Research Topics
Species | Michael RussellSummaryAffiliation: University at Buffalo Country: USA Publications
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Publications
A Caries Vaccine? The state of the science of immunization against dental cariesMichael W Russell
Department of Oral Biology, University at Buffalo, Buffalo, NY 14214, USA
Caries Res 38:230-5. 2004..Progress towards practical vaccine development requires evaluation of candidate vaccines in clinical trials. Promising strategies of passive immunization also require further clinical evaluation...
Tolerance and protection against infection in the genital tractMichael W Russell
Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, New York 14214, USA
Immunol Invest 39:500-25. 2010..Mechanisms of immune response induction and delivery, as well as immune effector functions at the genital mucosae need to be considered in the development of vaccines against infections of the genital tract...- Humoral immune responses to microbial infections in the genital tractMichael W Russell
Department of Microbiology, and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, NY 14214, USA
Microbes Infect 4:667-77. 2002..Antibody responses to genital infections or to locally applied vaccines are usually modest, but alternative strategies for eliciting genital tract antibodies are being developed... - Immunization for protection of the reproductive tract: a reviewMichael W Russell
Department of Microbiology, and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, NY 14214, USA
Am J Reprod Immunol 47:265-8. 2002..Studies of immune responses to genital infections such as gonorrhea also support the concept that, lacking mucosal immune inductive sites, the reproductive tract is ill-equipped to mount effective immune responses... 
Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvantsHesham F Nawar
The Witebsky Center for Microbial Pathogenesis and Immunology, The Department of Microbiology and Immunology, University at Buffalo, Buffalo, New York 14214, USA
Infect Immun 75:621-33. 2007..LT-IIa(T14I) and LT-IIa(T14D) had extremely diminished toxicities in a mouse Y1 adrenal cell bioassay and reduced abilities to induce the accumulation of intracellular cyclic AMP in a macrophage cell line...- Mucosal adjuvant properties of mutant LT-IIa and LT-IIb enterotoxins that exhibit altered ganglioside-binding activitiesHesham F Nawar
Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 138 Farber Hall, 3435 Main St, Buffalo, NY 14214, USA
Infect Immun 73:1330-42. 2005..In contrast, LT-IIb(T13I) retained binding activity for T cells, B cells, and macrophages, indicating that this immunostimulatory mutant enterotoxin interacts with one or more unknown lymphoid cell receptors... - Intranasal administration of recombinant Neisseria gonorrhoeae transferrin binding proteins A and B conjugated to the cholera toxin B subunit induces systemic and vaginal antibodies in miceGregory A Price
Department of Microbiology and Immunology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
Infect Immun 73:3945-53. 2005..By contrast, antibodies elicited via subcutaneous immunization were not cross-bactericidal against heterologous strains, indicating that IN vaccination could be the preferred route for elicitation of biologically functional antibodies... - Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxinsGeorge Hajishengallis
Department of Microbiology, Immunology, and Parasitology, Louisiana State University, Health Sciences Center, New Orleans, LA 70119, USA
Infect Immun 73:1343-9. 2005..TLR2-dependent activation of mononuclear cells by type II enterotoxin B subunits appears to be a novel mechanism whereby these molecules may exert their immunomodulatory and adjuvant activities... - The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cellsGeorge Hajishengallis
Louisiana State University Health Sciences Center, Department of Microbiology, Immunology, and Parasitology, Center of Excellence in Oral and Craniofacial Biology, 1100 Florida Ave, Box 130, New Orleans 70119, USA
Infect Immun 72:6351-8. 2004..Moreover, the anti-inflammatory properties of the holotoxins may serve to suppress innate immunity and promote the survival of the pathogen... - Gonococcal transferrin binding protein chimeras induce bactericidal and growth inhibitory antibodies in miceGregory A Price
Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
Vaccine 25:7247-60. 2007..This study highlights the potential of using protective epitopes instead of full-length proteins in the development of an efficacious gonococcal vaccine... - In vitro induction of immunoglobulin A (IgA)- and IgM-secreting plasma blasts by cholera toxin depends on T-cell help and is mediated by CD154 up-regulation and inhibition of gamma interferon synthesisSergio Arce
The Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, 138 Farber Hall, 3435 Main St, Buffalo, NY 14214, USA
Infect Immun 75:1413-23. 2007..Neither LT-IIa or LT-IIb had these effects, indicating that type II enterotoxins augment Ab responses by other mechanisms... - Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine inductionGeorge Hajishengallis
Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA
Clin Diagn Lab Immunol 9:403-11. 2002..Our data suggest that the CD14-TLR2/4 system is involved in cytokine production and tolerance induction upon interaction with certain proinflammatory bacterial protein adhesins... - Induction and recall of immune memory by mucosal immunization with a non-toxic recombinant enterotoxin-based chimeric proteinChristine M Gockel
Department of Microbiology and Immunology, University of Buffalo, NY 14214, USA
Immunology 116:477-86. 2005..These findings show that SBR-CTA2/B is an immunogenic, not tolerogenic, chimeric protein that can induce and recall antigen-specific memory responses upon mucosal immunization... - Interactions of oral pathogens with toll-like receptors: possible role in atherosclerosisGeorge Hajishengallis
Department of Oral Biology, University at Buffalo, Buffalo, New York, USA
Ann Periodontol 7:72-8. 2002.... - Differential binding of Escherichia coli enterotoxins LT-IIa and LT-IIb and of cholera toxin elicits differences in apoptosis, proliferation, and activation of lymphoid cellsSergio Arce
Department of Microbiology and Immunology, The University of Buffalo, State University of New York at Buffalo, 138 Farber Hall, 3435 Main St, Buffalo, NY 12214, USA
Infect Immun 73:2718-27. 2005..Thus, LT-IIa, LT-IIb, and CT exhibit distinguishable immunomodulatory properties which are likely dependent upon their capacities to recognize different ganglioside receptors on lymphocytes... - Immunologic uniqueness of the genital tract: challenge for vaccine developmentJiri Mestecky
Department of Microbiology, University of Alabama at Birmingham, Box 1, 845 19th Street South, Birmingham, AL 35294, USA
Am J Reprod Immunol 53:208-14. 2005..Furthermore, combined systemic and mucosal (oral, rectal, and especially intranasal) immunization may induce protective humoral responses in both the systemic and mucosal compartments of the immune system... - Perspectives on mucosal vaccines: is mucosal tolerance a barrier?Jiri Mestecky
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 179:5633-8. 2007..Optimization of mucosal vaccination strategies has the potential for enhancing protective immune responses and suppressing systemic responses to autoantigens desirable for the treatment of autoimmune diseases... - Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfacesJiri Mestecky
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35295 2170, USA
Immunol Lett 124:57-62. 2009..In embodying both adaptive and innate immune mechanisms within a single molecule, S-IgA maintains comprehensive protection of mucosal surfaces with economy of structure and function... - Identification and characterization of a nonimmunoglobulin factor in human saliva that inhibits Streptococcus mutans glucosyltransferaseChristina Jespersgaard
Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Infect Immun 70:1136-42. 2002..mutans colonization in the oral cavity... - The A subunit of type IIb enterotoxin (LT-IIb) suppresses the proinflammatory potential of the B subunit and its ability to recruit and interact with TLR2Shuang Liang
Center for Oral Health and Systemic Disease, Department of Periodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
J Immunol 178:4811-9. 2007..coli may suppress TLR-mediated innate immunity through the action of the enterotoxin A subunit... - Tissue distribution of lymphocytes and plasma cells and the role of the gutReinhard Pabst
Trends Immunol 29:206-8; author reply 209-10. 2008
Research Grants
- MUCOSAL VACCINES AGAINST GONORRHEAMichael Russell; Fiscal Year: 2003..The information gained about genital tract immunity and the techniques used may also be applicable to other sexually transmitted diseases. ..
- ANTIGENS OF STREPTOCOCCUS MUTANS IN CARIES IMMUNITYMichael Russell; Fiscal Year: 2007..p RESEARCHGRANT TABLE OF CONTENTS Page Numbers Face Page ................................................................................................................................................ 1 Description, ..