Research Topics
Species | David T RubinSummaryAffiliation: University of Chicago Country: USA Publications
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Publications
An updated approach to dysplasia in IBDDavid T Rubin
University of Chicago Medical Center, 5841 S Maryland Ave, MC 4076, Chicago, IL 60637, USA
J Gastrointest Surg 12:2153-6. 2008....- Impact of ulcerative colitis from patients' and physicians' perspectives: Results from the UC: NORMAL surveyDavid T Rubin
Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA
Inflamm Bowel Dis 15:581-8. 2009..Two national internet surveys were conducted to understand how patients perceive the impact of ulcerative colitis (UC) relative to gastroenterologists... - Positron emission tomography (PET) used to image subclinical inflammation associated with ulcerative colitis (UC) in remissionDavid T Rubin
Inflammatory Bowel Disease Center, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA
Inflamm Bowel Dis 15:750-5. 2009..The aim of this study was to perform PET/computed tomography (CT) on patients with quiescent ulcerative colitis (UC) to understand the limits of this technology for assessing inflammatory activity... 
Surveillance of dysplasia in inflammatory bowel disease: The gastroenterologist-pathologist partnershipDavid T Rubin
Department of Medicine, University of Chicago, Chicago, Illinois, USA
Clin Gastroenterol Hepatol 4:1309-13. 2006..We address the challenge of management of polypoid lesions and incorporate new information about degree of inflammation as an additional risk of neoplasia in these patients...- The peri-appendiceal red patch in ulcerative colitis: review of the University of Chicago experienceDavid T Rubin
University of Chicago Inflammatory Bowel Disease Center, 5841 S Maryland Ave MC4076, Chicago, IL 60637, USA
Dig Dis Sci 55:3495-501. 2010..The clinical significance and prognostic implications of this finding are unknown. We used a tertiary care center database to review the clinical characteristics of UC patients with PARP... 
Colorectal cancer in inflammatory bowel disease: molecular and clinical considerationsDavid T Rubin
Reva and David Logan Center for Research in Gastroenterology, The University of Chicago, 5841 South Maryland Avenue, MC 4076, Chicago, IL 60637, USA
Curr Treat Options Gastroenterol 9:211-20. 2006..These include ursodeoxycholic acid (in patients with PSC and UC), aminosalicylates, and possibly statins...- Outcome after surveillance of low-grade and indefinite dysplasia in patients with ulcerative colitisJoel R Pekow
University of Chicago, Section of Gastroenterology, Hepatology, and Nutrition, Chicago, Illinois, USA
Inflamm Bowel Dis 16:1352-6. 2010..The management of low-grade (LGD) and indefinite dysplasia (IND) in patients with ulcerative colitis (UC) remains controversial, as outcomes after a diagnosis of LGD or IND in previous studies vary widely... - Are dysplasia and colorectal cancer endoscopically visible in patients with ulcerative colitis?David T Rubin
The Reva and David Logan Gastrointestinal Clinical Research Center at the University of Chicago, Chicago, Illinois 60637, USA
Gastrointest Endosc 65:998-1004. 2007..Given the imperfect nature of this random approach, recent work has focused on improved surveillance techniques and suggests that neoplasia is endoscopically visible in many patients... - Identification of patients at increased risk for colorectal cancer in an open access endoscopy centerJeffrey W Nathanson
Section of Gastroenterology, University of Chicago Medical Center, Chicago, IL 60637, USA
J Clin Gastroenterol 42:1025-31. 2008..To determine whether patients referred for open access endoscopy (OAE) are being appropriately identified as "increased risk" or "average risk" for colorectal cancer (CRC) by referring physicians... - Association of colorectal cancer and prostate cancer and impact of radiation therapyDezheng Huo
Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
Cancer Epidemiol Biomarkers Prev 18:1979-85. 2009..The decreased prostate cancer risk in men who received radiation therapy for rectal cancer may be related to the use of PSA for prostate cancer screening or the cure of occult prostate cancer... - Genetic testing for inflammatory bowel disease: focus group analysis of patients and family membersJeffrey R Lewis
Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA
Genet Test Mol Biomarkers 13:495-503. 2009..Further, preferences and concerns of patients and their family members regarding a genetic test for this condition are not well studied... - The impact of ulcerative colitis on patients' lives compared to other chronic diseases: a patient surveyDavid T Rubin
Section of Gastroenterology, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 4076, Chicago, IL, 60637, USA
Dig Dis Sci 55:1044-52. 2010..Overall, 451 patients with UC, 309 with rheumatoid arthritis, 305 with asthma, and 305 with migraine headaches were recruited in an Internet survey designed to assess a variety of disease-impact indices... - miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenesJoel R Pekow
Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Illinois, USA
Inflamm Bowel Dis 18:94-100. 2012..We speculated that miR-143 and miR-145 might also be downregulated and contribute to malignant transformation of colonic epithelium in longstanding ulcerative colitis (UC)... - Active Crohn's disease in the small bowel: evaluation by diffusion weighted imaging and quantitative dynamic contrast enhanced MR imagingAytekin Oto
Department of Radiology, The University of Chicago, Chicago, Illinois, USA
J Magn Reson Imaging 33:615-24. 2011..To determine relative diagnostic value of MR diffusion and perfusion parameters in detection of active small bowel inflammation in patients with Crohn's disease (CD)... - Effect of adalimumab on clinical laboratory parameters in patients with Crohn's disease: results from the CHARM trialDavid T Rubin
University of Chicago Medical Center, Chicago, Illinois 60637, USA
Inflamm Bowel Dis 18:818-25. 2012..Nutritional deficiencies and anemia are common in Crohn's disease (CD)... - Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformationChristopher R Weber
Department of Pathology, University of Chicago, Chicago, IL 60637, USA
Lab Invest 88:1110-20. 2008..We speculate that increased claudin-1 and claudin-2 expression may be involved at early stages of transformation in IBD-associated neoplasia... - Predictors of adalimumab dose escalation in patients with Crohn's disease at a tertiary referral centerRussell D Cohen
Inflammatory Bowel Disease Center, University of Chicago, Illinois, USA
Inflamm Bowel Dis 18:10-6. 2012..Our objective was to determine which patient-, disease-, and therapy-related factors were associated with DE in CD patients treated with ADA... - Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and updateDavid T Rubin
University of Chicago Medical Center, Chicago, IL 60637, USA
Inflamm Bowel Dis 14:265-74. 2008..This article provides a comprehensive overview of the issues discussed and should act as a guide to shaping the design of future studies in this area... - Surveillance for cancer and dysplasia in inflammatory bowel diseaseDavid T Rubin
Section of Gastroenterology, and the MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL 60637, USA
Gastroenterol Clin North Am 35:581-604. 2006..In meantime, existing guidelines should be emphasized and ongoing education of clinicians and patients must occur... - Colonic infiltration with chronic myelomonocytic leukemiaAndelka D LoSavio
Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, IL 60637, USA
Nat Clin Pract Gastroenterol Hepatol 4:229-33. 2007..Over several months, the patient's symptoms progressed, which resulted in significant weight loss. The patient's course of disease was ultimately complicated by acute disseminated encephalomyelitis and death... - A practical, evidence-based guide to the use of adalimumab in Crohn's diseaseDavid T Rubin
University of Chicago Medical Center, Chicago, IL 60637, USA
Curr Med Res Opin 27:1803-13. 2011..Here we provide a practical, evidence-based guide to help clinicians optimize the use of adalimumab in patients with CD... - Quantitative analysis of dynamic contrast enhanced MRI for assessment of bowel inflammation in Crohn's disease pilot studyAytekin Oto
Department of Radiology, University of Chicago, 5841 S Maryland Avenue, MC 2026, Chicago, IL 60637, USA
Acad Radiol 16:1223-30. 2009..The aim of this study was to evaluate the feasibility of quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data in the detection of bowel inflammation in patients with Crohn's disease... - Fecal bacteriotherapy for ulcerative colitis: patients are ready, are we?Stacy A Kahn
University of Chicago, Inflammatory Bowel Disease Center, Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, MacLean Center for Clinical Medical Ethics, Chicago, Illinois 60637, USA
Inflamm Bowel Dis 18:676-84. 2012..We performed a qualitative study to explore the attitudes and concerns of adult patients and parents of children with UC regarding FB as a potential treatment... - Secondary gastrointestinal cancer in childhood cancer survivors: a cohort studyTara O Henderson
University of Chicago Department of Pediatrics, Section of Hematology, Oncology and Stem Cell Transplantation, 5841 South Maryland Avenue, MC 4060, Chicago, IL 60637, USA
Ann Intern Med 156:757-66, W-260. 2012..Childhood cancer survivors develop gastrointestinal cancer more frequently and at a younger age than the general population, but the risk factors have not been well-characterized... - Association between colorectal cancer and urologic cancersAudrey H Calderwood
Department of Medicine, Section of Gastroenterology, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
Arch Intern Med 168:1003-9. 2008..We sought to quantify the risk for CRC after urologic cancer and the risk for urologic cancer after CRC in patients without known genetic syndromes... - Colorectal cancer and dysplasia in inflammatory bowel diseaseTimothy L Zisman
The University of Chicago Medical Center, Chicago, IL 60637, United States
World J Gastroenterol 14:2662-9. 2008.... - Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitisDavid T Rubin
The Reva and David Logan Center for Research in Gastrointestinal Diseases, University of Chicago, Chicago, Illinois, USA
Clin Gastroenterol Hepatol 4:1346-50. 2006..Aminosalicylates have been suggested as chemopreventive agents for colorectal cancer (CRC) in ulcerative colitis (UC). We studied the effect of aminosalicylate use on dysplasia and CRC risk in chronic UC... - Performance of CT colonography in clinical trialsJonathan A Rosenberg
Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 4076, Chicago, IL 60637 1463, USA
Gastrointest Endosc Clin N Am 20:193-207. 2010..The data suggest that CTC is effective especially for the detection of larger lesions and when more advanced imaging technology is used... - Do colorectal cancer patients understand that their family is at risk?David T Rubin
The University of Chicago Medical Center, Chicago, IL, USA
Dig Dis Sci 54:2473-83. 2009..The aim of this study was to assess whether patients with colorectal cancer (CRC) are aware of the risk to family members and to test an educational intervention... - Computer-aided diagnosis scheme for detection of polyps at CT colonographyHiroyuki Yoshida
Department of Radiology, University of Chicago, 5841 S Maryland Ave, MC20206, IL 60637, USA
Radiographics 22:963-79. 2002..This CAD scheme permits accurate detection of suspicious lesions and thus has the potential to reduce radiologists' interpretation time and improve their diagnostic accuracy in the detection of polyps at CT colonography... - Computerized detection of colonic polyps at CT colonography on the basis of volumetric features: pilot studyHiroyuki Yoshida
Department of Radiology, University of Chicago, Chicago, IL 60637, USA
Radiology 222:327-36. 2002..To develop a computer-aided diagnosis (CAD) scheme for automated detection of colonic polyps on the basis of volumetric features and to assess its accuracy on the basis of colonoscopy, the standard... - Long-term treatment of patients with a history of ulcerative colitis who develop gastritis and pan-enteritis after colectomyFrank Hoentjen
Inflammatory Bowel Disease Center, University of Chicago Medical Center, Chicago, IL, USA
J Clin Gastroenterol 47:52-7. 2013..Corticosteroids are effective for induction of remission of this condition, but it is not clear how these patients should be managed long term... - Infectious proctitis: when to suspect it is not inflammatory bowel diseaseFrank Hoentjen
Inflammatory Bowel Disease Center, University of Chicago Medical Center, 5841 S Maryland Avenue, MC4076, Chicago, IL 60637, USA
Dig Dis Sci 57:269-73. 2012..Co-infections, HIV testing, and treatment of sexual partners should always be considered... - What is the most effective way to communicate results after endoscopy?David T Rubin
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Gastrointest Endosc 66:108-12. 2007.... - Rifaximin Is Effective for the Treatment of Clostridium difficile-Associated Diarrhea: Results of an Open-Label Pilot StudyDavid T Rubin
University of Chicago Medical Center, Chicago, IL 60637, USA
Gastroenterol Res Pract 2011:106978. 2011..One patient had recurrent CDAD during a repeat hospitalization. Conclusions. Rifaximin was effective and safe as first-line treatment for CDAD and did not result in recurrence in most patients... - p53 mutations are associated with dysplasia and progression of dysplasia in patients with Crohn's diseaseJeffrey W Nathanson
Reva and David Logan Gastrointestinal Clinical Research Center at the University of Chicago, Chicago, IL, USA
Dig Dis Sci 53:474-80. 2008..Mutations in the tumor suppressor gene p53 are associated with neoplasia in ulcerative colitis, but little is understood of their significance in Crohn's disease (CD)... - The complexity and challenges of genetic counseling and testing for inflammatory bowel diseaseShelly A Cummings
Cancer Risk Clinic, The University of Chicago, Section of Hematology Oncology, 5841 South Maryland Avenue, MC 2115, Chicago, IL 60637, USA
J Genet Couns 15:465-76. 2006..Effective incorporation of clinical genetic testing for IBD into practice will require appropriate education and counseling... - Fever and right upper quadrant pain in a pregnant woman at 30 weeks' gestationLaura E Harrell
Section of Gastroenterology and Nutrition, University of Chicago, IL, USA
Nat Clin Pract Gastroenterol Hepatol 1:113-6; quiz 1 p following 116. 2004..DIAGNOSIS: Crohn's disease flare complicated by an intra-abdominal abscess. MANAGEMENT: Antibiotics (ceftizoxime, metronidazole and amoxicillin/clavulanate potassium), parenteral nutrition and ileocecectomy... - Low-dose smoking resumption in ex-smokers with refractory ulcerative colitisEmma Calabrese
Section of Gastroenterology, Hepatology and Nutrition, University of Chicago, Chicago, IL 60637, USA
J Crohns Colitis 6:756-62. 2012..We report outcomes of ex-smokers with refractory UC who resumed low-dose cigarette smoking... - Total abdominal colectomy for refractory ulcerative colitis. Surgical treatment in evolutionAlessandro Fichera
Department of Surgery, University of Chicago Medical Center, Chicago, IL 60637, USA
J Gastrointest Surg 15:1909-16. 2011..This study illustrates the laparoscopic evolution towards a truly minimally invasive approach comparing three phases of a single colorectal surgeon experience... - Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reductionFrank Hoentjen
Inflammatory Bowel Disease Center, University of Chicago, Chicago, IL, USA
Dig Dis Sci 57:250-3. 2012.... - Medical professionalism and the doctor-patient relationshipLydia S Dugdale
Department of Medicine, Yale New Haven Hospital, New Haven, CT, USA
Perspect Biol Med 51:547-53. 2008.... - Do patients with inflammatory bowel disease want genetic testing?Vani Konda
Reva and David Logan Gastrointestinal Clinical Research Center, University of Chicago, Chicago, Illinois 60637, USA
Inflamm Bowel Dis 12:497-502. 2006..Thus, the goal of this study was to assess the interest of patients with IBD in genetic testing and their willingness to accept the uncertainty inherent in complex genetics... - Comparison of routine and unprepped CT colonography augmented by low fiber diet and stool tagging: a pilot studyAbraham H Dachman
Department of Radiology, The University of Chicago, MC 2026, 5841 S Maryland Ave, Chicago, IL 60637, USA
Abdom Imaging 32:96-104. 2007..Prior reports of tagging were limited in that the residual stool was neither measured and stratified by size nor did prior reports subjectively evaluate the ease of interpretation by a reader experienced in interpreting CTC examinations... - Role of antibiotics in the management of inflammatory bowel disease: a reviewDavid T Rubin
Reva and David Logan Inflammatory Bowel Disease Center, University of Chicago, Chicago, Illinois, USA
Rev Gastroenterol Disord 5:S10-5. 2005..A proposal for future therapies is provided that might include a combination therapy aimed at both a reduction in pathogenetic bacteria and immune modulation to achieve the most durable remission of disease... - Superior mesenteric vein thrombosis after colectomy in a patient with Crohn's diseaseAndrew S Ross
Department of Surgery, University of Chicago, IL, USA
Nat Clin Pract Gastroenterol Hepatol 2:281-5; quiz 1 p following 285. 2005..DIAGNOSIS: Acute mesenteric ischemia secondary to superior mesenteric vein thrombosis. MANAGEMENT: Resection of necrotic bowel, antibiotics and systemic anticoagulation... - To test or "NOD-2" test: what are the questions? The balanced viewpointDavid T Rubin
Section of Gastroenterology, Reva and David Logan Center for Inflammatory Bowel Disease, The MacLean Center for Clinical Medical Ethics, University of Chicago, Illinois, USA
Inflamm Bowel Dis 11:510-2. 2005 - Prospective comparison of patient experience with colon imaging testsHayden B Bosworth
Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC, USA
Am J Med 119:791-9. 2006..This finding has important implications for physicians considering different colon imaging tests... - Maximizing patient adherence and clinical outcomes with mesalamine in mildly-to-moderately active ulcerative colitisGary R Lichtenstein
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Rev Gastroenterol Disord 8:21-30; quiz 31-2. 2008..Novel formulations of mesalamine and newly devised, high-dose regimens offer additional therapeutic options and may lead to improved treatment adherence, longer-lasting periods of remission, and enhanced patient well-being... - The challenge of compliance and persistence: focus on ulcerative colitisSunanda V Kane
Mayo Clinic College of Medicine, Division of Gastroenterology and Hepatology, 200 First Street, SW, 19th Floor, Rochester, MN 55905, USA
J Manag Care Pharm 14:s2-12; quiz s13-5. 2008..An estimated 20% to 50% of patients with ulcerative colitis (UC) do not take their medications as prescribed, resulting in higher disease-recurrence rates and potentially higher health care costs... - 5-Aminosalicylic acid therapy and the risk of colorectal cancer among patients with inflammatory bowel diseaseJonathan P Terdiman
University of California, San Francisco, San Francisco, California 94143 1623, USA
Inflamm Bowel Dis 13:367-71. 2007..The objective of this observational study was to determine if an association between 5-ASA therapy and CRC risk exists in IBD patients... - Will a 5-ASA a day keep the cancer (and dysplasia) away?David T Rubin
Am J Gastroenterol 100:1354-6. 2005..The authors conclude that the safety and current maintenance use of 5-ASA warrant its acceptance as a probable chemopreventive agent at this time... - The changing face of colorectal cancer in inflammatory bowel disease: progress at last!David T Rubin
Gastroenterology 130:1350-2. 2006 - Inflammation's role in rectal cancer following prostate radiotherapy, and emerging evidence for a protective role for balsalazideChristopher D Jahraus
Gastroenterology 129:770-2. 2005 - The case: can doctors say "enough"?Jeffrey S Groeger
Intensive Care Unit, Memorial Sloan Kettering Cancer Center, New York City, USA
Camb Q Healthc Ethics 12:215-23. 2003