Research Topics
| M S SacksSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Multiaxial mechanical behavior of biological materialsMichael S Sacks
Engineered Tissue Mechanics Laboratory, McGowan Institute for Regenerative Medicine and the Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
Annu Rev Biomed Eng 5:251-84. 2003..The focus of this review is to describe the application of multiaxial testing techniques to soft tissues and their relation to modern biomechanical constitutive theories...
Heart valve function: a biomechanical perspectiveMichael S Sacks
Engineered Tissue Mechanics and Mechanobiology Laboratory, Department of Bioengineering and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Philos Trans R Soc Lond B Biol Sci 362:1369-91. 2007..While we focus on the work from the authors' respective laboratories, the works of most investigators known to the authors have been included whenever appropriate. We conclude with a summary and underscore important future trends...- Incorporation of experimentally-derived fiber orientation into a structural constitutive model for planar collagenous tissuesMichael S Sacks
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, Room 749 Benedum Hall, 3700 Ohara St, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Biomech Eng 125:280-7. 2003..This result supports the assumption of affine strain to estimate the fiber strains. However, future evaluations will have to be performed for tissue subjected to a wider range of strain to more fully validate the current approach... - A structural model for the flexural mechanics of nonwoven tissue engineering scaffoldsGeorge C Engelmayr
Engineered Tissue Mechanics Laboratory, Department of Bioengineering and McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
J Biomech Eng 128:610-22. 2006..These important results underscore the need for structural approaches in modeling the effects of engineered tissue formation on nonwoven scaffolds, and their potential utility in scaffold design... - Surface strains in the anterior leaflet of the functioning mitral valveM S Sacks
Engineered Tissue Mechanics Laboratory, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Ann Biomed Eng 30:1281-90. 2002..These studies represent a first step in improving our understanding of normal MV function and to help establish the principles for repair and replacement... - In vivo biomechanical assessment of triglycidylamine crosslinked pericardiumMichael S Sacks
Department of Bioengineering, Engineered Tissue Mechanics Laboratory, McGowan Institute for Regenerative Medicine, 100 Technology Drive, Room 234, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 28:5390-8. 2007..We conclude that TGA-MABP crosslinked bovine pericardium, when subjected to in vivo BHV stress levels in a blood-contacting environment, maintains stable functionality... - Bioprosthetic heart valve heterograft biomaterials: structure, mechanical behavior and computational simulationMichael S Sacks
Engineered Tissue Mechanics Laboratory, Department of Bioengineering and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Expert Rev Med Devices 3:817-34. 2006.... - In-vivo dynamic deformation of the mitral valve anterior leafletMichael S Sacks
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
Ann Thorac Surg 82:1369-77. 2006..However, these data do not presently exist. In the present study, a sheep model and sonomicrometry were used to compute the in-surface Eulerian strain tensor of the anterior leaflet over the cardiac cycle at varying afterloads... 
Bioengineering challenges for heart valve tissue engineeringMichael S Sacks
Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pennsylvania 15219, USA
Annu Rev Biomed Eng 11:289-313. 2009..Overall, such approaches need to be structured to address these fundamental issues to lay the basis for TEHVs that can be developed and designed according to truly sound scientific and engineering principles...- On the biomechanics of heart valve functionMichael S Sacks
Department of Bioengineering, Engineered Tissue Mechanics and Mechanobiology Laboratory, The McGowan Institute, University of Pittsburgh, Pittsburgh, PA, United States
J Biomech 42:1804-24. 2009..While we focus on the work from the author's laboratories, relevant works of other investigators have been included whenever appropriate. We conclude with a summary of important future trends... - Simulated bioprosthetic heart valve deformation under quasi-static loadingWei Sun
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
J Biomech Eng 127:905-14. 2005..The present study also underscores the need for rigorous experimentation and accurate constitutive models in simulating BHV function and design... - Biaxial mechanical response of bioprosthetic heart valve biomaterials to high in-plane shearWei Sun
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
J Biomech Eng 125:372-80. 2003..The results of this study underscore the limited predictive ability of current soft tissue models, and the need to collect experimental data for soft tissue simulations over the complete functional range... - The effects of collagen fiber orientation on the flexural properties of pericardial heterograft biomaterialsAli Mirnajafi
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, McGowan Institute for Regenerative Medicine, Room 234, 100 Technology Drive, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 26:795-804. 2005..These findings can be used to guide the development of novel chemical treatment methods that seek to optimize biomechanical properties of heterograft biomaterials... - The relation between collagen fibril kinematics and mechanical properties in the mitral valve anterior leafletJun Liao
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
J Biomech Eng 129:78-87. 2007..These unique mechanical characteristics are likely necessary for normal valvular function... - A method for planar biaxial mechanical testing that includes in-plane shearM S Sacks
Department of Bioengineering, University of Pittsburgh, PA 15261, USA
J Biomech Eng 121:551-5. 1999..Further, the method is very general and can be applied to any anisotropic planar tissue that has identifiable material axes... - Prediction of extracellular matrix stiffness in engineered heart valve tissues based on nonwoven scaffoldsGeorge C Engelmayr
Engineered Tissue Mechanics Laboratory ETML, Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
Biomech Model Mechanobiol 7:309-21. 2008.... - Fiber kinematics of small intestinal submucosa under biaxial and uniaxial stretchThomas W Gilbert
Department of Bioengineering, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
J Biomech Eng 128:890-8. 2006..Nonaffine structural models will be necessary to fully predict the fiber kinematics under large uniaxial strains in SIS... - On the biaxial mechanical properties of the layers of the aortic valve leafletJohn A Stella
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
J Biomech Eng 129:757-66. 2007.... - Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications for engineered heart valve tissuesGeorge C Engelmayr
Engineering Tissue Mechanics Laboratory, Department of Bioengineering and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
Biomaterials 27:6083-95. 2006..We thus demonstrated that cyclic flexure and laminar flow can synergistically accelerate BMSC-mediated tissue formation, providing a basis for the rational design of in vitro conditioning regimens for BMSC-seeded TEHV... - A novel flex-stretch-flow bioreactor for the study of engineered heart valve tissue mechanobiologyGeorge C Engelmayr
Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
Ann Biomed Eng 36:700-12. 2008..We conclude that the present design provides a robust tool for the study of mechanical stimuli on in vitro engineered heart valve tissue formation... - Age dependency of the biaxial biomechanical behavior of human abdominal aortaJonathan P Vande Geest
Department of Surgery, Division of Vascular Surgery, University of Pittfsburgh, Pittsburgh, PA 15219, USA
J Biomech Eng 126:815-22. 2004..Such information may be useful for the clinician or researcher in identifying key changes in the biomechanical response of abdominal aorta in the presence of an aneurysm... - In-situ deformation of the aortic valve interstitial cell nucleus under diastolic loadingHsiao Ying Shadow Huang
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
J Biomech Eng 129:880-89. 2007.... - Effects of boundary conditions on the estimation of the planar biaxial mechanical properties of soft tissuesWei Sun
Engineered Tissue Mechanics Laboratory, Department of Bioengineerirng, University of Pittsburgh, Pittsburgh, PA, USA
J Biomech Eng 127:709-15. 2005.... - Effects of collagen fiber orientation on the response of biologically derived soft tissue biomaterials to cyclic loadingTiffany L Sellaro
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Biomed Mater Res A 80:194-205. 2007..Taken as a whole, the results of this study suggest that initial collagen orientation plays a critical role in bioprosthetic heart valve biomaterial fatigue response... - Planar biaxial creep and stress relaxation of the mitral valve anterior leafletJonathan S Grashow
Department of Bioengineering, Engineered Tissue Mechanics Laboratory, University of Pittsburgh, 100 Technology Drive, Room 234, PA 15219, USA
Ann Biomed Eng 34:1509-18. 2006..Moreover, insight into these specialized characteristics can help guide and inform efforts directed toward surgical repair and engineered valvular tissue replacements... - The effects of aneurysm on the biaxial mechanical behavior of human abdominal aortaJonathan P Vande Geest
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Biomech 39:1324-34. 2006..It was concluded that aneurysmal degeneration of the abdominal aorta is associated with an increase in mechanical anisotropy, with preferential stiffening in the circumferential direction... - Molecular orientation of collagen in intact planar connective tissues under biaxial stretchJun Liao
Department of Bioengineering and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Acta Biomater 1:45-54. 2005..The results of this first study suggest that collagen fiber/molecular kinematics under biaxial stretch are more complex than under uniaxial deformation, and warrant future studies... - The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissueGeorge C Engelmayr
Engineered Tissue Mechanics Laboratory, McGowan Institute for Regenerative Medicine and the Department of Bioengineering, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
Biomaterials 26:175-87. 2005..These results show that cyclic flexure can have independent effects on TEHV cell and ECM development, and may be useful in predicting the mechanical properties of TEHV constructed using novel scaffold materials... - Cyclic loading response of bioprosthetic heart valves: effects of fixation stress state on the collagen fiber architectureSarah M Wells
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Room 234, Pittsburgh, PA 15219, USA
Biomaterials 26:2611-9. 2005..Our findings also suggest that without in vivo remodeling, any collagenous tissue used to fabricate BHV may undergo similar degenerative, irreversible changes in vivo... - Effects of cyclic flexural fatigue on porcine bioprosthetic heart valve heterograft biomaterialsAli Mirnajafi
Cardiovascular Biomechanics Laboratory, Department of Bioengineering and the McGowan Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
J Biomed Mater Res A 94:205-13. 2010..c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010... - A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterialsGeorge C Engelmayr
Engineered Tissue Mechanics Laboratory, McGowan Institute for Regenerative Medicine, Department of Bioengineering, University of Pittsburgh, 100 Technology Drive, Room 250, Pittsburgh, PA 15219, USA
Biomaterials 24:2523-32. 2003.... - Effects of fixation pressure on the biaxial mechanical behavior of porcine bioprosthetic heart valves with long-term cyclic loadingSarah M Wells
Department of Bioengineering, University of Pittsburgh, PA 15261, USA
Biomaterials 23:2389-99. 2002..This study further underscores that chemically treated collagen fibers can undergo conformational changes under long-term cyclic loading not associated with damage... - Effects of decellularization on the mechanical and structural properties of the porcine aortic valve leafletJun Liao
Engineered Tissue Mechanics and Mechanobiology Laboratory, Department of Bioengineering and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 29:1065-74. 2008..In conclusion, changes in mechanical and structural properties of decellularized leaflets were likely associated with disruption of the ECM, which may impact the durability of the leaflets... - Design and analysis of tissue engineering scaffolds that mimic soft tissue mechanical anisotropyTodd Courtney
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 27:3631-8. 2006..The results of this study will help to provide the basis for rationally designed mechanically anisotropic soft tissue engineered implants... - Biaixal stress-stretch behavior of the mitral valve anterior leaflet at physiologic strain ratesJonathan S Grashow
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Ann Biomed Eng 34:315-25. 2006..The mechanisms underlying this quasi-elastic behavior are as yet unknown, but are likely an important functional aspect of native mitral valve tissues and clearly warrant further study... - The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cellsSharan Ramaswamy
Cardiovascular Biomechanics Laboratory, Department of Bioengineering, Swanson School of Engineering, The McGowan Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 31:1114-25. 2010.... - Viscoelastic properties of the aortic valve interstitial cellW David Merryman
Engineered Tissue Mechanics and Mechanobiology Laboratory, Department of Bioengineering, and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219
J Biomech Eng 131:041005. 2009..92% and 7.35%, respectively). We conclude that while AVIC viscoelastic effects are negligible during valve closure, they likely contribute to the deformation time-history of AVIC deformation during diastole... - Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesisW David Merryman
Dept. of Bioengineering, Univ. of Pittsburgh, Pittsburgh, PA 15219, USA
Am J Physiol Heart Circ Physiol 290:H224-31. 2006..This functional VIC stress-dependent biosynthetic relation may be crucial in maintaining valvular tissue homeostasis and also prove useful in understanding valvular pathologies... - Biaxial mechanical properties of muscle-derived cell seeded small intestinal submucosa for bladder wall reconstitutionShing-Hwa Lu
Department of Urology, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 26:443-9. 2005..These results suggest that MDC growth was supported by SIS and that initial remodeling of the SIS ECM had occurred within the first 10 days of incubation, but may have slowed once the MDC had grown to confluence within the SIS... - Changes in the biaxial viscoelastic response of the urinary bladder following spinal cord injuryJiro Nagatomi
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
Ann Biomed Eng 32:1409-19. 2004.... - Finite element implementation of a generalized Fung-elastic constitutive model for planar soft tissuesWei Sun
Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomech Model Mechanobiol 4:190-9. 2005..Moreover, since our approach is formulated within a general FE code, it can be straightforwardly adopted across multiple software platforms... - Orthotropic mechanical properties of chemically treated bovine pericardiumM S Sacks
Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA
Ann Biomed Eng 26:892-902. 1998..Thus, structural control leads to an improved understanding of chemically treated BP mechanical properties. Judicious use of this knowledge can facilitate the design and enhanced long-term performance of bioprosthetic heart valves... - Local mechanical anisotropy in human cranial dura mater allograftsM S Sacks
Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33124 0621, USA
J Biomech Eng 120:541-4. 1998..The testing methods established in this study can be used in the evaluation of new CDM processing methods and post-implant allograft mechanical integrity... - Collagen fiber disruption occurs independent of calcification in clinically explanted bioprosthetic heart valvesMichael S Sacks
Tissue Mechanics Laboratory, Department of Bioengineering, Room 749 Benedum Hall, 3500 Ohara St, University of Pittsburgh, Pittsburgh, Pennsyvlania 15261, USA
J Biomed Mater Res 62:359-71. 2002..Our results suggest a mechanism of noncalcific degradation dependent on cuspal mechanics that could contribute to porcine aortic BHV failure... - Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applicationsJianjun Guan
McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA
Biomaterials 26:3961-71. 2005..These biodegradable and flexible scaffolds demonstrate potential for future application as cell scaffolds in cardiovascular tissue engineering or other soft tissue applications... - On the mechanical role of de novo synthesized elastin in the urinary bladder wallSilvia Wognum
Department of Bioengineering, McGowan Institute, University of Pittsburgh, PA 15219, USA
J Biomech Eng 131:101018. 2009..In conclusion, our results suggest that the urinary bladder responds to prolonged periods of high strain by increasing its effective compliance through the interaction between collagen and de novo synthesized elastic fibers... - The collagen fibers of the anteroinferior capsulolabrum have multiaxial orientation to resist shoulder dislocationRichard E Debski
Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, PO Box 71199, Pittsburgh, PA 15213, USA
J Shoulder Elbow Surg 12:247-52. 2003..Moreover, a biomechanical evaluation of the anteroinferior capsulolabrum that investigates the possibility that the mechanical properties may be directionally independent should be conducted... - The flexural rigidity of the aortic valve leaflet in the commissural regionAli Mirnajafi
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, 100 Technology Drive, Room 234, Pittsburgh, PA 15219, USA
J Biomech 39:2966-73. 2006..From a valve design perspective, these findings can be used as design criteria in fabricating prosthetic devices AV resulting in better functional performance... - The biomechanical effects of fatigue on the porcine bioprosthetic heart valveM S Sacks
Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, Room 749 Benedum Hall, 3700 Ohara St, Pittsburgh, PA 15261, USA
J Long Term Eff Med Implants 11:231-47. 2001..We discuss the implications of these results that point toward the development of chemical-treatment methods that seek to maintain the integrity of the amorphous extracellular matrix to ultimately extend BHV long-term durability... - In vivo three-dimensional surface geometry of abdominal aortic aneurysmsM S Sacks
Department of Bioengineering, University of Pittsburgh, PA 15261, USA
Ann Biomed Eng 27:469-79. 1999..Our results indicate that AAA surface geometry is highly complex and cannot be simulated by simple axisymmetric models, and suggests an equally complex wall stress distribution... - Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblastW David Merryman
Engineered Tissue Mechanics Laboratory, Department of Bioengineering and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Cardiovasc Pathol 16:268-76. 2007..Therefore, we hypothesized that isolated and combined treatments of cyclic tension and transforming growth factor-beta1 would alter the phenotype and subsequent collagen biosynthesis of aortic valve interstitial cells in situ... - Time-dependent biaxial mechanical behavior of the aortic heart valve leafletJohn A Stella
Engineered Tissue Mechanics Laboratory, Department of Bioengineering and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
J Biomech 40:3169-77. 2007..These mechanisms are an important functional aspect of native valvular tissues, and are likely critical to improve our understanding of valvular disease and help guide the development of valvular tissue engineering and surgical repair... - Tissue-to-cellular level deformation coupling in cell micro-integrated elastomeric scaffoldsJohn A Stella
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 29:3228-36. 2008..This result has fundamental implications when attempting to elucidate the events of de-novo tissue development and remodeling in engineered tissues, which are thought to depend substantially on cellular deformations... - Design and hydrodynamic evaluation of a novel pulsatile bioreactor for biologically active heart valvesDaniel K Hildebrand
Engineered Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
Ann Biomed Eng 32:1039-49. 2004..Extensive testing and evaluation demonstrated the device's ability to subject a biologically active heart valve to highly controlled pulsatile waveforms that can be modulated during the course of sterile incubation... - Generating elastin-rich small intestinal submucosa-based smooth muscle constructs utilizing exogenous growth factors and cyclic mechanical stimulationRebecca Long Heise
Engineered Tissue Mechanics and Mechanobiology Laboratory, Department of Bioengineering and McGowan Institute, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
Tissue Eng Part A 15:3951-60. 2009..Moreover, our results suggest that a strategy involving growth factors and controlled mechanical stimulation may be used to engineer functional, elastin-rich tissue replacements using decellularized biologically derived scaffolds... - On the biomechanical function of scaffolds for engineering load-bearing soft tissuesJohn A Stella
Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
Acta Biomater 6:2365-81. 2010.... - The role of MMP-I up-regulation in the increased compliance in muscle-derived stem cell-seeded small intestinal submucosaRebecca A Long
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 27:2398-404. 2006..These findings suggest that the release of MMP-I in response to initial seeding on SIS and subsequent breakdown of collagen fibers is the mechanism responsible for an increase in mechanical compliance... - Stability and function of glycosaminoglycans in porcine bioprosthetic heart valvesJoshua J Lovekamp
Cardiovascular Implant Research Laboratory, Department of Bioengineering, Clemson University, 501 Rhodes Engineering Research Center, Clemson, SC 29634, USA
Biomaterials 27:1507-18. 2006..Controlling the extent of pre-implantation GAG degradation in BHVs and development of improved GAG crosslinking techniques are expected to improve the mechanical durability of future cardiovascular bioprostheses... - Biodegradable poly(ether ester urethane)urea elastomers based on poly(ether ester) triblock copolymers and putrescine: synthesis, characterization and cytocompatibilityJianjun Guan
McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA
Biomaterials 25:85-96. 2004.... - Biomechanics of the fetal membrane prior to mechanical failure: review and implicationsErinn M Joyce
The Swanson School of Engineering, Department of Bioengineering, and the McGowan Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA
Eur J Obstet Gynecol Reprod Biol 144:S121-7. 2009..This integrated approach will further the understanding of this unique physiological event and thereby provide insight into how to anticipate and when appropriate, intervene to prevent preterm FM rupture... - Functional collagen fiber architecture of the pulmonary heart valve cuspErinn M Joyce
Department of Bioengineering and the McGowan Institute, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
Ann Thorac Surg 87:1240-9. 2009..This necessity is especially the case for novel tissue-engineered PV, which rely on extensive in-vivo remodeling for long-term function... - Effects of cell seeding and cyclic stretch on the fiber remodeling in an extracellular matrix-derived bioscaffoldTan D Nguyen
Department of Bioengineering, Musculoskeletal Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Tissue Eng Part A 15:957-63. 2009..The better-aligned ECM-SIS has the prospect of eliciting improved effects on enhancing the healing of ligaments and tendons... - Scale-dependent fiber kinematics of elastomeric electrospun scaffolds for soft tissue engineeringJohn A Stella
Department of Bioengineering, Swanson School of Engineering and the McGowan Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
J Biomed Mater Res A 93:1032-42. 2010.... - Synthesis, characterization, and cytocompatibility of elastomeric, biodegradable poly(ester-urethane)ureas based on poly(caprolactone) and putrescineJianjun Guan
McGowan Institute for Regenerative Medicine, University of Pittsburgh, 300 Technology Drive, Pennsylvania 15219, USA
J Biomed Mater Res 61:493-503. 2002..01) and >160% (p < 0.001) of polystyrene on RGDS-modified PEUUs. These biodegradable PEUUs demonstrate potential for future application as cell scaffolds in cardiovascular tissue-engineering or other soft-tissue applications... - Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrixThomas W Gilbert
McGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 29:4775-82. 2008..There are distinct differences in the mechanical behavior of different layers of ECM from the porcine urinary bladder, and the processing methods can substantially alter the mechanical behavior observed... - Contribution of the extracellular matrix to the viscoelastic behavior of the urinary bladder wallJiro Nagatomi
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomech Model Mechanobiol 7:395-404. 2008..e., smooth muscle hypertrophy and altered ECM synthesis) under various pathological conditions... - In vivo dynamic deformation of the mitral valve annulusChad E Eckert
Engineered Tissue Mechanics and Mechanobiology Laboratory, Department of Bioengineering, Swanson School of Engineering, The McGowan Institute, School of Medicine, University of Pittsburgh, 100 Technology Drive, Room 234, Pittsburgh, PA 15219, USA
Ann Biomed Eng 37:1757-71. 2009.... - Passive biaxial mechanical properties of the rat bladder wall after spinal cord injuryD Claire Gloeckner
Department of Bioengineering (Tissue Mechanics Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Urol 167:2247-52. 2002..These changes represent an important component of the bladder response to spinal cord injury... - Experimentally tractable, pseudo-elastic constitutive law for biomembranes: II. ApplicationJohn C Criscione
Dept of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
J Biomech Eng 125:100-5. 2003..This paper illustrates the experimental advantages of this novel constitutive theory via analysis of biaxial test data obtained from chemically treated bovine pericardium... - The material properties of the native porcine mitral valve chordae tendineae: an in vitro investigationJennifer Ritchie
Wallace H. Coulter, Department of Biomedical Engineering, Cardiovascular Fluid Mechanics Laboratory, Georgia Institute of Technology, Emory University, 313 Ferst Drive, Room 2119, Atlanta, GA 30332, USA
J Biomech 39:1129-35. 2006..In conclusion, a non-destructive technique was developed to measure in vitro chordal strain in the mitral valve. This technique allows the investigation of the behavior of biological tissues under physiologic loading conditions... - An experimentally derived stress resultant shell model for heart valve dynamic simulationsHyunggun Kim
Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
Ann Biomed Eng 35:30-44. 2007.... - In vitro dynamic strain behavior of the mitral valve posterior leafletZhaoming He
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, Atlanta, GA 30332 0535, USA
J Biomech Eng 127:504-11. 2005..We conclude that PM positions may influence the posterior strain in a different way as compared to the anterior leaflet... - Dynamic simulation pericardial bioprosthetic heart valve functionHyunggun Kim
Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
J Biomech Eng 128:717-24. 2006..Dynamic simulations with experimentally determined leaflet material specification can be potentially used to modify the valve towards an optimal design to minimize regions of stress concentration and structural failure... - Transforming growth factor-beta1 modulates extracellular matrix production, proliferation, and apoptosis of endothelial progenitor cells in tissue-engineering scaffoldsVirna L Sales
Department of Cardiac Surgery, Children's Hospital Boston, 300 Longwood Ave, Boston, Massachusetts 02115, USA
Circulation 114:I193-9. 2006.... - From stem cells to viable autologous semilunar heart valveFraser W H Sutherland
Department of Cardiothoracic Surgery, Children s Hospital, Boston, Mass, USA
Circulation 111:2783-91. 2005..Recent advances in tissue engineering and our understanding of stem cell biology may provide a lifelong solution to these problems... - Effect of length of the engineered tendon construct on its structure-function relationships in cultureVictor S Nirmalanandhan
Department of Biomedical Engineering, University of Cincinnati, 2901 Woodside Drive, 827 Engineering Research Center, Cincinnati, OH 45221 0048, USA
J Biomech 40:2523-9. 2007..0404). We now plan to use principles of functional tissue engineering to determine if repairs containing central regions of longer MSC-collagen constructs improve defect repair biomechanics after implantation at surgery... - Experimentally tractable, pseudo-elastic constitutive law for biomembranes: I. TheoryJohn C Criscione
Dept of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
J Biomech Eng 125:94-9. 2003..This paper is part 1 of 2 with "I. Theory" and "II. Application.".. - Effects of papillary muscle position on in-vitro dynamic strain on the porcine mitral valveZhaoming He
Cardiovascular Fluid Mechanics Laboratory, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332-0535, USA
J Heart Valve Dis 12:488-94. 2003..The slack PM position led to a delay in complete valve closure and more rapid leaflet loading in late systole. This increase in loading rate may have long-term consequences in MV function... - Protein precoating of elastomeric tissue-engineering scaffolds increased cellularity, enhanced extracellular matrix protein production, and differentially regulated the phenotypes of circulating endothelial progenitor cellsVirna L Sales
Department of Cardiac Surgery, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Circulation 116:I55-63. 2007..We assessed the effect of different protein precoatings on a single scaffold type (elastomeric poly (glycerol sebacate)) with a single cell source (endothelial progenitor cells)... - Prevention of polyurethane valve cusp calcification with covalently attached bisphosphonate diethylamino moietiesIvan Alferiev
Division of Cardiology, The Children's Hospital of Philadelphia, Abramson Research Bldg, 3516 Civic Center Blvd, Philadelphia, Pennsylvania 19104-4318, USA
J Biomed Mater Res A 66:385-95. 2003..CONCLUSION: DBP polyurethane possesses physical (water absorption) and biomechanical properties comparable to unmodified polyurethane and can resist intrinsic heart-valve leaflet calcification in blood-stream implants... - The effects of anisotropy on the stress analyses of patient-specific abdominal aortic aneurysmsJonathan P Vande Geest
Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson, AZ 85721, USA
Ann Biomed Eng 36:921-32. 2008..non-ruptured AAAs, the lower p-value when using the anisotropic model suggests including it into patient-specific AAAs may help better identify AAAs at high risk... - Dynamic simulation of bioprosthetic heart valves using a stress resultant shell modelHyunggun Kim
Department of Biomedical Engineering, College of Engineering, University of Iowa, 1402 SC, Iowa City, IA 52242, USA
Ann Biomed Eng 36:262-75. 2008..It is expected that the developed experimental and computational methodology will aid in the understanding of the complex dynamic behavior of native and bioprosthetic valves and in the development of tissue engineered valve substitutes... - Biomechanics of engineered heart valve tissuesMichael S Sacks
Conf Proc IEEE Eng Med Biol Soc 1:853-4. 2006..The purpose of this paper is to present a review of the structure-strength relationships for native and engineered heart valve tissues...
Research Grants
- Biomechanical optimization of TE heart valvesMichael S Sacks; Fiscal Year: 2010..Specific Aim 3 - Evaluate the EPC-seeded ES-PEUU scaffold's ability to perform in-vivo using a single leaflet model. ..
- Mechanisms of In-Vivo Remodeling in Tissue Engineered Heart ValvesMichael Sacks; Fiscal Year: 2007..Relevance to public health includes the develop of valved pulmonary conduits for the pediatric population that can grow with the patient, minimizing the need for continued re-operations to bring the patient to adulthood. ..
- Training in Biomechanics in Regenerative MedicineMichael Sacks; Fiscal Year: 2007..Coursework includes intensive life science, and biomechanics is utilized to provide the students with a thorough grounding in both areas. Skills acquired in these courses are combined in later courses and the trainees' research. ..
- Biomechanical optimization of TE heart valvesMichael Sacks; Fiscal Year: 2007..Specific Aim 3 - Evaluate the EPC-seeded ES-PEUU scaffold's ability to perform in-vivo using a single leaflet model. ..
- Biomechanical optimization of TE heart valvesMichael Sacks; Fiscal Year: 2004..3) Perform in-vitro evaluation of TEHV fabricated using optimal scaffold designs and 3D guided RV outflow track geometry using novel bioreactor loop imaging system. ..
- ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVESMichael Sacks; Fiscal Year: 2004..Determine how chemical treatment alters cuspal layer micromechanics. 2. Quantify PBHV cuspal deformation during the cardiac cycle. 3. Determine how long-term cyclic fatigue alters PBHV later structure and mechanical properties. ..
- Mechanisms of In-Vivo Remodeling in Tissue Engineered Heart ValvesMichael S Sacks; Fiscal Year: 2010..Relevance to public health includes the develop of valved pulmonary conduits for the pediatric population that can grow with the patient, minimizing the need for continued re-operations to bring the patient to adulthood. ..