Genomes and Genes
Affiliation: University of Pennsylvania
- The molecular pathogenesis of pancreatic cancer: clarifying a complex circuitryAnil K Rustgi
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Genes Dev 20:3049-53. 2006
- Models of esophageal carcinogenesisAnil K Rustgi
University of Pennsylvania, Philadelphia, PA 19104, USA
Semin Oncol 33:S57-8. 2006..It is hoped that development of these models for carcinogenesis will permit formulation of effective chemoprevention, diagnostic, and therapeutic strategies...
- The pancreatic and duodenal homeobox protein PDX-1 regulates the ductal specific keratin 19 through the degradation of MEIS1 and DNA bindingJohannes von Burstin
Division of Gastroenterology, Department of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 5:e12311. 2010..In this study, we investigate the role of different domains of PDX-1 and elucidate the functional interplay of PDX-1 and MEIS1 necessary for Krt19 regulation...
- Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagusDouglas B Stairs
Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
PLoS ONE 3:e3534. 2008..Despite this well-defined epidemiologic association between acid reflux and Barrett's esophagus, the genetic changes that induce this transdifferentiation process in esophageal keratinocytes have remained undefined...
- Matricellular proteins: priming the tumour microenvironment for cancer development and metastasisG S Wong
Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, 951 BRB, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Br J Cancer 108:755-61. 2013....
- LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanismsC E King
Gastroenterology Division and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Oncogene 30:4185-93. 2011..Our findings establish a new role for LIN28B in human colon cancer pathogenesis, and suggest LIN28B post-transcriptionally regulates LGR5 and PROM1 through a let-7-independent mechanism...
- The house of gastrointestinal medicine: how academic medical centers can build a sustainable economic clinical modelAnil K Rustgi
Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Electronic address
Clin Gastroenterol Hepatol 11:1370-3. 2013..In this issue, Dr Anil Rustgi and I offer some insights into how AMCs must alter their business model to be sustainable in our new world of ..
- BRAF: a driver of the serrated pathway in colon cancerAnil K Rustgi
Division of Gastroenterology, Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, 952 BRB, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Cancer Cell 24:1-2. 2013..These findings provide translational insights into potential therapeutic intervention for BRAF mutant colon cancers. ..
- Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivoClaudia D Andl
Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA
Cancer Res 66:9878-85. 2006..Our results, which suggest that E-cadherin regulates TbetaRII function, have important implications for epithelial carcinogenesis characterized through the frequent occurrence of E-cadherin and TbetaRII loss...
- The genetics of hereditary colon cancerAnil K Rustgi
Dapartment of Medicine Gastrointestinal, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Genes Dev 21:2525-38. 2007....
- Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cellsMercedes Lioni
The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
Am J Pathol 170:709-21. 2007..We also demonstrate a critical role for claudin-7 expression in the regulation of E-cadherin in these cells, suggesting this may be one mechanism for the loss of epithelial architecture and invasion observed in esophageal SCC...
- N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruptionTherese B Deramaudt
Gastroenterology Division, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104 2144, USA
Mol Cell Biol 26:4185-200. 2006..Thus, we are able to define molecules that in part are directly affected by Ki-RAS and p53 during pancreatic ductal carcinogenesis, and this provides a platform for potential new molecularly based therapeutic interventions...
- Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factorsShinya Ohashi
Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Res 70:4174-84. 2010....
- Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancerOlena Barbash
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cancer Cell 14:68-78. 2008..Collectively, these data reveal that inactivation of the cyclin D1 E3 ligase likely contributes to cyclin D1 overexpression in a significant fraction of human cancer...
- Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinomaLinda Hanlon
Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601Spruce Street, Philadelphia, PA 19104, USA
Cancer Res 70:4280-6. 2010..Unexpectedly, the loss of Notch1 in this model resulted in increased tumor incidence and progression, implying that Notch1 can function as a tumor suppressor gene in PDAC...
- Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancerLin Zhang
Center for Research on Early Detection and Cure of Ovarian Cancer and Gynecology, Department of Obstetrics, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 105:7004-9. 2008..Therefore, our results suggest that miRNAs may offer new biomarkers and therapeutic targets in epithelial ovarian cancer...
- The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiationTakaomi Okawa
Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Genes Dev 21:2788-803. 2007....
- Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceSunil R Hingorani
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Cell 7:469-83. 2005..These findings have clear implications for understanding mechanisms of disease pathogenesis, and for the development of detection and targeted treatment strategies...
- EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytesClaudia D Andl
Gastroenterology Division, Department of Medicine, Abramson Cancer Center and Family Cancer Research Institute, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA
Am J Physiol Gastrointest Liver Physiol 287:G1227-37. 2004..Taken together, we find that the recruitment of the STAT-JAK complex by EGFR is responsible for keratinocyte migration that, in turn, might be mediated by MMP-1 activation...
- Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivationHideki Harada
Gastroenterology Division, University of Pennsylvania, Philadelphia, PA 19104, USA
Mol Cancer Res 1:729-38. 2003..These comprehensive results indicate that the expression of telomerase induces immortalization of normal human esophageal keratinocytes without inactivation of p16INK4a/pRb pathway or abrogation of the p53 pathway...
- Colon cancer screening practices following genetic testing for hereditary nonpolyposis colon cancer (HNPCC) mutationsChanita Hughes Halbert
Abramson Cancer Center, Department of Psychiatry, and Annenberg Public Policy Center, University of Pennsylvania, 19104, USA
Arch Intern Med 164:1881-7. 2004..This study investigated colonoscopy practices following genetic testing for HNPCC mutations...
- A mouse model of human oral-esophageal cancerOliver G Opitz
Division of Gastroenterology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 110:761-9. 2002..These data demonstrate that L2D1(+)/p53(+/-) mice provide a well-defined, novel, and faithful model of oral-esophageal cancer, which allows for the testing of novel chemopreventive, diagnostic, and therapeutic approaches...
- Detection of proximal adenomatous polyps with screening sigmoidoscopy: a systematic review and meta-analysis of screening colonoscopyJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Dr, Seventh Floor Blockley Hall, Philadelphia, PA 19104 6021, USA
Arch Intern Med 163:413-20. 2003..To address this, we performed a systematic review and meta-analysis of screening colonoscopy studies...
- The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic miceFelix H Brembeck
Gastrointestinal Unit, Abramson Cancer Center and Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19014, USA
Cancer Res 63:2005-9. 2003..Taken together, we have defined how mutant K-ras signaling modulates important molecular events in the initiating events of pancreatic and gastric carcinogenesis...
- Pancreatic cancer: translating lessons from mouse models and hereditary syndromesMelanie P Wescott
University of Pennsylvania, 600 CRB, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Cancer Prev Res (Phila) 1:503-6. 2008..These preclinical models and clinical syndromes provide the first tangible basis for progress in screening and prevention in high-risk populations and in the development of molecular diagnostics and experimental therapeutics...
- Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasionKatharine D Grugan
Gastroenterology Division, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
Proc Natl Acad Sci U S A 107:11026-31. 2010..These results highlight the potential benefit of the therapeutic targeting of HGF/Met signaling in ESCC and potentially other squamous cancers where this pathway is deregulated...
- Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous RasSeok Hyun Kim
Laboratory of Molecular Oncology and Cell Cycle Regulation, Department of Medicine Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cancer Res 66:10415-24. 2006..These genetically engineered models may provide new platforms for understanding human esophagus cancer and may assist in the evaluation of new therapies...
- Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivoClaudia D Andl
Gastroenterology Division, Abramson Cancer Center and Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 278:1824-30. 2003..EGFR modulates cell migration through the up-regulation of matrix metalloproteinase 1. Taken together, the functional effects of EGFR overexpression help to explain its role in the initiating steps of esophageal squamous carcinogenesis...
- No one-way street: cross-talk between e-cadherin and receptor tyrosine kinase (RTK) signaling: a mechanism to regulate RTK activityClaudia D Andl
Gastroenterology Division, Department of Medicine, Abramson Cancer Center and Family Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 4:28-31. 2005..This is a novel mechanism by which E-cadherin inhibits RTKs, and suggests that downregulation of E-cadherin may contribute to the frequently observed activation of RTKs in tumors...
- Induction of intestinalization in human esophageal keratinocytes is a multistep processJianping Kong
Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA
Carcinogenesis 30:122-30. 2009..We conclude that ectopic proliferation signals, alterations in epigenetic gene regulation and the inhibition of tumor suppressor mechanisms are required for Cdx2-mediated intestinalization of human esophageal keratinocytes in BE...
- A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specificationJiri Kalabis
Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 118:3860-9. 2008..These studies therefore provide a basis for understanding the regenerative capacity and biology of the esophageal epithelium when it is faced with injurious insults...
- The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in miceJennifer M Oliver-Krasinski
Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Clin Invest 119:1888-98. 2009....
- Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epitheliumTomoyuki Okumura
Department of Medicine, Columbia University Medical Center, New York, NY, USA
Lab Invest 89:1410-22. 2009..Taken together, our results show that bone marrow-derived MSCs can contribute to the gastric epithelium. The K19-positive MSC fraction that is induced by chronic H. felis infection appears to be the important subset in this process...
- Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinomaJacqueline F Morris
Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
Hum Pathol 44:766-76. 2013..This nuclear localization and correlation with tumor differentiation in adenocarcinoma suggests a potentially important transcriptional and biochemical role of this phosphorylation site in carcinogenesis of this tumor type...
- Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplicationPriya Aggarwal
The Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Genes Dev 21:2908-22. 2007..Collectively, the data presented reveal mechanistic insights into how uncoupling of critical cell cycle regulatory events will perturb DNA replication fidelity, thereby contributing to neoplastic transformation...
- Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cellsTakaaki Mizushima
Gastroenterology Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Res 62:277-82. 2002..A comparison of extracellular stimuli suggests that specific Wnt family members stabilize beta-catenin with resulting activation of TCF-dependent transcription in ESCC...
- Cleavage of MCM2 licensing protein fosters senescence in human keratinocytesHideki Harada
Gastroenterology Division and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cell Cycle 7:3534-8. 2008..The absence of multiple MCM2 transcripts implied a possible posttranslational molecular cleavage in generation of the MCM2-related fragment, and a potential functional role in the regulation of the activity of the MCM protein complex...
- Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancerCarmen Z Michaylira
Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Res 70:5281-92. 2010..Collectively, our studies reveal periostin as an important mediator of ESCC tumor invasion and they indicate that organotypic (three-dimensional) culture can offer an important tool to discover novel biological effectors in cancer...
- Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylationCameron N Johnstone
Department of Medicine, Abramson Cancer Center, University of Pennsylvania, 600 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
Mol Cell Biol 28:687-704. 2008..Importantly, Parvin-beta suppressed breast cancer growth in vivo, with associated decreased proliferation. These data suggest that Parvin-beta might influence breast cancer progression...
- Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesisLouise Y Y Fong
Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 63:4244-52. 2003..Thus, cyclin D1 overexpression, in cooperation with ZD, decontrols cell proliferation, ensuring cell expansion, a prerequisite for cancer development...
- ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancersCameron N Johnstone
Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadellphia, PA 19104, USA
Gene 336:59-71. 2004..Taken together, ARHGAP8 encodes a novel RHOGAP with unique functional domains that is highly homologous to ARHGAP1/CDC42GAP/p50RHOGAP...
- Mutant KRAS in the initiation of pancreatic cancerTherese Deramaudt
Department of Medicine GI and Genetics, Abramson Cancer Center, 600 CRB, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA
Biochim Biophys Acta 1756:97-101. 2005..As a result, mechanistic insights are now possible into how K-Ras contributes to pancreatic ductal carcinogenesis, what cooperating events are required, and armed with this knowledge, new therapeutic approaches can be pursued and tested...
- Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factorMelanie P Wescott
Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Mol Biol Cell 20:4838-44. 2009..From these observations we propose that Pdx1 might be involved temporally in a program of gene expression sufficient to facilitate the biochemical and morphological changes necessary for branching morphogenesis...
- Differential secreted proteome approach in murine model for candidate biomarker discovery in colon cancerKannan Rangiah
Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
J Proteome Res 8:5153-64. 2009..Differential secretion into the serum was observed for several proteins when Apc(min) mice were compared with control mice. These findings were then confirmed by Western blot analysis...
- Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogeneFranz S Schreiber
Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia 19104 2144, USA
Gastroenterology 127:250-60. 2004..Because Ki-RAS mutation has prognostic significance in patients treated with radiation, we studied the influence of Ki-RAS status on radiation survival...
- Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cellsSeok Hyun Kim
Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, Department of Medicine, Genetics, and Pharmacology, Abramson Cancer Center, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
J Biol Chem 279:40044-52. 2004..This result suggests a possible therapeutic application of caspase 9 inhibition as a strategy to reverse TRAIL toxicity. Hyper-oligomerized TRAIL may be considered as an alternative agent for testing in clinical trials...
- Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathwayMercedes Lioni
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Mol Cancer Ther 7:2866-75. 2008..We therefore suggest that p38 MAPK pathway activation is an excellent potential therapeutic strategy in ESCC. It is further suggested that bortezomib could be added to existing ESCC therapeutic regimens...
- Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferasePriya Aggarwal
Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, 19104, USA
Cancer Cell 18:329-40. 2010..Importantly, human cancers harboring mutations in Fbx4, the cyclin D1 E3 ligase, exhibit nuclear cyclin D1 accumulation and increased PRMT5 activity...
- The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoterTherese B Deramaudt
Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
J Biol Chem 281:38385-95. 2006..Furthermore, PDX1 may inhibit the ductal differentiation program in the pancreatic endocrine compartment, particularly beta cells...
- Barrett's esophagus and its progression to adenocarcinomaCarlo C Maley
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Natl Compr Canc Netw 4:367-74. 2006..However, most of these results should be confirmed in additional cohorts before they are used to change clinical practice...
- Genetic alterations in esophageal cancerJun Ichi Okano
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
Methods Mol Biol 222:131-45. 2003
- Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiationJohn P Plastaras
Laboratory of Molecular Oncology and Cell Cycle Regulation, Department of Medicine Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Res 67:9443-54. 2007..This study establishes a foundation for clinical testing of sequential fractionated radiation followed by sorafenib in gastrointestinal and other malignancies...
- Stable isotope dilution multidimensional liquid chromatography-tandem mass spectrometry for pancreatic cancer serum biomarker discoveryKenneth H Yu
Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Proteome Res 8:1565-76. 2009..This technique allows for the detection of low-abundance proteins, and focuses only on biologically relevant proteins derived from pancreatic cancer cells...
- PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomasCameron N Johnstone
Department of Medicine, Gastroenterology Division, University of Pennsylvania, Philadelphia, PA 19104, USA
Genomics 85:338-51. 2005..Thus, PRR5 may represent a potential candidate tumor suppressor gene in breast cancer...
- Characterization of proteins in human pancreatic cancer serum using differential gel electrophoresis and tandem mass spectrometryKenneth H Yu
Division of Hematology Oncology, Center for Cancer Pharmacology, and Genomics Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
J Proteome Res 4:1742-51. 2005..These results suggest that affinity column enrichment and 2-D DIGE can be used to identify numerous proteins differentially expressed in serum from individuals with pancreatic cancer...
- A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4)Carol J Gallione
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Lancet 363:852-9. 2004..Although there are reports of patients and families with phenotypes of both disorders combined, the genetic aetiology of this association is unknown...
- Alternative splicing of the APC gene in the neural retina and retinal pigment epitheliumGregory I Liou
Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912, USA
Mol Vis 10:383-91. 2004..Distinctive APC isoforms exist in different cell types due to alternative splicing of the APC transcripts. We hypothesize that differences in expression patterns of APC protein isoforms are critical to RPE proliferation/differentiation...
- Breaking the barriers to colorectal cancer screeningAnil K Rustgi
Gastroenterology 126:1232-3. 2004
- Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancerPerry S Mongroo
Cancer Research Program, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
Oncogene 23:8959-70. 2004..These results indicated that ParvB inhibits ILK signaling downstream of receptor tyrosine kinases. Our results suggest that loss of ParvB expression is a novel mechanism for upregulating ILK activity in tumors...
- Epigenetic silencing of CDX2 is a feature of squamous esophageal cancerMingzhou Guo
Department of Oncology, Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
Int J Cancer 121:1219-26. 2007..Our results suggest that the inactivation of CDX2 in esophageal cancer associated with DNA methylation may be an important determinant of the squamous or non-adenomatous phenotype...
- Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesisGitta Goessel
Department of Medicine and Institute for Molecular Medicine and Cell Research, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
Proc Natl Acad Sci U S A 102:15599-604. 2005....
- Evaluation of PARVG located on 22q13 as a candidate tumor suppressor gene for colorectal and breast cancerSergi Castellvi-Bel
Department of Gastroenterology, Institut de Malalties Digestives, Hospital Clinic, Barcelona, Catalonia, Spain
Cancer Genet Cytogenet 144:80-2. 2003..We have identified several DNA variants that are not compatible with pathogenic mutations. Accordingly, PARVG appears not to be a tumor suppressor gene involved in CRC and breast cancer development and progression...
- Hepatitis B "X" gene linked to cellular calcium releaseAnil K Rustgi
Gastroenterology 122:255. 2002
- The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implicationsDaniel C Chung
Gastrointestinal Unit, GI Cancer Genetics Service, GRJ 825, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
Ann Intern Med 138:560-70. 2003..The study of HNPCC has provided an example of the powerful interplay between molecular genetics and clinical care...
- Advances and challenges in aerodigestive epithelial cancer: meeting summary and research opportunitiesJennifer R Grandis
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cancer Res 67:7556-8. 2007
- Common activation of canonical Wnt signaling in pancreatic adenocarcinomaMarina Pasca di Magliano
Diabetes Center, Department of Medicine, University of California at San Francisco, San Francisco, California, United States of America
PLoS ONE 2:e1155. 2007..Wnt inhibition blocked proliferation and induced apoptosis of cultured adenocarcinoma cells, thereby providing evidence to support the development of novel therapeutical strategies for Wnt inhibition in pancreatic adenocarcinoma...
- Pancreatic cancer: novel approaches to diagnosis and therapyAnil K Rustgi
Gastroenterology 129:1344-7. 2005
- Pancreatic cancer in mice and man: the Penn Workshop 2004Ralph H Hruban
Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cancer Res 66:14-7. 2006..The working groups presented their reports on the final day of the conference, and highlights of selected individual presentations and working group recommendations are summarized here and in an accompanying pathology consensus report...
- Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytesWeiming Ouyang
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Cancer Res 65:9287-93. 2005..Taken together, our results show that arsenite-induced cell cycle from G(1) to S phase transition is through IKKbeta/NF-kappaB/cyclin D1-dependent pathway...
- Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediatesAnna L Means
Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Development 132:3767-76. 2005....
- Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinaseZheng Fu
Department of Pharmacology and Internal Medicine, University of Virginia School, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
Mol Cell Biol 25:6047-64. 2005..Our studies establish ICK as the prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs...
- Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent developmentJoyce A O'Shaughnessy
Baylor Sammons Cancer Center, US Oncology, Collins 5, 3535 Worth Street, Dallas, TX 75246, USA
Clin Cancer Res 8:314-46. 2002..The IEN Task Force proposes several clinical trial designs that provide practical and feasible approaches to the rapid development of new agents to treat and prevent precancer...
- REGULATION OF ESOPHAGEAL EPITHELIAL GENE EXPRESSIONAnil Rustgi; Fiscal Year: 2001..Three specific aims are proposed: (1) to isolate cDNA clones encoding KSF, (2) to characterize the tissue expression of KSF, and (3) to characterize the regulation of expression of the keratin 4 promoter by KSF. ..