Stefan W Ryter

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance
    Stefan W Ryter
    Department of Medicine, University of Pittsburgh Medical Center, PA 15213, USA
    Mol Cell Biochem 234:249-63. 2002
  2. ncbi request reprint Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1
    Hong Pyo Kim
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 175:2622-9. 2005
  3. ncbi request reprint Mitogen activated protein kinase (MAPK) pathway regulates heme oxygenase-1 gene expression by hypoxia in vascular cells
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 4:587-92. 2002
  4. ncbi request reprint Heme oxygenase-1: molecular mechanisms of gene expression in oxygen-related stress
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, MUH628NW, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 4:625-32. 2002
  5. ncbi request reprint Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Physiol Rev 86:583-650. 2006
  6. ncbi request reprint Carbon monoxide in biology and medicine
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, PA, USA
    Bioessays 26:270-80. 2004
  7. pmc FLIP protects against hypoxia/reoxygenation-induced endothelial cell apoptosis by inhibiting Bax activation
    Xue Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, 3459 Fifth Ave, MUH NW 628, Pittsburgh, PA 15213, USA
    Mol Cell Biol 25:4742-51. 2005
  8. doi request reprint The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1
    Xiao Mei Wang
    Division of Pulmonary, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 182:3809-18. 2009
  9. pmc Carbon monoxide prevents ventilator-induced lung injury via caveolin-1
    Alexander Hoetzel
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 37:1708-15. 2009
  10. pmc Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1
    Yang Jin
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 39:171-9. 2008

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance
    Stefan W Ryter
    Department of Medicine, University of Pittsburgh Medical Center, PA 15213, USA
    Mol Cell Biochem 234:249-63. 2002
    ..By virtue of these effects, CO confers protection in oxidative lung injury models, and likely plays a role in HO-1 mediated tissue protection...
  2. ncbi request reprint Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1
    Hong Pyo Kim
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 175:2622-9. 2005
    ..These data provide a novel mechanism for the protective effects of CO and underscore a potential application of this gaseous molecule in anti-inflammatory therapies...
  3. ncbi request reprint Mitogen activated protein kinase (MAPK) pathway regulates heme oxygenase-1 gene expression by hypoxia in vascular cells
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 4:587-92. 2002
    ..These results suggest a relationship between MAPK and hypoxic regulation of ho-1 in vascular cells, involving AP-1...
  4. ncbi request reprint Heme oxygenase-1: molecular mechanisms of gene expression in oxygen-related stress
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, MUH628NW, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 4:625-32. 2002
    ..This review will examine the potential roles of iron, glutathione, and reactive oxygen species in the upstream events leading to ho-1 activation following oxygen related stress...
  5. ncbi request reprint Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Physiol Rev 86:583-650. 2006
    ..Finally, this presentation aspires to lay a foundation for potential future clinical applications of these systems...
  6. ncbi request reprint Carbon monoxide in biology and medicine
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, PA, USA
    Bioessays 26:270-80. 2004
    ..This review will delve into the biological significance and medical applications of this gas molecule...
  7. pmc FLIP protects against hypoxia/reoxygenation-induced endothelial cell apoptosis by inhibiting Bax activation
    Xue Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, 3459 Fifth Ave, MUH NW 628, Pittsburgh, PA 15213, USA
    Mol Cell Biol 25:4742-51. 2005
    ..The inhibitory effects of FLIP on Bax activation and plasma membrane DISC formation may play significant roles in protecting endothelial cells from the lethal effects of hypoxia/reoxygenation...
  8. doi request reprint The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1
    Xiao Mei Wang
    Division of Pulmonary, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 182:3809-18. 2009
    ..Upon LPS stimulation, HO-1 trafficked to the caveolae by a p38 MAPK-dependent mechanism, where it down-regulated proinflammatory signaling. These results reveal an anti-inflammatory network involving cav-1 and HO-1...
  9. pmc Carbon monoxide prevents ventilator-induced lung injury via caveolin-1
    Alexander Hoetzel
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 37:1708-15. 2009
    ..We sought to determine the role of caveolin-1 in lung susceptibility to VILI in mice. Furthermore, we assessed the role of caveolin-1 in the tissue-protective effects of CO in the VILI model...
  10. pmc Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1
    Yang Jin
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 39:171-9. 2008
    ..These studies identify caveolin-1 as a novel component involved in hyperoxia-induced lung injury...
  11. ncbi request reprint FLIP inhibits endothelial cell apoptosis during hyperoxia by suppressing Bax
    Xue Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, 3459 Fifth Avenue, MUH 628NW, Pittsburgh, PA 15213, USA
    Free Radic Biol Med 42:1599-609. 2007
    ..In conclusion, FLIP exerted novel inhibitory effects on extrinsic and intrinsic apoptotic pathways, which significantly protected endothelial cells from the lethal effects of hyperoxia...
  12. ncbi request reprint Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation
    Xue Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 282:1718-26. 2007
    ..We also show that carbon monoxide promoted an interaction of heme oxygenase-1 with Bax. These results define novel mechanisms underlying the antiapoptotic effects of carbon monoxide during hyperoxic stress...
  13. ncbi request reprint Bcl-XL disrupts death-inducing signal complex formation in plasma membrane induced by hypoxia/reoxygenation
    Xue Wang
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    FASEB J 18:1826-33. 2004
    ..The inhibitory effects of Bcl-X(L) on DISC formation may play significant roles in protecting endothelial cells from H/R-induced cell death...
  14. ncbi request reprint Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1
    Hong Pyo Kim
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, MUH 628NW, Pittsburgh, Pennsylvania, USA
    Autophagy 4:887-95. 2008
    ..An understanding of the regulation of cell death pathways during smoke exposure may provide therapeutic strategies in smoke-related illness...
  15. ncbi request reprint Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 7:80-91. 2005
    ..HO-1 remains widely regarded as a protective mechanism against oxidative tissue injury...
  16. pmc Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1
    Alexander Hoetzel
    Department of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 177:1223-32. 2008
    ..Ventilator-induced lung injury (VILI) leads to an unacceptably high mortality. In this regard, the antiinflammatory properties of inhaled carbon monoxide (CO) may provide a therapeutic option...
  17. ncbi request reprint Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells
    Xue Wang
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 279:5237-43. 2004
    ..The inhibition of Bid/Bax-induced cell death by hepatocyte growth factor primarily involved p38 MAPK and in part Akt-dependent pathways but not ERK1/ERK2...
  18. pmc Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death
    Dirk Jan Slebos
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, MUH 628NW, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Am J Respir Cell Mol Biol 36:409-17. 2007
    ..We demonstrate the functional compartmentalization of heme oxygenase-1 in the mitochondria of lung epithelial cells, and its potential role in defense against mitochondria-mediated cell death during CSE exposure...
  19. pmc Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide
    Hong Pyo Kim
    Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 102:11319-24. 2005
    ..Thus, we demonstrate that CO, by activating p38beta MAPK, up-regulates caveolin-1, which acts as a tumor suppressor protein that mediates the growth inhibitory properties of this gas...
  20. ncbi request reprint Mechanisms of cell death in oxidative stress
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Antioxid Redox Signal 9:49-89. 2007
    ..Among these, the heme oxygenase-1/carbon monoxide system has emerged as a major intracellular antiapoptotic mechanism...
  21. doi request reprint Analyzing autophagy in clinical tissues of lung and vascular diseases
    Hong Pyo Kim
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Methods Enzymol 453:197-216. 2009
    ..This chapter provides protocols for the isolation of distinct lung cell types, such as epithelial, endothelial, macrophages, and fibroblasts; as well as protocols for the analysis of autophagy in lung cells and tissues...
  22. pmc Identifying targets for COPD treatment through gene expression analyses
    Zhi Hua Chen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Int J Chron Obstruct Pulmon Dis 3:359-70. 2008
    ..These studies have shed new light on the molecular mechanisms of COPD, and suggest novel targets for clinical treatments...
  23. pmc Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts
    Kiichi Nakahira
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 203:2377-89. 2006
    ..Thus, CO negatively controlled TLR signaling pathways by inhibiting translocation of TLR to lipid rafts through suppression of NADPH oxidase-dependent ROS generation...
  24. ncbi request reprint Carbon monoxide in sepsis
    Alexander Hoetzel
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, MUH 628 NW, 3459 Fifth Ave, Pittsburgh, Pennsylvania 15213, USA
    Antioxid Redox Signal 9:2013-26. 2007
    ..This review summarizes evidence for salutary effects of carbon monoxide in sepsis of various organs, including lung, heart, kidney, liver, and intestine, and discusses the potential translation of the data into human clinical trials...
  25. ncbi request reprint Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Antioxid Redox Signal 9:2157-73. 2007
    ..This review summarizes recent findings on the functions of heme oxygenase-1 in the respiratory system, with an emphasis on possible roles in disease progression and therapies...
  26. ncbi request reprint Caveolae compartmentalization of heme oxygenase-1 in endothelial cells
    Hong Pyo Kim
    Division of Pulmonary, Allergy, and Critical Care Medicine, Dept of Medicine, MUH 628NW, 3459 Fifth Ave, Pittsburgh, PA, 15213, USA
    FASEB J 18:1080-9. 2004
    ..We demonstrate for the first time the localization of heme degradation enzymes to plasma membrane caveolae, and present novel evidence that caveolin-1 interacts with and modulates HO activity...
  27. ncbi request reprint Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, MUH 628 NW 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Novartis Found Symp 280:165-75; discussion 175-81. 2007
    ..Additional candidate mechanisms in anti-inflammatory effects of CO include the increased expression of heat shock proteins and the tumour suppressor protein caveolin 1...
  28. pmc Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
    Zhi Hua Chen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 3:e3316. 2008
    ..Autophagy is a degradative process involving lysosomal turnover of cellular components, though its role in human diseases remains unclear...
  29. pmc Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury
    Tamas Dolinay
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 3:e1601. 2008
    ....
  30. pmc Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation
    Jin Fu Xu
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Respir Crit Care Med 185:547-56. 2012
    ..The role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in the development or progression of interstitial lung disease (ILD) is controversial...
  31. pmc Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs
    Wei Wu
    Dorothy P and Richard P Simmons Center for Interstitial Lung Disease, Div of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Physiol Genomics 36:24-34. 2008
    ..We confirmed the temporal expression changes of 12 genes (including the Esr1 gene and 4 ESR1 target genes) in intermittent hypoxia and 8 genes in sustained hypoxia with quantitative real-time PCR...
  32. ncbi request reprint Therapeutic applications of carbon monoxide in lung disease
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, MUH 628 NW, 3459 Fifth Ave, Pittsburgh PA 15213, USA
    Curr Opin Pharmacol 6:257-62. 2006
    ..Despite the success of CO therapy in animal models, the utility of CO as therapy in humans remains uncertain...
  33. pmc Carbon monoxide and bilirubin: potential therapies for pulmonary/vascular injury and disease
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, PA 15213, USA
    Am J Respir Cell Mol Biol 36:175-82. 2007
    ..Thus, the exogenous application of HO end products may provide an alternative to pharmacologic or gene therapy approaches to harness the therapeutic potential of HO-1...
  34. ncbi request reprint Heme Oxygenase-1/CO as protective mediators in cigarette smoke- induced lung cell injury and chronic obstructive pulmonary disease
    Tamas Dolinay
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Pharm Biotechnol 13:769-76. 2012
    ..To date, a single clinical trial has addressed the possible therapeutic potential of CO in COPD patients. The implications of the cytoprotective potential of HO-1/CO system in CS-induced lung injury and COPD are discussed...
  35. ncbi request reprint CO as a cellular signaling molecule
    Hong Pyo Kim
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Annu Rev Pharmacol Toxicol 46:411-49. 2006
    ..In this review, we summarize recent findings of the beneficial or detrimental effects of endogenous CO with an emphasis on the signaling pathways and downstream targets that trigger the action of this gas...
  36. ncbi request reprint Carbon monoxide: to boldly go where NO has gone before
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, MUH 628 NW, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Sci STKE 2004:RE6. 2004
    ..This review highlights new advances in the interaction of CO with cellular signaling processes...
  37. ncbi request reprint Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway
    Xue Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:29184-91. 2003
    ..We have, for the first time, identified a predominant role for the caspase-8/Bid pathway in signaling associated with hyperoxic lung injury and cell death in vivo and in vitro...
  38. ncbi request reprint Functional significance of apoptosis in chronic obstructive pulmonary disease
    Jeong Woong Park
    Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    COPD 4:347-53. 2007
    ..Therefore, understanding functional relationships between apoptosis and protease/antiprotease imbalance, inflammation, oxidative stress and other factors potentially involved in COPD pathogenesis may uncover crucial therapeutic targets...
  39. ncbi request reprint Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols
    Rajib Sengupta
    Department of Surgery, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biochemistry 46:8472-83. 2007
    ..The data obtained are discussed within the general reaction mechanisms encompassing the cellular homeostasis of S-nitrosothiols...
  40. ncbi request reprint Nitric oxide-deficiency regulates hepatic heme oxygenase-1
    Alexander Hoetzel
    Department of Anesthesiology and Critical Care Medicine, University of Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
    Nitric Oxide 18:61-9. 2008
    ..This interdependence has important implications for the development of therapeutic strategies aimed at modulating the activity of these hepatoprotective mediator systems...
  41. ncbi request reprint Hemodynamic and molecular response to intermittent hypoxia (IH) versus continuous hypoxia (CH) in normal humans
    George W Rodway
    University of Pittsburgh Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh School of Nursing corrected USA
    Transl Res 149:76-84. 2007
    ..The negative correlation between BP and iNOS mRNA with IH, but not CH, may suggest differential modulation of the hemodynamic response to the 2 exposure patterns...
  42. ncbi request reprint Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase alterations in experimental hepatopulmonary syndrome
    Junlan Zhang
    Department of Internal Medicine, Liver Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294 0005, USA
    Gastroenterology 125:1441-51. 2003
    ..Our aim was to explore the role of the heme oxygenase-1/carbon monoxide pathway in the pathogenesis of experimental hepatopulmonary syndrome...
  43. pmc Heme oxygenase-1 and carbon monoxide in pulmonary medicine
    Dirk Jan Slebos
    Department of Pulmonary Diseases, University Hospital Groningen, Groningen, The Netherlands
    Respir Res 4:7. 2003
    ..The implications of the HO-1/CO system in pulmonary diseases will be discussed in this review, with an emphasis on inflammatory states...
  44. doi request reprint Caveolin-1: a critical regulator of pulmonary vascular architecture and nitric oxide bioavailability in pulmonary hypertension
    Stefan W Ryter
    Am J Physiol Lung Cell Mol Physiol 294:L862-4. 2008
  45. ncbi request reprint Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis
    Jeong Woong Park
    Department of Pulmonary and Critical Care Medicine, Gachon Medical School, Gil Medical Center, Inchon, Republic of Korea
    J Immunol 180:4668-78. 2008
    ..These results suggest that modulation of PKC may have therapeutic potential in the prevention of smoke-related lung injury...