Research Topics
| A J RushSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
Does pretreatment anxiety predict response to either bupropion SR or sertraline?A J Rush
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
J Affect Disord 64:81-7. 2001..The purpose of this study was to determine whether higher baseline anxiety is associated with different antidepressant responses to bupropion sustained release (SR) or sertraline...
Anticipated Benefits of Care (ABC): psychometrics and predictive value in psychiatric disordersD Warden
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
Psychol Med 40:955-65. 2010..No measure of patients' anticipated benefits of treatment on domains of everyday functioning has previously been available...
Do bupropion SR and sertraline differ in their effects on anxiety in depressed patients?M H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390, USA
J Clin Psychiatry 62:776-81. 2001..To examine the effects of bupropion sustained release (SR) and sertraline on anxiety in outpatients with recurrent DSM-IV-defined major depressive disorder...
A comparison of alternative assessments of depressive symptom severity: a pilot studyM M Biggs
Department of Psychiatry, University of Texas, Southwestern Medical Center, Dallas, TX 75390 9086, USA
Psychiatry Res 95:55-65. 2000..While the clinician-rated itemized symptom severity rating scale remains the standard to assess the symptomatic outcome of the treatment of MDD, a self-report of identical symptomatology may be a reasonable alternative for many patients...
A comparison of alternative assessments of depressive symptom severity: a pilot studyM M Biggs
Department of Psychiatry, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
Psychiatry Res 96:269-79. 2000..While the clinician-rated itemized symptom severity rating scale remains the standard to assess the symptomatic outcome of the treatment of MDD, a self-report of identical symptomatology may be a reasonable alternative for many patients...
Controlled comparison of electrophysiological sleep in families of probands with unipolar depressionD E Giles
Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA
Am J Psychiatry 155:192-9. 1998..This study presents polysomnographic data and psychiatric history for parents and siblings of probands with unipolar depression and short REM latency, probands with unipolar depression and normal REM latency, and normal comparison probands...
Adrenergic receptors in premenstrual dysphoric disorder. II. Neutrophil beta2-adrenergic receptors: Gs protein coupling, phase of menstrual cycle and prediction of luteal phase symptom severityG N Gurguis
The Department of Veterans Affairs Medical Center, Dallas, TX, USA
Psychiatry Res 79:31-42. 1998..Further exploration of the role of beta-adrenergic receptor kinase, sex steroid hormones and antidepressants on beta-adrenergic receptor regulation in PMDD is warranted...
Platelet alpha2A-adrenoceptor function in major depression: Gi coupling, effects of imipramine and relationship to treatment outcomeG N Gurguis
Mental Health Services, Department of Veterans Affairs Medical Center, Dallas, TX, USA
Psychiatry Res 89:73-95. 1999..Increased alpha(2A)AR density may represent a trait marker in MDD. The results provide indirect evidence for abnormal protein kinase A (PKA) and protein kinase C (PKC) in MDD which may be pursued in future investigations...
A multicenter, double-blind comparison of the effects of nefazodone and fluoxetine on sleep architecture and quality of sleep in depressed outpatientsR Armitage
University of Texas Southwestern Medical Center, Depart of Psychiatry 75235 9070, USA
J Clin Psychopharmacol 17:161-8. 1997..Significantly greater improvement in clinician- and patient-rated sleep disturbance was found with nefazodone compared with fluoxetine. Nefazodone was associated with better sleep quality...
Effects of fluoxetine on the polysomnogram in outpatients with major depressionM H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235, USA
Neuropsychopharmacology 20:447-59. 1999..Conversely, subjective measures of sleep indicated a steady improvement during acute phase treatment. After fluoxetine was discontinued, total REM sleep and sleep efficiency were found to be increased as compared to baseline...
Neutrophil beta(2)-adrenoceptor function in major depression: G(s) coupling, effects of imipramine and relationship to treatment outcomeG N Gurguis
The Department of Veterans Affairs Medical Center, Dallas, TX, USA
Eur J Pharmacol 386:135-44. 1999..The results indirectly implicate abnormal agonist-mediated beta(2)-adrenoceptor gene expression, protein kinase A, and protein kinase C in major depressive disorder...
Indicators of pretreatment suicidal ideation in adults with major depressive disorderD W Morris
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
Acta Psychiatr Scand 121:480-4. 2010..The purpose of this report is to identify sociodemographic and clinical features that are associated with SI in major depressive disorder (MDD) patients prior to treatment with a selective serotonin reuptake inhibitor...
Effect size of lithium, divalproex sodium, and carbamazepine in children and adolescents with bipolar disorderR A Kowatch
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas 75235 9070, USA
J Am Acad Child Adolesc Psychiatry 39:713-20. 2000..To develop effect sizes for 3 mood stabilizers--lithium, divalproex sodium, and carbamazepine--for the acute-phase treatment of bipolar I or II disorder, mixed or manic episode, in children and adolescents aged 8 to 18 years...
The Texas Children's Medication Algorithm Project: report of the Texas Consensus Conference Panel on Medication Treatment of Childhood Major Depressive DisorderC W Hughes
University of Texas Southwestern Medical Center, Dallas, USA
J Am Acad Child Adolesc Psychiatry 38:1442-54. 1999..A final goal is to develop an approach that can be tested as to whether it improves clinical outcomes for children and adolescents with MDD...
The Texas Medication Algorithm Project (TMAP) schizophrenia algorithmsA L Miller
Department of Psychiatry, The University of Texas Health Science Center, San Antonio 78284 7792, USA
J Clin Psychiatry 60:649-57. 1999..They also specify response criteria at each stage of the algorithm for both positive and negative symptoms. The rationale and evidence for each aspect of the algorithms are presented...
Prediction of response to fluoxetine and placebo in children and adolescents with major depression: a hypothesis generating studyR A Kowatch
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas 75235 9070, USA
J Affect Disord 54:269-76. 1999..The results of multivariate analyses to identify potential predictors of response to fluoxetine or placebo separately in 96 child and adolescent outpatients with major depressive disorder from a recent controlled trial are presented...
Neutrophil beta2-adrenergic receptor coupling efficiency to Gs protein in subjects with post-traumatic stress disorder and normal controlsG N Gurguis
Laboratory of Clinical Neuroscience, Mental Health 116A, Department of Veterans Affairs, Dallas, TX 75216, USA
Psychopharmacology (Berl) 143:131-40. 1999..Dysregulation in Gs protein function is postulated and, agonist-mediated regulation of betaAR expression and/or betaAR kinase activity in PTSD should be investigated in future studies...
Dyadic discord at baseline is associated with lack of remission in the acute treatment of chronic depressionW H Denton
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, TX 75390 9121, USA
Psychol Med 40:415-24. 2010..This study investigated pretreatment dyadic discord as a predictor of non-remission and its relationship to depressive symptom change during acute treatment for chronic depression...
Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorderS L McElroy
Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
Am J Psychiatry 158:420-6. 2001..Therefore, the authors assessed comorbid lifetime and current axis I disorders in 288 patients with bipolar disorder and the relationships of these comorbid disorders to selected demographic and historical illness variables...
Diagnostic utility of the Quick Inventory of Depressive Symptomatology (QIDS-C16 and QIDS-SR16) in the elderlyP Murali Doraiswamy
Department of Psychiatry, and the Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA
Acta Psychiatr Scand 122:226-34. 2010..the Quick Inventory of Depressive Symptomatology-Clinician-rated (QIDS-C(16)) and Self-report (QIDS-SR(16)) scales to detect a current major depressive episode in the elderly...
The Texas Medication Algorithm Project: development and implementation of the schizophrenia algorithmJ A Chiles
Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284 7792, USA
Psychiatr Serv 50:69-74. 1999..htm. The authors present and describe the original and current versions of the algorithm, outline the feedback process by which it will be refined, and discuss how new medications will be incorporated as they enter the market...
The importance of irritability as a symptom of major depressive disorder: results from the National Comorbidity Survey ReplicationM Fava
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Mol Psychiatry 15:856-67. 2010..Further investigation is warranted of distinct family aggregation, risk factors and treatment response. Consideration should also be given to including irritability as a nondiagnostic symptom of adult MDD in DSM-V and ICD-11...
Slow-wave activity in NREM sleep: sex and age effects in depressed outpatients and healthy controlsR Armitage
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Psychiatry Res 95:201-13. 2000..These findings provide further support that the pathophysiology of depression differs for men and women and suggest that maturational effects on SWA in depression differ from those observed in healthy individuals...
Response in relation to baseline anxiety levels in major depressive disorder treated with bupropion sustained release or sertralineA J Rush
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9086, USA
Neuropsychopharmacology 25:131-8. 2001..Thus, the clinical decision to select between these two agents when treating depressed outpatients cannot rest on either levels of pretreatment anxiety or on anticipation of more rapid or more complete anxiolysis...
Delta sleep EEG in depressed adolescent females and healthy controlsR Armitage
Sleep Study Unit, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235 9070, USA
J Affect Disord 63:139-48. 2001..To date, these methodologies have not been used in early onset MDD...
Characteristics of norepinephrine and clonidine displacement of [3H]yohimbine binding to platelet alpha2-adrenoreceptors in healthy volunteersG N Gurguis
Department of Veterans Affairs Medical Center 116A, Dallas, TX 75216, USA
Psychiatry Res 85:305-14. 1999..The combined use of antagonist-saturation and agonist-displacement experiments to examine possible dysregulation in alpha2AR coupling to Gi protein in psychiatric disorders is recommended...
Which depressed patients respond to nefazodone and when?M H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA madhukar trivedi utsouthwestern edu
J Clin Psychiatry 62:158-63. 2001....
Treating major depression in primary care practice: an update of the Agency for Health Care Policy and Research Practice GuidelinesH C Schulberg
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
Arch Gen Psychiatry 55:1121-7. 1998..Future research should focus on how guidelines are best implemented in routine practice, since conventional dissemination strategies have little impact...
Is there a role for continuation phase cognitive therapy for depressed outpatients?R B Jarrett
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas 75235 9149, USA
J Consult Clin Psychol 66:1036-40. 1998..If replicated, this result suggests that C-CT can reduce depressive relapse or recurrence. Alternative explanations are presented...
Adrenergic receptor function in panic disorder. II. Neutrophil beta 2 receptors: Gs protein coupling, effects of imipramine treatment and relationship to treatment outcomeG N Gurguis
Department of Veterans Affairs Medical Center, Laboratory of Clinical Neuroscience, Dallas, TX 75216, USA
J Psychiatr Res 33:309-22. 1999..Antidepressants downregulate beta AR density and induce uncoupling from Gs protein in PD. Future studies may investigate beta AR coupling in relationship to treatment outcome and the role of beta AR kinase in PD...
Implementing evidence-based practices for persons with severe mental illnessesW C Torrey
Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA
Psychiatr Serv 52:45-50. 2001..Special materials will address the concerns of mental health authorities (funders), administrators of provider organizations, clinicians, and consumers and their families...
Onset and persistence of postpartum depression in an inner-city maternal health clinic systemK A Yonkers
Department of Psychiatry, University of Texas, Southwestern Medical Center, Dallas, USA
Am J Psychiatry 158:1856-63. 2001....
Ketoconazole in bipolar patients with depressive symptoms: a case series and literature reviewE S Brown
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9070, USA
Bipolar Disord 3:23-9. 2001..The literature on the use of cortisol-lowering strategies in mood disorders is reviewed, and a case series illustrating the use of ketoconazole in bipolar depression is presented...
Texas Medication Algorithm Project: development and feasibility testing of a treatment algorithm for patients with bipolar disorderT Suppes
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9070, USA
J Clin Psychiatry 62:439-47. 2001....
Evidence for the segregation of a major gene for human plasma GABA levelsF Petty
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX, USA
Mol Psychiatry 4:587-9. 1999..Our results suggest that plasma GABA levels are under single gene control. Future research should address the precise mechanisms which may account for the abnormality in GABA levels seen in a subset of patients with mood disorders...
Sleep polysomnography as a predictor of recurrence in children and adolescents with major depressive disorderG J Emslie
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 75390 8589, USA
Int J Neuropsychopharmacol 4:159-68. 2001..Depression in children and adolescents is frequently a chronic, recurrent illness. Factors that can predict clinical course are important in increasing our understanding of depression in this age group...
Regional cerebral blood flow response to oral amphetamine challenge in healthy volunteersM D Devous
Nuclear Medicine Center and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9061, USA
J Nucl Med 42:535-42. 2001..Frontopolar and temporal increases observed in our study appear to be unique to humans...
