CRAIG RUSH

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Pretreatment with hydromorphone, a mu-opioid agonist, does not alter the acute behavioral and physiological effects of ethanol in humans
    C R Rush
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington 40506 0086, USA
    Alcohol Clin Exp Res 25:9-17. 2001
  2. ncbi request reprint Risperidone attenuates the discriminative-stimulus effects of d-amphetamine in humans
    Craig R Rush
    Department of Behavioral Science, University of Kentucky, Lexington, KY 40536 0086, USA
    J Pharmacol Exp Ther 306:195-204. 2003
  3. ncbi request reprint Discriminative-stimulus effects of modafinil in cocaine-trained humans
    Craig R Rush
    Department of Behavioral Science, University of Kentucky, Lexington, KY 40536 0086, USA
    Drug Alcohol Depend 67:311-22. 2002
  4. ncbi request reprint Reinforcing, subject-rated, and physiological effects of intranasal methylphenidate in humans: a dose-response analysis
    William W Stoops
    Department of Behavioral Science, College of Medicine, College of Medicine Office Building Rm 127, University of Kentucky, Lexington, KY 40536 0086, USA
    Drug Alcohol Depend 71:179-86. 2003
  5. ncbi request reprint Acute behavioral and physiological effects of modafinil in drug abusers
    C R Rush
    Department of Behavioral Science, University of Kentucky, Lexington, Kentucky 40536 0086, USA
    Behav Pharmacol 13:105-15. 2002
  6. ncbi request reprint Alprazolam attenuates the behavioral effects of d-amphetamine in humans
    Craig R Rush
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536 0086, USA
    J Clin Psychopharmacol 24:410-20. 2004
  7. ncbi request reprint Behavioral pharmacological similarities between methylphenidate and cocaine in cocaine abusers
    C R Rush
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, USA
    Exp Clin Psychopharmacol 9:59-73. 2001
  8. ncbi request reprint Reinforcing and subject-rated effects of methylphenidate and d-amphetamine in non-drug-abusing humans
    C R Rush
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington 40536 0086, USA
    J Clin Psychopharmacol 21:273-86. 2001
  9. ncbi request reprint Discriminative-stimulus effects of triazolam in light and moderate drinkers
    Craig R Rush
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, USA
    Alcohol Clin Exp Res 27:638-46. 2003
  10. ncbi request reprint Aripiprazole attenuates the discriminative-stimulus and subject-rated effects of D-amphetamine in humans
    Joshua A Lile
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536 0086, USA
    Neuropsychopharmacology 30:2103-14. 2005

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Pretreatment with hydromorphone, a mu-opioid agonist, does not alter the acute behavioral and physiological effects of ethanol in humans
    C R Rush
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington 40506 0086, USA
    Alcohol Clin Exp Res 25:9-17. 2001
    ..The aim of the present study was to assess the acute subject-rated effects of ethanol (0, 0.5, and 1 g/kg) after pretreatment with hydromorphone, a mu-opioid agonist...
  2. ncbi request reprint Risperidone attenuates the discriminative-stimulus effects of d-amphetamine in humans
    Craig R Rush
    Department of Behavioral Science, University of Kentucky, Lexington, KY 40536 0086, USA
    J Pharmacol Exp Ther 306:195-204. 2003
    ..The results of these studies might guide the development of a pharmacotherapy for the treatment of amphetamine abuse/dependence...
  3. ncbi request reprint Discriminative-stimulus effects of modafinil in cocaine-trained humans
    Craig R Rush
    Department of Behavioral Science, University of Kentucky, Lexington, KY 40536 0086, USA
    Drug Alcohol Depend 67:311-22. 2002
    ..The results of the present experiment suggest that cocaine discrimination in humans is pharmacologically specific within and across drug classes...
  4. ncbi request reprint Reinforcing, subject-rated, and physiological effects of intranasal methylphenidate in humans: a dose-response analysis
    William W Stoops
    Department of Behavioral Science, College of Medicine, College of Medicine Office Building Rm 127, University of Kentucky, Lexington, KY 40536 0086, USA
    Drug Alcohol Depend 71:179-86. 2003
    ..Future studies should test higher doses and directly compare the behavioral effects of intranasal methylphenidate to those of a prototypical abused stimulant (e.g. cocaine)...
  5. ncbi request reprint Acute behavioral and physiological effects of modafinil in drug abusers
    C R Rush
    Department of Behavioral Science, University of Kentucky, Lexington, Kentucky 40536 0086, USA
    Behav Pharmacol 13:105-15. 2002
    ..A full characterization of the abuse potential of modafinil will become important as the use of this drug increases...
  6. ncbi request reprint Alprazolam attenuates the behavioral effects of d-amphetamine in humans
    Craig R Rush
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536 0086, USA
    J Clin Psychopharmacol 24:410-20. 2004
    ..Future laboratory experiments with humans should also determine if benzodiazepines with lower abuse potential (eg, oxazepam) might also attenuate the behavioral effects of D-amphetamine...
  7. ncbi request reprint Behavioral pharmacological similarities between methylphenidate and cocaine in cocaine abusers
    C R Rush
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, USA
    Exp Clin Psychopharmacol 9:59-73. 2001
    ..Consistent with in vivo behavioral neuropharmacological data, the discriminative-stimulus, participant-rated, and physiological effects of oral cocaine and methylphenidate were similar...
  8. ncbi request reprint Reinforcing and subject-rated effects of methylphenidate and d-amphetamine in non-drug-abusing humans
    C R Rush
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington 40536 0086, USA
    J Clin Psychopharmacol 21:273-86. 2001
    ....
  9. ncbi request reprint Discriminative-stimulus effects of triazolam in light and moderate drinkers
    Craig R Rush
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, USA
    Alcohol Clin Exp Res 27:638-46. 2003
    ..The aim of this study was to further assess the behavioral effects of a benzodiazepine in light and moderate drinkers...
  10. ncbi request reprint Aripiprazole attenuates the discriminative-stimulus and subject-rated effects of D-amphetamine in humans
    Joshua A Lile
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536 0086, USA
    Neuropsychopharmacology 30:2103-14. 2005
    ....
  11. ncbi request reprint Oxazepam does not modulate the behavioral effects of d-amphetamine in humans
    Joshua A Lile
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536 0086, United States
    Pharmacol Biochem Behav 82:270-9. 2005
    ..The results of this experiment are discordant with previous research and suggest that benzodiazepines differ in their ability to modulate the behavioral effects of d-amphetamine...
  12. pmc The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance II: increased aripipirazole dose and maintenance period
    Joshua A Lile
    Department of Behavioral Science, University of Kentucky Medical Center, Lexington, Kentucky, USA
    Am J Drug Alcohol Abuse 34:721-9. 2008
    ..This experiment determined the safety and tolerability of intranasal cocaine during aripiprazole maintenance...
  13. ncbi request reprint Reinforcing effects of methylphenidate: influence of dose and behavioral demands following drug administration
    William W Stoops
    Department of Psychology, University of Kentucky, Lexington, KY 40536 0086, USA
    Psychopharmacology (Berl) 177:349-55. 2005
    ..The reinforcing effects of stimulant drugs such as D-amphetamine, caffeine, and cocaine are modulated by behavioral demands following drug administration...
  14. doi request reprint Behavioral effects of d-amphetamine in humans: influence of subclinical levels of inattention and hyperactivity
    Rajkumar J Sevak
    Department of Behavioral Science, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0086, USA
    Am J Drug Alcohol Abuse 36:220-7. 2010
    ..g., inattention and hyperactivity). To further assess the nature of this relationship, the present study examined the association between subclinical symptoms of inattention and hyperactivity and the behavioral effects of d-amphetamine...
  15. ncbi request reprint Acute performance-impairing and subject-rated effects of triazolam and temazepam, alone and in combination with ethanol, in humans
    Cathy A Simpson
    Department ofPsychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, USA
    J Psychopharmacol 16:23-34. 2002
    ..g. smoke alarms or middle-of-the-night child care)...
  16. doi request reprint Effects of potential agonist-replacement therapies for stimulant dependence on inhibitory control in cocaine abusers
    Andrea R Vansickel
    Department of Psychology, University of Kentucky, Lexington, Kentucky, USA
    Am J Drug Alcohol Abuse 34:293-305. 2008
    ..The results of these studies may have implications for the use of these drugs as agonist-replacement therapies for stimulant dependence...
  17. ncbi request reprint Behavioral and physiological effects of cocaine in humans following triazolam
    Jamie L Haga
    Department of Behavioral Science, University of Kentucky, Lexington, KY 40536 0086, USA
    Pharmacol Biochem Behav 76:383-92. 2003
    ..Cocaine abuse represents a significant public health problem. Gamma-aminobutyric acid (GABA) agonists may attenuate the behavioral effects of cocaine and may be effective pharmacotherapies for cocaine abuse and dependence...
  18. doi request reprint Stimulant-induced changes in smoking and caloric intake: influence of rate of onset
    Andrea R Vansickel
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Pharmacol Biochem Behav 92:597-602. 2009
    ..Smoking should be monitored in patients that are prescribed stimulant medications, regardless of the formulation type...
  19. ncbi request reprint The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance
    William W Stoops
    Department of Behavioral Science, University of Kentucky Medical Center, Lexington, Kentucky 40536 0086, USA
    Am J Drug Alcohol Abuse 33:769-76. 2007
    ..Aripiprazole was generally devoid of effects, but did alter temperature-increasing and subject-rated effects of cocaine as a function of cocaine dose...
  20. pmc Human sex differences in d-amphetamine self-administration
    Andrea R Vansickel
    Department of Psychology, University of Kentucky, Lexington, KY, USA
    Addiction 105:727-31. 2010
    ..Women and men may respond differently to the effects of stimulants such as amphetamine and cocaine...
  21. pmc Similar discriminative-stimulus effects of D-amphetamine in women and men
    Andrea R Vansickel
    Department of Behavioral Science, University of Kentucky, United States
    Pharmacol Biochem Behav 87:289-96. 2007
    ..g. drug self-administration) to determine if women and men respond differently to the effects of D-amphetamine...
  22. ncbi request reprint A low dose of aripiprazole attenuates the subject-rated effects of d-amphetamine
    William W Stoops
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, 40536 0086, USA
    Drug Alcohol Depend 84:206-9. 2006
    ..Future research should examine the effects of chronic aripiprazole administration in combination with methamphetamine or cocaine...
  23. pmc Safety, tolerability and subject-rated effects of acute intranasal cocaine administration during atomoxetine maintenance
    William W Stoops
    Department of Behavioral Science, University of Kentucky College of Medicine, College of Medicine Office Building, Lexington, KY 40536 0086, USA
    Drug Alcohol Depend 92:282-5. 2008
    ..These results indicate that cocaine is well tolerated during atomoxetine maintenance. Further research is needed to better determine the effects of atomoxetine and cocaine combinations...
  24. pmc Acute d-amphetamine pretreatment does not alter stimulant self-administration in humans
    William W Stoops
    Department of Behavioral Science, University of Kentucky Medical Center, KY 40536 0086, USA
    Pharmacol Biochem Behav 87:20-9. 2007
    ..These results indicate that acute d-amphetamine pretreatment does not increase stimulant self-administration...
  25. ncbi request reprint Methylphenidate increases cigarette smoking
    Craig R Rush
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Psychopharmacology (Berl) 181:781-9. 2005
    ..The effects of methylphenidate on smoking have not been assessed although it is the most commonly prescribed pharmacotherapy for ADHD and individuals with ADHD are at increased risk for smoking...
  26. ncbi request reprint Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humans
    William W Stoops
    Departments of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536 0086, USA
    J Psychopharmacol 18:534-43. 2004
    ..These findings are consistent with epidemiological data and previous findings from laboratory studies that suggest methylphenidate has at least some abuse potential...
  27. doi request reprint Subjective and physiological effects of acute intranasal methamphetamine during d-amphetamine maintenance
    Craig R Rush
    Department of Behavioral Science, University of Kentucky College of Medicine, College of Medicine Office Building, Lexington, KY 40536 0086, USA
    Psychopharmacology (Berl) 214:665-74. 2011
    ..However, many patients enrolled in behavioral therapies are unable to achieve significant periods of abstinence, suggesting other strategies like pharmacotherapy are needed...
  28. ncbi request reprint A pharmacological analysis of stimulant-induced increases in smoking
    Andrea R Vansickel
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Psychopharmacology (Berl) 193:305-13. 2007
    ..Stimulants increase tobacco smoking in healthy adults under controlled laboratory conditions. The mechanisms that mediate stimulant-induced increases in smoking are not known...
  29. ncbi request reprint Polydrug abusers display impaired discrimination-reversal learning in a model of behavioural control
    Mark T Fillmore
    Department of Psychology, University of Kentucky, Lexington, KY 40506 0044, USA
    J Psychopharmacol 20:24-32. 2006
    ..The findings contribute to growing evidence that suggests cocaine and alcohol use could produce broad inhibitory impairments that increase the risk for learning deficits and poor impulse control...
  30. ncbi request reprint Clinical neuropharmacology of drugs of abuse: a comparison of drug-discrimination and subject-report measures
    Thomas H Kelly
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington 40536 0086, USA
    Behav Cogn Neurosci Rev 2:227-60. 2003
    ....
  31. ncbi request reprint Baclofen does not alter the reinforcing, subject-rated or cardiovascular effects of intranasal cocaine in humans
    Joshua A Lile
    Department of Behavioral Science, College of Medicine, Room 127, College of Medicine Office Building, University of Kentucky, Lexington, KY 40536 0086, USA
    Psychopharmacology (Berl) 171:441-9. 2004
    ..There is evidence from research in animals and humans that the gamma-aminobutyric acid B receptor subtype (GABA(B)) agonist baclofen may have promise as a pharmacotherapy for cocaine addiction...
  32. pmc Discriminative stimulus and subject-rated effects of methamphetamine, d-amphetamine, methylphenidate, and triazolam in methamphetamine-trained humans
    Rajkumar J Sevak
    Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, KY 40536 0086, USA
    J Pharmacol Exp Ther 328:1007-18. 2009
    ..Future studies should assess whether the similarity in the behavioral effects of methamphetamine and related stimulants can be extended to other behavioral assays, such as measures of reinforcement, in humans...
  33. ncbi request reprint Acute effects of oral cocaine on inhibitory control of behavior in humans
    Mark T Fillmore
    Department of Psychology, University of Kentucky, Lexington, KY 40506 0044, USA
    Drug Alcohol Depend 67:157-67. 2002
    ..These findings are important because they identify a specific disinhibiting effect of cocaine that could help explain the documented association between long-term cocaine use and poor impulse control...
  34. ncbi request reprint Effects of d-amphetamine on behavioral control in stimulant abusers: the role of prepotent response tendencies
    Mark T Fillmore
    Department of Psychology, University of Kentucky, Lexington, KY 40506 0044, USA
    Drug Alcohol Depend 71:143-52. 2003
    ..Identification of environmental conditions in which stimulants are likely to disinhibit behavior could provide insight into mechanisms that underlie the association between long-term stimulant use and poor impulse control...
  35. pmc Cocaine effects during D-amphetamine maintenance: a human laboratory analysis of safety, tolerability and efficacy
    Craig R Rush
    Department of Behavioral Science, University of Kentucky College of Medicine, College of Medicine Office Building, Lexington, KY 40536 0086, USA
    Drug Alcohol Depend 99:261-71. 2009
    ..g., higher cocaine doses) and behavioral arrangements (e.g., drug self-administration or discrimination)...
  36. pmc The reinforcing, subject-rated, performance, and cardiovascular effects of d-amphetamine: influence of sensation-seeking status
    William W Stoops
    Department of Behavioral Science, College of Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Addict Behav 32:1177-88. 2007
    ..These results suggest that increased stimulant drug use and abuse among high sensation seekers may be related, in part, to increased sensitivity to the reinforcing effects of stimulants among these individuals...
  37. pmc Individual differences in drug abuse vulnerability: d-amphetamine and sensation-seeking status
    Thomas H Kelly
    Department of Behavioral Science, College of Medicine and College of Arts and Sciences, University of Kentucky, Lexington, KY 40536 0086, USA
    Psychopharmacology (Berl) 189:17-25. 2006
    ..While the personality dimensions of novelty seeking and sensation seeking are associated with drug abuse vulnerability, the mechanisms associated with this vulnerability remain obscure...
  38. ncbi request reprint Discriminative stimulus and self-reported effects of methylphenidate, d-amphetamine, and triazolam in methylphenidate-trained humans
    William W Stoops
    Department of Psychology, University of Kentucky, Lexington, KY 40536 0086, USA
    Exp Clin Psychopharmacol 13:56-64. 2005
    ....
  39. ncbi request reprint d-Amphetamine-induced enhancement of inhibitory mechanisms involved in visual search
    Mark T Fillmore
    Department of Psychology, University of Kentucky, Lexington, KY 40506 0044, USA
    Exp Clin Psychopharmacol 13:200-8. 2005
    ..By increasing the delay in returning attention to a previously attended location, d-amphetamine might reduce time spent searching previously attended locations, increasing the efficiency of visual searches...
  40. ncbi request reprint Cocaine improves inhibitory control in a human model of response conflict
    Mark T Fillmore
    Department of Psychology, University of Kentucky, Lexington, 40506, USA
    Exp Clin Psychopharmacol 13:327-35. 2005
    ..The current study provides a useful model to investigate the effects of other drugs reported to have performance-enhancing effects...
  41. pmc Intranasal cocaine functions as reinforcer on a progressive ratio schedule in humans
    William W Stoops
    University of Kentucky College of Medicine, Department of Behavioral Science, 140 Medical Behavioral Science Building, Lexington, KY 40536 0086, USA
    Eur J Pharmacol 644:101-5. 2010
    ..These procedures may be useful for examining the influence of putative pharmacological and behavioral interventions on intranasal cocaine self-administration...
  42. doi request reprint Cocaine choice in humans during D-amphetamine maintenance
    Craig R Rush
    Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, KY 40536 0086, USA
    J Clin Psychopharmacol 30:152-9. 2010
    ..These results are concordant with those of previous preclinical experiments, human laboratory studies, and clinical trials that suggest that agonist replacement therapy may be a viable strategy for managing cocaine dependence...
  43. ncbi request reprint Impaired inhibitory control of behavior in chronic cocaine users
    Mark T Fillmore
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Drug Alcohol Depend 66:265-73. 2002
    ..These findings are important because they identify a specific deficit involving behavioral inhibition that could contribute to cocaine abuse, and explain its association with other disorders of self-regulation, such as ADHD...
  44. ncbi request reprint Acute effects of cocaine in two models of inhibitory control: implications of non-linear dose effects
    Mark T Fillmore
    Department of Psychology, University of Kentucky, Lexington, KY 40506 0044, USA
    Addiction 101:1323-32. 2006
    ..This study examined dose-response effects of oral cocaine on the inhibitory control of behavior in adult cocaine users using two different behavioral models of inhibitory control...
  45. doi request reprint The influence of acute varenicline administration on smoking and eating behavior in humans
    William W Stoops
    Department of Behavioral Science, University of Kentucky College of Medicine, USA
    Pharmacol Biochem Behav 91:165-9. 2008
    ....
  46. pmc Methylphenidate increases choice of cigarettes over money
    William W Stoops
    Department of Behavioral Science, University of Kentucky College of Medicine, 140 Medical Behavioral Science Building, Lexington, KY 40536 0086, USA
    Nicotine Tob Res 13:29-33. 2011
    ..The effects of methylphenidate on a 9-trial, discrete cigarette versus money ($0.25) choice task were tested to elucidate the mechanisms underlying stimulant-induced increases in smoking...
  47. ncbi request reprint Reinforcing effects of modafinil: influence of dose and behavioral demands following drug administration
    William W Stoops
    Department of Psychology, University of Kentucky, Lexington, KY, USA
    Psychopharmacology (Berl) 182:186-93. 2005
    ..The reinforcing effects of stimulant drugs are modulated by behavioral demands following drug administration...
  48. pmc Methylphenidate enhances the abuse-related behavioral effects of nicotine in rats: intravenous self-administration, drug discrimination, and locomotor cross-sensitization
    Thomas E Wooters
    Department of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, KY 40536 0509, USA
    Neuropsychopharmacology 33:1137-48. 2008
    ..Taken together with recent clinical findings, these results suggest that methylphenidate may enhance the abuse-related behavioral effects of nicotine, perhaps increasing vulnerability to tobacco dependence...
  49. ncbi request reprint Discriminative-stimulus, self-reported, performance, and cardiovascular effects of atomoxetine in methylphenidate-trained humans
    Joshua A Lile
    Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, 40536 0086, USA
    Exp Clin Psychopharmacol 14:136-47. 2006
    ..These data suggest that the behavioral effects of atomoxetine overlap to a small degree with psychomotor stimulants and that it has low abuse potential...
  50. ncbi request reprint Alcohol choice and amphetamine effects in light and moderate drinkers
    William W Stoops
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40536 0086, USA
    Alcohol Clin Exp Res 27:804-11. 2003
    ..g., diazepam or ethanol). The purpose of this experiment was to determine whether light and moderate drinkers respond differentially to the effects of ethanol and d-amphetamine...
  51. ncbi request reprint Acute administration of the GABA reuptake inhibitor tiagabine does not alter the effects of oral cocaine in humans
    Joshua A Lile
    Department of Behavioral Science, College of Medicine, University of Kentucky, College of Medicine Office Building Room No 127, Lexington, KY 40536 0086, USA
    Drug Alcohol Depend 76:81-91. 2004
    ..In general, acute administration of tiagabine did not alter the effects of oral cocaine. These findings suggest that tiagabine would not be effective at preventing continued cocaine use by blocking its acute, abuse-related effects...
  52. ncbi request reprint Differential effects in humans after repeated administrations of zolpidem and triazolam
    William W Stoops
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, Kentucky 40536 0086, USA
    Am J Drug Alcohol Abuse 29:281-99. 2003
    ..Future studies should assess the tolerance-producing effects of zolpidem across a range of doses, as well as other novel sedatives such as zaleplon...
  53. pmc Monetary alternative reinforcers more effectively decrease intranasal cocaine choice than food alternative reinforcers
    William W Stoops
    University of Kentucky College of Medicine, Department of Behavioral Science, 140 Medical Behavioral Science Building, Lexington, KY 40536 0086, USA
    Pharmacol Biochem Behav 95:187-91. 2010
    ..Future research should determine the sensitivity of this model to specific behavioral aspects of contingency management and whether food could compete with drugs as reinforcers in humans under laboratory conditions...
  54. ncbi request reprint Discriminative-stimulus effects of triazolam in women and men
    Andrea R Vansickel
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, Kentucky 40536 0086, USA
    Am J Drug Alcohol Abuse 32:329-49. 2006
    ..e., significant effect of dose). The women and men did not differ significantly on any measure. The results of the present experiment suggest that women and men are not differentially sensitive to the behavioral effects of triazolam...
  55. ncbi request reprint Sensitization to the cardiovascular but not subject-rated effects of oral cocaine in humans
    Scott H Kollins
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, North Carolina, USA
    Biol Psychiatry 51:143-50. 2002
    ..This study examined the effects of repeated cocaine in individuals with histories of abuse and dependence...
  56. ncbi request reprint Wake-promoting agents with different mechanisms of action: comparison of effects of modafinil and amphetamine on food intake and cardiovascular activity
    Angela P Makris
    Weight and Eating Disorders Program, Suite 3121, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Appetite 42:185-95. 2004
    ..Modafinil may have less adverse health consequences than some anorectic agents and greater treatment efficacy...
  57. ncbi request reprint Behavioral and subjective effects of d-amphetamine and modafinil in healthy adults
    Angela P Makris
    Center for Obesity Research and Education, Temple University, Philadelphia, PA 19140, USA
    Exp Clin Psychopharmacol 15:123-33. 2007
    ..These results suggest that modafinil engenders alerting effects and increases performance in healthy non-sleep-deprived individuals comparable with that of d-amphetamine...

Research Grants29

  1. Human Cocaine Discrimination
    CRAIG RUSH; Fiscal Year: 2006
    ..Elucidating the role of dopamine in mediating the effects of cocaine may guide the development of pharmacological interventions for cocaine. ..
  2. Agonist Replacement Therapy for Cocaine Dependence: Identifying Novel Medications
    CRAIG RUSH; Fiscal Year: 2007
    ..Identifying novel agonist replacement therapies is important because clinicians may be reluctant to use d-amphetamine because of its abuse potential. ..
  3. Preventing Cocaine Relapse: Developing Pharmacotherapies
    CRAIG RUSH; Fiscal Year: 2007
    ..Reducing relapse to drug use is important because intravenous abuse of cocaine may be associated with increased risk of acquired immunodeficiency syndrome (A.I.D.S.). ..
  4. Agonist Replacement Therapy for Methamphetamine Dependence: Human Lab Studies
    CRAIG RUSH; Fiscal Year: 2009
    ....
  5. Agonist Replacement Therapy for Cocaine Dependence: Identifying Novel Medications
    CRAIG RUSH; Fiscal Year: 2009
    ..Identifying novel agonist replacement therapies is important because clinicians may be reluctant to use d-amphetamine because of its abuse potential. ..
  6. Stimulant Abuse Pharmacotherapy: Novel Antipsychotics
    CRAIG RUSH; Fiscal Year: 2009
    ..The proposed research will provide initial scientific and clinical information regarding the use of aripiprazole as a pharmacotherapy for the treatment of methamphetamine dependence, and guide the design of future clinical trials. ..
  7. COCAINE DISCRIMINATION AND PHARMACOLOGICAL SPECIFICITY
    CRAIG RUSH; Fiscal Year: 2001
    ..Finally, because the interoceptive and discriminative stimulus effects of cocaine clearly contribute to its abuse, the experiments proposed in this application could provide information relevant to the treatment of cocaine abuse. ..
  8. GABA Agonists as Pharmacotherapies for Cocaine Abuse
    CRAIG RUSH; Fiscal Year: 2003
    ..Finally, the proposed research will allow us to conduct retrospective analyses to determine the influence of individual differences (e.g., gender, other drug use) on the reinforcing and subjective effects of cocaine. ..
  9. ASSESSING ABUSE POTENTIAL IN HUMAN--CNS STIMULANTS
    CRAIG RUSH; Fiscal Year: 2004
    ..abstract_text> ..
  10. GABAA Modulation as a Target for Developing Medications for Methamphetamine Abuse
    CRAIG RUSH; Fiscal Year: 2009
    ..The proposed research will provide important clinical information regarding the viability of targeting GABAA receptor modulation for the development of medications to manage methamphetamine dependence. ..