SEAN RYDER

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Regulation of maternal mRNAs in early development
    Brian M Farley
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Crit Rev Biochem Mol Biol 43:135-62. 2008
  2. ncbi request reprint Insights into the structural basis of RNA recognition by STAR domain proteins
    Sean P Ryder
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, LRB 906, Worcester, Massachusetts 01605, USA
    Adv Exp Med Biol 693:37-53. 2010
  3. ncbi request reprint Pumilio RNA recognition: the consequence of promiscuity
    Sean P Ryder
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, LRB 906, Worcester, MA 01605, USA
    Structure 19:277-9. 2011
  4. pmc RNA target specificity of the embryonic cell fate determinant POS-1
    Brian M Farley
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    RNA 14:2685-97. 2008
  5. pmc RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3
    John M Pagano
    Department of Biochemistry and Molecular Pharmacology, 364 Plantation Street, LRB 906, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:20252-7. 2009
  6. pmc Structure and function of nematode RNA-binding proteins
    Ebru Kaymak
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Struct Biol 20:305-12. 2010

Collaborators

  • Brian M Farley
  • John M Pagano
  • Ebru Kaymak
  • L M Wee
  • Kingsley I Essien

Detail Information

Publications6

  1. ncbi request reprint Regulation of maternal mRNAs in early development
    Brian M Farley
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Crit Rev Biochem Mol Biol 43:135-62. 2008
    ..Where possible, insights from mechanistic studies are presented...
  2. ncbi request reprint Insights into the structural basis of RNA recognition by STAR domain proteins
    Sean P Ryder
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, LRB 906, Worcester, Massachusetts 01605, USA
    Adv Exp Med Biol 693:37-53. 2010
    ..This chapter reviews the relevant literature on STAR domain protein structure and provides insights into how these proteins discriminate between different RNA sequences...
  3. ncbi request reprint Pumilio RNA recognition: the consequence of promiscuity
    Sean P Ryder
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, LRB 906, Worcester, MA 01605, USA
    Structure 19:277-9. 2011
    ..The structures suggest an appealing model where nucleotides that do not contribute to binding affinity define Pumilio regulatory activity by adopting distinctive conformations with differential ability to recruit regulatory cofactors...
  4. pmc RNA target specificity of the embryonic cell fate determinant POS-1
    Brian M Farley
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    RNA 14:2685-97. 2008
    ..The results enable prediction of novel targets that explain the pleiotropy of the pos-1 phenotype...
  5. pmc RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3
    John M Pagano
    Department of Biochemistry and Molecular Pharmacology, 364 Plantation Street, LRB 906, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:20252-7. 2009
    ..Based on this work, we identify several candidate MEX-3 targets that help explain its dual role in regulating germline stem cell totipotency and embryonic cell fate specification...
  6. pmc Structure and function of nematode RNA-binding proteins
    Ebru Kaymak
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Struct Biol 20:305-12. 2010
    ..In this review, we highlight example structures and identify the variable regions that likely contribute to functional divergence in nematodes...

Research Grants6

  1. Small molecule effectors of maternal gene expression in C. elegans embryogenesis
    SEAN RYDER; Fiscal Year: 2007
    ..Moreover, the lessons learned from this project will contribute to our understanding of the biological processes that allow stem cells to change into all types of adult cells. ..
  2. RNA recognition by maternal gene silencers in nematodes
    SEAN PATRICK RYDER; Fiscal Year: 2010
    ..Lessons learned from this project may aid in understanding human biology that contributes to inflammatory disease, neurological and psychiatric disorders, and congenital developmental abnormalities. ..
  3. RNA recognition by maternal gene silencers in nematodes
    SEAN PATRICK RYDER; Fiscal Year: 2010
    ..This work may lead to new breakthroughs relevant to polyinflammatory arthritides including rheumatoid arthritis and other autoimmune disorders including multiple sclerosis. ..