Amir A Sadighi Akha

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity
    Amir A Sadighi Akha
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:30344-51. 2011
  2. pmc Enhancement of CD8 T-cell function through modifying surface glycoproteins in young and old mice
    Amir A Sadighi Akha
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Immunology 119:187-94. 2006
  3. pmc CD43-independent augmentation of mouse T-cell function by glycoprotein cleaving enzymes
    Scott B Berger
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Immunology 119:178-86. 2006
  4. ncbi request reprint A glycoprotein endopeptidase enhances calcium influx and cytokine production by CD4+ T cells of old and young mice
    Scott B Berger
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA
    Int Immunol 17:983-91. 2005
  5. pmc Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells
    Gonzalo G Garcia
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    J Immunol 179:6403-9. 2007
  6. pmc Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age
    Liou Sun
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 64:711-22. 2009
  7. ncbi request reprint T cells in aging mice: genetic, developmental, and biochemical analyses
    Richard A Miller
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, 48109, USA
    Immunol Rev 205:94-103. 2005
  8. pmc Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress
    Adam B Salmon
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, USA
    J Gerontol A Biol Sci Med Sci 63:232-41. 2008
  9. ncbi request reprint Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells
    Gonzalo G Garcia
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Eur J Immunol 35:622-31. 2005
  10. pmc Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Biol 4:e374. 2006

Collaborators

Detail Information

Publications12

  1. pmc Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity
    Amir A Sadighi Akha
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:30344-51. 2011
    ..These results, together with recent findings in Caenorhabditis elegans daf-2 mutants, point to a potential interplay between insulin/IGF-1 signals and unfolded protein response signaling...
  2. pmc Enhancement of CD8 T-cell function through modifying surface glycoproteins in young and old mice
    Amir A Sadighi Akha
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Immunology 119:187-94. 2006
    ....
  3. pmc CD43-independent augmentation of mouse T-cell function by glycoprotein cleaving enzymes
    Scott B Berger
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Immunology 119:178-86. 2006
    ..The preferential ability of PNGase F and ST-Siase(2,3) to improve the function of T cells from aged mice may involve cleavage of glycoproteins containing alpha2,3-linked sialic acid residues on N-linked or O-linked glycans or both...
  4. ncbi request reprint A glycoprotein endopeptidase enhances calcium influx and cytokine production by CD4+ T cells of old and young mice
    Scott B Berger
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA
    Int Immunol 17:983-91. 2005
    ..These data support a model in which O-glycosylated surface proteins inhibit CD4+ lymphocyte activation in both young and old mice, and in which such glycoproteins contribute to the age-related decline in cytokine production...
  5. pmc Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells
    Gonzalo G Garcia
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    J Immunol 179:6403-9. 2007
    ..In addition, CD4 T cells from aged mice show defects in the Rho GTPase activities known to control ERM function...
  6. pmc Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age
    Liou Sun
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 64:711-22. 2009
    ..These results introduce new protocols that can increase maximal life span and suggest that the spectrum of metabolic changes induced by low-calorie and low-methionine diets may differ in instructive ways...
  7. ncbi request reprint T cells in aging mice: genetic, developmental, and biochemical analyses
    Richard A Miller
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, 48109, USA
    Immunol Rev 205:94-103. 2005
    ....
  8. pmc Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress
    Adam B Salmon
    Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, USA
    J Gerontol A Biol Sci Med Sci 63:232-41. 2008
    ..The sensitivity of both Snell dwarf and NMR cells to ER stress suggests that alterations in the unfolded protein response might modulate cell survival and aging rate...
  9. ncbi request reprint Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells
    Gonzalo G Garcia
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Eur J Immunol 35:622-31. 2005
    ..These data support the idea that changes in T cell surface glycosylation could play an important role in immune senescence...
  10. pmc Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Biol 4:e374. 2006
    ..It underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome...
  11. ncbi request reprint Signal transduction in the aging immune system
    Amir A Sadighi Akha
    Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48109 0940, USA
    Curr Opin Immunol 17:486-91. 2005
    ..Evidence for intrinsic signal defects in aged B cells is more limited, but might involve pathways that activate the transcription factor E47, which has been implicated in somatic hypermutation and class-switch recombination...
  12. doi request reprint Acute infection of mice with Clostridium difficile leads to eIF2α phosphorylation and pro-survival signalling as part of the mucosal inflammatory response
    Amir A Sadighi Akha
    Divisions of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Immunology 140:111-22. 2013
    ..difficile and highlight eIF2α phosphorylation and the interleukin-22-pSTAT3-RegIIIγ axis as two of the pathways that could be used to contain and counteract the damage inflicted on the intestinal epithelium. ..