Richard Rozmahel

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype
    Richard Rozmahel
    Center for Research in Neurodegenerative Diseases, Department of Pharmacology, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 99:14452-7. 2002
  2. pmc Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
    Peter Mastrangelo
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 3H2
    Proc Natl Acad Sci U S A 102:8972-7. 2005
  3. ncbi request reprint Loss of nicastrin elicits an apoptotic phenotype in mouse embryos
    Van Nguyen
    Dept of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Brain Res 1086:76-84. 2006
  4. ncbi request reprint Differential display analysis of presenilin 1-deficient mouse brains
    Jennifer Liauw
    Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Brain Res Mol Brain Res 109:56-62. 2002
  5. ncbi request reprint Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice
    Kim S Sugamori
    Department of Pharmacology, University of Toronto, Medical Sciences Building 1, King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pharmacol 64:170-9. 2003
  6. ncbi request reprint Mouse genome modification
    Richard Rozmahel
    Department of Pharmacology, University of Toronto, Toronto, Canada
    Methods Mol Med 89:529-44. 2003
  7. ncbi request reprint Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice
    Christina K Haston
    Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Mamm Genome 13:605-13. 2002

Collaborators

Detail Information

Publications7

  1. pmc Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype
    Richard Rozmahel
    Center for Research in Neurodegenerative Diseases, Department of Pharmacology, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 99:14452-7. 2002
    ..The dissociation of Notch S3-site and APP gamma-site cleavage activities will facilitate development of gamma-secretase inhibitors for treatment of Alzheimer's disease...
  2. pmc Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
    Peter Mastrangelo
    Centre for Research in Neurodegenerative Diseases, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 3H2
    Proc Natl Acad Sci U S A 102:8972-7. 2005
    ..Instead, our studies define functionally distinct gamma-secretase variants. We speculate that extrinsic components, in combination with core complexes, may tailor functional variants of this enzyme to their preferred substrates...
  3. ncbi request reprint Loss of nicastrin elicits an apoptotic phenotype in mouse embryos
    Van Nguyen
    Dept of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Brain Res 1086:76-84. 2006
    ....
  4. ncbi request reprint Differential display analysis of presenilin 1-deficient mouse brains
    Jennifer Liauw
    Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Brain Res Mol Brain Res 109:56-62. 2002
    ....
  5. ncbi request reprint Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice
    Kim S Sugamori
    Department of Pharmacology, University of Toronto, Medical Sciences Building 1, King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pharmacol 64:170-9. 2003
    ..This knockout mouse model should be helpful in delineating the role that variation in acetylating enzymes plays in mediating interindividual differences in susceptibility to arylamine-induced chemical toxicity and/or carcinogenesis...
  6. ncbi request reprint Mouse genome modification
    Richard Rozmahel
    Department of Pharmacology, University of Toronto, Toronto, Canada
    Methods Mol Med 89:529-44. 2003
  7. ncbi request reprint Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice
    Christina K Haston
    Program of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Mamm Genome 13:605-13. 2002
    ..Most of these putative loci are specific to the sex of the animals. These results suggest that multiple genes can influence the severity of CF lung disease in mice...