Research Topics
| H RubinSummaryAffiliation: University of California Country: USA Publications
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Publications
Cell damage, aging and transformation: a multilevel analysis of carcinogenesisH Rubin
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3206, USA
Anticancer Res 19:4877-86. 1999..The order that controls heterogeneity is weakened with age and contributes to the origin and progression of disordered growth...- Complementary approaches to understanding the role of proteases and their natural inhibitors in neoplastic development: retrospect and prospectHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley 94720 3200, USA
Carcinogenesis 24:803-16. 2003.... 
Cancer cachexia: its correlations and causesHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Proc Natl Acad Sci U S A 100:5384-9. 2003..Reevaluation of all of the evidence supports a central role for proteolytically generated peptides derived from tumors in producing cancer cachexia...- Systemic effects of cancer: role of multiple proteases and their toxic peptide productsHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Med Sci Monit 11:RA221-8. 2005..These observations argue for a central role of multiple proteases and their proteolytic products in producing the debilitating systemic effects of cancer... - Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesisHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, California, CA 94720 3200, USA
Oncogene 21:7392-411. 2002..Certain dietary modifications that appear to be effective in moderating the promotional phase of animal and human carcinogenesis are suggested for trial in managing lung cancer... - The disparity between human cell senescence in vitro and lifelong replication in vivoHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Nat Biotechnol 20:675-81. 2002..The risk may be especially high in sun-exposed skin, where there are usually thousands of p53-mutant clones of keratinocytes predisposed to cancer... - Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updatesH Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Carcinogenesis 22:1903-30. 2001..Lung adenoma development by inhalation has been induced in mice by the gas phase of cigarette smoke. The role of selection has not been evaluated in either of these cases... - Selected cell and selective microenvironment in neoplastic developmentH Rubin
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
Cancer Res 61:799-807. 2001..The varied observations in cell culture draw attention to analogous features of carcinogenesis in experimental animals and the development of human cancer... - The membrane, magnesium, mitosis (MMM) model of cell proliferation controlH Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley 94720 3200, USA
Magnes Res 18:268-74. 2005..Those two proteins directly regulate the initiation of protein synthesis, the driving force of the process... - Walter Elsasser, prophet of biological complexity, seeker of simplifying rulesH Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Cell Mol Biol (Noisy-le-grand) 51:599-606. 2005..Those experiments add a concrete dimension to his abstractions that hopefully will promote a dialog between theory and practice to facilitate development of a non-reductionist biology... - Multistage carcinogenesis in cell cultureH Rubin
Department of Molecular and Cell Biology, University of California, Berkeley 94720-3206, USA
Dev Biol (Basel) 106:61-6; discussion 67, 143-60. 2001.... - The role of selection in progressive neoplastic transformationH Rubin
Department of Molecular and Cell Biology, University of California at Berkeley, 94720, USA
Adv Cancer Res 83:159-207. 2001..These considerations support a role for an altered microenvironment (as in the aging process) in selective growth of rogue clones... - The logic of the Membrane, Magnesium, Mitosis (MMM) model for the regulation of animal cell proliferationHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Arch Biochem Biophys 458:16-23. 2007..Experimental support of this conclusion is presented here and is represented in the MMM model of cell proliferation control... - What keeps cells in tissues behaving normally in the face of myriad mutations?Harry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Bioessays 28:515-24. 2006..These varied relationships are manifestations of the unifying biological principle of "order in the large over heterogeneity in the small"... - Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotypeHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Proc Natl Acad Sci U S A 105:6215-21. 2008..Spontaneous transformation in culture can be used to identify dietary components that are required for promotion and may therefore be applicable in prevention of human cancer... - Degrees and kinds of selection in spontaneous neoplastic transformation: an operational analysisHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Proc Natl Acad Sci U S A 102:9276-81. 2005..The operational model of variation and selection presented here may aid in understanding chemical carcinogenesis and cancer recurrence after chemotherapy... - Central roles of Mg2+ and MgATP2- in the regulation of protein synthesis and cell proliferation: significance for neoplastic transformationHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California Berkeley, 94720-3200, USA
Adv Cancer Res 93:1-58. 2005..The results suggest that the activity of Mg(2+) within the cell is a central regulator of normal cell growth, and the loss of its membrane-mediated control can account for the neoplastic phenotype... - Magnesium: The missing element in molecular views of cell proliferation controlHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Bioessays 27:311-20. 2005.... - Membrane stabilization by intimate contact between cells reduces their Mg2+ activity and suppresses the neoplastic phenotypeHarry Rubin
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
Semin Cancer Biol 15:121-31. 2005..Evidence against a need for junctional communication supports membrane stabilization with restoration of Mg(2+) regulation as the mechanism of normalization... - Microenvironmental regulation of the initiated cellHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720-3200, USA
Adv Cancer Res 90:1-62. 2003..It would be informative to determine whether high concentrations of FBS would inhibit the neoplastic development of initiated keratinocytes... 
Contact interactions between cells that suppress neoplastic development: can they also explain metastatic dormancy?Harry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Adv Cancer Res 100:159-202. 2008..Hence, a program is outlined for further operational experiments on cell-cell interactions in tumor suppression to deepen our understanding of the neoplastic process, and provide possible avenues for its control...- Mg2+ as activator of uridine phosphorylation in coordination with other cellular responses to growth factorsCharles Vidair
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720 3200, USA
Proc Natl Acad Sci U S A 102:662-6. 2005..The rate of uridine uptake is suggested as a direct indicator of free cytosolic Mg2+ that drives the shift from quiescence to proliferation... - Ordered heterogeneity and its decline in cancer and agingHarry Rubin
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, California 94720, USA
Adv Cancer Res 98:117-47. 2007..Whereas contact between cells is required for these processes to occur, gap junctional communication is not required... - Correspondence re: G. Anderson et al., Intrachromosomal genomic instability in human sporadic colorectal cancer measured by genome-wide allelotyping and inter-(simple sequence repeat) PCR. Cancer Res., 61: 8274-8283, 2001Harry Rubin
Cancer Res 62:6350-1; author reply 6351. 2002