Research Topics
Genomes and GenesSpecies | ALICE S contact RYANSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
The insertion/deletion polymorphism of the ACE gene is related to insulin sensitivity in overweight womenA S Ryan
Department of Medicine, Division of Gerontology at the University of Maryland School of Medicine, Baltimore, MD, USA
Diabetes Care 24:1646-52. 2001..The purpose of this study was to investigate the association of the I/D polymorphism of the ACE gene with insulin sensitivity and CHD risk factors...- Aerobic exercise is necessary to improve glucose utilization with moderate weight loss in womenAlice S Ryan
Department of Medicine, Division of Gerontology at the University of Maryland School of Medicine, VA Maryland Health Care System, Baltimore, MD 21201, USA
Obesity (Silver Spring) 14:1064-72. 2006.... - Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal womenAlice S Ryan
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Diabetes Care 27:1699-705. 2004..The purpose of this study was to determine whether improvements in insulin sensitivity with weight loss are mediated by changes in inflammation in obese, postmenopausal women... 
Exercise with calorie restriction improves insulin sensitivity and glycogen synthase activity in obese postmenopausal women with impaired glucose toleranceAlice S Ryan
Division of Gerontology, Baltimore Veterans Affairs Medical Center, 10 N Greene St, Baltimore, MD 21201, USA
Am J Physiol Endocrinol Metab 302:E145-52. 2012..We conclude that the greatest benefits at the whole body and cellular level (insulin activation of GS) in older women at highest risk for diabetes are derived from a lifestyle intervention that includes exercise and diet...- Regional bone mineral density after resistive training in young and older men and womenAlice S Ryan
Department of Medicine, University of Maryland School of Medicine, Baltimore VA Medical Center, Baltimore, MD 21201, USA
Scand J Med Sci Sports 14:16-23. 2004..The purpose of this study was to determine the effects of 6 months of whole-body resistive training (RT) on total and regional bone mineral density (BMD) and bone mineral content (BMC) by age and gender in young and older men and women... - Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal womenA S Ryan
Department of Medicine, Division of Gerontology at the University of Maryland School of Medicine, Baltimore, MD 21201, USA
Int J Obes Relat Metab Disord 27:1066-71. 2003..The purpose of this study was to determine changes in adiponectin levels with moderate weight loss, weight loss plus aerobic exercise, or weight loss plus resistive exercise in overweight and obese, sedentary postmenopausal women... - Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesityAlice S Ryan
Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Diabetes Care 26:2383-8. 2003..The purpose of this study was to determine the relationships between plasma adiponectin and leptin levels, total and central obesity, and glucose utilization across the adult age span... - Plasma adiponectin levels are associated with insulin sensitivity in stroke survivorsAlice S Ryan
Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, MD, USA
J Stroke Cerebrovasc Dis 18:214-20. 2009.... - Skeletal muscle hypertrophy and muscle myostatin reduction after resistive training in stroke survivorsAlice S Ryan
Division of Gerontology and Geriatric Medicine, BVAMC, Baltimore, MD 21201, USA
Stroke 42:416-20. 2011.... - Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal womenAlice S Ryan
Department of Medicine, Division of Gerontology at the University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Diabetes Care 25:127-33. 2002.... - Hemiparetic muscle atrophy and increased intramuscular fat in stroke patientsAlice S Ryan
Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, MD, USA
Arch Phys Med Rehabil 83:1703-7. 2002..To determine if skeletal muscle atrophy and greater fat deposition within the muscle are present in the hemiparetic limb of chronic (>6 mo) hemiparetic stroke patients... - Racial differences in insulin resistance and mid-thigh fat deposition in postmenopausal womenAlice S Ryan
Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Obes Res 10:336-44. 2002..To determine whether racial differences in insulin resistance between African American (AA) and white women exist in postmenopausal women and whether they are related to physical fitness and/or obesity... - Atrophy and intramuscular fat in specific muscles of the thigh: associated weakness and hyperinsulinemia in stroke survivorsAlice S Ryan
Baltimore VA Medical Center, University of Maryland School of Medicine, Baltimore, MD, USA
Neurorehabil Neural Repair 25:865-72. 2011.... - Sex differences in insulin action and body fat distribution in overweight and obese middle-aged and older men and womenCynthia M Ferrara
Division of Gerontology, University of Maryland, Baltimore, and Baltimore VA Medical Center, Geriatric Research, Education and Clinical Center, Baltimore, MD 21201, USA
Appl Physiol Nutr Metab 33:784-90. 2008..This difference in insulin sensitivity is not explained by abdominal fat distribution, therefore other metabolic factors contribute to the sex differences in insulin sensitivity... - Comparison of VO2max and disease risk factors between perimenopausal and postmenopausal womenNicole A Lynch
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
Menopause 9:456-62. 2002.... - Lifestyle intervention of hypocaloric dieting and walking reduces abdominal obesity and improves coronary heart disease risk factors in obese, postmenopausal, African-American and Caucasian womenBarbara J Nicklas
Department of Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 58:181-9. 2003..This study determined the efficacy of a lifestyle weight loss intervention in reducing total and abdominal obesity and improving CHD risk factors in obese Caucasian and African-American postmenopausal women... - Regulation of lipolysis and lipoprotein lipase after weight loss in obese, postmenopausal womenDora M Berman
Division of Gerontology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
Obes Res 12:32-9. 2004.... - Effects of aerobic and resistive exercise training on glucose disposal and skeletal muscle metabolism in older menCynthia M Ferrara
Division of Gerontology, University of Maryland, Baltimore, and Baltimore Department of Veterans Affairs Medical Center, Geriatric Research, Education, and Clinical Center GRECC, USA
J Gerontol A Biol Sci Med Sci 61:480-7. 2006..We hypothesized that aerobic (AEX) or resistive (RT) exercise training would result in comparable improvements in glucose disposal in older men, but that there would be different metabolic adaptations in skeletal muscle... - Addition of aerobic exercise to a weight loss program increases BMD, with an associated reduction in inflammation in overweight postmenopausal womenNatalie E Silverman
University of Maryland School of Medicine, Geriatric Research, Education and Clinical Center of the Baltimore Veterans Affairs Medical Center, GRECC BT 18 GR, 10 North Greene Street, Baltimore, MD 21201 1524, USA
Calcif Tissue Int 84:257-65. 2009..Our findings suggest that the addition of aerobic exercise is recommended to decrease inflammation and increase BMD during weight loss in overweight postmenopausal women... - Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complicationsRong Ze Yang
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
PLoS Med 3:e287. 2006..However, the molecular and cellular mechanisms that link obesity to chronic inflammation and CVD are poorly understood... - Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal womenSusan K Fried
Geriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA
J Lipid Res 51:1193-200. 2010..Overall, these data are consistent with the hypothesis that decreased responsiveness of Abd adipocytes to antilipolytic effectors may contribute to higher FA availability and thereby to racial differences in insulin resistance... - Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR-alpha agonist (K-111) administration in rhesus monkeysHeidi K Ortmeyer
Obesity and Diabetes Research Center, Deparment of Physiology, University of Maryland School of Medicine, 10 N Greene St, Rm 4B 201, Baltimore, MD 21201, USA
Am J Physiol Regul Integr Comp Physiol 288:R1509-17. 2005.... - Differences in adipose tissue metabolism between postmenopausal and perimenopausal womenCynthia M Ferrara
Department of Medicine, University of Maryland School of Medicine, and the Geriatric Research, Education and Clinical Center, Baltimore VA Medical Center, Baltimore, Maryland 21201, USA
J Clin Endocrinol Metab 87:4166-70. 2002..The lower lipolysis and higher AT-LPL activity in postmenopausal women may predispose them to gain body fat after menopause... 
Impaired leg vasodilatory function after stroke: adaptations with treadmill exercise trainingFrederick M Ivey
Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201 1524, USA
Stroke 41:2913-7. 2010..Our objective was to compare the effects of regular treadmill exercise (TM) with an active control regimen of supervised stretching (CONTROL) on peripheral hemodynamic function...- ADRB2 haplotype is associated with glucose tolerance and insulin sensitivity in obese postmenopausal womenSteven J Prior
Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
Obesity (Silver Spring) 19:396-401. 2011..This suggests that ADRB2 haplotypes may mediate insulin action, glucose tolerance, and potentially risk for type 2 diabetes mellitus (T2DM) in obese, postmenopausal women... - High prevalence of abnormal glucose metabolism and poor sensitivity of fasting plasma glucose in the chronic phase of strokeFrederick M Ivey
Division of Gerontology, School of Medicine, University of Maryland, Baltimore, MD 21117, USA
Cerebrovasc Dis 22:368-71. 2006.... - Reduced skeletal muscle capillarization and glucose intoleranceSteven J Prior
Baltimore Geriatric Research, Education and Clinical Center, VA Maryland Health Care System, Baltimore, Maryland 21201, USA
Microcirculation 16:203-12. 2009..We hypothesized that compared to sedentary controls, stroke subjects have reduced skeletal muscle capillarization that is associated with glucose intolerance and reduced peak oxygen consumption (Vo(2peak))... - Skeletal muscle changes after hemiparetic stroke and potential beneficial effects of exercise intervention strategiesCharlene E Hafer-Macko
Division of Gerontology, University of Maryland School of Medicine, Baltimore, MD, USA
J Rehabil Res Dev 45:261-72. 2008..Aerobic exercise improves fitness, strength, and ambulatory performance in subjects with chronic stroke. Therapeutic exercise may modify or reverse skeletal muscle abnormalities... - Treadmill aerobic training improves glucose tolerance and indices of insulin sensitivity in disabled stroke survivors: a preliminary reportFrederick M Ivey
Departments of Medicine, University of Maryland School of Medicine, Baltimore VA Medical Center, Geriatrics Service GRECC BT 18 GR, 10 North Greene St, Baltimore, MD 21201 1524, USA
Stroke 38:2752-8. 2007..We compared the effects of a progressive T-AEX intervention to an attention-matched stretching intervention (CONTROL) on glucose tolerance and indices of insulin sensitivity in stroke survivors... - Determinants of walking function after stroke: differences by deficit severityShawnna L Patterson
Department of Neurology, Baltimore Veterans Affairs Maryland Health Care System, Baltimore, MD, USA
Arch Phys Med Rehabil 88:115-9. 2007.... - Reduction in midthigh low-density muscle with aerobic exercise training and weight loss impacts glucose tolerance in older menSteven J Prior
Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Clin Endocrinol Metab 92:880-6. 2007..Intramuscular lipid content increases with aging and obesity and is directly related to impaired glucose tolerance and insulin resistance... - Elevated tumor necrosis factor-alpha in skeletal muscle after strokeCharlene E Hafer-Macko
Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Stroke 36:2021-3. 2005..This study investigates whether TNF-alpha mRNA levels are elevated in paretic compared with nonparetic leg muscles of chronic ischemic stroke patients and age-matched controls... - Racial differences in adipocyte size and relationship to the metabolic syndrome in obese womenThomas J Tittelbach
Baltimore VA Medical Center, Geriatric Research, Education, and Clinical Center BT GR 18, 10 N Greene Street, MD 21201, USA
Obes Res 12:990-8. 2004..To determine whether racial differences exist in the relationship of the abnormalities defining the metabolic syndrome (MS) to regional adiposity and fat cell size (FCS) in obese postmenopausal women... - Older elite football players have reduced cardiac and osteoporosis risk factorsNicole A Lynch
Baltimore Veterans Administration Medical Center, Geriatric Research, Education and Clinical Center GRECC, Baltimore, MD 21201, USA
Med Sci Sports Exerc 39:1124-30. 2007..The purpose of this study was to determine whether former professional football athleticism would be associated with reduced risk factors for CVD and osteoporosis, and higher muscle mass in later life... - Muscle molecular phenotype after stroke is associated with gait speedPatrick G De Deyne
Departments of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, Maryland, USA
Muscle Nerve 30:209-15. 2004..Our findings demonstrate significant and potentially modifiable secondary biologic changes in hemiparetic muscle phenotype that may contribute to the disability of stroke... - Central activation, muscle performance, and physical function in men infected with human immunodeficiency virusWayne B Scott
Department of Physical Therapy and Rehabilitation Science, School of Medicine, University of Maryland, 100 Penn Street, Baltimore, Maryland 21201 1082, USA
Muscle Nerve 36:374-83. 2007..Further investigation is warranted in a larger, more diverse population before more definitive claims are made... - Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in womenBarbara J Nicklas
Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Diabetes Care 26:1413-20. 2003..This study determined whether there is a critical level of visceral adipose tissue (VAT) associated with elevated coronary heart disease (CHD) risk factors in a cohort of women >45 years of age... - The metabolic syndrome in obese postmenopausal women: relationship to body composition, visceral fat, and inflammationTongjian You
Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Clin Endocrinol Metab 89:5517-22. 2004..We conclude that obese older women with the MS are characterized by high lean mass, high visceral fat, and elevated sTNFR1, and the severity of the MS is associated with body composition, visceral adiposity, and inflammation... - Association of African genetic admixture with resting metabolic rate and obesity among womenJose R Fernandez
Department of Nutrition Sciences and the Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Obes Res 11:904-11. 2003.... - Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal womenTongjian You
Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Clin Endocrinol Metab 89:1739-46. 2004..In addition, modification of chronic inflammation is associated with changes in local adipose tissue metabolism in response to diet and exercise... - Vitamin D receptor FokI genotype influences bone mineral density response to strength training, but not aerobic trainingKarma M Rabon-Stith
Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
Exp Physiol 90:653-61. 2005..058) compared to f homozygotes. There were no significant genotype relationships in the AT group. These data indicate that VDR FokI genotype may influence femoral neck BMD response to ST, but not AT... - Metabolic effects of the addition of resistive to aerobic exercise in older menCynthia M Ferrara
Department of Physical Therapy, University of Massachusetts Lowell, Lowell, MA 01854-5124, USA
Int J Sport Nutr Exerc Metab 14:73-80. 2004..In conclusion, the addition of resistive exercise training to an existing aerobic exercise program may improve insulin sensitivity in overweight, older men, and thus prevent the development of type 2 diabetes... - Association between body fat response to exercise training and multilocus ADR genotypesDana A Phares
Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
Obes Res 12:807-15. 2004..To examine the contribution of adrenergic receptor (ADR) gene polymorphisms and their gene-gene interactions to the variability of exercise training-induced body fat response...
Research Grants
- Diet and Exercise: Race, Postmenopause and MetabolismALICE RYAN; Fiscal Year: 2005..These findings may provide a rationale for targeting specific populations of women who might improve glucose and fat metabolism more from the addition of exercise to hypocaloric weight loss than weight loss alone. ..
- Aging, Inflammation and Exercise in Chronic StrokeALICE RYAN; Fiscal Year: 2009..This research will identify a strategy to treat insulin resistance in stroke survivors and establish the biological basis for recommending lifestyle modifications to reduce inflammation and improve the metabolic profile in stroke. ..
- Aging, Inflammation and Exercise in Chronic StrokeALICE S contact RYAN; Fiscal Year: 2010..This research will identify a strategy to treat insulin resistance in stroke survivors and establish the biological basis for recommending lifestyle modifications to reduce inflammation and improve the metabolic profile in stroke. ..