Genomes and Genes
Amir A Sadighi Akha
Affiliation: University of Michigan
- Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevityAmir A Sadighi Akha
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 286:30344-51. 2011..These results, together with recent findings in Caenorhabditis elegans daf-2 mutants, point to a potential interplay between insulin/IGF-1 signals and unfolded protein response signaling...
- Enhancement of CD8 T-cell function through modifying surface glycoproteins in young and old miceAmir A Sadighi Akha
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
Immunology 119:187-94. 2006....
- CD43-independent augmentation of mouse T-cell function by glycoprotein cleaving enzymesScott B Berger
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
Immunology 119:178-86. 2006..The preferential ability of PNGase F and ST-Siase(2,3) to improve the function of T cells from aged mice may involve cleavage of glycoproteins containing alpha2,3-linked sialic acid residues on N-linked or O-linked glycans or both...
- A glycoprotein endopeptidase enhances calcium influx and cytokine production by CD4+ T cells of old and young miceScott B Berger
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA
Int Immunol 17:983-91. 2005..These data support a model in which O-glycosylated surface proteins inhibit CD4+ lymphocyte activation in both young and old mice, and in which such glycoproteins contribute to the age-related decline in cytokine production...
- Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cellsGonzalo G Garcia
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
J Immunol 179:6403-9. 2007..In addition, CD4 T cells from aged mice show defects in the Rho GTPase activities known to control ERM function...
- Life-span extension in mice by preweaning food restriction and by methionine restriction in middle ageLiou Sun
Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, 48109 2200, USA
J Gerontol A Biol Sci Med Sci 64:711-22. 2009..These results introduce new protocols that can increase maximal life span and suggest that the spectrum of metabolic changes induced by low-calorie and low-methionine diets may differ in instructive ways...
- T cells in aging mice: genetic, developmental, and biochemical analysesRichard A Miller
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, 48109, USA
Immunol Rev 205:94-103. 2005....
- Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stressAdam B Salmon
Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, USA
J Gerontol A Biol Sci Med Sci 63:232-41. 2008..The sensitivity of both Snell dwarf and NMR cells to ER stress suggests that alterations in the unfolded protein response might modulate cell survival and aging rate...
- Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in miceAmir A Sadighi Akha
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
Immunology 144:587-97. 2015..difficile infection. They also underscore the additive effects of IL-22 and CD160 in mediating both the pro-inflammatory and pro-survival aspects of the host mucosal response in this infection. ..
- Acute infection of mice with Clostridium difficile leads to eIF2α phosphorylation and pro-survival signalling as part of the mucosal inflammatory responseAmir A Sadighi Akha
Divisions of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 5642, USA
Immunology 140:111-22. 2013..difficile and highlight eIF2α phosphorylation and the interleukin-22-pSTAT3-RegIIIγ axis as two of the pathways that could be used to contain and counteract the damage inflicted on the intestinal epithelium. ..
- Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cellsGonzalo G Garcia
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
Eur J Immunol 35:622-31. 2005..These data support the idea that changes in T cell surface glycosylation could play an important role in immune senescence...
- Signal transduction in the aging immune systemAmir A Sadighi Akha
Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48109 0940, USA
Curr Opin Immunol 17:486-91. 2005..Evidence for intrinsic signal defects in aged B cells is more limited, but might involve pathways that activate the transcription factor E47, which has been implicated in somatic hypermutation and class-switch recombination...
- Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsD Thomas Rutkowski
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
PLoS Biol 4:e374. 2006..It underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome...