Neal D Ryan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Major depressive disorder in children and adolescents: clinical trial design and antidepressant efficacy
    Graham J Emslie
    Child and Adolescent Psychiatry Division, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
    J Clin Psychiatry 66:14-20. 2005
  2. ncbi request reprint Treatment of depression in children and adolescents
    Neal D Ryan
    University of Pittsburgh Medical Center, Pittsburgh, PA15213, USA
    Lancet 366:933-40. 2005
  3. ncbi request reprint Medication treatment for depression in children and adolescents
    Neal D Ryan
    Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
    CNS Spectr 8:283-7. 2003
  4. ncbi request reprint Child and adolescent depression: short-term treatment effectiveness and long-term opportunities
    Neal D Ryan
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Int J Methods Psychiatr Res 12:44-53. 2003
  5. pmc Negative life events in children and adolescents with bipolar disorder
    Soledad Romero
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania, USA
    J Clin Psychiatry 70:1452-60. 2009
  6. pmc Daily emotional dynamics in depressed youth: a cell phone ecological momentary assessment study
    Jennifer S Silk
    Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Child Psychol 110:241-57. 2011
  7. pmc Factors associated with the persistence and onset of new anxiety disorders in youth with bipolar spectrum disorders
    Regina Sala
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 73:87-94. 2012
  8. pmc Psychosocial functioning among bipolar youth
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
    J Affect Disord 114:174-83. 2009
  9. pmc Comorbid anxiety in children and adolescents with bipolar spectrum disorders: prevalence and clinical correlates
    Regina Sala
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 71:1344-50. 2010
  10. pmc Family environment and suicidal ideation among bipolar youth
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Arch Suicide Res 13:378-88. 2009

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Major depressive disorder in children and adolescents: clinical trial design and antidepressant efficacy
    Graham J Emslie
    Child and Adolescent Psychiatry Division, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
    J Clin Psychiatry 66:14-20. 2005
    ....
  2. ncbi request reprint Treatment of depression in children and adolescents
    Neal D Ryan
    University of Pittsburgh Medical Center, Pittsburgh, PA15213, USA
    Lancet 366:933-40. 2005
    ..Thus, there is substantial debate about the best approach to treat this serious disorder. Here, we discuss the treatment options for depression in children and adolescents...
  3. ncbi request reprint Medication treatment for depression in children and adolescents
    Neal D Ryan
    Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
    CNS Spectr 8:283-7. 2003
    ..The right approaches to these aspects of effective treatment are greatly understudied...
  4. ncbi request reprint Child and adolescent depression: short-term treatment effectiveness and long-term opportunities
    Neal D Ryan
    Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Int J Methods Psychiatr Res 12:44-53. 2003
    ....
  5. pmc Negative life events in children and adolescents with bipolar disorder
    Soledad Romero
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania, USA
    J Clin Psychiatry 70:1452-60. 2009
    ....
  6. pmc Daily emotional dynamics in depressed youth: a cell phone ecological momentary assessment study
    Jennifer S Silk
    Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Child Psychol 110:241-57. 2011
    ....
  7. pmc Factors associated with the persistence and onset of new anxiety disorders in youth with bipolar spectrum disorders
    Regina Sala
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 73:87-94. 2012
    ..Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder, but, to our knowledge, no studies examined the course of anxiety disorders in youth and adults with bipolar disorder...
  8. pmc Psychosocial functioning among bipolar youth
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
    J Affect Disord 114:174-83. 2009
    ..However, little is known about the association between psychosocial functioning and episodes of illness, demographic, and clinical variables in this population...
  9. pmc Comorbid anxiety in children and adolescents with bipolar spectrum disorders: prevalence and clinical correlates
    Regina Sala
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 71:1344-50. 2010
    ..Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder. We aimed to examine the prevalence and correlates of comorbid anxiety disorders among youth with bipolar disorder...
  10. pmc Family environment and suicidal ideation among bipolar youth
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Arch Suicide Res 13:378-88. 2009
    ..Clinicians treating bipolar youth should consider family stress when conducting suicide risk assessment. Treatment goals may include enhancing family communication and addressing issues of loss...
  11. pmc Significance of cigarette smoking among youths with bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Addict 17:364-71. 2008
    ..Daily heavy smokers had greater prevalence of SUD and suicide attempts, and worse depression versus daily light smokers. Smoking among youths with BP is independently associated with suicide attempts and SUD...
  12. pmc Expressed emotion in mothers of currently depressed, remitted, high-risk, and low-risk youth: links to child depression status and longitudinal course
    Jennifer S Silk
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Child Adolesc Psychol 38:36-47. 2009
    ..Higher initial critical expressed emotion was associated with a greater likelihood of having a future onset of a depressive episode in high-risk and depressed participants. Diagnostic groups did not differ in Emotional Overinvolvement...
  13. pmc Predictors of prospectively examined suicide attempts among youth with bipolar disorder
    Tina R Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Arch Gen Psychiatry 69:1113-22. 2012
    ..Individuals with early onset of bipolar disorder are at high risk for suicide. Yet, no study to date has examined factors associated with prospective risk for suicide attempts among youth with bipolar disorder...
  14. pmc Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depression
    Dana L McMakin
    University of Pittsburgh, Western PsychiatricInstitute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 51:404-11. 2012
    ..To identify symptom dimensions of depression that predict recovery among selective serotonin reuptake inhibitor (SSRI) treatment-resistant adolescents undergoing second-step treatment...
  15. pmc "I won, but I'm not getting my hopes up": depression moderates the relationship of outcomes and reward anticipation
    Thomas M Olino
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Psychiatry Res 194:393-5. 2011
    ..This finding has implications for understanding the developmental pathophysiology of MDD and suggests specific contexts where altered motivational system functioning may play a role in maintaining depression...
  16. pmc Preliminary findings regarding overweight and obesity in pediatric bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 69:1953-9. 2008
    ..Overweight/obesity is highly prevalent among adults with bipolar disorder and has been associated with illness severity. Little is known regarding overweight/obesity among youth with bipolar disorder...
  17. pmc A longitudinal study of childhood depression and anxiety in relation to weight gain
    Dana L Rofey
    Children s Hospital of Pittsburgh, Weight Management and Wellness Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Child Psychiatry Hum Dev 40:517-26. 2009
    ..The major finding that depression and anxiety are associated with increased BMI percentiles in a non-obese sample suggests that childhood psychopathology is an important factor that should be carefully monitored...
  18. pmc Sustained neural alterations in anxious youth performing an attentional bias task: a pupilometry study
    Rebecca B Price
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Depress Anxiety 30:22-30. 2013
    ..We investigated early, intermediate, and sustained forms of bias using behavioral measures and pupillary reactivity, an index of cognitive and affective load, to gain insight into potential neurocognitive targets for early intervention...
  19. pmc Altered error-related brain activity in youth with major depression
    Cecile D Ladouceur
    Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Dev Cogn Neurosci 2:351-62. 2012
    ....
  20. pmc Pediatric functional magnetic resonance neuroimaging: tactics for encouraging task compliance
    Michael W Schlund
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
    Behav Brain Funct 7:10. 2011
    ....
  21. pmc Reward-related brain function as a predictor of treatment response in adolescents with major depressive disorder
    Erika E Forbes
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cogn Affect Behav Neurosci 10:107-18. 2010
    ..Final levels of severity and anxiety symptoms were associated with pretreatment striatal reactivity, and rate of anxiety symptom reduction was associated with greater striatal reactivity and lower medial PFC reactivity...
  22. ncbi request reprint Clinical differences between suicidal and nonsuicidal depressed children and adolescents
    Rémy P Barbe
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 66:492-8. 2005
    ..To examine the clinical symptoms and comorbid psychiatric disorders of depressed children and adolescents with and without clinically significant suicidal ideation...
  23. pmc "You can do it!": The role of parental encouragement of bravery in child anxiety treatment
    Jennifer S Silk
    University of Pittsburgh, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Anxiety Disord 27:439-46. 2013
    ..Encouragement of bravery increased from pre- to post-treatment for youth who received CBT but not CCT, and pre-treatment encouragement of bravery predicted a better response to treatment, particularly for youth receiving CBT. ..
  24. pmc The bidirectional association between daytime affect and nighttime sleep in youth with anxiety and depression
    Jennifer C Cousins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh PA 15213, USA
    J Pediatr Psychol 36:969-79. 2011
    ..This study examines relationships between affect and sleep in youth with affective disorders using ecological momentary assessment (EMA)...
  25. pmc Substance use disorders among adolescents with bipolar spectrum disorders
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 10:469-78. 2008
    ..We set out to examine the prevalence and correlates of substance use disorders (SUD) in a large sample of adolescents with bipolar disorder (BP)...
  26. pmc Objective sleep in pediatric anxiety disorders and major depressive disorder
    Erika E Forbes
    University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 47:148-55. 2008
    ..To examine objective and subjective sleep problems in early-onset anxiety and depression...
  27. pmc Course of subthreshold bipolar disorder in youth: diagnostic progression from bipolar disorder not otherwise specified
    David A Axelson
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 50:1001-16.e3. 2011
    ....
  28. ncbi request reprint Processing emotional facial expressions influences performance on a Go/NoGo task in pediatric anxiety and depression
    Cecile D Ladouceur
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
    J Child Psychol Psychiatry 47:1107-15. 2006
    ..This study investigated whether processing emotionally salient information such as emotional facial expressions influences the performance on a cognitive control task in pediatric anxiety and depression...
  29. pmc Neural response to reward as a predictor of increases in depressive symptoms in adolescence
    Judith K Morgan
    University of Pittsburgh, Department of Psychiatry Pittsburgh, PA 15213, USA
    Neurobiol Dis 52:66-74. 2013
    ..monetary reward directly and the longitudinal assessment of parallel changes in pubertal development, neural response to reward, and depressive symptoms...
  30. pmc Weekend-weekday advances in sleep timing are associated with altered reward-related brain function in healthy adolescents
    Brant P Hasler
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA 15213, USA
    Biol Psychol 91:334-41. 2012
    ..We speculate that circadian misalignment associated with weekend shifts in sleep timing may contribute to reward-related problems such as depression and substance abuse...
  31. pmc Emotional reactivity and regulation in anxious and nonanxious youth: a cell-phone ecological momentary assessment study
    PATRICIA Z TAN
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    J Child Psychol Psychiatry 53:197-206. 2012
    ..However, no study has examined anxious youth's emotional reactivity and regulation in real-world contexts...
  32. pmc The Child Behavior Checklist (CBCL) and the CBCL-bipolar phenotype are not useful in diagnosing pediatric bipolar disorder
    Rasim Somer Diler
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Child Adolesc Psychopharmacol 19:23-30. 2009
    ..The purpose of this study was to evaluate the usefulness of the CBCL and CBCL-PBD to identify BP in children <12 years old...
  33. pmc Mother-child interactions in depressed children and children at high risk and low risk for future depression
    Laura J Dietz
    Department of Psychiatry at the University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 47:574-82. 2008
    ..To compare mother-child interactions and parenting styles in families of children with major depressive disorder, youths at high risk for depression, and healthy controls...
  34. pmc Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder
    Erika E Forbes
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Loeffler 319, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:64-73. 2009
    ..The authors tested differences in reward-related brain function in healthy and depressed adolescents, and the authors examined direct links between reward-related brain function and positive mood that occurred in real-world contexts...
  35. pmc Abnormal corpus callosum myelination in pediatric bipolar patients
    Sheila C Caetano
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Affect Disord 108:297-301. 2008
    ..Here we compared the callosal signal intensity of children and adolescents with bipolar disorder to that of matched healthy subjects, to investigate the hypothesis that callosal myelination is abnormal in pediatric bipolar patients...
  36. pmc MRI study of the cerebellum in young bipolar patients
    E Serap Monkul
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:613-9. 2008
    ..Our results are preliminary, but consistent with the findings from studies in adult bipolar patients suggesting the involvement of structural changes in cerebellar vermis in the pathophysiology of bipolar disorder...
  37. pmc Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measures
    Jennifer S Silk
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:1873-80. 2007
    ....
  38. pmc Nothing to fear? Neural systems supporting avoidance behavior in healthy youths
    Michael W Schlund
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
    Neuroimage 52:710-9. 2010
    ..The present approach may offer developmental affective neuroscience a conceptual and methodological framework for investigating avoidance in childhood anxiety...
  39. pmc LOOKING UNDER THE HOOD OF THE DOT-PROBE TASK: AN fMRI STUDY IN ANXIOUS YOUTH
    Rebecca B Price
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Depress Anxiety 31:178-87. 2014
    ..In particular, neural mechanisms of threat disengagement, a clinically relevant construct, have been inadequately explored...
  40. pmc Mom-it helps when you're right here! Attenuation of neural stress markers in anxious youths whose caregivers are present during fMRI
    Olivia L Conner
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    PLoS ONE 7:e50680. 2012
    ..Capitalizing on the ability of anxious youths to manifest low levels of anxiety-like information processing in the presence of a caregiver could help in modeling adaptive function in behavioral treatments...
  41. ncbi request reprint Measuring mood and complex behavior in natural environments: use of ecological momentary assessment in pediatric affective disorders
    David A Axelson
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    J Child Adolesc Psychopharmacol 13:253-66. 2003
    ..Potential applications of the EMA methodology to the study of neurobehavioral systems and the pathophysiology of pediatric affective disorders are discussed...
  42. ncbi request reprint Differentiating depressed adolescent 24 h cortisol secretion in light of their adult clinical outcome
    Sanjay J Mathew
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, USA
    Neuropsychopharmacology 28:1336-43. 2003
    ..Dysregulation of the HPA axis, combined with dysfunction of sleep-onset mechanisms previously reported in this same cohort, might serve as premorbid biological substrates that predict suicide attempts during follow-up...
  43. pmc A randomized controlled trial of risperidone, lithium, or divalproex sodium for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents
    Barbara Geller
    Department of Psychiatry, Washington University in St Louis, 660 S Euclid, St Louis, MO 63110, USA
    Arch Gen Psychiatry 69:515-28. 2012
    ..There was a paucity of comparative pharmacological research for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents...
  44. ncbi request reprint Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localization
    Cecile D Ladouceur
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
    J Child Psychol Psychiatry 47:1073-82. 2006
    ....
  45. ncbi request reprint Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder
    Barbara K Chen
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 56:399-405. 2004
    ....
  46. ncbi request reprint Gastrointestinal distress to serotonergic challenge: a risk marker for emotional disorder?
    John V Campo
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 42:1221-6. 2003
    ..The authors' aim was to determine whether inadvertent gastrointestinal (GI) distress to serotonergic challenge predicted future major depressive and/or anxiety disorders in exposed children...
  47. pmc Healthy adolescents' neural response to reward: associations with puberty, positive affect, and depressive symptoms
    Erika E Forbes
    University of Pittsburgh, USA
    J Am Acad Child Adolesc Psychiatry 49:162-72.e1-5. 2010
    ..The current study focused on puberty-specific changes in brain function and their association with mood...
  48. ncbi request reprint Twenty-four-hour cortisol secretion patterns in prepubertal children with anxiety or depressive disorders
    Adriana Feder
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, USA
    Biol Psychiatry 56:198-204. 2004
    ..In this study, we combined data from two independent, consecutive studies to achieve a larger sample size. Our goal was to identify potential alterations in the circadian pattern of cortisol secretion in anxious or depressed children...
  49. ncbi request reprint Positive and negative affect in depression: influence of sex and puberty
    Erika E Forbes
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1021:341-7. 2004
    ..Cortisol was generally unrelated to depression and mood. Findings are consistent with emotion-based models of depression and with the literature on depression and emotion regulation during adolescence...
  50. ncbi request reprint Psychosocial functioning in youths at high risk to develop major depressive disorder
    Boris Birmaher
    Department of Child Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 43:839-46. 2004
    ..To compare the psychosocial functioning of children and adolescents at high risk of major depressive disorder with youths with acute major depressive disorder and healthy controls...
  51. pmc Neural systems of threat processing in adolescents: role of pubertal maturation and relation to measures of negative affect
    Erika E Forbes
    Department of Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Dev Neuropsychol 36:429-52. 2011
    ..Amygdala and VLPFC reactivity were correlated with negative affect and depressive symptoms. Threat-processing changes during puberty may facilitate changes in social behavior and negative affect...
  52. ncbi request reprint First episode of depression in children at low and high familial risk for depression
    Douglas E Williamson
    Department of Child and Adolescent Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 43:291-7. 2004
    ..To examine the development of first-onset major depressive disorder (MDD) in children at high and low familial risk for depression in a prospective study...
  53. ncbi request reprint Clinical presentation and course of depression in youth: does onset in childhood differ from onset in adolescence?
    Boris Birmaher
    University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 43:63-70. 2004
    ..To simultaneously and prospectively compare the clinical presentation, course, and parental psychiatric history between children and adolescents with major depressive disorder...
  54. ncbi request reprint The stressful life events schedule for children and adolescents: development and validation
    Douglas E Williamson
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Psychiatry Res 119:225-41. 2003
    ..48). The results of this study indicate that the SLES has good psychometric properties. The SLES is a useful, cost-effective tool for assessing stressful life events in children and adolescents...
  55. ncbi request reprint Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot study
    Ronald E Dahl
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Alcohol 30:193-200. 2003
    ..75-4.50 Hz) during the second REM period. These findings are consistent with results from previous studies, demonstrating that EEG alpha power is positively associated with a family history of alcohol use disorders...
  56. pmc Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) study
    David A Brent
    University of Pittsburgh School of Medicine, Western University School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Suite 112, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 166:418-26. 2009
    ..The authors sought to identify predictors of self-harm adverse events in treatment-resistant, depressed adolescents during the first 12 weeks of treatment...
  57. ncbi request reprint Altered emotional processing in pediatric anxiety, depression, and comorbid anxiety-depression
    Cecile D Ladouceur
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Abnorm Child Psychol 33:165-77. 2005
    ..Further, research is needed to replicate this study and delineate underlying neural mechanisms...
  58. pmc Reward-related decision-making in pediatric major depressive disorder: an fMRI study
    Erika E Forbes
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15218, USA
    J Child Psychol Psychiatry 47:1031-40. 2006
    ..Depression is postulated to involve decreased activity in reward-related affective systems...
  59. ncbi request reprint Resilience among children and adolescents at risk for depression: Mediation and moderation across social and neurobiological contexts
    Jennifer S Silk
    University of Pittsburgh School of Medicine, Pittsburgh, USA
    Dev Psychopathol 19:841-65. 2007
    ..The paper concludes with a discussion of clinical implications of this approach...
  60. ncbi request reprint Stressful life events in anxious and depressed children
    Douglas E Williamson
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA Williamson
    J Child Adolesc Psychopharmacol 15:571-80. 2005
    ..The aim of this study was to examine the occurrence of stressful life events in anxious and depressed children...
  61. pmc Peri-sleep-onset cortisol levels in children and adolescents with affective disorders
    Erika E Forbes
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Biol Psychiatry 59:24-30. 2006
    ..Evidence also indicates that pubertal development may influence the expression of HPA dysregulation. We hypothesized that adolescents with depression and youth with anxiety disorders exhibit elevated peri-sleep-onset cortisol...
  62. ncbi request reprint A genetic epidemiologic perspective on comorbidity of depression and anxiety
    Douglas E Williamson
    Department of Psychiatry, University of Pittsburgh, School of Medicine Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Child Adolesc Psychiatr Clin N Am 14:707-26, viii. 2005
    ..In addition, anxious children are at increased risk for developing depression particularly during adolescence...
  63. pmc Antidepressant exposure as a predictor of clinical outcomes in the Treatment of Resistant Depression in Adolescents (TORDIA) study
    Dara J Sakolsky
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 31:92-7. 2011
    ..Antidepressant concentration may be useful in optimizing treatment for depressed adolescents receiving fluoxetine or citalopram...
  64. ncbi request reprint Superior temporal gyrus volumes in pediatric generalized anxiety disorder
    Michael D De Bellis
    University of Pittsburgh Medical Center, Developmental Traumatology Program Developmental Family Health Clinic and Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, Rm 392, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Biol Psychiatry 51:553-62. 2002
    ..Larger amygdala volumes were previously reported in pediatric GAD; however, the brain regions involved in social intelligence were not examined in this pilot study...
  65. ncbi request reprint Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study
    Hua Hsua Chen
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Neurosci Lett 363:65-8. 2004
    ..Decreased white matter connections may be the core of abnormalities in STG, which is an important region for speech, language and communication, and could possibly underlie neurocognitive deficits present in bipolar patients...
  66. ncbi request reprint Developmental abnormalities in striatum in young bipolar patients: a preliminary study
    Marsal Sanches
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Bipolar Disord 7:153-8. 2005
    ..To investigate whether these abnormalities are present early in illness course, we compared the volume of striatal structures in young bipolar patients and healthy controls...
  67. ncbi request reprint Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging study
    Marsal Sanches
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Curl Drive, San Antonio, TX 87229, USA
    Psychiatry Res 138:43-9. 2005
    ..55 +/- 73.67 mm(3), respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents...
  68. pmc History of suicide attempts in pediatric bipolar disorder: factors associated with increased risk
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Bipolar Disord 7:525-35. 2005
    ..Despite evidence indicating high morbidity associated with pediatric bipolar disorder (BP), little is known about the prevalence and clinical correlates of suicidal behavior among this population...
  69. pmc Anatomical measurements of the orbitofrontal cortex in child and adolescent patients with bipolar disorder
    Pablo Najt
    MOOD CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Neurosci Lett 413:183-6. 2007
    ..Male patients exhibit smaller gray matter volumes, while female patients exhibit larger volumes in some OFC sub-regions. Gender differences in OFC abnormalities may be involved in illness pathophysiology among young bipolar patients...
  70. ncbi request reprint Subjective sleep complaints in pediatric depression: a controlled study and comparison with EEG measures of sleep and waking
    Michele A Bertocci
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 44:1158-66. 2005
    ..This article examines subjective sleep reports of children with MDD and healthy controls focusing on comparing subjective and objective sleep measures...
  71. ncbi request reprint Heritability of fearful-anxious endophenotypes in infant rhesus macaques: a preliminary report
    Douglas E Williamson
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 53:284-91. 2003
    ..These efforts might be aided by the study of related behavioral phenotypes in model organisms, such as monkeys...
  72. ncbi request reprint The Joaquim Puig-Antich legacy
    Neal D Ryan
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    J Child Adolesc Psychopharmacol 13:223-6. 2003
  73. ncbi request reprint Growth hormone response to growth hormone-releasing hormone and clonidine in young monkeys: correlation with behavioral characteristics
    Kristine Coleman
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    J Child Adolesc Psychopharmacol 13:227-41. 2003
    ..Further studies will be necessary to determine if the characteristics of low GH responsiveness and low behavioral reactivity predict an increased propensity to develop anxious or depressive behaviors over the course of the life span...
  74. ncbi request reprint Clinical characteristics of depressive symptoms in children and adolescents with major depressive disorder
    Ozgur Yorbik
    Gulhane Military Medical Faculty, The Department of Child and Adolescent Psychiatry, Ankara, Turkey
    J Clin Psychiatry 65:1654-9; quiz 1760-1. 2004
    ..Very few studies have compared the symptoms of major depressive disorder (MDD) and rates of comorbid psychiatric disorders between depressed children and adolescents. The aim of this study was to reproduce and extend these findings...
  75. ncbi request reprint Heterogeneity in EEG sleep findings in adolescent depression: unipolar versus bipolar clinical course
    Uma Rao
    Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90024 1759, USA
    J Affect Disord 70:273-80. 2002
    ..This investigation was designed to assess whether some of the observed variability is related to undifferentiated unipolar and bipolar disorders in a sample that was reported previously...
  76. pmc Rapid eye movement sleep in relation to overweight in children and adolescents
    Xianchen Liu
    Department of Psychiatry and Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Gen Psychiatry 65:924-32. 2008
    ..Short sleep duration is associated with obesity, but few studies have examined the relationship between obesity and specific physiological stages of sleep...
  77. pmc Caffeine consumption, sleep, and affect in the natural environments of depressed youth and healthy controls
    Diana J Whalen
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Pediatr Psychol 33:358-67. 2008
    ..We examined caffeine use and its relation to sleep and affect in youth's natural environments...
  78. ncbi request reprint Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents
    J Christopher May
    Department of Psychology, New York University, New York, NY, USA
    Biol Psychiatry 55:359-66. 2004
    ....
  79. ncbi request reprint ACNP Task Force report on SSRIs and suicidal behavior in youth
    J John Mann
    Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 31:473-92. 2006
    ....
  80. doi request reprint Continuation treatment with antidepressants in child and adolescent major depression
    Neal D Ryan
    Am J Psychiatry 165:411-2. 2008
  81. ncbi request reprint Adaptive strategies for treating childhood mania
    Ree Dawson
    Frontier Science Technology and Research Foundation, Boston, Massachusetts 02215, USA
    Biol Psychiatry 61:758-64. 2007
    ..Our exposition is developed in the specific clinical context of childhood mania to maximize accessibility of the ideas but applies more generally to other chronic mental and physical health disorders that are difficult to treat...
  82. ncbi request reprint National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders
    Dennis S Charney
    Division of Intramural Research Programs, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:262-70. 2002
    ..Research is needed on the ethical conduct of studies to limit risks of medication-free intervals and facilitate poststudy treatment. Patients must fully understand the risks and lack of individualized treatment involved in research...

Research Grants4

  1. Child Intervention Prevention & Service Summer Institute
    Neal Ryan; Fiscal Year: 2007
    ..Collectively, they span the breadth of intervention, prevention, and services research, and thus can promote the development of a broader training perspective to program participants than any single training site. ..
  2. Neurobehavioral Changes in Pediatric Affective Disorder
    Neal Ryan; Fiscal Year: 2006
    ....