Research Topics
| M E RuppSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Detail Information
Publications
Designing a biocontainment unit to care for patients with serious communicable diseases: a consensus statementPhilip W Smith
Biocontainment Unit, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
Biosecur Bioterror 4:351-65. 2006..The consensus recommendations are presented to standardize the planning, design, construction, and operation of BPCUs as one element of the U.S. preparedness effort...
Hospital-wide assessment of compliance with central venous catheter dressing recommendationsMark E Rupp
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE Department of Infection Control and Epidemiology, Nebraska Medical Center, Omaha, NE Electronic address
Am J Infect Control 41:89-91. 2013..001). No correlation between CVC site maintenance and central line-associated bloodstream infections was detected (Spearman's correlation coefficient = 0.007; P = 0.98)...- Effect of hospital-wide chlorhexidine patient bathing on healthcare-associated infectionsMark E Rupp
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Infect Control Hosp Epidemiol 33:1094-100. 2012..The objective was to determine the effect of hospital-wide CHG patient bathing on healthcare-associated infections (HAIs)... - Adequate disinfection of a split-septum needleless intravascular connector with a 5-second alcohol scrubMark E Rupp
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
Infect Control Hosp Epidemiol 33:661-5. 2012..Define optimum vascular catheter connector valve disinfection practices under laboratory and clinical conditions... 
Validation and comparison of clinical prediction rules for invasive candidiasis in intensive care unit patients: a matched case-control studyElizabeth D Hermsen
Department of Pharmaceutical and Nutrition Care, The Nebraska Medical Center, 981090 Nebraska Medical Center, Omaha, NE 68198 1090, USA
Crit Care 15:R198. 2011..The aims of this study were to validate and compare the Paphitou and Ostrosky-Zeichner clinical prediction rules in ICU patients in a 689-bed academic medical center...- Prospective, controlled, cross-over trial of alcohol-based hand gel in critical care units Mark E Rupp
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA
Infect Control Hosp Epidemiol 29:8-15. 2008..There are limited data from prospective studies to indicate whether improvement in hand hygiene associated with the use of alcohol-based hand hygiene products results in improved patient outcomes... - Phase II, randomized, multicenter, double-blind, placebo-controlled trial of a polyclonal anti-Staphylococcus aureus capsular polysaccharide immune globulin in treatment of Staphylococcus aureus bacteremiaMark E Rupp
Division of Infectious Diseases, University of Nebraska Medical Center, 984031 Nebraska Medical Center, Omaha, NE 68198 4031, USA
Antimicrob Agents Chemother 51:4249-54. 2007..gov number NCT00063089)... - Effect of subinhibitory concentrations of vancomycin, cefazolin, ofloxacin, L-ofloxacin and D-ofloxacin on adherence to intravascular catheters and biofilm formation by Staphylococcus epidermidisM E Rupp
Department of Internal Medicine, The University of Nebraska Medical Center, Omaha 68198 5400, USA
J Antimicrob Chemother 41:155-61. 1998..However, later aggregative stages of adherence, associated with biofilm production, may be influenced by cell wall-active agents such as cefazolin and vancomycin... - Extended spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae: considerations for diagnosis, prevention and drug treatmentMark E Rupp
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Drugs 63:353-65. 2003..Unfortunately, use of carbapenems has been associated with the emergence of carbapenem-resistant bacterial species such as Stenotrophomonas sp. or Pseudomonas sp... - Outbreak of bloodstream infection temporally associated with the use of an intravascular needleless valveMark E Rupp
Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA
Clin Infect Dis 44:1408-14. 2007..In March 2005, a dramatic increase in bloodstream infections was noted in multiple patient care units of a hospital in temporal association with the introduction of a needleless valve into use... - Effect of a second-generation venous catheter impregnated with chlorhexidine and silver sulfadiazine on central catheter-related infections: a randomized, controlled trialMark E Rupp
University of Nebraska Medical Center, Omaha, Nebraska, USA
Ann Intern Med 143:570-80. 2005..Central venous catheter-related infections are a significant medical problem. Improved preventive measures are needed... - Effect of LY333328 against vancomycin-resistant Enterococcus faecium in a rat central venous catheter-associated infection modelM E Rupp
Department of Internal Medicine, 984031 University of Nebraska Medical Center, Omaha, NE 68198 4031, USA
J Antimicrob Chemother 47:705-7. 2001..01). All animals in the control group had evidence of metastatic disease compared with none of the treated group (P < 0.01). LY333328 was effective against the strain of VRE tested in this model... - Characterization of the importance of Staphylococcus epidermidis autolysin and polysaccharide intercellular adhesin in the pathogenesis of intravascular catheter-associated infection in a rat modelM E Rupp
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 4031, USA
J Infect Dis 183:1038-42. 2001..These results confirm the importance of initial adherence, associated with AtlE, and biofilm production, mediated by PIA, in the pathogenesis of S. epidermidis experimental CVC infection... - Characterization of the importance of polysaccharide intercellular adhesin/hemagglutinin of Staphylococcus epidermidis in the pathogenesis of biomaterial-based infection in a mouse foreign body infection modelM E Rupp
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
Infect Immun 67:2627-32. 1999..These results confirm the importance of biofilm production, mediated by PIA/HA, in the pathogenesis of S. epidermidis experimental foreign body infection... - Characterization of Staphylococcus epidermidis polysaccharide intercellular adhesin/hemagglutinin in the pathogenesis of intravascular catheter-associated infection in a rat modelM E Rupp
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Infect Immun 67:2656-9. 1999..These results confirm the importance of biofilm production, mediated by PIA/HA, in the pathogenesis of S. epidermidis experimental CVC-associated infection... - Effect of silver-coated urinary catheters: efficacy, cost-effectiveness, and antimicrobial resistanceMark E Rupp
Department of Internal Medicine, University of Nebraska Medical Center, 984031 Nebraska Medical Center, Omaha, NE 68198, USA
Am J Infect Control 32:445-50. 2004.... - Characterization of the relationship between polysaccharide intercellular adhesin and hemagglutination in Staphylococcus epidermidisP D Fey
Division of Infectious Disease, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
J Infect Dis 179:1561-4. 1999..It was concluded that production of PIA and hemagglutination are strongly associated and that PIA, at least in part, mediates hemagglutination in S. epidermidis... - SigmaB and SarA independently regulate polysaccharide intercellular adhesin production in Staphylococcus epidermidisL D Handke
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 6280, USA
Can J Microbiol 53:82-91. 2007..It is concluded that sigmaB and SarA operate independently of each other to regulate PIA production and biofilm development in S. epidermidis... - Staphylococcus epidermidis saeR is an effector of anaerobic growth and a mediator of acute inflammationL D Handke
Department of Pathology, University of Nebraska Medical Center, Omaha, NE 68198 6280, USA
Infect Immun 76:141-52. 2008.... - Ceftriaxone-resistant salmonella infection acquired by a child from cattleP D Fey
Nebraska Public Health Laboratory, and Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198 5400, USA
N Engl J Med 342:1242-9. 2000..We analyzed the molecular characteristics of a ceftriaxone-resistant strain of Salmonella enterica serotype typhimurium isolated from a 12-year-old boy with fever, abdominal pain, and diarrhea... - The presence of icaADBC is detrimental to the colonization of human skin by Staphylococcus epidermidisK L Rogers
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6280, USA
Appl Environ Microbiol 74:6155-7. 2008..epidermidis strain 1457 was outcompeted at 1, 3, and 10 days by an isogenic icaADBC mutant (1457 ica::dhfr), suggesting a fitness cost for carriage of icaADBC... - Outbreak of vancomycin-resistant Enterococcus faecium in a neonatal intensive care unitM E Rupp
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-4031, USA
Infect Control Hosp Epidemiol 22:301-3. 2001.... - The intercellular adhesin locus ica is present in clinical isolates of Staphylococcus aureus from bacteremic patients with infected and uninfected prosthetic jointsV G Fowler
Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27706, USA
Med Microbiol Immunol 189:127-31. 2001..epidermidis and S. aureus and that PIA may be expressed only under in vivo conditions. Future investigations should include animal models to approximate the complex milieu surrounding implanted prosthetic medical devices... - Ethanol lock technique: review of the literatureMelissa Maiefski
Department of Pharmaceutical and Nutrition Care, Nebraska Medical Center, Omaha, Nebraska 68198 4031, USA
Infect Control Hosp Epidemiol 30:1096-108. 2009..Definitive catheter integrity data are limited. Clinical trials report tolerable adverse events with ethanol locks, as well as encouraging results for prevention and treatment of CLA BSI... - Adherence of Staphylococcus epidermidis to biomaterials is augmented by PIAM E Olson
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
Clin Orthop Relat Res 451:21-4. 2006..PIA appears to play a critical role in the adherence of S. epidermidis to orthopaedic biomaterials, and may serve as an important virulence determinant in orthopaedic prosthetic device infections... - Genetic and phenotypic analysis of biofilm phenotypic variation in multiple Staphylococcus epidermidis isolatesL D Handke
Department of Pathology, University of Nebraska Medical Center, Omaha, NE, USA
J Med Microbiol 53:367-74. 2004..It is concluded that mutation and transcriptional regulation of ica are the primary mechanisms that govern phenotypic variation of biofilm formation within IS256-negative S. epidermidis... - Evaluation of the revised MicroScan dried overnight gram-positive identification panel to identify Enterococcus speciesP C Iwen
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6495, USA
J Clin Microbiol 37:3756-8. 1999..gallinarum and increased the accuracy of the panel for identifying Enterococcus species to 98.5%... - Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxicSara E Cosgrove
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Clin Infect Dis 48:713-21. 2009..This study evaluated the association between this practice and nephrotoxicity... - Inappropriate intravascular device use: a prospective studyM M Tiwari
College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA
J Hosp Infect 78:128-32. 2011..These results may be used to develop strategies to systematically reduce excessive intravascular device use which would be expected to reduce adverse events associated with morbidity, mortality, and excess healthcare costs... - Antimicrobial effects of lidocaine in bronchoalveolar lavage fluidK M Olsen
Department of Pharmacy Practice, University of Nebraska Medical Center, Omaha, NE 68198 6045, USA
J Antimicrob Chemother 45:217-9. 2000..The recovery of isolates of S. pneumoniae may be reduced below the critical threshold of 10(5) cfu/mL during bronchoscopy when using lidocaine as a local anaesthetic... - Utilization of the internal transcribed spacer regions as molecular targets to detect and identify human fungal pathogensP C Iwen
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 6495, USA
Med Mycol 40:87-109. 2002..Development of rapid and accurate amplification-based ITS assays to diagnose invasive fungal infections could potentially impact care and improve outcome for affected patients... - Effect of once-daily dosing vs. multiple daily dosing of tobramycin on enzyme markers of nephrotoxicityKeith M Olsen
Department of Pharmacy Practice, University of Nebraska Medical Center, 986045 Nebraska Medical Center, Omaha, NE 68198, USA
Crit Care Med 32:1678-82. 2004..To determine the incidence of nephrotoxicity of once-daily dosing (ODD) and multiple daily dosing (MDD) regimens of tobramycin in critically ill patients... - Vancomycin susceptibility trends and prevalence of heterogeneous vancomycin-intermediate Staphylococcus aureus in clinical methicillin-resistant S. aureus isolatesAdam M Pitz
Department of Pharmacy Practice, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198 6045, USA
J Clin Microbiol 49:269-74. 2011..In conclusion, reduced vancomycin susceptibility was not detected in our hospital over a 9-year period using three different MIC methodologies, and the hVISA incidence was 1.2%, as determined by Etest GRD and PAP-AUC... - Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: a systematic review and meta-analysisAndre C Kalil
University of Nebraska Medical Center, Omaha, NE, USA
Crit Care Med 38:1802-8. 2010..However, clinical superiority has not been demonstrated... - Molecular epidemiology in the public health and hospital environmentsPaul D Fey
Department of Internal Medicine, Division of Infectious Disease and Pathology and Microbiology, University of Nebraska Medical Center, 985400 Nebraska Medical Center, Omaha, NE 68198 5400, USA
Clin Lab Med 23:885-901. 2003..Nevertheless, the typing methods discussed in this article and those yet to be developed have significantly improved the quality of health care worldwide... - Disseminated aspergillosis caused by Aspergillus ustus in a patient following allogeneic peripheral stem cell transplantationP C Iwen
Departments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
J Clin Microbiol 36:3713-7. 1998..ustus. In vitro susceptibility testing indicated probable resistance to AMB but not to ITR. This case supports the need for the development of rapid methods to determine antifungal susceptibility... - Prevalence of non-O157:H7 shiga toxin-producing Escherichia coli in diarrheal stool samples from NebraskaP D Fey
University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
Emerg Infect Dis 6:530-3. 2000..2%) of 335 specimens were positive by at least one method (CT-SMAC culture [6 of 14], EHEC enzyme immunoassay [13 of 14], stx1,2 PCR [14 of 14]). Six contained serogroup O157, while non-O157 were as prevalent as O157 serogroups... - Monsel's solution: a potential vector for nosocomial infection?Mark E Rupp
University of Nebraska Medical Center, Omaha 68198 4031, USA
Infect Control Hosp Epidemiol 24:142-4. 2003..However, microbiologic inoculation studies and contamination surveys indicate that Monsel's solution has properties that prohibit microbial growth, making it an unlikely vector for nosocomial infection... - Infection control experience in a cooperative care center for transplant patientsAhmad Nusair
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 4031, USA
Infect Control Hosp Epidemiol 29:424-9. 2008..To characterize infection control experience during a 6.5-year period in a cooperative care center for transplant patients... - Impact of the more-potent antibiotics quinupristin-dalfopristin and linezolid on outcome measure of patients with vancomycin-resistant Enterococcus bacteremiaKristine Mace Erlandson
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198 4031, USA
Clin Infect Dis 46:30-6. 2008..There are limited data comparing patient outcomes during the early era of vancomycin resistance with the period of more-potent antibiotic availability... - Comparative molecular analysis of community- or hospital-acquired methicillin-resistant Staphylococcus aureusP D Fey
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Antimicrob Agents Chemother 47:196-203. 2003..CA-MRSA poses a serious health risk not only because it is resistant to the antibiotics of choice for community-acquired staphylococcal infections but also because of its ability to cause nmTSS via superantigen production... - Pharmacoeconomic analysis of microbiologic techniques for differentiating staphylococci directly from blood culture bottlesElizabeth D Hermsen
Department of Pharmaceutical and Nutrition Care, The Nebraska Medical Center, 988485 Nebraska Medical Center, Omaha, Nebraska 68198 8485, USA
J Clin Microbiol 46:2924-9. 2008..The advantage of TCT4 and TCT24 remained robust upon sensitivity analysis. TCT4 should be further evaluated as a rapid, cost-effective means for identification of S. aureus in blood cultures... - Arthralgias and myalgias related to quinupristin-dalfopristin administrationK M Olsen
Department of Pharmacy Practice, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198 6045, USA
Clin Infect Dis 32:e83-6. 2001..Clinicians should be aware of these adverse events associated with quinupristin-dalfopristin, which may occur more frequently than has been previously reported... - Comparison of the Modification of Diet in Renal Disease and Cockcroft-Gault equations for dosing antimicrobialsElizabeth D Hermsen
Department of Pharmaceutical and Nutrition Care, The Nebraska Medical Center, Omaha, Nebraska 68198 4031, USA
Pharmacotherapy 29:649-55. 2009.... - Coagulase-negative staphylococcal infectionsKathie L Rogers
Department of Pathology and Microbiology, University of Nebraska Medical Center, 986280 Nebraska Medical Center, Omaha, NE 68198 6280, USA
Infect Dis Clin North Am 23:73-98. 2009..This article deals with the clinical syndromes, epidemiology, prevention, and management of infections caused by this unique group of organisms... - Improvement in prescribing habits and economic outcomes associated with the introduction of a standardized approach for surgical antimicrobial prophylaxisElizabeth D Hermsen
Department of Pharmaceutical and Nutrition Care, Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198 8485, USA
Infect Control Hosp Epidemiol 29:457-61. 2008.... - Incidence of surgical site infection associated with robotic surgeryElizabeth D Hermsen
Pharmacy Relations and Clinical Decision Support, the Department of Pharmaceutical and Nutrition Care, Nebraska Medical Center, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198 4031, USA
Infect Control Hosp Epidemiol 31:822-7. 2010..We aimed to determine the duration of robot-assisted surgical procedures and the incidence of postoperative surgical site infection (SSI) and to compare our data with the SSI incidence for open procedures according to national data... - Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureusVance G Fowler
Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 355:653-65. 2006..Alternative therapies for Staphylococcus aureus bacteremia and endocarditis are needed... - Public disclosure of healthcare-associated infections: the role of the Society for Healthcare Epidemiology of AmericaEdward S Wong
Society for Healthcare Epidemiology of America, 66 Canal Center Plaza, Suite 600, Alexandria, VA 22314, USA
Infect Control Hosp Epidemiol 26:210-2. 2005