D R Royall

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Insular Alzheimer's disease pathology as a cause of "age-related" autonomic dysfunction and mortality in the non-demented elderly
    Donald R Royall
    Department of Psychiatry, South Texas Veterans Health System Audie L Murphy Division GRECC and the University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78284 7792, United
    Med Hypotheses 67:747-58. 2006
  2. doi request reprint Latent variables may be useful in pain's assessment
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive MC 7792, San Antonio, TX 78229, USA
    Health Qual Life Outcomes 12:13. 2014
  3. doi request reprint Does ethnicity moderate dementia's biomarkers?
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA Department of Medicine, The University of Texas Health Science Center, San Antonio, TX, USA Department of Family and Community Medicine, The University of Texas Health Science Center, San Antonio, TX, USA South Texas Veterans Health System, Audie L Murphy Division GRECC, San Antonio, TX, USA Electronic address
    Neurobiol Aging 35:336-44. 2014
  4. doi request reprint Validation of a latent construct for dementia case-finding in Mexican-Americans
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    J Alzheimers Dis 37:89-97. 2013
  5. doi request reprint Alzheimer's disease pathology does not mediate the association between depressive symptoms and subsequent cognitive decline
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    Alzheimers Dement 9:318-25. 2013
  6. pmc The default mode network may be the key substrate of depressive symptom-related cognitive changes
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    J Alzheimers Dis 34:547-59. 2013
  7. doi request reprint Fortress brain
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    Med Hypotheses 80:118-21. 2013
  8. pmc The default mode network and related right hemisphere structures may be the key substrates of dementia
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    J Alzheimers Dis 32:467-78. 2012
  9. ncbi request reprint Estimating the temporal evolution of Alzheimer's disease pathology with autopsy data
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    J Alzheimers Dis 32:23-32. 2012
  10. doi request reprint Modeling regional vulnerability to Alzheimer pathology
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX 78284 7792, USA
    Neurobiol Aging 33:1556-63. 2012

Research Grants

  1. Dyspraxia and Autonomic Control in Very Early AD
    Donald Royall; Fiscal Year: 2004
  2. Insular AD Pathology and Autonomic Function
    Donald Royall; Fiscal Year: 2006
  3. VAS-COG 2007
    Donald Royall; Fiscal Year: 2007
  4. Insular Autonomic Function in Depression
    Donald R Royall; Fiscal Year: 2010

Detail Information

Publications72

  1. ncbi request reprint Insular Alzheimer's disease pathology as a cause of "age-related" autonomic dysfunction and mortality in the non-demented elderly
    Donald R Royall
    Department of Psychiatry, South Texas Veterans Health System Audie L Murphy Division GRECC and the University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78284 7792, United
    Med Hypotheses 67:747-58. 2006
    ..If true, then preclinical AD pathology should be considered as a possible explanation for arrhythmia/fall related morbidity and mortality in non-demented elderly persons...
  2. doi request reprint Latent variables may be useful in pain's assessment
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive MC 7792, San Antonio, TX 78229, USA
    Health Qual Life Outcomes 12:13. 2014
    ..Unobserved "latent" variables have the potential to minimize "measurement error" inherent to any single clinical assessment or categorical diagnosis...
  3. doi request reprint Does ethnicity moderate dementia's biomarkers?
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA Department of Medicine, The University of Texas Health Science Center, San Antonio, TX, USA Department of Family and Community Medicine, The University of Texas Health Science Center, San Antonio, TX, USA South Texas Veterans Health System, Audie L Murphy Division GRECC, San Antonio, TX, USA Electronic address
    Neurobiol Aging 35:336-44. 2014
    ..Independent of covariates, δ is associated significantly with 12 serum biomarkers. These associations appear to be specific to non-Hispanic white participants. ..
  4. doi request reprint Validation of a latent construct for dementia case-finding in Mexican-Americans
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    J Alzheimers Dis 37:89-97. 2013
    ..Ethnicity has a small effect on dMA's performance. These results suggest that it may be possible to validly export dMA into other MA populations, or to export δ homolog factor scores from one population to another. ..
  5. doi request reprint Alzheimer's disease pathology does not mediate the association between depressive symptoms and subsequent cognitive decline
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    Alzheimers Dement 9:318-25. 2013
    ....
  6. pmc The default mode network may be the key substrate of depressive symptom-related cognitive changes
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    J Alzheimers Dis 34:547-59. 2013
    ..This conclusion suggests new opportunities for the latter's diagnosis, prevention, and treatment...
  7. doi request reprint Fortress brain
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    Med Hypotheses 80:118-21. 2013
    ..This suggests a defense in depth of a structure, the brain, that is inherently vulnerable to invasion along its neural networks...
  8. pmc The default mode network and related right hemisphere structures may be the key substrates of dementia
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    J Alzheimers Dis 32:467-78. 2012
    ..The latent variable d localizes to elements of the default mode network and related structures in the R hemisphere...
  9. ncbi request reprint Estimating the temporal evolution of Alzheimer's disease pathology with autopsy data
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    J Alzheimers Dis 32:23-32. 2012
    ..The mediation effect of cognitive change on both AD lesion models effectively dates them within the period of cognitive surveillance. Additional analyses could lead to an improved understanding of lesion propagation in AD...
  10. doi request reprint Modeling regional vulnerability to Alzheimer pathology
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX 78284 7792, USA
    Neurobiol Aging 33:1556-63. 2012
    ..This is the first application of LGC models to spatially-ordered data. The result is a quantification of the interindividual variation in the interregional vulnerability to Alzheimer's disease lesions...
  11. doi request reprint Validation of a latent variable representing the dementing process
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Alzheimers Dis 30:639-49. 2012
    ..Our approach results in "error free" continuous variables. This suggests that δ can serve as a dementia specific endophenotype. As a result, future studies may be able to associate δ with inflammatory and genetic biomarkers...
  12. doi request reprint Getting Past "g": testing a new model of dementing processes in persons without dementia
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    J Neuropsychiatry Clin Neurosci 24:37-46. 2012
    ..These results have implications for the clinical assessment of dementia and suggest that functional status should assume a more important role...
  13. ncbi request reprint Misclassification is likely in the assessment of mild cognitive impairment
    Donald R Royall
    Department of Psychiatry, South Texas Veterans Health System Audie L Murphy Division GRECC and University of Texas Health Science Center, San Antonio, TX 78284, USA
    Neuroepidemiology 23:185-91. 2004
    ..Isolated ECF impairment is not consistent with the natural history of preclinical Alzheimer's disease, suggests other conditions, and can be disabling, independently of age and/or memory loss...
  14. ncbi request reprint Prevalence and patterns of executive impairment in community dwelling Mexican Americans: results from the Hispanic EPESE Study
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX 78284 7792, USA
    Int J Geriatr Psychiatry 19:926-34. 2004
    ..We have determined the prevalence of cognitive impairment and impaired ECF in a community dwelling Mexican American elderly population, and their associations with functional status...
  15. ncbi request reprint Executive control mediates memory's association with change in instrumental activities of daily living: the Freedom House Study
    Donald R Royall
    Department of Psychiatry, South Texas Veterans Health System Audie L Murphy Division Geriatric Research, Education and Clinical Center, and the University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Am Geriatr Soc 53:11-7. 2005
    ..To assess the relative independent contribution of changes in executive control function (ECF) and memory to changes in functional status...
  16. ncbi request reprint Normal rates of cognitive change in successful aging: the freedom house study
    Donald R Royall
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284 7792, USA
    J Int Neuropsychol Soc 11:899-909. 2005
    ..Nonverbal measures appear to be particularly well suited for the prediction of age-related functional decline. These observations are relevant to the definition and diagnosis of "dementing" conditions...
  17. ncbi request reprint Location, location, location!
    Donald R Royall
    Division of Aging and Geriatric Psychiatry, The University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, Mail Code 7792, United States
    Neurobiol Aging 28:1481-2; discussion 1483. 2007
  18. ncbi request reprint Cognitive predictors of mortality in elderly retirees: results from the Freedom House study
    Donald R Royall
    Department of Psychiatry, South Texas Veterans Health System Audie L Murphy Division GRECC and the University of Texas Health Science Center, San Antonio, TX 78284 7792, USA
    Am J Geriatr Psychiatry 15:243-51. 2007
    ..The objective of this longitudinal cohort study was to study the cognitive domains associated with five-year longitudinal survival among healthy, well-educated, noninstitutionalized elderly...
  19. ncbi request reprint Depression and mortality in elders referred for geriatric psychiatry consultation
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Am Med Dir Assoc 8:318-21. 2007
    ..The association between depressive symptoms and mortality was assessed in a 7-year longitudinal follow-up of subjects referred for geropsychiatric consultation...
  20. ncbi request reprint The cognitive correlates of functional status: a review from the Committee on Research of the American Neuropsychiatric Association
    Donald R Royall
    Department of Psychiatry, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Neuropsychiatry Clin Neurosci 19:249-65. 2007
    ..Better integration of cognitive and functional assessments would offer greater clinical utility. However, psychometric batteries may have to be redesigned to maximize their capacity to capture the variance in functional outcomes...
  21. doi request reprint Clock-drawing potentially mediates the effect of depression on mortality: replication in three cohorts
    Donald R Royall
    Department of Psychiatry, The South Texas Veterans Health System Audie L Murphy Division GRECC and the University of Texas Health Science Center, San Antonio, TX, USA
    Int J Geriatr Psychiatry 23:821-9. 2008
    ..Previously studies have associated visuospatial tasks, particularly 'clock-drawing', with mortality. We sought to determine whether clock-drawing also mediates the association between depressive symptoms and mortality...
  22. ncbi request reprint Insular Alzheimer disease pathology and the psychometric correlates of mortality
    Donald R Royall
    Department of Psychiatry, South Texas Veterans Health System Audie L Murphy Division, Geriatric Research Education and Clinical Center, San Antonio, TX, USA
    Cleve Clin J Med 75:S97-9. 2008
    ..Thus, AD pathology should be considered as a possible explanation for autonomic morbidity and mortality in nondemented elderly persons...
  23. doi request reprint Asymmetric insular function predicts positional blood pressure in nondemented elderly
    Donald Royall
    Department of Psychiatry, The University of Texas Health Science Center, 7703 Floyd Curl Dr, Mail Code 7792, San Antonio, TX 78229 3900, USA
    J Neuropsychiatry Clin Neurosci 21:173-80. 2009
    ..This subset had significantly increased positional drops in systolic blood pressure. While these data cannot address Alzheimer's disease as the specific cause, this possibility is being investigated in other cohorts...
  24. doi request reprint Sertraline improves executive function in patients with vascular cognitive impairment
    Donald R Royall
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    J Neuropsychiatry Clin Neurosci 21:445-54. 2009
    ..Our findings suggest that sertraline may have both statistical and clinically meaningful effects on executive control function in ischemic cerebrovascular disease. The authors discuss the implications for future clinical trials...
  25. doi request reprint Depressive symptoms predict longitudinal change in executive control but not memory
    Donald R Royall
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Geriatr Psychiatry 27:89-96. 2012
    ..Depression in non-demented persons has been identified as a possible risk factor for incident Alzheimer's disease (AD)...
  26. ncbi request reprint Executive control and the validity of survey data
    Donald R Royall
    Departments of Psychiatry Medicine and Pharmacology, The University of Texas Health Sciences Center at San Antonio, Texas 78229, USA
    Int J Geriatr Psychiatry 19:696-8. 2004
  27. ncbi request reprint Executive control function: a review of its promise and challenges for clinical research. A report from the Committee on Research of the American Neuropsychiatric Association
    Donald R Royall
    The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Neuropsychiatry Clin Neurosci 14:377-405. 2002
    ..The prevalence and severity of ECF deficits in many disorders remain to be determined, and treatment has been attempted in only a few disorders. Much more research in these areas is necessary...
  28. ncbi request reprint Executive cognitive impairment: a novel perspective on dementia
    D R Royall
    Department of Psychiatry, South Texas Veterans Health System Audie L Murphy Division GRECC, San Antonio, TX, USA
    Neuroepidemiology 19:293-9. 2000
    ..The total number of dementia cases may be much greater than previously thought and we are likely to be selectively missing cases with reversible causes of ECF impairment...
  29. ncbi request reprint Validation of a Spanish translation of the CLOX for use in Hispanic samples: the Hispanic EPESE study
    Donald R Royall
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7792, USA
    Int J Geriatr Psychiatry 18:135-41. 2003
    ..We investigated a Spanish language translation of CLOX: an executive CDT, in a community sample of Hispanic elders...
  30. ncbi request reprint Decline in learning ability best predicts future dementia type: the Freedom House Study
    Donald R Royall
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78284 7792, USA
    Exp Aging Res 29:385-406. 2003
    ..Serial administrations of memory tests may help identify nondemented persons at greater or lesser risk for conversion to frank dementia in the near-term...
  31. ncbi request reprint Declining executive control in normal aging predicts change in functional status: the Freedom House Study
    Donald R Royall
    Department of Psychiatry, South Texas Veterans Health System Audie L Murphy Division GRECC, and the University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Am Geriatr Soc 52:346-52. 2004
    ..To assess the contribution of executive control function (ECF) to functional status...
  32. ncbi request reprint Severe dysosmia is specifically associated with Alzheimer-like memory deficits in nondemented elderly retirees
    D R Royall
    Department of Psychiatry, The Audie L Murphy VA Geriatric Research Education Clinical Center and University of Texas Health Science Center at San Antonio, Tex, 78229 3900, USA
    Neuroepidemiology 21:68-73. 2002
    ....
  33. ncbi request reprint Frontal MRI findings associated with impairment on the Executive Interview (EXIT25)
    D R Royall
    Departments of Psychiatry, Medicine, and Pharmacology, South Texas Veterans Health System, Geriatric Research, Education and Clinical Center GRECC, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Exp Aging Res 27:293-308. 2001
    ..This conclusion is consistent with earlier functional neuroimaging studies associating EXIT25 performance with left mesiofrontal perfusion...
  34. ncbi request reprint Executive dyscontrol in normal aging: normative data, factor structure, and clinical correlates
    Donald R Royall
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Curr Neurol Neurosci Rep 3:487-93. 2003
    ..Moreover, associations with functional status should not be casually extrapolated from regional frontal clinical correlations, particularly with the dorsolateral prefrontal cortex...
  35. pmc CLOX: an executive clock drawing task
    D R Royall
    Department of Psychiatry, University of Texas, Health Science Center at San Antonio, 78284 7792, USA
    J Neurol Neurosurg Psychiatry 64:588-94. 1998
    ..To describe a clock drawing task (CLOX) designed to elicit executive impairment and discriminate it from non-executive constructional failure...
  36. ncbi request reprint Frontal systems impairment in major depression
    D R Royall
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78264 7792, USA
    Semin Clin Neuropsychiatry 4:13-23. 1999
    ..This should cause doctors to reconsider their approach to depression. Treatment for the cognitive aspects of depression may be needed to ensure improvement in functional domains...
  37. ncbi request reprint Correlates of disability among elderly retirees with "subclinical" cognitive impairment
    D R Royall
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284 7792, USA
    J Gerontol A Biol Sci Med Sci 55:M541-6. 2000
    ..We assessed the effects of impaired Executive Control Function (ECF) on Instrumental Activities of Daily Living (IADL) and level of care among noninstitutionalized elderly retirees with "subclinical" cognitive impairment...
  38. ncbi request reprint Clock drawing is sensitive to executive control: a comparison of six methods
    D R Royall
    Department of Psychiatry, South Texas Veterans Health System Audie L Murphy Division GRECC, San Antonio, USA
    J Gerontol B Psychol Sci Soc Sci 54:P328-33. 1999
    ..68) and MMSE scores (R2 = .72). Clock drawing draws upon both executive and general cognitive resources. CLOX explains incrementally more variance in ECF than other CDTs...
  39. ncbi request reprint Mexican-American ethnicity and cognitive function: findings from an elderly southwestern sample
    Peter L Heller
    Departments of Neuropsychiatry and Behavioral Science, Texas Tech University Health Sciences Center, El Paso, TX, USA
    J Neuropsychiatry Clin Neurosci 18:350-5. 2006
    ..The authors conclude that a dependable and clinically meaningful negative association exists between Mexican-American ethnicity and late-life cognitive function in this region that is mediated by as yet unmeasured variables...
  40. ncbi request reprint Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging
    P Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, Research Imaging Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Neuroimage 35:478-87. 2007
    ..These data are consistent with the hypothesis that late-myelinating regions of the brain bear the brunt of age-related degenerative changes...
  41. pmc Loss of cerebral white matter structural integrity tracks the gray matter metabolic decline in normal aging
    P Kochunov
    Research Imaging Center, University of Texas Health Science Center, San Antonio, 78284, USA
    Neuroimage 45:17-28. 2009
    ..Specifically, age-related WM degradation in the thinly myelinated association tracts appears to track the decreases in global and regional rates of glucose uptake...
  42. doi request reprint Missing data? Plan on it!
    Raymond F Palmer
    Department of Family and Community Medicine, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Am Geriatr Soc 58:S343-8. 2010
    ..How the purposeful planning of missing data in research designs can reduce subject burden, improve data quality and statistical power, and manage costs is then described...
  43. ncbi request reprint Clock drawing phenotypes in community-dwelling African Americans and Caucasians: results from the University of Alabama at Birmingham study of aging
    Jason E Schillerstrom
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Neuroepidemiology 28:175-80. 2007
    ..The aim of this study was to describe the prevalence of these phenotypes in community-dwelling African American and Caucasian elders...
  44. ncbi request reprint Prevalence of executive impairment in patients seen by a psychiatry consultation service
    Jason E Schillerstrom
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Psychosomatics 44:290-7. 2003
    ..Because impairment of executive function has been specifically associated with behavioral and functional disability, routine assessment of executive function should be integrated into psychiatric case management...
  45. doi request reprint Prospective evaluation of pretreatment executive cognitive impairment and depression in patients referred for radiotherapy
    Clifton D Fuller
    Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Int J Radiat Oncol Biol Phys 72:529-33. 2008
    ....
  46. doi request reprint Executive function in self-neglecting adult protective services referrals compared with elder psychiatric outpatients
    Jason E Schillerstrom
    University of Texas Health Science Center at San Antonio, TX 78229, USA
    Am J Geriatr Psychiatry 17:907-10. 2009
    ....
  47. doi request reprint Depression, disability and intermediate pathways: a review of longitudinal studies in elders
    Jason E Schillerstrom
    Department of Psychiatry The University of Texas Health Seience Center, San Antonio, TX 78229, USA
    J Geriatr Psychiatry Neurol 21:183-97. 2008
    ....
  48. ncbi request reprint A diagnostic dilemma: is "Alzheimer's dementia" Alzheimer's disease, vascular dementia, or both?
    Gustavo C Roman
    University of Texas Health Science Center at San Antonio and the Audie L Murphy Veterans Hospital, San Antonio, Texas, USA
    Lancet Neurol 3:141. 2004
  49. ncbi request reprint Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia
    Gustavo C Roman
    Department of Medicine Neurology, University of Texas HSC at San Antonio and the Audie Murphy Veterans Administration Hospital, Mail Code 7883, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Neurol Sci 226:81-7. 2004
    ..It would include specific disease entities such as post-stroke VCI, post-stroke VaD, CADASIL, Binswanger disease, and AD plus CVD. This category explicitly excludes isolated cognitive dysfunctions such as those mentioned above...
  50. ncbi request reprint An empiric approach to level of care determinations: the importance of executive measures
    Donald R Royall
    Department of Psychiatry, University of Texas Health Science, San Antonio, TX 78229 3900, USA
    J Gerontol A Biol Sci Med Sci 60:1059-64. 2005
    ..They were given a battery of cognitive measures that included tests of general cognition, memory, and executive control function. A multivariate discriminant model of level of care was compared with a classification tree...
  51. ncbi request reprint Prevalence, course, and risk factors for executive impairment in patients hospitalized on a general medicine service
    Jason E Schillerstrom
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Psychosomatics 46:411-7. 2005
    ..The prevalence of executive impairment on general medicine services is high. Although improvement in executive function occurs during hospitalization, many patients remained impaired...
  52. ncbi request reprint The impact of medical illness on executive function
    Jason E Schillerstrom
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229, and the Geriatric Research Education and Clinical Center, Audie L Murphy Division, South Texas Veterans Health Administration, USA
    Psychosomatics 46:508-16. 2005
    ..The changes in functional status associated with executive impairment as well as pathophysiology and treatment strategies are also discussed...
  53. ncbi request reprint Pathological determinants of the transition to clinical dementia in Alzheimer's disease
    Donald R Royall
    Departments of Psychiatry, Medicine, and Pharmacology, South Texas Veterans Health System, Audie L Murphy Division GRECC, University of Texas Health Science Center, San Antonio, Texas, USA
    Exp Aging Res 28:143-62. 2002
    ..A22, A23, and A39 provide major afferents to other frontal systems and have previously been implicated in very early clinical Alzheimer's disease...
  54. ncbi request reprint Back to the future of mental capacity assessment
    Donald R Royall
    Department of Psychiatry, The Audie Murphy VA Geriatric Research, Education and Clinical Center, University of Texas Health Science Center, San Antonio, TX, USA
    J Am Geriatr Soc 50:1884-5. 2002
  55. ncbi request reprint Executive function and capacity to consent to a noninvasive research protocol
    Jason E Schillerstrom
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Am J Geriatr Psychiatry 15:159-62. 2007
    ..This study measured the association between executive function and decision-making capacity in subjects consenting to a noninvasive research protocol...
  56. ncbi request reprint Alzheimer disease as a vascular disorder: nosological evidence
    Donald R Royall
    Stroke 33:2147-8; author reply 2147-8. 2002
  57. ncbi request reprint Not all clock-drawing tasks are the same
    Donald R Royall
    J Am Geriatr Soc 50:1166-7. 2002
  58. ncbi request reprint Mild cognitive impairment and functional status
    Donald R Royall
    J Am Geriatr Soc 54:163-5. 2006
  59. ncbi request reprint Re: De Jager, CA, et al. Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer's disease
    Donald R Royall
    Psychol Med 34:761-2. 2004
  60. doi request reprint In regard to fuller et Al
    Donald R Royall
    Int J Radiat Oncol Biol Phys 72:301. 2008
  61. ncbi request reprint Double jeopardy
    Donald R Royall
    Chest 130:1636-8. 2006
  62. ncbi request reprint Pet peeves
    Donald R Royall
    J Am Geriatr Soc 52:1218. 2004
  63. ncbi request reprint The new "silent" epidemic
    Donald R Royall
    J Am Geriatr Soc 52:1212-3. 2004
  64. ncbi request reprint Donepezil's effects remain uncertain
    Donald R Royall
    J Am Geriatr Soc 52:843-4; author reply 845-6. 2004
  65. ncbi request reprint Is disability required for dementia case-finding?
    Donald R Royall
    Int J Geriatr Psychiatry 23:224-5. 2008
  66. ncbi request reprint The emperor has no clothes: dementia treatment on the eve of the aging era
    Donald R Royall
    J Am Geriatr Soc 53:163-4. 2005
  67. ncbi request reprint ECF impairment is common
    Donald R Royall
    Age Ageing 33:206-7; author reply 207. 2004
  68. ncbi request reprint The "subsyndromal" syndromes of aging
    Donald R Royall
    J Am Geriatr Soc 52:463-5. 2004
  69. ncbi request reprint Catie's lessons
    Donald R Royall
    J Am Geriatr Soc 55:636-7. 2007
  70. ncbi request reprint Slippery slopes
    Donald R Royall
    J Gerontol A Biol Sci Med Sci 63:107; author reply 107-8. 2008
  71. ncbi request reprint Pathological determinants of dementia in Alzheimer's disease (AD)
    Donald R Royall
    Exp Aging Res 29:107-10. 2003
  72. ncbi request reprint Geriatric depression and chronic medical disease: another world of hurt
    Donald R Royall
    J Am Geriatr Soc 50:969-70. 2002

Research Grants6

  1. Dyspraxia and Autonomic Control in Very Early AD
    Donald Royall; Fiscal Year: 2004
    ..Some dementia treatments are known to reduce HRV, and possibly mortality as well. Alternatively, some psychotropics may increase arrhythmia-related mortality, possibly via a central mechanism. ..
  2. Insular AD Pathology and Autonomic Function
    Donald Royall; Fiscal Year: 2006
    ..Autonomic dysfunction could provide a sensitive indicator of future AD dementia conversion risk, while interventions against supraventricular bradyarrhythmias may decrease mortality in the earlier stages of AD. ..
  3. VAS-COG 2007
    Donald Royall; Fiscal Year: 2007
    ..Many vascular cognitive disorders are preventable and potentially reversible. VAS-COG will provide a forum in which information on these important conditions can be exchanged and disseminated. ..
  4. Insular Autonomic Function in Depression
    Donald R Royall; Fiscal Year: 2010
    ..Minorities may be disporportionately at risk. Moreover, insular dysfunction could explain recent reports of increased mortality in eldely patients receiving several types of psychotropic medications. ..