Genomes and Genes
Affiliation: University of Alabama at Birmingham
- Menstrual blood as a potential source of endometrial derived CD3+ T cellsSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 6:e28894. 2011..These data may open new avenues of investigation for cell mediated immune studies involving the female reproductive tract without the need for biopsies...
- Glycoprotein B vaccine is capable of boosting both antibody and CD4 T-cell responses to cytomegalovirus in chronically infected womenSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
J Infect Dis 203:1534-41. 2011..These data suggest that this vaccine is capable of boosting immunity in a population of CMV-infected women and warrants additional evaluation to determine whether these boosted responses may prevent mother to child transmission of CMV...
- Cross-reactive CD8+ T cell epitopes identified in US adolescent minoritiesSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Acquir Immune Defic Syndr 33:426-38. 2003..Frequent recognition of several of these CTL epitopes in persons of diverse racial backgrounds bodes well for the development of a broadly reactive HIV-1 vaccine...
- Functionally competent antigen-specific CD127(hi) memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatmentSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
J Infect Dis 195:108-17. 2007..These studies show that functionally competent subsets of antigen-specific memory CD8+ T cells in HIV-infected individuals are maintained but only if control of viremia is attained early during the course of infection...
- T cell responses in HIV type 1-infected adolescent minorities share similar epitope specificities with whites despite significant differences in HLA class I allelesAnju Bansal
Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
AIDS Res Hum Retroviruses 19:1017-26. 2003..Hence host genetic variation among different racial groups may have less impact on the utility of candidate HIV-1 vaccines than previously suspected...
- CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptidesAnju Bansal
Department of Medicine, University of Alabama at Birmingham, 20th Street South, Birmingham, AL 35294, USA
AIDS 19:241-50. 2005..To understand the mechanisms underlying the differential targeting of T-cell responses during HIV-1 disease progression...
- CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcriptionAnju Bansal
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Exp Med 207:51-9. 2010..These findings indicate that the HIV-1 genome might encode and deploy a large potential repertoire of unconventional epitopes to enhance vaccine-induced antiviral immunity...
- Breast milk-derived antigen-specific CD8+ T cells: an extralymphoid effector memory cell population in humansSteffanie Sabbaj
Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
J Immunol 174:2951-6. 2005..These results demonstrate a population of extralymphoid CD8(+) T cells with an effector memory phenotype in humans, which could contribute to enhanced local virologic control and the relative lack of HIV transmission via this route...
- Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell helpMichael J Fuller
Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
J Immunol 174:5926-30. 2005..Analyses of cytokine-producing activities by both mouse and human CD8 T cells further document that the extended maintenance of T cells in a CD127(low) state has functional consequences which manifest as an impairment of IL-2 production...
- Human immunodeficiency virus-specific CD8(+) T cells in human breast milkSteffanie Sabbaj
Departments of Medicine, University of Alabama at Birmingham, 35294 2170, USA
J Virol 76:7365-73. 2002..Their presence suggests a role in limiting transmission and provides a rationale for vaccine strategies to enhance these responses...
- Hormonal contraception and HIV-1 infection: medroxyprogesterone acetate suppresses innate and adaptive immune mechanismsRichard P H Huijbregts
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
Endocrinology 154:1282-95. 2013..The presented results suggest that MPA suppresses both innate and adaptive arms of the immune system resulting in a reduction of host resistance to invading pathogens...
- Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersLatonya D Williams
University of Alabama at Birmingham, Department of Medicine, Birmingham, AL 35294, USA
J Virol 85:2316-24. 2011..Our results demonstrate that HIV-1-specific IL-21-producing CD8 T cells are induced following primary infection and enriched in elite controllers, suggesting a critical role for these cells in the maintenance of viremia control...
- Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppressionOlusimidele T Akinsiku
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
J Acquir Immune Defic Syndr 58:132-40. 2011..To further investigate this, we measured the capacity of virus-specific CD8 T cells to inhibit HIV-1 replication in an in vitro suppression assay...
- HIV-specific CD8+ T cells from elite controllers are primed for survivalJiyu Yan
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Virol 87:5170-81. 2013..Furthermore, a better understanding of cellular markers that can be utilized to predict response durability in disease- or vaccine-elicited responses will advance the field...
- CD8 T-cell proliferative capacity is compromised in primary HIV-1 infectionSonya L Heath
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
J Acquir Immune Defic Syndr 56:213-21. 2011..Furthermore, the heterogeneity of this population suggests that a simple measure of an effective vaccine response remains elusive...
- Immune activation is associated with CD8 T cell interleukin-21 production in HIV-1-infected individualsLatonya D Williams
Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Virol 88:10259-63. 2014..Instead, IL-21 production by CD8 T cells was associated with high levels of activation, suggesting that these cells emerge as a consequence of excessive chronic immune activation rather than CD4 lymphopenia. ..
- Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individualsJiri Mestecky
Departments of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
AIDS Res Hum Retroviruses 20:972-88. 2004..Therefore, in striking contrast to other mucosally encountered microbial infections, HIV-1 does not induce vigorous specific IgA responses in any body fluid examined or in ASC in peripheral blood...
- Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasmaBradley H Edwards
Department of Medicine, University of Alabama, 845 19th Street South, BBRB 226, Birmingham, AL 35294, USA
J Virol 76:2298-305. 2002..These data serve as strong evidence that major histocompatibility complex class I presentation of Gag peptides is an essential feature for any HIV-1 vaccine designed to elicit optimal CD8+ T-cell responses...
- Dimorphic HLA-B signal peptides differentially influence HLA-E- and natural killer cell-mediated cytolysis of HIV-1-infected target cellsA M Merino
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
Clin Exp Immunol 174:414-23. 2013..Overall, our experiments indicate that the anti-HIV-1 function mediated by NK cells is compromised by P2-M, corroborating the association of HLA-B genotype encoding P2-M with accelerated HIV-1 acquisition. ..
- Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitisYudong Liu
Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294
J Immunol 192:59-72. 2014..Inhibition of the JAK/STAT pathway has clinical efficacy in multiple preclinical models of MS, suggesting the feasibility of the JAK/STAT pathway as a target for neuroinflammatory diseases. ..
- Host factor transcriptional regulation contributes to preferential expression of HIV type 1 in IL-4-producing CD4 T cellsMingce Zhang
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Immunol 189:2746-57. 2012....