John Rubenstein

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development
    Ugo Borello
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Neural Dev 3:17. 2008
  2. pmc Analysis of four DLX homeobox genes in autistic probands
    Steven P Hamilton
    Department of Psychiatry, University of California, San Francisco, CA, USA
    BMC Genet 6:52. 2005
  3. pmc Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders
    John L R Rubenstein
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94158 2324, USA
    J Child Psychol Psychiatry 52:339-55. 2011
  4. doi request reprint Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder
    John L R Rubenstein
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California, USA
    Curr Opin Neurol 23:118-23. 2010
  5. ncbi request reprint DLX5 regulates development of peripheral and central components of the olfactory system
    Jason E Long
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, California 94143 0984, USA
    J Neurosci 23:568-78. 2003
  6. pmc Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain
    Magdalena A Petryniak
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158 2611, USA
    Neuron 55:417-33. 2007
  7. ncbi request reprint Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation
    Jason E Long
    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:3230-43. 2007
  8. doi request reprint Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2
    Jeremy A Cholfin
    Medical Scientist Training Program, University of California, San Francisco, San Francisco, California 94143 2611, USA
    J Comp Neurol 509:144-55. 2008
  9. pmc Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7380-9. 2006
  10. ncbi request reprint Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
    Elaine E Storm
    Department of Anatomy, University of California, San Francisco, CA 94143 2711, USA
    Development 133:1831-44. 2006

Research Grants

  1. Genetic Control of Basal Telencephalic Development
    John Rubenstein; Fiscal Year: 2009
  2. Genetic Control of Basal Telencephalic Development
    John L R Rubenstein; Fiscal Year: 2010
  3. NKX HOMEOBOX GENE REGULATION OF VENTRAL CNS DEVELOPMENT
    John Rubenstein; Fiscal Year: 2003
  4. Regulation of craniofacial development by the Dlx genes.
    John Rubenstein; Fiscal Year: 2003
  5. FUNCTION OF DLX GENES IN FOREBRAIN DEVELOPMENT
    John Rubenstein; Fiscal Year: 2002
  6. GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENT
    John Rubenstein; Fiscal Year: 2005
  7. Regulation of craniofacial development by the Dix genes.
    John Rubenstein; Fiscal Year: 2006
  8. GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENT
    John L R Rubenstein; Fiscal Year: 2010
  9. GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENT
    John Rubenstein; Fiscal Year: 2007
  10. GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    John Rubenstein; Fiscal Year: 2007

Detail Information

Publications77

  1. pmc FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development
    Ugo Borello
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Neural Dev 3:17. 2008
    ..FGF8 and FGF17 signaling have major roles in specification and morphogenesis of the rostroventral telencephalon, whereas the functions of FGF15 and FGF18 in the rostral patterning center have not been established...
  2. pmc Analysis of four DLX homeobox genes in autistic probands
    Steven P Hamilton
    Department of Psychiatry, University of California, San Francisco, CA, USA
    BMC Genet 6:52. 2005
    ..We investigated the role that sequence variants in DLX genes play in autism by in-depth resequencing of these genes in 161 autism probands from the AGRE collection...
  3. pmc Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders
    John L R Rubenstein
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94158 2324, USA
    J Child Psychol Psychiatry 52:339-55. 2011
    ..The paper concludes with an examination of four possible developmental mechanisms that could contribute to some forms of neurodevelopmental disorders, such as autism...
  4. doi request reprint Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder
    John L R Rubenstein
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California, USA
    Curr Opin Neurol 23:118-23. 2010
    ..Molecular and genetic insights into the etiology of autism spectrum disorders are now available. The field now needs to understand how these perturbations affect development and function of the brain...
  5. ncbi request reprint DLX5 regulates development of peripheral and central components of the olfactory system
    Jason E Long
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, California 94143 0984, USA
    J Neurosci 23:568-78. 2003
    ..In addition, the mutation has a noncell-autonomous effect on the morphogenesis of mitral cells...
  6. pmc Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain
    Magdalena A Petryniak
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158 2611, USA
    Neuron 55:417-33. 2007
    ..Our results identify another role for Dlx genes as modulators of neuron versus oligodendrocyte development in the ventral embryonic forebrain...
  7. ncbi request reprint Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation
    Jason E Long
    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:3230-43. 2007
    ....
  8. doi request reprint Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2
    Jeremy A Cholfin
    Medical Scientist Training Program, University of California, San Francisco, San Francisco, California 94143 2611, USA
    J Comp Neurol 509:144-55. 2008
    ..We have integrated our results to propose a model for how fibroblast growth factors regulate FC patterning through regulation of regional transcription factor expression within the FC anlage...
  9. pmc Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7380-9. 2006
    ..Grafted MGE cells, therefore, can be used to modify neural circuits and selectively increase local inhibition. These findings could have important implications for reparative cell therapies for brain disorders...
  10. ncbi request reprint Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
    Elaine E Storm
    Department of Anatomy, University of California, San Francisco, CA 94143 2711, USA
    Development 133:1831-44. 2006
    ..These data suggest that Fgf8 functions to coordinate multiple patterning centers, and that modifications in the relative strength of FGF signaling can have profound effects on the relative size and nature of telencephalic subdivisions...
  11. ncbi request reprint Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon
    Kyuson Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, 401 Parnassus, Box 0984, 94143 0984, USA
    Development 129:5029-40. 2002
    ..We suggest that alternate cell fate choices in the developing telencephalon are controlled by coordinated functions of bHLH and homeobox transcription factors through their differential affects on Notch signaling...
  12. pmc Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways
    Jason E Long
    Department of Psychiatry and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, California 94158 2324, USA
    J Comp Neurol 512:556-72. 2009
    ..These analyses define core transcriptional components that differentially specify the identity and differentiation of the striatum, nucleus accumbens, and septum...
  13. ncbi request reprint The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158 2611, USA
    J Comp Neurol 483:292-303. 2005
    ..Therefore, our results suggest evolutionarily conserved functions of Dlx genes in regulating Arx expression between Drosophila and vertebrates...
  14. ncbi request reprint A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors
    Minoree Kohwi
    Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:6878-91. 2007
    ..Our results suggest that some OB interneurons are derived from progenitors outside the LGE and that precursors expressing what has classically been considered a pallial transcription factor generate GABAergic interneurons...
  15. pmc Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice
    Cindy L Yee
    Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, Genetics and Development, San Francisco, California 94158 2611, USA
    J Comp Neurol 517:37-50. 2009
    ..These results have implications for the genetic control of arcuate development and function and for the utility of the Nkx2.1-Cre and Dlx5/6i-Cre mouse lines to alter gene expression in the developing arcuate...
  16. pmc A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development
    Konstantinos Zarbalis
    Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, USA
    PLoS Biol 2:E219. 2004
    ..Our results also highlight the utility of focused screens in the mouse, in addition to the large-scale and broadly targeted screens that are being carried out at mutagenesis centers...
  17. ncbi request reprint The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice
    Sonia Garel
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143 0984, USA
    Development 129:5621-34. 2002
    ..These observations suggest that the topography of thalamocortical projections is not strictly determined by cues located within the neocortex and may be regulated by the relative positioning of thalamic axons inside the basal ganglia...
  18. ncbi request reprint Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections
    Oscar Marin
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, University of California, San Francisco, USA
    Development 129:761-73. 2002
    ..Furthermore, analysis of the expression of candidate molecules in the basal telencephalon and hypothalamus of Nkx2-1 mutants suggests that Slit2 contributes to this activity...
  19. pmc The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons
    Pierre Flandin
    Department of Psychiatry, University of California at San Francisco, San Francisco, California 94158 2611, USA
    J Neurosci 30:2812-23. 2010
    ..Finally, our analysis provided evidence for a novel cellular component (Nkx2-1(-);Npas1(+)) of the globus pallidus...
  20. ncbi request reprint Specification of jaw subdivisions by Dlx genes
    Michael J Depew
    Nina Ireland Laboratory of Developmental Neurobiology, 401 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143 0984, USA
    Science 298:381-5. 2002
    ..We suggest that nested Dlx expression in the arches patterns their proximodistal axes. Evolutionary acquisition and subsequent refinement of jaws may have been dependent on modification of Dlx expression...
  21. ncbi request reprint Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants
    Sonia Garel
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Development 130:1903-14. 2003
    ..Overall, our study demonstrates the role of endogenous Fgf8 in regulating early gradients of transcription factors in cortical progenitor cells and in molecular regionalization of the cortical plate...
  22. ncbi request reprint Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction
    Oscar Marin
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, 401 Parnassus Avenue, University of California San Francisco, CA 94143, USA
    Development 130:1889-901. 2003
    ....
  23. ncbi request reprint Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb
    Minoree Kohwi
    Department of Neurological Surgery, Program in Developmental and Stem Cell Biology, University of California, San Francisco, California 94143, USA
    J Neurosci 25:6997-7003. 2005
    ..Our data show that SVZ neuroblasts are heterogeneous and that Pax6 is required in a cell-autonomous manner for the production of cells in the dopaminergic lineage...
  24. ncbi request reprint Fgf8 regulates the development of intra-neocortical projections
    Kelly J Huffman
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
    J Neurosci 24:8917-23. 2004
    ..Therefore, neocortical patterning by Fgf8 also contributes to arealization through mediating early development of intra-neocortical connectivity...
  25. ncbi request reprint Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other
    Robert F Hevner
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
    J Comp Neurol 447:8-17. 2002
    ..This type of mechanism ensures that thalamocortical and corticothalamic axons project reciprocally. However, the exact nature of the interaction between cortical and thalamic pioneer axons remains to be elucidated...
  26. ncbi request reprint Distinct origins of neocortical projection neurons and interneurons in vivo
    Stewart A Anderson
    Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA
    Cereb Cortex 12:702-9. 2002
    ..Conversely, cortical projection neurons, but few if any interneurons, are generated within the proliferative zones of the neocortex...
  27. pmc Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways
    Jason E Long
    Department of Psychiatry and the Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, CA 94158 2324, USA
    Cereb Cortex 19:i96-106. 2009
    ..These analyses define core transcriptional components that differentially specify the identity and differentiation of the globus pallidus, basal telencephalon, and pallial interneurons...
  28. pmc Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling
    Guangnan Li
    Program in Neuroscience, and Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 28:1085-98. 2008
    ....
  29. ncbi request reprint Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression
    Thorsten Stühmer
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California at San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Development 129:245-52. 2002
    ..We find that Dlx2 can induce Dlx5 expression, and that Dlx1, Dlx2 and Dlx5 can induce expression from a Dlx5/6-lacZ enhancer/"reporter construct...
  30. ncbi request reprint Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia
    Kyuson Yun
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California at San Francisco, San Francisco, California 94143 0984, USA
    J Comp Neurol 461:151-65. 2003
    ..These findings highlight the developmental interdependence of adjacent telencephalic structures...
  31. ncbi request reprint Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons
    Thorsten Stühmer
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California at San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Cereb Cortex 12:75-85. 2002
    ..We show that this population is largely identical with the adult cortical and hippocampal interneuron population, providing further evidence for their subpallial origin...
  32. pmc Patterning of frontal cortex subdivisions by Fgf17
    Jeremy A Cholfin
    Medical Scientist Training Program, University of California, San Francisco, CA 94143 2611, USA
    Proc Natl Acad Sci U S A 104:7652-7. 2007
    ..Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC...
  33. doi request reprint Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs
    Juhee Jeong
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Development 135:2905-16. 2008
    ..We propose a new model for Dlx-mediated mammalian jaw patterning...
  34. pmc COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling
    Andrea Faedo
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94158, USA
    Cereb Cortex 18:2117-31. 2008
    ..We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and beta-catenin signaling...
  35. pmc Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice
    Scott C Baraban
    Department of Neurological Surgery and Psychiatry, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:15472-7. 2009
    ..Our findings suggest that MGE-derived interneurons could be used to ameliorate abnormal excitability and possibly act as an effective strategy in the treatment of epilepsy...
  36. doi request reprint Genes and signaling events that establish regional patterning of the mammalian forebrain
    Renée V Hoch
    Department of Psychiatry, University of California, San Francisco, CA 94143 2611, USA
    Semin Cell Dev Biol 20:378-86. 2009
    ....
  37. pmc Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons
    Yanling Wang
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:5334-45. 2010
    ..This contrasts with Dlx1, whose function is required for dendrite innervating (calretinin(+), somatostatin(+), and neuropeptide Y(+)) interneurons (Cobos et al., 2005)...
  38. pmc Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons
    Gregory B Potter
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158 2611, USA
    Mol Cell Neurosci 40:167-86. 2009
    ..Finally, we provide the first in vivo evidence that both I12b and URE2 are direct targets of DLX2 and require Dlx1 and Dlx2 expression for proper activity...
  39. ncbi request reprint Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
    Nat Neurosci 8:1059-68. 2005
    ..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss...
  40. ncbi request reprint Dlx transcription factors promote migration through repression of axon and dendrite growth
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 54:873-88. 2007
    ....
  41. pmc Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times
    Andrea Faedo
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158 2611, USA
    J Neurosci 30:4015-23. 2010
    ..Finally, we provide evidence that Coup-TFI, a transcription factor that promotes caudal fate, does so through repressing Fgf signaling, in part by promoting Spry expression...
  42. pmc CXCR4 and CXCR7 have distinct functions in regulating interneuron migration
    Yanling Wang
    Department of Psychiatry, University of California, San Francisco, CA 94158, USA
    Neuron 69:61-76. 2011
    ..On the other hand, CXCL12 stimulation of CXCR7, but not CXCR4, promoted MAP kinase signaling. Thus, we suggest that CXCR4 and CXCR7 have distinct roles and signal transduction in regulating interneuron movement and laminar positioning...
  43. ncbi request reprint New neurons follow the flow of cerebrospinal fluid in the adult brain
    Kazunobu Sawamoto
    Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, CA 94143, USA
    Science 311:629-32. 2006
    ..Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons...
  44. ncbi request reprint Genetic regulation of prefrontal cortex development and function
    Jeremy A Cholfin
    Medical Scientist Training Program, University of California, San Francisco, CA 94143 2611, USA
    Novartis Found Symp 288:165-73; discussion 173-7, 276-81. 2007
    ..Recent evidence shows that FGFs, including Fgf17, regulate the graded expression of regulatory genes in the cortical neuroepithelium, which may specify the initial distribution of PFC regional subdivisions and ultimately mature areas...
  45. pmc Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain
    Elaine E Storm
    Department of Anatomy, School of Medicine, University of California, San Francisco, CA 94143 0452, USA
    Proc Natl Acad Sci U S A 100:1757-62. 2003
    ..Our data provide insight into the function of FGF8 in forebrain development and underscore the value of using multiple alleles and different experimental approaches to unravel the complexities of gene function in vertebrate development...
  46. ncbi request reprint Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development
    Margarita García-López
    Department of Human Anatomy, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
    J Comp Neurol 506:46-74. 2008
    ..Our study provides a molecular and morphological foundation for understanding the complex embryonic origins and adult organization of the centromedial and extended amygdala...
  47. ncbi request reprint Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 27:9682-95. 2007
    ..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains...
  48. pmc Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain
    Anju Vasudevan
    Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Neurosci 11:429-39. 2008
    ....
  49. ncbi request reprint Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex
    Kathie M Bishop
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 22:7627-38. 2002
    ..Thus, our findings indicate that EMX2 and PAX6 regulate, in opposing manners, arealization of the neocortex and impart positional identity to cortical cells, whereas EMX1 appears not to have a role in this process...
  50. pmc Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants
    Yangu Zhao
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Comp Neurol 510:79-99. 2008
    ....
  51. doi request reprint Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons
    Gaia Colasante
    Department of Biological and Technological Research, San Raffaele Scientific Institute, Stem Cell Research Institute, Vita e Salute San Raffaele University, 20132 Milan, Italy
    J Neurosci 28:10674-86. 2008
    ..These findings contribute elucidating the genetic hierarchy that likely underlies the etiology of a variety of human neurodevelopmental disorders...
  52. pmc Functional disturbances in the striatum by region-specific ablation of NMDA receptors
    Nobuhisa Ohtsuka
    Center for Systems Neurobiology, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 105:12961-6. 2008
    ..These results demonstrate that the NMDA receptor plays an essential role in the integration of dopamine signaling in the striatum and that is required in behavioral function...
  53. ncbi request reprint Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons
    Noel Ghanem
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Neurosci 27:5012-22. 2007
    ..These data suggest that interneuron subtypes use distinct combinations of Dlx1/Dlx2 enhancers from the time they are specified through adulthood...
  54. ncbi request reprint Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons
    Robert F Hevner
    Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Wash 98104 2499, USA
    Dev Neurosci 25:139-51. 2003
    ..These studies suggest that molecular profiles can be used advantageously for classifying cortical projection cells, for analyzing their neurogenesis and fate specification, and for evaluating cortical malformations...
  55. ncbi request reprint Forebrain gene expression domains and the evolving prosomeric model
    Luis Puelles
    Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
    Trends Neurosci 26:469-76. 2003
    ..By contrast, we continue to postulate that prosomeres p1-p3 (i.e. the pretectum, thalamus and prethalamus) are the caudal forebrain...
  56. ncbi request reprint Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4
    Perry J Blackshear
    Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Development 130:4539-52. 2003
    ..These findings may be relevant to human congenital hydrocephalus, a birth defect that affects approximately 0.6 per 1000 newborns...
  57. pmc The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain
    Yangu Zhao
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:9005-10. 2003
    ..These results provide genetic evidence supporting an important role for Lhx8 in development of cholinergic neurons in the forebrain...
  58. ncbi request reprint Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus
    Gracie L Andrews
    Biology and Biochemistry Departments, Cell and Molecular Biology Graduate Program, University of Nevada, Reno 89557, USA
    Mol Cell Neurosci 23:107-20. 2003
    ..These data suggest that DLX genes act as forebrain-specific factors linking general neuron-inducing signals to region-specific neuron differentiation programs...
  59. pmc Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters
    Noel Ghanem
    Ottawa Health Research Institute and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9
    Genome Res 13:533-43. 2003
    ....
  60. ncbi request reprint Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding
    Kathie M Bishop
    Molecular Neurobiology Lab, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 457:345-60. 2003
    ..The more severe phenotypes in Emx double mutants suggest that Emx1 and Emx2 cooperate to regulate multiple features of cortical development...
  61. ncbi request reprint Developmental functions of the Distal-less/Dlx homeobox genes
    Grace Panganiban
    Department of Anatomy, University of Wisconsin, Madison, WI 53706, USA
    Development 129:4371-86. 2002
    ..We review what is known about the invertebrate and vertebrate Dll/Dlx genes and their varied roles during development. We propose revising the vertebrate nomenclature to reflect phylogenetic relationships among the Dlx genes...
  62. ncbi request reprint Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage
    Jessica A Gorski
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 22:6309-14. 2002
    ..Structures that are located near the basal ganglia (e.g., the amygdala and endopiriform nuclei) are not uniformly derived from Emx1-expressing cells...
  63. ncbi request reprint Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis
    Andrea Faedo
    Stem Cell Research Institute SCRI, Istituto Scientifico HS Raffaele, Via Olgettina, 58 Milan, Italy
    Mech Dev 116:157-60. 2002
    ....
  64. ncbi request reprint Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complex
    Loreta Medina
    Department of Human Anatomy, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
    J Comp Neurol 474:504-23. 2004
    ..The lateral pallial and ventral pallial divisions of the claustroamygdaloid complex appear to have some different sets of connections, although this requires further investigation...
  65. ncbi request reprint Expression of regulatory genes during differentiation of thalamic nuclei in mouse and monkey
    Edward G Jones
    Center for Neuroscience, University of California, Davis, Davis, California 95616, USA
    J Comp Neurol 477:55-80. 2004
    ..The centre médian nucleus was marked by high expression of Id2, which was expressed only weakly in very few nuclei of mice...
  66. ncbi request reprint Intermediate targets in formation of topographic projections: inputs from the thalamocortical system
    Sonia Garel
    INSERM U368, Ecole Normale Supérieure 46 rue d Ulm 75230 Paris cedex 05, France
    Trends Neurosci 27:533-9. 2004
    ....
  67. ncbi request reprint Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation
    Elena Colombo
    Stem Cell Research Department, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Neurosci 27:4786-98. 2007
    ..Altogether, these results highlight the critical functions of Arx in promoting neural migration and regulating basal ganglia differentiation in mice, consistent with the phenotype of XLAG patients...
  68. ncbi request reprint Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon
    Andrea Faedo
    Stem Cell Research Institute, DIBIT, H S Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Dev Dyn 231:614-20. 2004
    ..5 and in the dorsal, lateral, and ventral pallium at embryonic day 14.5...
  69. ncbi request reprint Severe hearing loss in Dlxl mutant mice
    Daniel B Polley
    Coleman Memorial Laboratory, Department of Otolaryngology, University of California, San Francisco, CA 94143, USA edu
    Hear Res 214:84-8. 2006
    ..Thus, abnormal mor-phogenesis of the incus and stapes that has been documented previously with histological measures is now known to result in a severe peripheral hearing deficit...
  70. pmc Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development
    Michael J Depew
    Department of Craniofacial Development, King s College London, Guy s Hospital, London, UK
    J Anat 207:501-61. 2005
    ....
  71. ncbi request reprint Patterning and plasticity of the cerebral cortex
    Mriganka Sur
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Ave, 46 6237, Cambridge, MA 02139, USA
    Science 310:805-10. 2005
    ..Recent evidence has begun to transform our understanding of how cortical areas form, make specific connections with other brain regions, develop unique processing networks, and adapt to changes in inputs...
  72. ncbi request reprint The nuclear receptor COUP-TFI represses differentiation of Cajal-Retzius cells
    Michele Studer
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    Brain Res Bull 66:394-401. 2005
    ..Furthermore, general differentiation is not affected, strongly suggesting that COUP-TFI represses differentiation of CR cells...
  73. pmc Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families
    Marjory L Givens
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093 0674, USA
    J Biol Chem 280:19156-65. 2005
    ..These findings strongly support a role for MSX and DLX in contributing to spatiotemporal regulation of GnRH transcription during development...
  74. ncbi request reprint Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina
    Jimmy de Melo
    Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 3J7, Canada
    Development 132:311-22. 2005
    ..Herein, we propose a model whereby early-born RGCs are Dlx1 and Dlx2 independent, but Dlx function is necessary for terminal differentiation of late-born RGC progenitors...
  75. ncbi request reprint Identification of Tbr-1/CASK complex target genes in neurons
    Ting Fang Wang
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    J Neurochem 91:1483-92. 2004
    ..We suggest that Tbr-1/CASK protein complex regulates expression of these downstream target genes and thus modulates neuronal activity and function...
  76. ncbi request reprint Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 San Joan d Alacant, Spain
    Neuron 44:251-61. 2004
    ..These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system...
  77. ncbi request reprint Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
    ....

Research Grants51

  1. Genetic Control of Basal Telencephalic Development
    John Rubenstein; Fiscal Year: 2009
    ..Disruption of these mechanisms can cause psychiatric and neurological disorders that include mental retardation, autism, schizophrenia, movement disorders and addiction. ..
  2. Genetic Control of Basal Telencephalic Development
    John L R Rubenstein; Fiscal Year: 2010
    ..Disruption of these mechanisms can cause psychiatric and neurological disorders that include mental retardation, autism, schizophrenia, movement disorders and addiction. ..
  3. NKX HOMEOBOX GENE REGULATION OF VENTRAL CNS DEVELOPMENT
    John Rubenstein; Fiscal Year: 2003
    ..A collaborator, Dr. Puelles, will visit the lab twice, for two months each, to help analyze the expression patterns and morphological mutant phenotypes. ..
  4. Regulation of craniofacial development by the Dlx genes.
    John Rubenstein; Fiscal Year: 2003
    ..In addition, we will study the cellular and molecular mechanisms through which the D1x genes regulate craniofacial development. ..
  5. FUNCTION OF DLX GENES IN FOREBRAIN DEVELOPMENT
    John Rubenstein; Fiscal Year: 2002
    ....
  6. GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENT
    John Rubenstein; Fiscal Year: 2005
    ..These studies will have implications for understanding human disorders that range from gross malformations of the forebrain to dysfunction of individual subdivisions of the cerebral cortex. ..
  7. Regulation of craniofacial development by the Dix genes.
    John Rubenstein; Fiscal Year: 2006
    ..In addition, we will study the cellular and molecular mechanisms through which the D1x genes regulate craniofacial development. ..
  8. GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENT
    John L R Rubenstein; Fiscal Year: 2010
    ..abstract_text> ..
  9. GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENT
    John Rubenstein; Fiscal Year: 2007
    ....
  10. GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    John Rubenstein; Fiscal Year: 2007
    ..abstract_text> ..
  11. GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    John Rubenstein; Fiscal Year: 2007
    ..This application is a competitive renewal for two NIMH grants: MH49428 and MH51561; the proposed projects herein are a synthesis of the scientific goals of MH49428 and MH51561. ..
  12. Regulation of craniofacial development by the Dix genes.
    John Rubenstein; Fiscal Year: 2007
    ..function, we are studying craniofacial molecular and tissue patterning in Dlx compound mutants In addition, we will study the cellular and molecular mechanisms through which the Dlx genes regulate claniofacial development ..
  13. GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    John Rubenstein; Fiscal Year: 2002
    ....
  14. STRUCTURE, EXPRESSION & FUNCTION OF THE DLX GENE FAMILY
    John Rubenstein; Fiscal Year: 2001
    ....
  15. GENES THAT REGULATE TELENCEPHALON DEVELOPMENT
    John Rubenstein; Fiscal Year: 1993
    ..Functional studies will include construction of transgenic mice which express the LacZ gene under the control of the TES-l promoter, and construction of strains of mice containing mutations in TES- l...
  16. GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENT
    John Rubenstein; Fiscal Year: 1999
    ....