EDWIN RUBEL

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Choosing axonal real estate: location, location, location
    Edwin W Rubel
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 448:1-5. 2002
  2. pmc Characterization of damage and regeneration in cultured avian utricles
    J I Matsui
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology HNS, University of Washington, Seattle, WA 98195, USA
    J Assoc Res Otolaryngol 1:46-63. 2000
  3. ncbi request reprint Auditory system development: primary auditory neurons and their targets
    Edwin W Rubel
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle 98195 7923, USA
    Annu Rev Neurosci 25:51-101. 2002
  4. ncbi request reprint FGFR3 expression during development and regeneration of the chick inner ear sensory epithelia
    O Bermingham-McDonogh
    Virginia Merrill Bloedel Hearing Research Center, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Dev Biol 238:247-59. 2001
  5. ncbi request reprint Temporal, spatial, and morphologic features of hair cell regeneration in the avian basilar papilla
    J S Stone
    Department of Otolaryngology and Head and Neck Surgery, Virginia Merrill Bloedel Hearing Research Center, University of Washington School of Medicine, Seattle 98195 7923, USA
    J Comp Neurol 417:1-16. 2000
  6. ncbi request reprint Delta1 expression during avian hair cell regeneration
    J S Stone
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, University of Washington, Seattle, WA 98195 7923, USA
    Development 126:961-73. 1999
  7. ncbi request reprint Development of the base of the cochlea: place code shift in the gerbil
    D M Mills
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Washington, Seattle 98195 7923, USA
    Hear Res 122:82-96. 1998
  8. ncbi request reprint Induction of cell proliferation in avian inner ear sensory epithelia by insulin-like growth factor-I and insulin
    E C Oesterle
    Department of Otolaryngology HNS, University of Washington, Seattle 98195, USA
    J Comp Neurol 380:262-74. 1997
  9. ncbi request reprint Development of distortion product emissions in the gerbil: "filter" response and signal delay
    D M Mills
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle 98195, USA
    J Acoust Soc Am 101:395-411. 1997
  10. ncbi request reprint Development of the cochlear amplifier
    D M Mills
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle 98195 7923, USA
    J Acoust Soc Am 100:428-41. 1996

Research Grants

  1. AFFERENT INFLUENCES ON AUDITORY SYSTEM ONTOGENY
    EDWIN RUBEL; Fiscal Year: 2003
  2. ONTOGENY OF VERTEBRATE SENSORY PROCESSES
    EDWIN RUBEL; Fiscal Year: 2004
  3. AFFERENT INFLUENCES ON AUDITORY SYSTEM ONTOGENY
    EDWIN RUBEL; Fiscal Year: 2007
  4. AFFERENT INFLUENCES ON AUDITORY SYSTEM ONTOGENY
    Edwin W Rubel; Fiscal Year: 2010
  5. ONTOGENY OF VERTEBRATE SENSORY PROCESSES
    EDWIN RUBEL; Fiscal Year: 1991
  6. ONTOGENY OF SENSORY PROCESSES
    EDWIN RUBEL; Fiscal Year: 1993
  7. ONTOGENY OF VERTEBRATE SENSORY PROCESSES
    EDWIN RUBEL; Fiscal Year: 1999
  8. AFFERENT INFLUENCES ON AUDITORY SYSTEM ONTOGENY
    Edwin W Rubel; Fiscal Year: 2011

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Choosing axonal real estate: location, location, location
    Edwin W Rubel
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 448:1-5. 2002
  2. pmc Characterization of damage and regeneration in cultured avian utricles
    J I Matsui
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology HNS, University of Washington, Seattle, WA 98195, USA
    J Assoc Res Otolaryngol 1:46-63. 2000
    ..Numerous BrdU-positive/TuJ1-positive cells with phenotypic characteristics of immature hair cells were present in the cultures, and the number of such cells increased between 3 and 5 days in vitro, in a dose-dependent manner...
  3. ncbi request reprint Auditory system development: primary auditory neurons and their targets
    Edwin W Rubel
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle 98195 7923, USA
    Annu Rev Neurosci 25:51-101. 2002
    ..Ganglion cell innervation and synaptic activity are essential for normal development of neurons in the cochlear nucleus...
  4. ncbi request reprint FGFR3 expression during development and regeneration of the chick inner ear sensory epithelia
    O Bermingham-McDonogh
    Virginia Merrill Bloedel Hearing Research Center, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Dev Biol 238:247-59. 2001
    ....
  5. ncbi request reprint Temporal, spatial, and morphologic features of hair cell regeneration in the avian basilar papilla
    J S Stone
    Department of Otolaryngology and Head and Neck Surgery, Virginia Merrill Bloedel Hearing Research Center, University of Washington School of Medicine, Seattle 98195 7923, USA
    J Comp Neurol 417:1-16. 2000
    ..Examination of sister cells born at 3 days post-gentamicin reveals that there is equal likelihood that they will assume the hair cell or support cell fate (i.e., both asymmetric and symmetric differentiation occur)...
  6. ncbi request reprint Delta1 expression during avian hair cell regeneration
    J S Stone
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology and Head and Neck Surgery, University of Washington, Seattle, WA 98195 7923, USA
    Development 126:961-73. 1999
    ..This study provides initial evidence that Delta-Notch signaling may be involved in maintaining the correct cell types and patterns during postembryonic replacement of sensory epithelial cells in the chick inner ear...
  7. ncbi request reprint Development of the base of the cochlea: place code shift in the gerbil
    D M Mills
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Washington, Seattle 98195 7923, USA
    Hear Res 122:82-96. 1998
    ..Over the same time period, there was approximately a doubling of the rate of amplification with distance from the base, so that the cochlear amplifier gain at the peak actually changed very little from 15 days to adult...
  8. ncbi request reprint Induction of cell proliferation in avian inner ear sensory epithelia by insulin-like growth factor-I and insulin
    E C Oesterle
    Department of Otolaryngology HNS, University of Washington, Seattle 98195, USA
    J Comp Neurol 380:262-74. 1997
    ..DNA synthesis was also stimulated by insulin. These results suggest that stimulation of the IGF-I receptors by IGF-I or insulin binding stimulates cell proliferation in the mature avian vestibular sensory epithelium...
  9. ncbi request reprint Development of distortion product emissions in the gerbil: "filter" response and signal delay
    D M Mills
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle 98195, USA
    J Acoust Soc Am 101:395-411. 1997
    ..e., either 20 or 30 dB lower, the active signal delay decreased only slightly with age. Overall, both filter response and signal delay characteristics were found to be essentially mature near the onset of hearing...
  10. ncbi request reprint Development of the cochlear amplifier
    D M Mills
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle 98195 7923, USA
    J Acoust Soc Am 100:428-41. 1996
    ..The proposed increase in passive base cutoff frequency with age accounts for the known place code shift...
  11. ncbi request reprint Visual influences on the development and recovery of the vestibuloocular reflex in the chicken
    C T Goode
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195, USA
    J Neurophysiol 85:1119-28. 2001
    ..Thus an 8-wk-old chicken raised in a strobe environment from hatch would have the same gain as a streptomycin-treated chicken that recovers in a strobe environment...
  12. ncbi request reprint Tonotopic map of potassium currents in chick auditory hair cells using an intact basilar papilla
    A A Pantelias
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology-Head and Neck Surgery, P.O. Box 357923 CHDD CD 176, University of Washington, Seattle, WA 98195, USA
    Hear Res 156:81-94. 2001
    ..This study demonstrates a new preparation to study the electrical properties of hair cells in more detail along the tonotopic axis of the chick basilar papilla...
  13. ncbi request reprint Tyrosine phosphatase SHP-1 immunoreactivity increases in a subset of astrocytes following deafferentation of the chicken auditory brainstem
    D I Lurie
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 421:199-214. 2000
    ..We hypothesize that the expression of SHP-1 plays a role in negatively regulating the mitotic behavior of astrocytes following deafferentation...
  14. pmc Rapid regulation of microtubule-associated protein 2 in dendrites of nucleus laminaris of the chick following deprivation of afferent activity
    Y Wang
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington School of Medicine, Box 357923, Seattle, WA 98195, USA
    Neuroscience 154:381-9. 2008
    ..Our results suggest that the cytoskeletal protein MAP2, which is distributed in dendrites, perikarya, and postsynaptic densities, may play a role in deafferentation-induced dendritic remodeling...
  15. ncbi request reprint Accommodation enhances depolarizing inhibition in central neurons
    P Monsivais
    Graduate Program in Neurobiology and Behavior and Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 21:7823-30. 2001
    ....
  16. ncbi request reprint Hair cell regeneration and recovery of auditory thresholds following aminoglycoside ototoxicity in Bengalese finches
    S M Woolley
    Neurobiology and Behavior Program, Department of Otolaryngology-HNS and Virginia Merrill Bloedel Hearing Research Center, P.O. Box 357923, University of Washington, Seattle, WA 98195, USA
    Hear Res 153:181-95. 2001
    ..0 kHz and above were observed up to 12 weeks after treatment. Direct comparison of structural and functional recovery indicates that auditory thresholds recover maximally before a full complement of hair cells has regenerated...
  17. ncbi request reprint Patterns of cell death in mouse anteroventral cochlear nucleus neurons after unilateral cochlea removal
    S P Mostafapour
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 426:561-71. 2000
    ..These data suggest that bcl-2 is one effector of cell survival as these cells switch from afferent-dependent to -independent survival mechanisms...
  18. ncbi request reprint Chronic perilymphatic fistula: experimental model in the guinea pig
    P Flint
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle 98195
    Otolaryngol Head Neck Surg 99:380-8. 1988
    ..The morphologic changes observed occurred acutely (within 7 days) and were not progressive, despite the presence of a fistula. Hair cell loss or degeneration did not correlate with hearing loss...
  19. ncbi request reprint The level and integrity of synaptic input regulates dendrite structure
    Staci A Sorensen
    Virginia Merrill Bloedel Hearing Research Center, Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 26:1539-50. 2006
    ..These results suggest that balanced activation of the two sets of NL dendrites is required to maintain the relative amount of dendritic surface area allotted to each input...
  20. ncbi request reprint Mechanisms of hair cell death and protection
    Alan G Cheng
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Curr Opin Otolaryngol Head Neck Surg 13:343-8. 2005
    ..Current knowledge of these cell death mechanisms and potential therapeutic targets are discussed in this review...
  21. ncbi request reprint Gene expression differences over a critical period of afferent-dependent neuron survival in the mouse auditory brainstem
    Julie A Harris
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, and Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, 98195, USA
    J Comp Neurol 493:460-74. 2005
    ....
  22. ncbi request reprint Expression of GABA(B) receptor in the avian auditory brainstem: ontogeny, afferent deprivation, and ultrastructure
    R Michael Burger
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 489:11-22. 2005
    ..The characterization of GABA(B)R distribution enriches our understanding of the full complement of inhibitory influences on central auditory processing in this well-studied neuronal circuit...
  23. ncbi request reprint Avian superior olivary nucleus provides divergent inhibitory input to parallel auditory pathways
    R Michael Burger
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195 7923, USA
    J Comp Neurol 481:6-18. 2005
    ..We present a conceptual model that incorporates these results and suggest that SON circuitry, in part, functions to offset interaural intensity differences in interaural time difference processing...
  24. ncbi request reprint GABA(B) receptor activation modulates GABA(A) receptor-mediated inhibition in chicken nucleus magnocellularis neurons
    Yong Lu
    Virginia Merrill Bloedel Hearing Research Center, Deptartment of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA, USA
    J Neurophysiol 93:1429-38. 2005
    ..We propose that presynaptic GABA(B)Rs function as autoreceptors, regulating synaptic strength of GABA(A)R-mediated inhibition, and prevent NM neurons from generating firing during activation of the inhibitory inputs...
  25. ncbi request reprint Lateral line hair cell maturation is a determinant of aminoglycoside susceptibility in zebrafish (Danio rerio)
    Felipe Santos
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Box 357923, Seattle, WA 98195 7923, USA
    Hear Res 213:25-33. 2006
    ....
  26. ncbi request reprint Formation of the avian nucleus magnocellularis from the auditory anlage
    Susan J Hendricks
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Comp Neurol 498:433-42. 2006
    ..Our results suggest that NM neurons may play a central role in formation of tonotopic connections in the auditory system...
  27. ncbi request reprint Afferent regulation of neuron number in the cochlear nucleus: cellular and molecular analyses of a critical period
    Julie A Harris
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Graduate Program in Neurobiology and Behavior, University of Washington, WA 98195, USA
    Hear Res 216:127-37. 2006
    ....
  28. pmc JNK signaling in neomycin-induced vestibular hair cell death
    Kazuma Sugahara
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195 7923, USA
    Hear Res 221:128-35. 2006
    ..In addition, inhibition of JNK inhibited the activation of caspase-9 in hair cells. These results indicate that JNK plays an important role in neomycin-induced vestibular hair cell death and caspase-9 activation...
  29. pmc Development of spontaneous miniature EPSCs in mouse AVCN neurons during a critical period of afferent-dependent neuron survival
    Yong Lu
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Box 357923, Seattle, WA 98195, USA
    J Neurophysiol 97:635-46. 2007
    ..Taken together, mEPSCs in mouse AVCN bushy cells show dramatic developmental changes across this critical period, and cochlea ablation may lead to the emergence of excitatory synaptic inputs impinging on bushy cell dendrites...
  30. ncbi request reprint Auditory feedback and song production do not regulate seasonal growth of song control circuits in adult white-crowned sparrows
    Eliot A Brenowitz
    Department of Psychology, and The Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195 1525, USA
    J Neurosci 27:6810-4. 2007
    ..These results suggest that neither auditory input nor high rates of song production are necessary for seasonal growth of the adult song control system in this species...
  31. pmc Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line
    Henry C Ou
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Box 357923, Seattle, WA 98195, USA
    Hear Res 233:46-53. 2007
    ..These data demonstrate the feasibility and repeatability of cisplatin damage protocols in the zebrafish lateral line and set the stage for future evaluations of modulation of cisplatin-induced hair cell death...
  32. doi request reprint Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line
    Eva Y Ma
    Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
    J Neurosci 28:2261-73. 2008
    ..Excess hair cells result from increased support cell proliferation. These results suggest a model where Notch signaling limits the number of hair cells produced during regeneration by regulating support cell proliferation...
  33. pmc Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death
    Kelly N Owens
    Department of Biological Structure, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 4:e1000020. 2008
    ..The combination of chemical screening with traditional genetic approaches is a new strategy for identifying drugs and drug targets to attenuate hearing and balance disorders...
  34. ncbi request reprint Overexpression of Bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitro
    Lisa L Cunningham
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, 98195 7293, USA
    J Neurobiol 60:89-100. 2004
    ..These results suggest that the expression level of Bcl-2 has important effects on the pathway(s) important for the regulation of aminoglycoside-induced hair cell death...
  35. ncbi request reprint Hair cell regeneration: winging our way towards a sound future
    Olivia Bermingham-McDonogh
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology HNS, University of Washington Medical School, Box 357923, Seattle, Washington 98195 7923, USA
    Curr Opin Neurobiol 13:119-26. 2003
    ..We examine some of the key recent findings in both birds and mammals...
  36. pmc Hair cell death in the avian basilar papilla: characterization of the in vitro model and caspase activation
    Alan G Cheng
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle 98195, USA
    J Assoc Res Otolaryngol 4:91-105. 2003
    ..Specifically, the upstream caspases, caspase-8 and caspase-9, and the downstream caspase-3 are activated in aminoglycoside-damaged hair cells...
  37. ncbi request reprint Caspase activation in hair cells of the mouse utricle exposed to neomycin
    Lisa L Cunningham
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195 7293, USA
    J Neurosci 22:8532-40. 2002
    ..These data indicate that caspase-9 is the primary upstream caspase mediating neomycin-induced hair cell death in this preparation...
  38. ncbi request reprint Ultrastructural analysis of [3H]thymidine-labeled cells in the rat utricular macula
    Elizabeth C Oesterle
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 463:177-95. 2003
    ..These findings suggest that new hair cells can be generated in situ by means of a mitotic mechanism in the vestibular sensory epithelium of adult mammals...
  39. pmc Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio)
    Julie A Harris
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
    J Assoc Res Otolaryngol 4:219-34. 2003
    ..The results presented here provide a standardized preparation for studying and identifying genes that influence vertebrate hair cell death, survival, and regeneration following ototoxic insults...
  40. ncbi request reprint Timing and topography of nucleus magnocellularis innervation by the cochlear ganglion
    David Molea
    Virginia Merrill Bloedel Hearing Research Center, Department of Physiology and Biophysics, Department of Otolaryngology HNS, University of Washington, Seattle, Washington 98195 7923, USA
    J Comp Neurol 466:577-91. 2003
    ..These results indicate that topographic mapping of position (and ultimately characteristic frequency) between the basilar papilla and NM is established as cochlear nerve axons arrive in the NM prior to the onset of synaptic activity. ...
  41. ncbi request reprint Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio)
    Setsuko L Murakami
    Graduate Program in Audiology, University of Washington, Seattle, WA 98195, USA
    Hear Res 186:47-56. 2003
    ..Thus zebrafish hair cells show developmental differences in sensitivity to aminoglycoside-induced death similar to those reported for inner ear hair cells of birds and mammals...
  42. ncbi request reprint Ultrastructural analysis of aminoglycoside-induced hair cell death in the zebrafish lateral line reveals an early mitochondrial response
    Kelly N Owens
    VM Bloedel Hearing Research Center, Department of Biological Structure, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 502:522-43. 2007
    ..In vivo monitoring demonstrated that mitochondrial potential decreased following neomycin treatment. These results indicate that perturbation of the mitochondrion is an early, central event in aminoglycoside-induced damage...
  43. ncbi request reprint Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem
    Karina S Cramer
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 452:51-64. 2002
    ..Moreover, ephrin-B2 in growing axons may interact with the asymmetrically expressed EphA4 during the establishment of binaural segregation...
  44. ncbi request reprint Vocal memory and learning in adult Bengalese Finches with regenerated hair cells
    Sarah M N Woolley
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:7774-87. 2002
    ..Results suggest that, in Bengalese Finches, the degree of behavioral and neural plasticity in juvenile and adult birds may be less distinct that previously thought...
  45. ncbi request reprint bcl-2 Overexpression eliminates deprivation-induced cell death of brainstem auditory neurons
    Sam P Mostafapour
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology, Head and Neck Surgery, University of Washington, Seattle, Washington 98195
    J Neurosci 22:4670-4. 2002
    ..These data are the first to indicate that known apoptotic mediators can play a role in central neuronal plasticity in models of afferent deprivation...
  46. ncbi request reprint Effects of age on the distortion product otoacoustic emission growth functions
    George A Gates
    Department of Otolaryngology Head and Neck Surgery, Virginia Merrill Bloedel Hearing Research Center, University of Washington School of Medicine, Seattle, USA
    Hear Res 163:53-60. 2002
    ..This effect supports the hypothesis that strial dysfunction is a substantive factor in cochlear aging. The etiology and mechanisms for this dysfunction are conjectural at present...
  47. pmc Using the zebrafish lateral line to screen for ototoxicity
    Lynn L Chiu
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Box 356515, Seattle, WA 98195, USA
    J Assoc Res Otolaryngol 9:178-90. 2008
    ..This study represents an important step in validating the use of the zebrafish lateral line as a screening tool for the identification of potentially ototoxic drugs...
  48. ncbi request reprint Electron microscopy of degenerative changes in the chick basilar papilla after gentamicin exposure
    Keiko Hirose
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 470:164-80. 2004
    ....
  49. ncbi request reprint A developmental switch to GABAergic inhibition dependent on increases in Kv1-type K+ currents
    MacKenzie A Howard
    Department of Physiology and Biophysics and Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 27:2112-23. 2007
    ....
  50. ncbi request reprint Tonotopic gradients of Eph family proteins in the chick nucleus laminaris during synaptogenesis
    Abigail L Person
    University of Washington, Seattle, 98195, USA
    J Neurobiol 60:28-39. 2004
    ..These results of this study provide a basis for the functional examination of the role of Eph proteins in the formation of tonotopic maps in the brainstem...
  51. ncbi request reprint Activity-dependent regulation of the potassium channel subunits Kv1.1 and Kv3.1
    Yong Lu
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology HNS, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 470:93-106. 2004
    ..We conclude that the highly specialized abundant expression of Kv1.1 and 3.1 channel subunits is not permanently regulated by synaptic activity and that changes in overall protein levels do not predict membrane pools...
  52. ncbi request reprint A new method for imaging and 3D reconstruction of mammalian cochlea by fluorescent confocal microscopy
    Natalie A Hardie
    Virginia Merrill Bloedel Hearing Research Center and Otolaryngology HNS, University of Washington, Box 357923, Seattle, WA 98195 7923, USA
    Brain Res 1000:200-10. 2004
    ..Furthermore, semi-thin sections made from these preparations are compatible with traditional histological stains, as well as allowing brightly labelled epi-fluorescent images...
  53. ncbi request reprint EphA4 signaling promotes axon segregation in the developing auditory system
    Karina S Cramer
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology HNS, University of Washington, Seattle, WA 98195, USA
    Dev Biol 269:26-35. 2004
    ..These results suggest that EphA4 has multiple roles in the formation of auditory brainstem nuclei and their projections...
  54. ncbi request reprint Round window gentamicin application: an inner ear hair cell damage protocol for the mouse
    Jennifer L Heydt
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Box 356515, Seattle, WA 98195 7923, USA
    Hear Res 192:65-74. 2004
    ..In addition, this protocol produces no systemic toxicity and preserves the contralateral ear as a control...
  55. ncbi request reprint Activation of metabotropic glutamate receptors inhibits high-voltage-gated calcium channel currents of chicken nucleus magnocellularis neurons
    Yong Lu
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Box 357923, Seattle, WA 98195, USA
    J Neurophysiol 93:1418-28. 2005
    ..We propose that the inhibition of VGCC currents by mGluRs limits depolarization-induced Ca2+ entry into these highly active NM neurons and regulates their Ca2+ homeostasis...
  56. pmc Three-dimensional imaging of the intact mouse cochlea by fluorescent laser scanning confocal microscopy
    Glen H MacDonald
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology HNS, University of Washington, Seattle, WA 98195, USA
    Hear Res 243:1-10. 2008
    ..Furthermore, the MSBB is compatible with most non-protein fluorophores used for histological labeling, and may be removed with traditional transitional solvents to allow subsequent epoxy embedding for sectioning...

Research Grants32

  1. AFFERENT INFLUENCES ON AUDITORY SYSTEM ONTOGENY
    EDWIN RUBEL; Fiscal Year: 2003
    ..4. We will combine single cell labeling, electrophysiology and calcium imaging methods to study the cellular mechanisms of afferent regulation of dendritic structure. ..
  2. ONTOGENY OF VERTEBRATE SENSORY PROCESSES
    EDWIN RUBEL; Fiscal Year: 2004
    ..abstract_text> ..
  3. AFFERENT INFLUENCES ON AUDITORY SYSTEM ONTOGENY
    EDWIN RUBEL; Fiscal Year: 2007
    ..These studies make use of the unique binaural innervation of n. laminar is cells to allow spatial resolution of the relationships between afferent stimulation, calcium homeostasis, and structural dynamics of dendrites. ..
  4. AFFERENT INFLUENCES ON AUDITORY SYSTEM ONTOGENY
    Edwin W Rubel; Fiscal Year: 2010
    ..It is estimated that 10 to 20 percent of the US population have hearing impairments that significantly affect quality of life. Furthermore, 1 out of every 1,000 babies born in this country is seriously hearing impaired. ..
  5. ONTOGENY OF VERTEBRATE SENSORY PROCESSES
    EDWIN RUBEL; Fiscal Year: 1991
    ..Here, we will examine the development of topographic connections between two cell groups and the development of dendritic patterns in the vertebrate central nervous system...
  6. ONTOGENY OF SENSORY PROCESSES
    EDWIN RUBEL; Fiscal Year: 1993
    ..These studies include ultrastructural analyses of support cells in the auditory and vestibular epithelia, further delineation of the progenitor population, and in vitro analyses of molecular signals regulating mitotic activity...
  7. ONTOGENY OF VERTEBRATE SENSORY PROCESSES
    EDWIN RUBEL; Fiscal Year: 1999
    ....
  8. AFFERENT INFLUENCES ON AUDITORY SYSTEM ONTOGENY
    Edwin W Rubel; Fiscal Year: 2011
    ..It is estimated that 10 to 20 percent of the US population have hearing impairments that significantly affect quality of life. Furthermore, 1 out of every 1,000 babies born in this country is seriously hearing impaired. ..