D Rutkowski

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Regulation of basal cellular physiology by the homeostatic unfolded protein response
    D Thomas Rutkowski
    Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Cell Biol 189:783-94. 2010
  2. ncbi A gluconeogenic tryst in the nucleus, with ER stress as the third wheel
    D Thomas Rutkowski
    Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Sci Signal 2:pe72. 2009
  3. ncbi UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
    D Thomas Rutkowski
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Dev Cell 15:829-40. 2008
  4. ncbi Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Biol 4:e374. 2006
  5. ncbi That which does not kill me makes me stronger: adapting to chronic ER stress
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Trends Biochem Sci 32:469-76. 2007
  6. ncbi ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress
    Jun Wu
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Dev Cell 13:351-64. 2007
  7. ncbi Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    Kezhong Zhang
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Cell 124:587-99. 2006
  8. ncbi A trip to the ER: coping with stress
    D Thomas Rutkowski
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109-0650, USA
    Trends Cell Biol 14:20-8. 2004
  9. ncbi The role of p58IPK in protecting the stressed endoplasmic reticulum
    D Thomas Rutkowski
    Howard Hughes Medical Institute and Departments of Biological Chemistry and Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109 0650, USA
    Mol Biol Cell 18:3681-91. 2007
  10. ncbi All roads lead to ATF4
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Dev Cell 4:442-4. 2003

Research Grants

  1. Mechanisms of ER stress - induced fatty liver
    D Rutkowski; Fiscal Year: 2009
  2. Mechanisms of ER stress - induced fatty liver
    D Thomas Rutkowski; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. ncbi Regulation of basal cellular physiology by the homeostatic unfolded protein response
    D Thomas Rutkowski
    Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Cell Biol 189:783-94. 2010
    ..These findings are revealing that the UPR causally contributes to disease not just by its role in protein folding but also through its broad influence on cellular physiology...
  2. ncbi A gluconeogenic tryst in the nucleus, with ER stress as the third wheel
    D Thomas Rutkowski
    Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Sci Signal 2:pe72. 2009
    ..These findings hint at the possible functions of stress pathways as regulators of basal cellular homeostasis...
  3. ncbi UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
    D Thomas Rutkowski
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Dev Cell 15:829-40. 2008
    ..These results reveal an unanticipated direct link between ER homeostasis and the transcriptional regulation of metabolism, and suggest mechanisms by which ER stress might underlie fatty liver disease...
  4. ncbi Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Biol 4:e374. 2006
    ..It underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome...
  5. ncbi That which does not kill me makes me stronger: adapting to chronic ER stress
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Trends Biochem Sci 32:469-76. 2007
    ..Recent advances have improved our understanding of ER stress and the vertebrate UPR, which suggest possible mechanisms by which cells adapt to chronic stress...
  6. ncbi ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress
    Jun Wu
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Dev Cell 13:351-64. 2007
    ..These results suggest that the vertebrate ATF6alpha pathway evolved to maintain ER function when cells are challenged with chronic stress and provide a rationale for the overlap among the three UPR pathways...
  7. ncbi Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    Kezhong Zhang
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Cell 124:587-99. 2006
    ..Together, our studies delineate a molecular mechanism for activation of an ER-localized transcription factor, CREBH, and reveal an unprecedented link by which ER stress initiates an acute inflammatory response...
  8. ncbi A trip to the ER: coping with stress
    D Thomas Rutkowski
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109-0650, USA
    Trends Cell Biol 14:20-8. 2004
    ..This review highlights advances in these areas and attempts to forecast important issues that must be addressed soon...
  9. ncbi The role of p58IPK in protecting the stressed endoplasmic reticulum
    D Thomas Rutkowski
    Howard Hughes Medical Institute and Departments of Biological Chemistry and Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109 0650, USA
    Mol Biol Cell 18:3681-91. 2007
    ..These results identify a previously unanticipated location for p58(IPK) in the ER lumen where its putative function as a cochaperone explains the stress-sensitivity phenotype of knockout cells and mice...
  10. ncbi All roads lead to ATF4
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Dev Cell 4:442-4. 2003
    ..Exploring the consequences of this event has highlighted the ways in which stress is sensed and responded to via many distinct pathways...

Research Grants2

  1. Mechanisms of ER stress - induced fatty liver
    D Rutkowski; Fiscal Year: 2009
    ....
  2. Mechanisms of ER stress - induced fatty liver
    D Thomas Rutkowski; Fiscal Year: 2010
    ....