human immunodeficiency virus infection
    Partho S Kalyani
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7003, USA
    Am J Ophthalmol 153:734-42, 742.e1. 2012
  8. ncbi request reprint Nuclear factor-kappaB p65 and upregulation of interleukin-6 in retinal ischemia/reperfusion injury in rats
    Jiantao Wang
    Department of Ophthalmology, Doheny Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Brain Res 1081:211-8. 2006
  9. pmc Mathematically modeling the involvement of axons in Leber's hereditary optic neuropathy
    Billy X Pan
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 53:7608-17. 2012
  10. pmc Multifocal electroretinography in HIV-positive patients without infectious retinitis
    Iryna A Falkenstein
    Joan and Irwin Jacobs Retina Center, Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, La Jolla, California 92093, USA
    Am J Ophthalmol 146:579-88. 2008

Collaborators

Detail Information

Publications43

  1. doi request reprint Abnormalities of the optic disc
    Alfredo A Sadun
    Departments of Ophthalmology and Neurosurgery, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Handb Clin Neurol 102:117-57. 2011
    ..OCT can therefore be used to quantitate pathology or the response to therapy in various generalized CNS conditions, such as multiple sclerosis...
  2. doi request reprint Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy
    Alfredo A Sadun
    Doheny Eye Institute, Department of Ophthalmology, USC Keck School of Medicine, 1450 San Pablo St, Los Angeles, CA 90089 0228, USA
    Arch Neurol 69:331-8. 2012
    ..To evaluate the safety and efficacy of a new therapeutic agent, EPI-743, in Leber hereditary optic neuropathy (LHON) using standard clinical, anatomic, and functional visual outcome measures...
  3. ncbi request reprint Extensive investigation of a large Brazilian pedigree of 11778/haplogroup J Leber hereditary optic neuropathy
    Alfredo A Sadun
    Keck University of Southern California School of Medicine Doheny Eye Institute, Los Angeles, CA 90033, USA
    Am J Ophthalmol 136:231-8. 2003
    ..To conduct systematic epidemiologic, neuro-ophthalmologic, psychophysical, and mitochondrial DNA (mtDNA) genetic examinations on a newly identified pedigree with Leber hereditary optic neuropathy (LHON)...
  4. pmc A very large Brazilian pedigree with 11778 Leber's hereditary optic neuropathy
    Alfredo A Sadun
    University of Southern California Keck School of Medicine Doheny Eye Institute, Los Angeles, USA
    Trans Am Ophthalmol Soc 100:169-78; discussion 178-9. 2002
    ..We conducted extensive epidemiological, neuro-ophthalmological, psychophysical, and blood examinations on a newly discovered, very large pedigree with molecular analysis showing mtDNA mutation for Leber's hereditary optic neuropathy (LHON)...
  5. pmc Subclinical carriers and conversions in Leber hereditary optic neuropathy: a prospective psychophysical study
    Alfredo A Sadun
    Keck USC School of Medicine Doheny Eye Institute, Los Angeles, California, USA
    Trans Am Ophthalmol Soc 104:51-61. 2006
    ....
  6. ncbi request reprint TNF-alpha-induced optic nerve degeneration and nuclear factor-kappaB p65
    Yasushi Kitaoka
    Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 47:1448-57. 2006
    ..To characterize a model of optic nerve axonal degeneration induced by tumor necrosis factor (TNF)-alpha and to determine the role of nuclear factor (NF)-kappaB p65 in axonal degeneration...
  7. doi request reprint Association between retinal nerve fiber layer thickness and abnormalities of vision in people with human immunodeficiency virus infection
    Partho S Kalyani
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7003, USA
    Am J Ophthalmol 153:734-42, 742.e1. 2012
    ....
  8. ncbi request reprint Nuclear factor-kappaB p65 and upregulation of interleukin-6 in retinal ischemia/reperfusion injury in rats
    Jiantao Wang
    Department of Ophthalmology, Doheny Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Brain Res 1081:211-8. 2006
    ..These findings support the hypothesis that upregulation of endogenous retinal IL-6 in retinal I/R injury in microglial/phagocytic cells is controlled predominantly by NF-kappaB p65...
  9. pmc Mathematically modeling the involvement of axons in Leber's hereditary optic neuropathy
    Billy X Pan
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 53:7608-17. 2012
    ..The present study seeks to predict the order of axonal loss in LHON optic nerves using the Nerve Fiber Layer Stress Index (NFL-S(I)), which is a novel mathematical model...
  10. pmc Multifocal electroretinography in HIV-positive patients without infectious retinitis
    Iryna A Falkenstein
    Joan and Irwin Jacobs Retina Center, Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, La Jolla, California 92093, USA
    Am J Ophthalmol 146:579-88. 2008
    ..To evaluate early changes in the central retinal response in human immunodeficiency virus (HIV)-positive patients without infectious retinitis using multifocal electroretinography (mfERG)...
  11. doi request reprint Patterns of ganglion cell complex and nerve fiber layer loss in nonarteritic ischemic optic neuropathy by Fourier-domain optical coherence tomography
    Divya Aggarwal
    Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Invest Ophthalmol Vis Sci 53:4539-45. 2012
    ..To characterize by Fourier-domain optical coherence tomography (FD-OCT) the loss of nerve fiber layer (NFL) and ganglion cell complex (GCC) in nonarteritic ischemic optic neuropathy (NAION)...
  12. ncbi request reprint Novel 3D computer-automated threshold Amsler grid visual field testing of scotomas in patients with glaucoma
    Dieuthu T Nguyen
    Doheny Eye Institute and Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USA
    Eur J Ophthalmol 19:776-82. 2009
    ..Three-dimensional (3D) computer-automated threshold Amsler grid testing was used to identify and characterize scotomas typical of glaucoma...
  13. pmc Neuron-specific enolase is elevated in asymptomatic carriers of Leber's hereditary optic neuropathy
    Kenneth M Yee
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 53:6389-92. 2012
    ..We hypothesize that increased levels of blood NSE may characterize LHON carriers as a biomarker of ongoing RGC stress...
  14. pmc Morphometric analysis of optic nerves and retina from an end-stage retinitis pigmentosa patient with an implanted active epiretinal array
    Jeffrey G Eng
    Doheny Eye Institute, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 52:4610-6. 2011
    ..To characterize optic nerve and retinal changes in a patient with end-stage retinitis pigmentosa (RP) with an implanted active epiretinal array...
  15. ncbi request reprint Leber hereditary optic neuropathy possibly triggered by exposure to tire fire
    Ruben N Sanchez
    Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    J Neuroophthalmol 26:268-72. 2006
    ..All three had been exposed to smoke from two large rubber tire fires within the previous 24 months, suggesting the possibility of an epigenetic triggering factor...
  16. pmc Vision function in HIV-infected individuals without retinitis: report of the Studies of Ocular Complications of AIDS Research Group
    William R Freeman
    Joan and Irwin Jacobs Retina Center, Department of Ophthalmology, University of California, San Diego, La Jolla, California 92037, USA
    Am J Ophthalmol 145:453-462. 2008
    ..To evaluate the prevalence and risk factors for vision loss in patients with clinical or immunologic AIDS without infectious retinitis...
  17. pmc Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases
    Yimin Wang
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 52:840-5. 2011
    ..To investigate blood flow changes in retinal and optic nerve diseases with Doppler Fourier domain optical coherence tomography (OCT)...
  18. doi request reprint Risk factors for ethambutol optic toxicity
    Katherine Anne Talbert Estlin
    Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Int Ophthalmol 30:63-72. 2010
    ..Optic neuropathy is a well-known complication of ethambutol therapy and usually manifests as a decrease in visual acuity, cecocentral scotomas, and deficits in color vision...
  19. pmc Receptor for advanced glycation end products is upregulated in optic neuropathy of Alzheimer's disease
    Michelle Y Wang
    Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Acta Neuropathol 118:381-9. 2009
    ..The up-regulation of RAGE in the AD optic nerves indicates that RAGE may play a role in the pathophysiology of AD optic neuropathy...
  20. pmc Early detection of glaucoma by means of a novel 3D computer-automated visual field test
    Paul P Nazemi
    Doheny Eye Institute and Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA
    Br J Ophthalmol 91:1331-6. 2007
    ..Further, the location, shape and depth of these field defects were characterised. Finally, the visual fields were compared with those obtained by standard automated perimetry...
  21. pmc Low-density lipoprotein receptor-related protein is decreased in optic neuropathy of Alzheimer disease
    Lloyd M Cuzzo
    Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 0228, USA
    J Neuroophthalmol 31:139-46. 2011
    ..As a key player in the reaction to central nervous system injury, astrocytes associate with LRP in AD. This study investigates the role of LRP and astrocytes in the pathogenesis of AD optic neuropathy...
  22. ncbi request reprint Mitochondrial dysfunction as a cause of optic neuropathies
    Valerio Carelli
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Prog Retin Eye Res 23:53-89. 2004
    ....
  23. ncbi request reprint Optical coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathy
    Christopher I Zoumalan
    Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1355 San Pablo St, DVRC 311, Los Angeles, CA 90033, USA
    Graefes Arch Clin Exp Ophthalmol 243:410-6. 2005
    ..However, early on, when the toxic optic neuropathy is mild and partly reversible, the funduscopic findings are often subtle and easy to miss...
  24. pmc Correlation of Fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathy
    Tarek Alasil
    Department of Ophthalmology, University of Southern California, Los Angeles, California, USA
    Ophthalmic Surg Lasers Imaging 39:S71-9. 2008
    ..To correlate peripapillary retinal nerve fiber layer (NFL) loss and visual field defects in nonarteritic ischemic optic neuropathy (NAION)...
  25. doi request reprint Drug-related mitochondrial optic neuropathies
    Michelle Y Wang
    Department of Ophthalmology, USC School of Medicine, Los Angeles, California 90033, USA
    J Neuroophthalmol 33:172-8. 2013
    ..PMB fibers are most susceptible to injury as they are small, unmyelinated, and have high-energy demands. These optic neuropathies share a presumed common pathophysiology of mitochondrial dysfunction...
  26. doi request reprint Optic nerve histopathology in a case of Wolfram Syndrome: a mitochondrial pattern of axonal loss
    Fred N Ross-Cisneros
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Mitochondrion 13:841-5. 2013
    ..This arrangement of axonal degeneration, involving primarily the papillomacular bundle, closely resembled LHON and other mitochondrial optic neuropathies, supporting that mitochondrial dysfunction underlies its pathogenesis. ..
  27. ncbi request reprint Devastating complications from alcohol cauterization of recurrent Rathke cleft cyst. Case report
    Hugo Y Hsu
    Department of Ophthalmology, Doheny Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    J Neurosurg 100:1087-90. 2004
    ..The authors therefore advocate caution when attempting alcohol cauterization and advise that meticulous care be taken to ensure the patency of the cyst...
  28. ncbi request reprint First application of extremely high-resolution magnetic resonance imaging to study microscopic features of normal and LHON human optic nerve
    Alfredo A Sadun
    Department of Ophthalmology, Doheny Eye Institute, Keck USC School of Medicine, Los Angeles, California 90033, USA
    Ophthalmology 109:1085-91. 2002
    ..To apply new methods in magnetic resonance imaging (MRI) in resolving the histoarchitecture of the human optic nerve obtained from normal individuals and a Leber's hereditary optic neuropathy (LHON) case...
  29. ncbi request reprint Review: orbital amyloidosis
    Mehryar Taban
    Doheny Eye Institute, USC School of Medicine, Los Angeles, California 90033, USA
    Ophthal Plast Reconstr Surg 20:162-5. 2004
  30. ncbi request reprint Hertel curve: orbital volume increment and proptosis in a cadaver model
    Timothy B Neuschwander
    Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Ophthal Plast Reconstr Surg 21:431-4. 2005
    ..This study examined the relation between effective orbital volume increment and proptosis induced by an inflatable orbital implant in a human cadaver orbit...
  31. pmc Axonal degeneration in peripheral nerves in a case of Leber hereditary optic neuropathy
    Lilit Mnatsakanyan
    Doheny Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles, California 90033, USA
    J Neuroophthalmol 31:6-11. 2011
    ..We investigated possible qualitative and quantitative histological changes in the peripheral nerve of a patient with LHON as compared to normal controls...
  32. doi request reprint Bilateral oedipism
    Simon R Bababeygy
    Department of Ophthalmology, Doheny Eye Institute at University of Southern California, Los Angeles, CA 90033, USA
    Ophthal Plast Reconstr Surg 29:e11-2. 2013
    ..Examination revealed bilateral no light perception, fixed dilated pupils, complete ptosis, and complete ophthalmoplegia. The patient was admitted to the psychiatric ward and her vision and cranial nerve deficits did not improve...
  33. ncbi request reprint Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies
    Valerio Carelli
    Doheny Eye Institute, USC Keck School of Medicine, DVRC 311, 1355 San Pablo Street, Los Angeles, CA 90033, USA
    Neurochem Int 40:573-84. 2002
    ..Histological evidence of myelin pathology in LHON also suggests a role for oxidative stress, possibly affecting the oligodendrocytes of the optic nerves...
  34. ncbi request reprint Scotomas of age-related macular degeneration detected and characterized by means of a novel three-dimensional computer-automated visual field test
    Paul P Nazemi
    Doheny Eye Institute and Keck School of Medicine at the University of Southern California, Los Angeles, California 90033 4671, USA
    Retina 25:446-53. 2005
    ..We used the recently devised three-dimensional computer-based threshold Amsler grid test to acquire and identify typical patterns of visual field defects (scotomas) caused by age-related macular degeneration (AMD)...
  35. ncbi request reprint Death associated with an indwelling orbital catheter
    Sumit Garg
    Doheny Eye Institute, Department of Ophthalmology, Keck USC School of Medicine, Los Angeles, California 90033, USA
    Ophthal Plast Reconstr Surg 19:398-400. 2003
    ..This may be the first report of this type of outcome when using indwelling catheters for ophthalmic surgery. We recommend that placement of orbital indwelling catheters be performed in a controlled hospital setting...
  36. ncbi request reprint Metabolic optic neuropathies
    Alfredo A Sadun
    Department of Ophthalmology, Doheny Eye Institute, University of Southern California, 1450 San Pablo Street, Los Angeles, CA 90033, USA
    Semin Ophthalmol 17:29-32. 2002
    ....
  37. doi request reprint Mitochondrial optic neuropathies: our travels from bench to bedside and back again
    Alfredo A Sadun
    Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Clin Experiment Ophthalmol 41:702-12. 2013
    ..Basic science questions are often best answered by that extraordinary experiment of nature that we call clinical disease, and clinical questions are often best tested in the laboratory. ..
  38. pmc Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera
    Kelly S Rue
    Department of Neuro Ophthalmology, Doheny Eye Institute and Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Clin Ophthalmol 6:1763-5. 2012
    ..Thus, further study is warranted to elucidate the treatment of both polycythemia vera and interferon-induced impending AION...
  39. doi request reprint Mitochondrial dysfunction in optic neuropathies: animal models and therapeutic options
    Valerio Carelli
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
    Curr Opin Neurol 26:52-8. 2013
    ..We review the recent advances in animal models generated to study the complexities of mitochondrial optic neuropathies and the therapeutic strategies proposed for these disorders...
  40. doi request reprint Is Leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case
    Esfandiar J Sabet-Peyman
    Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Neuroophthalmol 32:54-7. 2012
    ..Our case report is in agreement with 2 large published series of patients with LHON treated with idebenone, raising hope for treatment of this visually devastating mitochondrial disorder...
  41. ncbi request reprint Interleukin-6 in retinal ischemia reperfusion injury in rats
    Ruben N Sanchez
    Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 44:4006-11. 2003
    ..To study the role of interleukin (IL)-6 after retinal ischemia-reperfusion (I/R) injury in rats...
  42. ncbi request reprint Leber's Hereditary Optic Neuropathy
    Alfredo A Sadun
    Thornton Professor of Vision, Departments of Ophthalmology and Neurosurgery, Doheny Eye Institute and Keck USC School of Medicine, Los Angeles, CA, 90033, USA
    Curr Treat Options Neurol 13:109-17. 2011
    ..Other therapeutic options are under scrutiny, including gene therapy, agents increasing mitochondrial biogenesis, and anti-apoptotic drugs...
  43. ncbi request reprint Lymphoepithelial carcinoma of the lacrimal gland
    Narsing A Rao
    Doheny Eye Institute, 1450 San Pablo St, DVR 211, Los Angeles, CA 90033, USA
    Arch Ophthalmol 120:1745-8. 2002