David W Russell

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint The enzymes, regulation, and genetics of bile acid synthesis
    David W Russell
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9046, USA
    Annu Rev Biochem 72:137-74. 2003
  2. pmc Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain
    David W Russell
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Annu Rev Biochem 78:1017-40. 2009
  3. pmc Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family
    Jeffrey B Cheng
    Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 279:37798-807. 2004
  4. pmc Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation
    Tiina Kotti
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:11394-9. 2008
  5. ncbi request reprint Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration
    Chonglun Xie
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8887, USA
    J Lipid Res 44:1780-9. 2003
  6. pmc Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
    Jia Li-Hawkins
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9046, USA
    J Clin Invest 110:1191-200. 2002
  7. pmc Brain cholesterol turnover required for geranylgeraniol production and learning in mice
    Tiina J Kotti
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:3869-74. 2006
  8. pmc Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid
    Ryan D Jones
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX 75390 9151, USA
    Am J Physiol Gastrointest Liver Physiol 303:G263-74. 2012
  9. pmc Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function
    Heidi C Shea
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:11526-33. 2007
  10. ncbi request reprint Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    Erik G Lund
    Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 278:22980-8. 2003

Research Grants

  1. Enzymes of Skin Lipid Metabolism
    David Russell; Fiscal Year: 2009
  2. ENDOCRINE ROLES OF STEROID 5 ALPHA REDUCTASE ISOZYMES
    David Russell; Fiscal Year: 2003

Collaborators

  • Jeffrey G McDonald
  • Stephen D Turley
  • David J Mangelsdorf
  • Erik G Lund
  • Kenneth D R Setchell
  • JOHN DIETSCHY
  • Charles E McKenna
  • Michael A Levine
  • Ingemar Bjorkhem
  • N H Bell
  • E M Brunt
  • Jeffrey B Cheng
  • Denise M O Ramirez
  • David R Bauman
  • Ryan D Jones
  • Rebekkah W Halford
  • Ashlee R Stiles
  • Tiina Kotti
  • Daphne D Head
  • Heidi C Shea
  • Anthony Donsante
  • Wenling Chen
  • Tiina J Kotti
  • Yildiz Yildiz
  • Chonglun Xie
  • George Vassilopoulos
  • Thomas A Kerr
  • Jia Li-Hawkins
  • Joyce J Repa
  • Guosheng Liang
  • Andrew D Bitmansour
  • Bonne M Thompson
  • Stefan Andersson
  • Mark S Sands
  • Guoxen Chen
  • Carole Vogler
  • Daphne L Head
  • Yi Li
  • Daniel G Miller
  • Brad E Pfeiffer
  • Rebekkah L Warren
  • F Kent Hamra
  • Jeremy C Allegood
  • Siegfried Matern
  • Kimberly M Huber
  • Robert E Hammer
  • Bonne Thompson
  • Heidrun Matern
  • Marie Gerhardt
  • Hisham Nazer
  • James E Heubi
  • Danièle Cresteil
  • Pei Rong Wang
  • Daniel L Motola
  • Emmanuel Jacquemin
  • Maria Olin
  • Manfred Schneider
  • Karen Schaefer
  • Margrit Schwarz
  • Sara Berdy
  • Ulla Andersson
  • Shigeru Saeki
  • Mats Gafvels
  • Thadd Redder
  • Gertrud Schuster
  • Bei Shan
  • Gosta Eggertsen

Detail Information

Publications25

  1. ncbi request reprint The enzymes, regulation, and genetics of bile acid synthesis
    David W Russell
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9046, USA
    Annu Rev Biochem 72:137-74. 2003
    ..Inherited mutations that impair bile acid synthesis cause a spectrum of human disease; this ranges from liver failure in early childhood to progressive neuropathy in adults...
  2. pmc Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain
    David W Russell
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Annu Rev Biochem 78:1017-40. 2009
    ..This review focuses on how the link between cholesterol metabolism and higher-order brain function was experimentally established...
  3. pmc Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family
    Jeffrey B Cheng
    Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 279:37798-807. 2004
    ..The data suggest that wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes...
  4. pmc Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation
    Tiina Kotti
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:11394-9. 2008
    ..We conclude that geranylgeraniol acts specifically and quickly to affect LTP in the Schaffer collaterals of the hippocampus...
  5. ncbi request reprint Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration
    Chonglun Xie
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8887, USA
    J Lipid Res 44:1780-9. 2003
    ..The other probably involves the movement of cholesterol or one of its metabolites across the blood-brain barrier and may more closely mirror sterol turnover in pools such as glial cell membranes and myelin...
  6. pmc Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
    Jia Li-Hawkins
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9046, USA
    J Clin Invest 110:1191-200. 2002
    ..Cholate restores CYP7A1 regulation in vivo and in vitro. The results implicate cholate as an important negative regulator of bile acid synthesis and provide preliminary evidence for ligand-specific gene activation by a nuclear receptor...
  7. pmc Brain cholesterol turnover required for geranylgeraniol production and learning in mice
    Tiina J Kotti
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:3869-74. 2006
    ..We conclude that cholesterol turnover in brain activates the mevalonate pathway and that a constant production of geranylgeraniol in a small subset of neurons is required for LTP and learning...
  8. pmc Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid
    Ryan D Jones
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX 75390 9151, USA
    Am J Physiol Gastrointest Liver Physiol 303:G263-74. 2012
    ..These findings underscore the importance of using moderate dietary BA levels in studies with animal models...
  9. pmc Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function
    Heidi C Shea
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:11526-33. 2007
    ..We conclude that the correct stereochemistry of a single hydroxyl group at carbon 3 in bile acids is required to maintain their physiologic and regulatory functions in mammals...
  10. ncbi request reprint Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    Erik G Lund
    Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 278:22980-8. 2003
    ..We conclude that cholesterol 24-hydroxylase constitutes a major tissue-specific pathway for cholesterol turnover in the brain...
  11. pmc Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice
    Wenling Chen
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 5:73-9. 2007
    ..We conclude that oxysterols are in vivo ligands for LXR...
  12. pmc Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
    Jeffrey B Cheng
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:7711-5. 2004
    ..These data identify CYP2R1 as a biologically relevant vitamin D 25-hydroxylase and reveal the molecular basis of a human genetic disease, selective 25-hydroxyvitamin D deficiency...
  13. doi request reprint Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain
    Denise M O Ramirez
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Comp Neurol 507:1676-93. 2008
    ..These findings reveal the microsomal localization of 24-hydroxylase and provide subcellular insight into cholesterol turnover in the brain...
  14. pmc Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan
    Rebekkah W Halford
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:3502-6. 2009
    ..These studies suggest that reducing de novo cholesterol synthesis in the brain will not substantially alter the course of Alzheimer's disease, but may confer a survival advantage...
  15. pmc CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions
    Ashlee R Stiles
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 284:28485-9. 2009
    ..The role of CYP7B1 in brain is under investigation; recent studies show that spastic paraplegia type 5, a progressive neuropathy, is caused by loss-of-function mutations in the human gene...
  16. pmc Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility
    Yildiz Yildiz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 116:2985-94. 2006
    ..We conclude that GBA2 is a glucosylceramidase whose loss causes accumulation of glycolipids and an endoplasmic reticulum storage disease...
  17. ncbi request reprint Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis
    Thomas A Kerr
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Dev Cell 2:713-20. 2002
    ..We conclude that input from three negative regulatory pathways controls bile acid synthesis. One is mediated by SHP, and two are SHP independent and invoked by liver damage and changes in bile acid pool size...
  18. pmc 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
    David R Bauman
    Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:16764-9. 2009
    ..The suppression of IgA class switching in B cells by a macrophage-derived sterol in response to TLR activation provides a mechanism for local and systemic negative regulation of the adaptive immune response by the innate immune system...
  19. ncbi request reprint Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease
    Jeffrey B Cheng
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Clin Endocrinol Metab 88:1833-41. 2003
    ..We conclude that a diverse spectrum of mutations in the HSD3B7 gene underlies this rare form of neonatal cholestasis...
  20. pmc A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma
    Jeffrey G McDonald
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Lipid Res 53:1399-409. 2012
    ..Application of this method to plasma samples revealed that at least 50 samples could be extracted in a routine day...
  21. ncbi request reprint De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase
    Jeffrey B Cheng
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75390, USA
    J Biol Chem 278:38084-93. 2003
    ..CYP2R1 mRNA is abundant in the liver and testis, and present at lower levels in other tissues. The data suggest that CYP2R1 is a strong candidate for the microsomal vitamin D 25-hydroxylase...
  22. pmc Fifty years of advances in bile acid synthesis and metabolism
    David W Russell
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    J Lipid Res 50:S120-5. 2009
    ..This review highlights findings in cholesterol catabolism from the last five decades with special emphasis on advances in bile acid synthesis, transport, and regulation...
  23. pmc Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions
    Jeffrey B Cheng
    Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 279:37789-97. 2004
    ..The data suggest that fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids...
  24. ncbi request reprint Transplanted bone marrow regenerates liver by cell fusion
    George Vassilopoulos
    Division of Hematology, University of Washington, Seattle, Washington 98195, USA
    Nature 422:901-4. 2003
    ..We also show that the haematopoietic donor genome adopts a more hepatocyte-specific expression profile after cell fusion, as the wild-type Fah gene was activated and the pan-haematopoietic CD45 marker was no longer expressed...
  25. ncbi request reprint AAV vector integration sites in mouse hepatocellular carcinoma
    Anthony Donsante
    Department of Internal Medicine, Washington University School of Medicine, Box 8007, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Science 317:477. 2007
    ..Transcripts from adjacent genes encoding snoRNAs and microRNAs were overexpressed in tumors. Our findings implicate this locus in the development of HCC and raise concerns over the clinical use of AAV vectors...

Research Grants13

  1. Enzymes of Skin Lipid Metabolism
    David Russell; Fiscal Year: 2009
    ..The research is relevant to skin disease, dry eye syndrome, and cholesterol metabolism. ..
  2. ENDOCRINE ROLES OF STEROID 5 ALPHA REDUCTASE ISOZYMES
    David Russell; Fiscal Year: 2003
    ....