Davide Ruggero

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Oncogenic AKTivation of translation as a therapeutic target
    A C Hsieh
    Department of Urology, School of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Helen Diller Family Cancer Research Building, Room 386, 1450 3rd Street, San Francisco, CA 94158 3110, USA
    Br J Cancer 105:329-36. 2011
  2. doi request reprint Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling
    Davide Ruggero
    Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Sci Signal 5:pe38. 2012
  3. pmc The role of Myc-induced protein synthesis in cancer
    Davide Ruggero
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94158, USA
    Cancer Res 69:8839-43. 2009
  4. pmc Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
    Michael Pourdehnad
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 110:11988-93. 2013
  5. pmc The translational landscape of the mammalian cell cycle
    Craig R Stumpf
    Department of Urology, University of California, San Francisco, CA 94158, USA Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA
    Mol Cell 52:574-82. 2013
  6. pmc Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
    Andrew C Hsieh
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA
    Cancer Cell 17:249-61. 2010
  7. pmc Assessing gene-level translational control from ribosome profiling
    Adam B Olshen
    Department of Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, Department of Medicine and Department of Urology, University of California, San Francisco, CA 94158, USA and Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
    Bioinformatics 29:2995-3002. 2013
  8. pmc H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation
    Cristian Bellodi
    School of Medicine and Department of Urology, UCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA 94115, USA
    Cell Rep 3:1493-502. 2013
  9. pmc Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita
    Cristian Bellodi
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Center, University of California, San Francisco, CA, USA
    EMBO J 29:1865-76. 2010
  10. doi request reprint Investigating Myc-dependent translational regulation in normal and cancer cells
    John T Cunningham
    School of Medicine, University of California San Francisco, San Francisco, CA, USA
    Methods Mol Biol 1012:201-12. 2013

Collaborators

Detail Information

Publications18

  1. pmc Oncogenic AKTivation of translation as a therapeutic target
    A C Hsieh
    Department of Urology, School of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Helen Diller Family Cancer Research Building, Room 386, 1450 3rd Street, San Francisco, CA 94158 3110, USA
    Br J Cancer 105:329-36. 2011
    ..However, it will be important to determine whether combined inhibition of ribosome biogenesis, translation initiation, and translation elongation can demonstrate improved therapeutic efficacy in tumours driven by oncogenic AKT...
  2. doi request reprint Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling
    Davide Ruggero
    Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Sci Signal 5:pe38. 2012
    ....
  3. pmc The role of Myc-induced protein synthesis in cancer
    Davide Ruggero
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94158, USA
    Cancer Res 69:8839-43. 2009
    ..Moreover, new genetic tools to restore aberrant increases in protein synthesis control are now available, which should enable the dissection of important mechanisms in cancer that rely on the translational machinery...
  4. pmc Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
    Michael Pourdehnad
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 110:11988-93. 2013
    ....
  5. pmc The translational landscape of the mammalian cell cycle
    Craig R Stumpf
    Department of Urology, University of California, San Francisco, CA 94158, USA Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA
    Mol Cell 52:574-82. 2013
    ..Our findings illuminate the prevalence and dynamic nature of translational regulation underlying the mammalian cell cycle. ..
  6. pmc Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
    Andrew C Hsieh
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA
    Cancer Cell 17:249-61. 2010
    ..Thus, the 4EBP-eIF4E axis downstream of mTOR is a druggable mediator of translational control and Akt-mediated tumorigenesis that has important implications for the treatment of human cancers...
  7. pmc Assessing gene-level translational control from ribosome profiling
    Adam B Olshen
    Department of Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, Department of Medicine and Department of Urology, University of California, San Francisco, CA 94158, USA and Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
    Bioinformatics 29:2995-3002. 2013
    ..Despite its promise for deeply characterizing mammalian proteomes, few analytical methods exist for the comprehensive analysis of this paired RNA and ribosome data...
  8. pmc H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation
    Cristian Bellodi
    School of Medicine and Department of Urology, UCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA 94115, USA
    Cell Rep 3:1493-502. 2013
    ..Altogether, these findings reveal that small noncoding RNA dysfunctions may contribute to the pleiotropic manifestation of human disease...
  9. pmc Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita
    Cristian Bellodi
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Center, University of California, San Francisco, CA, USA
    EMBO J 29:1865-76. 2010
    ..Importantly, re-introduction of wild-type DKC1 restores p53 expression in these cells. These results provide insight into the basis for cancer susceptibility in human syndromes associated with ribosome dysfunction...
  10. doi request reprint Investigating Myc-dependent translational regulation in normal and cancer cells
    John T Cunningham
    School of Medicine, University of California San Francisco, San Francisco, CA, USA
    Methods Mol Biol 1012:201-12. 2013
    ..The protocols described in this chapter can be used to understand how and to what extent Myc-dependent regulation of translation influences normal cellular functions as well as tumorigenesis. ..
  11. pmc Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
    Maria Barna
    Department of Biochemistry and Biophysics, University of California San Francisco, Rock Hall Room 384C, 1550 Fourth Street, San Francisco, California 94158 2517, USA
    Nature 456:971-5. 2008
    ....
  12. pmc The translational landscape of mTOR signalling steers cancer initiation and metastasis
    Andrew C Hsieh
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA
    Nature 485:55-61. 2012
    ..Together, these findings extend our understanding of how the 'cancerous' translation machinery steers specific cancer cell behaviours, including metastasis, and may be therapeutically targeted...
  13. doi request reprint Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer
    Andrew C Hsieh
    Department of Urology, Helen Diller Family Comprehensive Cancer Center, School of Medicine, University of California, San Francisco, San Francisco, California, USA
    Clin Cancer Res 16:4914-20. 2010
    ..In doing so, we also highlight the major differences between these therapeutics that may influence their mechanism of action...
  14. pmc New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization
    John T Cunningham
    Department of Urology, School of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California
    Cancer Discov 3:1099-102. 2013
    ....
  15. ncbi request reprint Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer
    John T Cunningham
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 157:1088-103. 2014
    ..Together, these studies identify a translationally anchored anabolic circuit critical for cancer cell survival and an unexpected vulnerability for "undruggable" oncogenes, such as Myc. PAPERFLICK:..
  16. pmc The cancerous translation apparatus
    Craig R Stumpf
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158 3110, USA
    Curr Opin Genet Dev 21:474-83. 2011
    ....
  17. pmc IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2
    John Paul Upton
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    Science 338:818-22. 2012
    ..Thus, IRE1α regulates translation of a proapoptotic protein through terminating microRNA biogenesis, and noncoding RNAs are part of the ER stress response...
  18. pmc Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis
    Cristian Bellodi
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Center, University of California, San Francisco, California 94158, USA
    Cancer Res 70:6026-35. 2010
    ....