Research Topics
| Neal D RyanSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Major depressive disorder in children and adolescents: clinical trial design and antidepressant efficacyGraham J Emslie
Child and Adolescent Psychiatry Division, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
J Clin Psychiatry 66:14-20. 2005....- Treatment of depression in children and adolescentsNeal D Ryan
University of Pittsburgh Medical Center, Pittsburgh, PA15213, USA
Lancet 366:933-40. 2005..Thus, there is substantial debate about the best approach to treat this serious disorder. Here, we discuss the treatment options for depression in children and adolescents... - Medication treatment for depression in children and adolescentsNeal D Ryan
Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
CNS Spectr 8:283-7. 2003..The right approaches to these aspects of effective treatment are greatly understudied... - Child and adolescent depression: short-term treatment effectiveness and long-term opportunitiesNeal D Ryan
Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
Int J Methods Psychiatr Res 12:44-53. 2003.... 
Negative life events in children and adolescents with bipolar disorderSoledad Romero
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania, USA
J Clin Psychiatry 70:1452-60. 2009....- Daily emotional dynamics in depressed youth: a cell phone ecological momentary assessment studyJennifer S Silk
Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Exp Child Psychol 110:241-57. 2011.... - Factors associated with the persistence and onset of new anxiety disorders in youth with bipolar spectrum disordersRegina Sala
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 73:87-94. 2012..Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder, but, to our knowledge, no studies examined the course of anxiety disorders in youth and adults with bipolar disorder... - Psychosocial functioning among bipolar youthTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
J Affect Disord 114:174-83. 2009..However, little is known about the association between psychosocial functioning and episodes of illness, demographic, and clinical variables in this population... - Family environment and suicidal ideation among bipolar youthTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Arch Suicide Res 13:378-88. 2009..Clinicians treating bipolar youth should consider family stress when conducting suicide risk assessment. Treatment goals may include enhancing family communication and addressing issues of loss... - Expressed emotion in mothers of currently depressed, remitted, high-risk, and low-risk youth: links to child depression status and longitudinal courseJennifer S Silk
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Child Adolesc Psychol 38:36-47. 2009..Higher initial critical expressed emotion was associated with a greater likelihood of having a future onset of a depressive episode in high-risk and depressed participants. Diagnostic groups did not differ in Emotional Overinvolvement... - Comorbid anxiety in children and adolescents with bipolar spectrum disorders: prevalence and clinical correlatesRegina Sala
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 71:1344-50. 2010..Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder. We aimed to examine the prevalence and correlates of comorbid anxiety disorders among youth with bipolar disorder... - Significance of cigarette smoking among youths with bipolar disorderBenjamin I Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Am J Addict 17:364-71. 2008..Daily heavy smokers had greater prevalence of SUD and suicide attempts, and worse depression versus daily light smokers. Smoking among youths with BP is independently associated with suicide attempts and SUD... - Predictors of prospectively examined suicide attempts among youth with bipolar disorderTina R Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
Arch Gen Psychiatry 69:1113-22. 2012..Individuals with early onset of bipolar disorder are at high risk for suicide. Yet, no study to date has examined factors associated with prospective risk for suicide attempts among youth with bipolar disorder... - Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depressionDana L McMakin
University of Pittsburgh, Western PsychiatricInstitute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 51:404-11. 2012..To identify symptom dimensions of depression that predict recovery among selective serotonin reuptake inhibitor (SSRI) treatment-resistant adolescents undergoing second-step treatment... - "I won, but I'm not getting my hopes up": depression moderates the relationship of outcomes and reward anticipationThomas M Olino
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Psychiatry Res 194:393-5. 2011..This finding has implications for understanding the developmental pathophysiology of MDD and suggests specific contexts where altered motivational system functioning may play a role in maintaining depression... - Preliminary findings regarding overweight and obesity in pediatric bipolar disorderBenjamin I Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 69:1953-9. 2008..Overweight/obesity is highly prevalent among adults with bipolar disorder and has been associated with illness severity. Little is known regarding overweight/obesity among youth with bipolar disorder... - A longitudinal study of childhood depression and anxiety in relation to weight gainDana L Rofey
Children s Hospital of Pittsburgh, Weight Management and Wellness Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Child Psychiatry Hum Dev 40:517-26. 2009..The major finding that depression and anxiety are associated with increased BMI percentiles in a non-obese sample suggests that childhood psychopathology is an important factor that should be carefully monitored... - Altered error-related brain activity in youth with major depressionCecile D Ladouceur
Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Dev Cogn Neurosci 2:351-62. 2012.... - Pediatric functional magnetic resonance neuroimaging: tactics for encouraging task complianceMichael W Schlund
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
Behav Brain Funct 7:10. 2011.... - Reward-related brain function as a predictor of treatment response in adolescents with major depressive disorderErika E Forbes
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cogn Affect Behav Neurosci 10:107-18. 2010..Final levels of severity and anxiety symptoms were associated with pretreatment striatal reactivity, and rate of anxiety symptom reduction was associated with greater striatal reactivity and lower medial PFC reactivity... - Clinical differences between suicidal and nonsuicidal depressed children and adolescentsRémy P Barbe
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 66:492-8. 2005..To examine the clinical symptoms and comorbid psychiatric disorders of depressed children and adolescents with and without clinically significant suicidal ideation... - Objective sleep in pediatric anxiety disorders and major depressive disorderErika E Forbes
University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 47:148-55. 2008..To examine objective and subjective sleep problems in early-onset anxiety and depression... - Substance use disorders among adolescents with bipolar spectrum disordersBenjamin I Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Bipolar Disord 10:469-78. 2008..We set out to examine the prevalence and correlates of substance use disorders (SUD) in a large sample of adolescents with bipolar disorder (BP)... - The bidirectional association between daytime affect and nighttime sleep in youth with anxiety and depressionJennifer C Cousins
Department of Psychiatry, University of Pittsburgh, Pittsburgh PA 15213, USA
J Pediatr Psychol 36:969-79. 2011..This study examines relationships between affect and sleep in youth with affective disorders using ecological momentary assessment (EMA)... - Course of subthreshold bipolar disorder in youth: diagnostic progression from bipolar disorder not otherwise specifiedDavid A Axelson
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 50:1001-16.e3. 2011.... - Processing emotional facial expressions influences performance on a Go/NoGo task in pediatric anxiety and depressionCecile D Ladouceur
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
J Child Psychol Psychiatry 47:1107-15. 2006..This study investigated whether processing emotionally salient information such as emotional facial expressions influences the performance on a cognitive control task in pediatric anxiety and depression... - Emotional reactivity and regulation in anxious and nonanxious youth: a cell-phone ecological momentary assessment studyPATRICIA Z TAN
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
J Child Psychol Psychiatry 53:197-206. 2012..However, no study has examined anxious youth's emotional reactivity and regulation in real-world contexts... - The Child Behavior Checklist (CBCL) and the CBCL-bipolar phenotype are not useful in diagnosing pediatric bipolar disorderRasim Somer Diler
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Child Adolesc Psychopharmacol 19:23-30. 2009..The purpose of this study was to evaluate the usefulness of the CBCL and CBCL-PBD to identify BP in children <12 years old... - Mother-child interactions in depressed children and children at high risk and low risk for future depressionLaura J Dietz
Department of Psychiatry at the University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 47:574-82. 2008..To compare mother-child interactions and parenting styles in families of children with major depressive disorder, youths at high risk for depression, and healthy controls... - Altered striatal activation predicting real-world positive affect in adolescent major depressive disorderErika E Forbes
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Loeffler 319, Pittsburgh, PA 15213, USA
Am J Psychiatry 166:64-73. 2009..The authors tested differences in reward-related brain function in healthy and depressed adolescents, and the authors examined direct links between reward-related brain function and positive mood that occurred in real-world contexts... - MRI study of the cerebellum in young bipolar patientsE Serap Monkul
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:613-9. 2008..Our results are preliminary, but consistent with the findings from studies in adult bipolar patients suggesting the involvement of structural changes in cerebellar vermis in the pathophysiology of bipolar disorder... - Abnormal corpus callosum myelination in pediatric bipolar patientsSheila C Caetano
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
J Affect Disord 108:297-301. 2008..Here we compared the callosal signal intensity of children and adolescents with bipolar disorder to that of matched healthy subjects, to investigate the hypothesis that callosal myelination is abnormal in pediatric bipolar patients... - Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measuresJennifer S Silk
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:1873-80. 2007.... - Nothing to fear? Neural systems supporting avoidance behavior in healthy youthsMichael W Schlund
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh PA, USA
Neuroimage 52:710-9. 2010..The present approach may offer developmental affective neuroscience a conceptual and methodological framework for investigating avoidance in childhood anxiety... - Measuring mood and complex behavior in natural environments: use of ecological momentary assessment in pediatric affective disordersDavid A Axelson
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
J Child Adolesc Psychopharmacol 13:253-66. 2003..Potential applications of the EMA methodology to the study of neurobehavioral systems and the pathophysiology of pediatric affective disorders are discussed... - Differentiating depressed adolescent 24 h cortisol secretion in light of their adult clinical outcomeSanjay J Mathew
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, USA
Neuropsychopharmacology 28:1336-43. 2003..Dysregulation of the HPA axis, combined with dysfunction of sleep-onset mechanisms previously reported in this same cohort, might serve as premorbid biological substrates that predict suicide attempts during follow-up... - A randomized controlled trial of risperidone, lithium, or divalproex sodium for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescentsBarbara Geller
Department of Psychiatry, Washington University in St Louis, 660 S Euclid, St Louis, MO 63110, USA
Arch Gen Psychiatry 69:515-28. 2012..There was a paucity of comparative pharmacological research for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents... - Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localizationCecile D Ladouceur
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
J Child Psychol Psychiatry 47:1073-82. 2006.... - Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorderBarbara K Chen
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
Biol Psychiatry 56:399-405. 2004..48, p = .03). CONCLUSIONS: The direct correlation between left amygdala volumes and age in bipolar patients, not present in healthy control subjects, may reflect abnormal developmental mechanisms in bipolar disorder... - Sustained neural alterations in anxious youth performing an attentional bias task: a pupilometry studyRebecca B Price
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Depress Anxiety 30:22-30. 2013..We investigated early, intermediate, and sustained forms of bias using behavioral measures and pupillary reactivity, an index of cognitive and affective load, to gain insight into potential neurocognitive targets for early intervention... - Mom-it helps when you're right here! Attenuation of neural stress markers in anxious youths whose caregivers are present during fMRIOlivia L Conner
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
PLoS ONE 7:e50680. 2012..Capitalizing on the ability of anxious youths to manifest low levels of anxiety-like information processing in the presence of a caregiver could help in modeling adaptive function in behavioral treatments... - Gastrointestinal distress to serotonergic challenge: a risk marker for emotional disorder?John V Campo
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 42:1221-6. 2003..The authors' aim was to determine whether inadvertent gastrointestinal (GI) distress to serotonergic challenge predicted future major depressive and/or anxiety disorders in exposed children... - Healthy adolescents' neural response to reward: associations with puberty, positive affect, and depressive symptomsErika E Forbes
University of Pittsburgh, USA
J Am Acad Child Adolesc Psychiatry 49:162-72.e1-5. 2010..The current study focused on puberty-specific changes in brain function and their association with mood... - Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) studyDavid A Brent
University of Pittsburgh School of Medicine, Western University School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Suite 112, Pittsburgh, PA 15213 2593, USA
Am J Psychiatry 166:418-26. 2009..The authors sought to identify predictors of self-harm adverse events in treatment-resistant, depressed adolescents during the first 12 weeks of treatment... - Neural systems of threat processing in adolescents: role of pubertal maturation and relation to measures of negative affectErika E Forbes
Department of Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Dev Neuropsychol 36:429-52. 2011..Amygdala and VLPFC reactivity were correlated with negative affect and depressive symptoms. Threat-processing changes during puberty may facilitate changes in social behavior and negative affect... - Positive and negative affect in depression: influence of sex and pubertyErika E Forbes
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Ann N Y Acad Sci 1021:341-7. 2004..Cortisol was generally unrelated to depression and mood. Findings are consistent with emotion-based models of depression and with the literature on depression and emotion regulation during adolescence... - A genetic epidemiologic perspective on comorbidity of depression and anxietyDouglas E Williamson
Department of Psychiatry, University of Pittsburgh, School of Medicine Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Child Adolesc Psychiatr Clin N Am 14:707-26, viii. 2005..In addition, anxious children are at increased risk for developing depression particularly during adolescence... - The stressful life events schedule for children and adolescents: development and validationDouglas E Williamson
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Psychiatry Res 119:225-41. 2003..48). The results of this study indicate that the SLES has good psychometric properties. The SLES is a useful, cost-effective tool for assessing stressful life events in children and adolescents... - Peri-sleep-onset cortisol levels in children and adolescents with affective disordersErika E Forbes
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Biol Psychiatry 59:24-30. 2006..Evidence also indicates that pubertal development may influence the expression of HPA dysregulation. We hypothesized that adolescents with depression and youth with anxiety disorders exhibit elevated peri-sleep-onset cortisol... - Altered emotional processing in pediatric anxiety, depression, and comorbid anxiety-depressionCecile D Ladouceur
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Abnorm Child Psychol 33:165-77. 2005..Further, research is needed to replicate this study and delineate underlying neural mechanisms... - Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot studyRonald E Dahl
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Alcohol 30:193-200. 2003..75-4.50 Hz) during the second REM period. These findings are consistent with results from previous studies, demonstrating that EEG alpha power is positively associated with a family history of alcohol use disorders... - Twenty-four-hour cortisol secretion patterns in prepubertal children with anxiety or depressive disordersAdriana Feder
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, USA
Biol Psychiatry 56:198-204. 2004..These findings suggest subtle alterations in HPA axis function in prepubertal children with anxiety disorders... - Psychosocial functioning in youths at high risk to develop major depressive disorderBoris Birmaher
Department of Child Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:839-46. 2004..To compare the psychosocial functioning of children and adolescents at high risk of major depressive disorder with youths with acute major depressive disorder and healthy controls... - First episode of depression in children at low and high familial risk for depressionDouglas E Williamson
Department of Child and Adolescent Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:291-7. 2004..To examine the development of first-onset major depressive disorder (MDD) in children at high and low familial risk for depression in a prospective study... - Stressful life events in anxious and depressed childrenDouglas E Williamson
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA Williamson
J Child Adolesc Psychopharmacol 15:571-80. 2005..The aim of this study was to examine the occurrence of stressful life events in anxious and depressed children... - Clinical presentation and course of depression in youth: does onset in childhood differ from onset in adolescence?Boris Birmaher
University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:63-70. 2004..To simultaneously and prospectively compare the clinical presentation, course, and parental psychiatric history between children and adolescents with major depressive disorder... - Resilience among children and adolescents at risk for depression: Mediation and moderation across social and neurobiological contextsJennifer S Silk
University of Pittsburgh School of Medicine, Pittsburgh, USA
Dev Psychopathol 19:841-65. 2007..The paper concludes with a discussion of clinical implications of this approach... - Reward-related decision-making in pediatric major depressive disorder: an fMRI studyErika E Forbes
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15218, USA
J Child Psychol Psychiatry 47:1031-40. 2006..Depression is postulated to involve decreased activity in reward-related affective systems... - Neural response to reward as a predictor of increases in depressive symptoms in adolescenceJudith K Morgan
University of Pittsburgh, Department of Psychiatry Pittsburgh, PA 15213, USA
Neurobiol Dis 52:66-74. 2013..monetary reward directly and the longitudinal assessment of parallel changes in pubertal development, neural response to reward, and depressive symptoms... - Antidepressant exposure as a predictor of clinical outcomes in the Treatment of Resistant Depression in Adolescents (TORDIA) studyDara J Sakolsky
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Clin Psychopharmacol 31:92-7. 2011..Antidepressant concentration may be useful in optimizing treatment for depressed adolescents receiving fluoxetine or citalopram... - Developmental abnormalities in striatum in young bipolar patients: a preliminary studyMarsal Sanches
Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Bipolar Disord 7:153-8. 2005..66, p = 0.02) and left putamen (r = -0.71, p = 0.01) in bipolar patients, not present in healthy controls. CONCLUSIONS: Abnormalities in striatal development may be involved in the pathophysiology of bipolar disorder... - Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging studyMarsal Sanches
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Curl Drive, San Antonio, TX 87229, USA
Psychiatry Res 138:43-9. 2005..55 +/- 73.67 mm(3), respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents... - Superior temporal gyrus volumes in pediatric generalized anxiety disorderMichael D De Bellis
University of Pittsburgh Medical Center, Developmental Traumatology Program (Developmental Family Health Clinic and Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, Rm 392, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Biol Psychiatry 51:553-62. 2002..CONCLUSIONS: These data agree with previous work implicating posterior right-hemispheric regions in anxiety disorders and may suggest developmental alterations in pediatric GAD... - Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging studyHua Hsua Chen
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Neurosci Lett 363:65-8. 2004..Decreased white matter connections may be the core of abnormalities in STG, which is an important region for speech, language and communication, and could possibly underlie neurocognitive deficits present in bipolar patients... - History of suicide attempts in pediatric bipolar disorder: factors associated with increased riskTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Bipolar Disord 7:525-35. 2005..Despite evidence indicating high morbidity associated with pediatric bipolar disorder (BP), little is known about the prevalence and clinical correlates of suicidal behavior among this population... - Anatomical measurements of the orbitofrontal cortex in child and adolescent patients with bipolar disorderPablo Najt
MOOD CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Neurosci Lett 413:183-6. 2007..Male patients exhibit smaller gray matter volumes, while female patients exhibit larger volumes in some OFC sub-regions. Gender differences in OFC abnormalities may be involved in illness pathophysiology among young bipolar patients... - Subjective sleep complaints in pediatric depression: a controlled study and comparison with EEG measures of sleep and wakingMichele A Bertocci
University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 44:1158-66. 2005..These findings raise provocative questions regarding the nature of sleep complaints associated with early-onset depression... - The Joaquim Puig-Antich legacyNeal D Ryan
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
J Child Adolesc Psychopharmacol 13:223-6. 2003 - Heritability of fearful-anxious endophenotypes in infant rhesus macaques: a preliminary reportDouglas E Williamson
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 53:284-91. 2003..Accordingly, these phenotypes, which are believed to represent the genetic liability for anxiety and depression, are good candidates for further genetic investigation in this population... - Growth hormone response to growth hormone-releasing hormone and clonidine in young monkeys: correlation with behavioral characteristicsKristine Coleman
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
J Child Adolesc Psychopharmacol 13:227-41. 2003..Further studies will be necessary to determine if the characteristics of low GH responsiveness and low behavioral reactivity predict an increased propensity to develop anxious or depressive behaviors over the course of the life span... - Heterogeneity in EEG sleep findings in adolescent depression: unipolar versus bipolar clinical courseUma Rao
Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90024 1759, USA
J Affect Disord 70:273-80. 2002..This investigation was designed to assess whether some of the observed variability is related to undifferentiated unipolar and bipolar disorders in a sample that was reported previously... - Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescentsJ Christopher May
Department of Psychology, New York University, New York, NY, USA
Biol Psychiatry 55:359-66. 2004.... - Clinical characteristics of depressive symptoms in children and adolescents with major depressive disorderOzgur Yorbik
Gulhane Military Medical Faculty, The Department of Child and Adolescent Psychiatry, Ankara, Turkey
J Clin Psychiatry 65:1654-9; quiz 1760-1. 2004..Very few studies have compared the symptoms of major depressive disorder (MDD) and rates of comorbid psychiatric disorders between depressed children and adolescents. The aim of this study was to reproduce and extend these findings... - ACNP Task Force report on SSRIs and suicidal behavior in youthJ John Mann
Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
Neuropsychopharmacology 31:473-92. 2006.... - Rapid eye movement sleep in relation to overweight in children and adolescentsXianchen Liu
Department of Psychiatry and Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Arch Gen Psychiatry 65:924-32. 2008..Short sleep duration is associated with obesity, but few studies have examined the relationship between obesity and specific physiological stages of sleep... - Continuation treatment with antidepressants in child and adolescent major depressionNeal D Ryan
Am J Psychiatry 165:411-2. 2008 - Caffeine consumption, sleep, and affect in the natural environments of depressed youth and healthy controlsDiana J Whalen
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Pediatr Psychol 33:358-67. 2008..We examined caffeine use and its relation to sleep and affect in youth's natural environments... - National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disordersDennis S Charney
Division of Intramural Research Programs, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Arch Gen Psychiatry 59:262-70. 2002..Research is needed on the ethical conduct of studies to limit risks of medication-free intervals and facilitate poststudy treatment. Patients must fully understand the risks and lack of individualized treatment involved in research... - Adaptive strategies for treating childhood maniaRee Dawson
Frontier Science Technology and Research Foundation, Boston, Massachusetts 02215, USA
Biol Psychiatry 61:758-64. 2007..Our exposition is developed in the specific clinical context of childhood mania to maximize accessibility of the ideas but applies more generally to other chronic mental and physical health disorders that are difficult to treat...
Research Grants
- Child Intervention Prevention & Service Summer InstituteNeal Ryan; Fiscal Year: 2007..Collectively, they span the breadth of intervention, prevention, and services research, and thus can promote the development of a broader training perspective to program participants than any single training site. ..
- Neurobehavioral Changes in Pediatric Affective DisorderNeal Ryan; Fiscal Year: 2006....