Research Topics
Genomes and Genes | Davide RuggeroSummaryAffiliation: University of California Country: USA Publications
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Publications
Revisiting the nucleolus: from marker to dynamic integrator of cancer signalingDavide Ruggero
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
Sci Signal 5:pe38. 2012....
The role of Myc-induced protein synthesis in cancerDavide Ruggero
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94158, USA
Cancer Res 69:8839-43. 2009..Moreover, new genetic tools to restore aberrant increases in protein synthesis control are now available, which should enable the dissection of important mechanisms in cancer that rely on the translational machinery...- Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4EAndrew C Hsieh
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA
Cancer Cell 17:249-61. 2010..Thus, the 4EBP-eIF4E axis downstream of mTOR is a druggable mediator of translational control and Akt-mediated tumorigenesis that has important implications for the treatment of human cancers... - Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiencyMaria Barna
Department of Biochemistry and Biophysics, University of California San Francisco, Rock Hall Room 384C, 1550 Fourth Street, San Francisco, California 94158 2517, USA
Nature 456:971-5. 2008.... - The translational landscape of mTOR signalling steers cancer initiation and metastasisAndrew C Hsieh
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94158, USA
Nature 485:55-61. 2012..Together, these findings extend our understanding of how the 'cancerous' translation machinery steers specific cancer cell behaviours, including metastasis, and may be therapeutically targeted... - Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancerAndrew C Hsieh
Department of Urology, Helen Diller Family Comprehensive Cancer Center, School of Medicine, University of California, San Francisco, San Francisco, California, USA
Clin Cancer Res 16:4914-20. 2010..In doing so, we also highlight the major differences between these therapeutics that may influence their mechanism of action... - The cancerous translation apparatusCraig R Stumpf
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158 3110, USA
Curr Opin Genet Dev 21:474-83. 2011.... - Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenitaCristian Bellodi
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Center, University of California, San Francisco, CA, USA
EMBO J 29:1865-76. 2010..Importantly, re-introduction of wild-type DKC1 restores p53 expression in these cells. These results provide insight into the basis for cancer susceptibility in human syndromes associated with ribosome dysfunction... - IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2John Paul Upton
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
Science 338:818-22. 2012..Thus, IRE1α regulates translation of a proapoptotic protein through terminating microRNA biogenesis, and noncoding RNAs are part of the ER stress response... - Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesisCristian Bellodi
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Center, University of California, San Francisco, California 94158, USA
Cancer Res 70:6026-35. 2010....