H Rubin

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The membrane, magnesium, mitosis (MMM) model of cell proliferation control
    H Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley 94720 3200, USA
    Magnes Res 18:268-74. 2005
  2. ncbi request reprint Cell damage, aging and transformation: a multilevel analysis of carcinogenesis
    H Rubin
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3206, USA
    Anticancer Res 19:4877-86. 1999
  3. ncbi request reprint Complementary approaches to understanding the role of proteases and their natural inhibitors in neoplastic development: retrospect and prospect
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley 94720 3200, USA
    Carcinogenesis 24:803-16. 2003
  4. pmc Cancer cachexia: its correlations and causes
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 100:5384-9. 2003
  5. ncbi request reprint Systemic effects of cancer: role of multiple proteases and their toxic peptide products
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Med Sci Monit 11:RA221-8. 2005
  6. ncbi request reprint Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, California, CA 94720 3200, USA
    Oncogene 21:7392-411. 2002
  7. ncbi request reprint The disparity between human cell senescence in vitro and lifelong replication in vivo
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Nat Biotechnol 20:675-81. 2002
  8. ncbi request reprint Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates
    H Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Carcinogenesis 22:1903-30. 2001
  9. ncbi request reprint Selected cell and selective microenvironment in neoplastic development
    H Rubin
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Cancer Res 61:799-807. 2001
  10. ncbi request reprint Walter Elsasser, prophet of biological complexity, seeker of simplifying rules
    H Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Cell Mol Biol (Noisy-le-grand) 51:599-606. 2005

Collaborators

  • Charles Vidair

Detail Information

Publications24

  1. ncbi request reprint The membrane, magnesium, mitosis (MMM) model of cell proliferation control
    H Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley 94720 3200, USA
    Magnes Res 18:268-74. 2005
    ..Those two proteins directly regulate the initiation of protein synthesis, the driving force of the process...
  2. ncbi request reprint Cell damage, aging and transformation: a multilevel analysis of carcinogenesis
    H Rubin
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3206, USA
    Anticancer Res 19:4877-86. 1999
    ..The order that controls heterogeneity is weakened with age and contributes to the origin and progression of disordered growth...
  3. ncbi request reprint Complementary approaches to understanding the role of proteases and their natural inhibitors in neoplastic development: retrospect and prospect
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley 94720 3200, USA
    Carcinogenesis 24:803-16. 2003
    ....
  4. pmc Cancer cachexia: its correlations and causes
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 100:5384-9. 2003
    ..Reevaluation of all of the evidence supports a central role for proteolytically generated peptides derived from tumors in producing cancer cachexia...
  5. ncbi request reprint Systemic effects of cancer: role of multiple proteases and their toxic peptide products
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Med Sci Monit 11:RA221-8. 2005
    ..These observations argue for a central role of multiple proteases and their proteolytic products in producing the debilitating systemic effects of cancer...
  6. ncbi request reprint Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, California, CA 94720 3200, USA
    Oncogene 21:7392-411. 2002
    ..Certain dietary modifications that appear to be effective in moderating the promotional phase of animal and human carcinogenesis are suggested for trial in managing lung cancer...
  7. ncbi request reprint The disparity between human cell senescence in vitro and lifelong replication in vivo
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Nat Biotechnol 20:675-81. 2002
    ..The risk may be especially high in sun-exposed skin, where there are usually thousands of p53-mutant clones of keratinocytes predisposed to cancer...
  8. ncbi request reprint Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates
    H Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Carcinogenesis 22:1903-30. 2001
    ..Lung adenoma development by inhalation has been induced in mice by the gas phase of cigarette smoke. The role of selection has not been evaluated in either of these cases...
  9. ncbi request reprint Selected cell and selective microenvironment in neoplastic development
    H Rubin
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Cancer Res 61:799-807. 2001
    ..The varied observations in cell culture draw attention to analogous features of carcinogenesis in experimental animals and the development of human cancer...
  10. ncbi request reprint Walter Elsasser, prophet of biological complexity, seeker of simplifying rules
    H Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Cell Mol Biol (Noisy-le-grand) 51:599-606. 2005
    ..Those experiments add a concrete dimension to his abstractions that hopefully will promote a dialog between theory and practice to facilitate development of a non-reductionist biology...
  11. ncbi request reprint Multistage carcinogenesis in cell culture
    H Rubin
    Department of Molecular and Cell Biology, University of California, Berkeley 94720-3206, USA
    Dev Biol (Basel) 106:61-6; discussion 67, 143-60. 2001
    ....
  12. ncbi request reprint The role of selection in progressive neoplastic transformation
    H Rubin
    Department of Molecular and Cell Biology, University of California at Berkeley, 94720, USA
    Adv Cancer Res 83:159-207. 2001
    ..These considerations support a role for an altered microenvironment (as in the aging process) in selective growth of rogue clones...
  13. ncbi request reprint The logic of the Membrane, Magnesium, Mitosis (MMM) model for the regulation of animal cell proliferation
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Arch Biochem Biophys 458:16-23. 2007
    ..Experimental support of this conclusion is presented here and is represented in the MMM model of cell proliferation control...
  14. ncbi request reprint What keeps cells in tissues behaving normally in the face of myriad mutations?
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Bioessays 28:515-24. 2006
    ..These varied relationships are manifestations of the unifying biological principle of "order in the large over heterogeneity in the small"...
  15. pmc Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 105:6215-21. 2008
    ..Spontaneous transformation in culture can be used to identify dietary components that are required for promotion and may therefore be applicable in prevention of human cancer...
  16. pmc Degrees and kinds of selection in spontaneous neoplastic transformation: an operational analysis
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 102:9276-81. 2005
    ..The operational model of variation and selection presented here may aid in understanding chemical carcinogenesis and cancer recurrence after chemotherapy...
  17. ncbi request reprint Central roles of Mg2+ and MgATP2- in the regulation of protein synthesis and cell proliferation: significance for neoplastic transformation
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California Berkeley, 94720 3200, USA
    Adv Cancer Res 93:1-58. 2005
    ..The results suggest that the activity of Mg(2+) within the cell is a central regulator of normal cell growth, and the loss of its membrane-mediated control can account for the neoplastic phenotype...
  18. ncbi request reprint Magnesium: The missing element in molecular views of cell proliferation control
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Bioessays 27:311-20. 2005
    ....
  19. ncbi request reprint Membrane stabilization by intimate contact between cells reduces their Mg2+ activity and suppresses the neoplastic phenotype
    Harry Rubin
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Semin Cancer Biol 15:121-31. 2005
    ..Evidence against a need for junctional communication supports membrane stabilization with restoration of Mg(2+) regulation as the mechanism of normalization...
  20. ncbi request reprint Microenvironmental regulation of the initiated cell
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Adv Cancer Res 90:1-62. 2003
    ..It would be informative to determine whether high concentrations of FBS would inhibit the neoplastic development of initiated keratinocytes...
  21. doi request reprint Contact interactions between cells that suppress neoplastic development: can they also explain metastatic dormancy?
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Adv Cancer Res 100:159-202. 2008
    ..Hence, a program is outlined for further operational experiments on cell-cell interactions in tumor suppression to deepen our understanding of the neoplastic process, and provide possible avenues for its control...
  22. pmc Mg2+ as activator of uridine phosphorylation in coordination with other cellular responses to growth factors
    Charles Vidair
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 102:662-6. 2005
    ..The rate of uridine uptake is suggested as a direct indicator of free cytosolic Mg2+ that drives the shift from quiescence to proliferation...
  23. ncbi request reprint Ordered heterogeneity and its decline in cancer and aging
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, California 94720, USA
    Adv Cancer Res 98:117-47. 2007
    ..Whereas contact between cells is required for these processes to occur, gap junctional communication is not required...
  24. ncbi request reprint Correspondence re: G. Anderson et al., Intrachromosomal genomic instability in human sporadic colorectal cancer measured by genome-wide allelotyping and inter-(simple sequence repeat) PCR. Cancer Res., 61: 8274-8283, 2001
    Harry Rubin
    Cancer Res 62:6350-1; author reply 6351. 2002