Genomes and Genes
James W Russell
Affiliation: University of Maryland
- Maintaining efficacy in the treatment of diabetic peripheral neuropathic pain: role of duloxetineLindsay Zilliox
Department of Neurology, Neuromuscular Division, The University of Maryland School of Medicine, Baltimore, MD, USA
Diabetes Metab Syndr Obes 3:7-17. 2010..One of these medications, duloxetine hydrochloride (duloxetine), is a balanced and potent selective serotonin and norepinephrine reuptake inhibitor...
- Oxidative injury and neuropathy in diabetes and impaired glucose toleranceJames W Russell
Department of Neurology, University of Maryland, 22 South Greene Street, Baltimore, MD 21201, USA
Neurobiol Dis 30:420-9. 2008..Our study supports the hypothesis that neuropathy develops in an animal model of IGT and is associated with evidence of oxidative injury in DRG and peripheral nerves...
- Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell deathAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
Diabetes 53:726-34. 2004..Furthermore, the ability to prevent UCP3 downregulation or to reproduce the uncoupling response in DRG neurons constitutes promising novel approaches to avert diabetic complications such as neuropathy...
- High glucose-induced oxidative stress and mitochondrial dysfunction in neuronsJames W Russell
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
FASEB J 16:1738-48. 2002..Glucotoxicity is blocked by inhibiting ROS induction, MMD, or caspase cleavage by specific inhibitors of electron transfer, or by stabilizing the ANT...
- Reliability of quantitative sudomotor axon reflex testing and quantitative sensory testing in neuropathy of impaired glucose regulationAmanda Peltier
Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA
Muscle Nerve 39:529-35. 2009..QSART reproducibility was significantly lower than QST. In this group of patients, the reproducibility of QSART was unacceptable for use as a secondary endpoint measure in clinical research trials...
- Multicenter trial of the proficiency of smart quantitative sensation testsPeter J Dyck
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, USA, 55905
Muscle Nerve 49:645-53. 2014..We assessed proficiency (accuracy and intra- and intertest reproducibility) of smart quantitative sensation tests (smart QSTs) in subjects without and with diabetic sensorimotor polyneuropathy (DSPN)...
- SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, 5017 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 0588, USA
Exp Neurol 208:216-27. 2007..DN was observed in the C57BL/6Jdb/db mouse, and decreased expression of SOD2 in these animals increased DN. Our data suggest that SOD2 activity is an important cellular modifier of neuronal oxidative defense against hyperglycemic injury...
- The Utah Early Neuropathy Scale: a sensitive clinical scale for early sensory predominant neuropathyJ Robinson Singleton
Department of Neurology, University of Utah School of Medicine, SOM 3R 152, Salt Lake City, UT 84132, USA
J Peripher Nerv Syst 13:218-27. 2008..UENS is a sensitive and reproducible clinical measure of sensory and small-fiber nerve injury and may be useful in trials of early neuropathy...
- Metabotropic glutamate receptors (mGluRs) and diabetic neuropathyMuragundla Anjaneyulu
Department of Neurology, University of Maryland Maryland, USA
Curr Drug Targets 9:85-93. 2008..Direct or indirect activation of mGluR2/3 in animal models protects against development of diabetic neuropathy. The potential mechanisms and role of mGluRs in protection against diabetic neuropathy will be reviewed...
- Oxidative stress in the pathogenesis of diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, Room 4414, Kresge III, 200 Zina Pitcher Place, Ann Arbor 48109, USA
Endocr Rev 25:612-28. 2004..We conclude that striving for superior antioxidative therapies remains essential for the prevention of neuropathy in diabetic patients...
- Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathyMuragundla Anjaneyulu
Department of Neurology, University of Maryland, School of Medicine, 22 South Greene Street, Box 175, Baltimore, MD 21201 1595, USA
Exp Neurol 211:469-79. 2008..In combination, these findings indicate a potential new target for treatment of diabetic peripheral neuropathy...
- PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathyJoungil Choi
VA Maryland Health Care System, University of Maryland, Baltimore, MD, USA Department of Neurology, University of Maryland, Baltimore, MD, USA
Neurobiol Dis 64:118-30. 2014....
- A trial of proficiency of nerve conduction: greater standardization still neededPeter J Dyck
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA
Muscle Nerve 48:369-74. 2013..The aim of this study was to test the proficiency (accuracy among evaluators) of measured attributes of nerve conduction (NC)...
- A novel PGC-1α isoform in brain localizes to mitochondria and associates with PINK1 and VDACJoungil Choi
Department of Neurology, University of Maryland, Baltimore, MD 21201, USA
Biochem Biophys Res Commun 435:671-7. 2013..This is the first report regarding mitochondrial localization of a novel 35 kDa PGC-1α isoform and its association with PINK1, suggesting possible regulatory roles for mitochondrial function in the brain...
- Oxidative stress and programmed cell death in diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
Ann N Y Acad Sci 959:368-83. 2002....
- Nitrosative injury and antioxidant therapy in the management of diabetic neuropathyRita M Cowell
Department of Neurology, University of Michigan, 200 Zina Pitcher Place, 4410 Kresge III, Ann Arbor, MI 48109 0585, USA
J Investig Med 52:33-44. 2004..Clinical studies of several antioxidants, including alpha-lipoic acid, vitamins C and E, aldose reductase inhibitors, and growth factors, in diabetic neuropathy are discussed...
- Microvascular complications of impaired glucose toleranceJ Robinson Singleton
Department of Neurology, University of Utah, Salt Lake City, Utah, USA
Diabetes 52:2867-73. 2003..To what degree intervention will limit recognized complications is not known...
- Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targetsVamshi K Nimmagadda
Veterans Affairs Maryland Healthcare System, Baltimore, MD 21201, USA
J Immunol 190:4595-607. 2013..These results suggest that SIRT1 reduces neuronal loss in this chronic demyelinating disease model and that this is associated with a reduction in inflammation...
- Autonomic dysfunction in obstructive sleep apnea is associated with impaired glucose regulationAmanda C Peltier
Department of Neurology, University of Michigan, Ann Arbor, MI, USA
Sleep Med 8:149-55. 2007....
- Treatment of diabetic sensory polyneuropathyLindsay Zilliox
Department of Neurology, University of Maryland, School of Medicine, 3S 129, 110 South Paca Street, Baltimore, MD, 21201 1595, USA
Curr Treat Options Neurol 13:143-59. 2011..The lidocaine patch is effective in relieving pain associated with postherpetic neuralgia, but only class III evidence supports its use for diabetic neuropathic pain. No current Class I or II studies support other treatment modalities...
- Does duloxetine safely and effectively reduce the severity of diabetic peripheral neuropathic pain?James W Russell
Department of Neurology, University of Michigan, MI 48109 0585, USA
Nat Clin Pract Neurol 2:18-9. 2006
- Assessing autonomic dysfunction in early diabetic neuropathy: the Survey of Autonomic SymptomsL Zilliox
Department of Neurology, University of Maryland and Maryland VA Healthcare System, Baltimore, MD, USA
Neurology 76:1099-105. 2011..Autonomic symptoms may occur frequently in diabetic and other neuropathies. There is a need to develop a simple instrument to measure autonomic symptoms in subjects with neuropathy and to test the validity of the instrument...
- Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentrationAlison Berent-Spillson
Neuroscience Program, University of Michigan, Ann Arbor, Michigan, USA
J Neurochem 101:342-54. 2007....
- Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3Alison Berent-Spillson
University of Michigan Neuroscience Program, Ann Arbor, Michigan 48109 0588, USA
J Neurochem 89:90-9. 2004..Inhibition of GCP II or mGluR3 may represent a novel mechanism to treat neuronal degeneration under high-glucose conditions...
- Metabotropic glutamate receptor regulation of neuronal cell deathAlison Berent Spillson
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
Exp Neurol 184:S97-105. 2003..More complete understanding of the complex PCD regulatory pathways mediated by mGluRs will provide new therapeutic approaches for the treatment of a wide variety of neurodegenerative diseases...
- Oxidative Stress Induces Apoptosis in Diabetic NeuronsJames Russell; Fiscal Year: 2006....