Laura M Rowland

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS study
    Laura M Rowland
    Department of Psychiatry, MIND Imaging Center, University of New Mexico, USA
    Am J Psychiatry 162:394-6. 2005
  2. ncbi request reprint Subanesthetic ketamine: how it alters physiology and behavior in humans
    Laura M Rowland
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Aviat Space Environ Med 76:C52-8. 2005
  3. pmc Neural changes associated with relational learning in schizophrenia
    Laura M Rowland
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 36:496-503. 2010
  4. pmc In vivo measurements of glutamate, GABA, and NAAG in schizophrenia
    Laura M Rowland
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Schizophr Bull 39:1096-104. 2013
  5. pmc GABA predicts inhibition of frequency-specific oscillations in schizophrenia
    Laura M Rowland
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    J Neuropsychiatry Clin Neurosci 25:83-7. 2013
  6. pmc White matter alterations in deficit schizophrenia
    Laura M Rowland
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 34:1514-22. 2009
  7. ncbi request reprint Oculomotor responses during partial and total sleep deprivation
    Laura M Rowland
    Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Aviat Space Environ Med 76:C104-13. 2005
  8. ncbi request reprint Selective cognitive impairments associated with NMDA receptor blockade in humans
    Laura M Rowland
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 30:633-9. 2005
  9. ncbi request reprint Proton magnetic resonance spectroscopy during initial treatment with antipsychotic medication in schizophrenia
    Juan R Bustillo
    Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Neuropsychopharmacology 33:2456-66. 2008
  10. ncbi request reprint Proton magnetic resonance spectroscopy of the hippocampus and occipital white matter in PTSD: preliminary results
    Gerardo Villarreal
    PTSD Clinic, Veterans Administration Hospital, Departments of Psychiatry and Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA
    Can J Psychiatry 47:666-70. 2002

Research Grants

Detail Information

Publications26

  1. ncbi request reprint Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS study
    Laura M Rowland
    Department of Psychiatry, MIND Imaging Center, University of New Mexico, USA
    Am J Psychiatry 162:394-6. 2005
    ..The authors' goal was to test in humans the hypothesis that N-methyl-d-aspartate receptor (NMDAR) antagonism results in increased cortical glutamate activity, as proposed by the NMDAR hypofunction model of schizophrenia...
  2. ncbi request reprint Subanesthetic ketamine: how it alters physiology and behavior in humans
    Laura M Rowland
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Aviat Space Environ Med 76:C52-8. 2005
    ..This review describes the clinical applications, potential adverse events, neurobiological, and behavioral effects of ketamine used at subanesthetic doses in humans...
  3. pmc Neural changes associated with relational learning in schizophrenia
    Laura M Rowland
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 36:496-503. 2010
    ..These findings suggest that the parietal lobe may be receptive to cognitive training interventions and that successful relational learning may be achieved in schizophrenia through the use of alternative extrahippocampal brain regions...
  4. pmc In vivo measurements of glutamate, GABA, and NAAG in schizophrenia
    Laura M Rowland
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Schizophr Bull 39:1096-104. 2013
    ..The study also highlights the importance of studies that combine MRS measurements of NAAG, GABA, and Glu for a more comprehensive neurochemical characterization of schizophrenia. ..
  5. pmc GABA predicts inhibition of frequency-specific oscillations in schizophrenia
    Laura M Rowland
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    J Neuropsychiatry Clin Neurosci 25:83-7. 2013
    ..Results revealed a strong association between GABA levels and gating of the theta-alpha and beta activities in schizophrenia...
  6. pmc White matter alterations in deficit schizophrenia
    Laura M Rowland
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 34:1514-22. 2009
    ..These findings provide further support for altered frontal-parietal network in deficit schizophrenia...
  7. ncbi request reprint Oculomotor responses during partial and total sleep deprivation
    Laura M Rowland
    Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Aviat Space Environ Med 76:C104-13. 2005
    ..Oculomotor responses related to the pupil light reflex (PLR) and saccadic velocity may be sensitive to the effects of sleepiness and therefore could be used to evaluate an individual's fitness for duty...
  8. ncbi request reprint Selective cognitive impairments associated with NMDA receptor blockade in humans
    Laura M Rowland
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 30:633-9. 2005
    ..Impaired cognition is a core feature of schizophrenia. A better understanding of NMDA antagonism, its physiological and cognitive consequences, may provide improved models of psychosis and cognitive therapeutics...
  9. ncbi request reprint Proton magnetic resonance spectroscopy during initial treatment with antipsychotic medication in schizophrenia
    Juan R Bustillo
    Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Neuropsychopharmacology 33:2456-66. 2008
    ..Early in the illness, schizophrenia patients already demonstrate subtle reductions in NAA. Treatment with typical or atypical antipsychotic medications for several months does not result in NAA changes...
  10. ncbi request reprint Proton magnetic resonance spectroscopy of the hippocampus and occipital white matter in PTSD: preliminary results
    Gerardo Villarreal
    PTSD Clinic, Veterans Administration Hospital, Departments of Psychiatry and Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA
    Can J Psychiatry 47:666-70. 2002
    ..However, other areas of the brain need to be explored. The objective of this study was to investigate the specificity of hippocampal NAA concentration changes in PTSD by also examining a control region, the occipital white matter (OWM)...
  11. ncbi request reprint Longitudinal follow-up of neurochemical changes during the first year of antipsychotic treatment in schizophrenia patients with minimal previous medication exposure
    Juan R Bustillo
    Department of Psychiatry, Research Division, University of New Mexico, 2400 Tucker NE, Albuquerque, NM 87131, USA
    Schizophr Res 58:313-21. 2002
    ..The well-described reduced frontal NAA in schizophrenia may not be a trait of the illness but may represent medication effect or progression of the disease...
  12. pmc Spatial memory deficits in a virtual reality eight-arm radial maze in schizophrenia
    Elena A Spieker
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, United States
    Schizophr Res 135:84-9. 2012
    ..Results provide further support for compromised prefrontal and hippocampal function underlying WM and RM deficits in SZ. The virtual RAM task could help bridge preclinical and clinical research for testing novel drug treatments of SZ...
  13. ncbi request reprint Sex differences in N-acetylaspartate correlates of general intelligence: an 1H-MRS study of normal human brain
    Rex E Jung
    Department of Neurology, University of New Mexico, Albuquerque, NM 87151, USA
    Neuroimage 26:965-72. 2005
    ..84, P < .001; adjusted r2 = .82]. Our results highlight a biochemical substrate of normal intellectual performance, mediated by sex, within white matter association fibers linking posterior to frontal brain regions...
  14. pmc Sequential neural changes during motor learning in schizophrenia
    Laura M Rowland
    Maryland Psychiatric Research Center and Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Psychiatry Res 163:1-12. 2008
    ..The visual system, however, appears to be highly compensated in schizophrenia and the inability to rapidly modulate the motor cortex may be substantially corrected by the schizophrenic group's visuomotor adaptations...
  15. ncbi request reprint Multimodal white matter imaging to investigate reduced fractional anisotropy and its age-related decline in schizophrenia
    Peter Kochunov
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA Department of Physics, University of Maryland Baltimore County, Baltimore, MD 21250, USA Electronic address
    Psychiatry Res 223:148-56. 2014
    ..Post hoc testing showed a similar trend for PDI of gray mater. Our study demonstrated that reduced FA and its accelerated decline with age in schizophrenia were explained by pathophysiology indexed by PDI, rather than HWM volume. ..
  16. pmc Reproducibility of brain spectroscopy at 7T using conventional localization and spectral editing techniques
    S Andrea Wijtenburg
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Magn Reson Imaging 38:460-7. 2013
    ..To evaluate the reproducibility of spectroscopic measurements from the anterior cingulate (AC) and the dorsolateral prefrontal cortex (DLPFC) regions at 7T using a 32-channel head coil...
  17. ncbi request reprint High choline concentrations in the caudate nucleus in antipsychotic-naive patients with schizophrenia
    Juan R Bustillo
    Department of Psychiatry, University of New Mexico School of Medicine, 87131, USA
    Am J Psychiatry 159:130-3. 2002
    ..Proton magnetic resonance spectroscopy ((1)H-MRS) studies of medicated patients with schizophrenia suggest high choline levels in the caudate nucleus. However, assessments of antipsychotic-naive patients are needed...
  18. ncbi request reprint Accelerated white matter aging in schizophrenia: role of white matter blood perfusion
    Susan N Wright
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Neurobiol Aging 35:2411-8. 2014
    ..The results suggest that factors other than reduced perfusion account for the accelerated age-related decline in white matter integrity in schizophrenia. ..
  19. ncbi request reprint Anterior cingulate GABA levels predict whole-brain cerebral blood flow
    Benjamin W Krause
    Neuroimaging Research Program, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Neurosci Lett 561:188-91. 2014
    ..We hypothesize that GABA-mediated inhibition of AC activation of the locus coeruleus-norepinephrine pathway may influence global CBF. ..
  20. doi request reprint Increased anterior brain activation to correct responses on high-conflict Stroop task in obsessive-compulsive disorder
    Kristina T Ciesielski
    Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA
    Clin Neurophysiol 122:107-13. 2011
    ....
  21. ncbi request reprint Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder
    Gerardo Villarreal
    Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, USA
    Biol Psychiatry 52:119-25. 2002
    ..The purpose of this study was to assess hippocampal and whole-brain volume in civilian PTSD...
  22. pmc The interactive effects of ketamine and nicotine on human cerebral blood flow
    Laura M Rowland
    Department of Psychiatry, Functional Neuroimaging Laboratory, Maryland Psychiatric Research Center, University of Maryland School of Medicine, 55 Wade Avenue, Baltimore, MD 21228 0247, USA
    Psychopharmacology (Berl) 208:575-84. 2010
    ..The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF)...
  23. ncbi request reprint Stress-induced increase in kynurenic Acid as a potential biomarker for patients with schizophrenia and distress intolerance
    Joshua Chiappelli
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore
    JAMA Psychiatry 71:761-8. 2014
    ..The pathophysiology of schizophrenia is commonly associated with stress, and stress plays a key regulatory role in the first, rate-limiting step of the kynurenine pathway, which produces KYNA...
  24. pmc Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression
    Peter Kochunov
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Biol Psychiatry 73:482-91. 2013
    ..We used diffusion tensor imaging derived fractional anisotropy (FA) as a biomarker of aging-related decline in white matter (WM) integrity to test the hypotheses of accelerated aging in SCZ and MDD...
  25. ncbi request reprint How schizophrenia and depression disrupt reward circuitry
    Henry H Holcomb
    Henry H Holcomb, MD Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, 55 Wade Avenue, Baltimore, MD 21228, USA
    Curr Treat Options Neurol 9:357-62. 2007
    ..Other neuropsychiatric disorders such as schizophrenia and depression may provide models of disturbed reward biology that may prove useful when thinking about altered reward circuitry and behavior in PD and other neurological disorders...
  26. ncbi request reprint Regarding "Increased prefrontal and hippocampal glutamate concentration in schizophrenia: evidence from a magnetic resonance spectroscopy study"
    Jean Th├ęberge
    Biol Psychiatry 61:1218-9; author reply 1219-20. 2007

Research Grants2

  1. Neural plasticity during relational learning in schizophrenia
    Laura Rowland; Fiscal Year: 2007
    ..We will use proton magnetic resonance spectroscopy (1H-MRS) for this phase of the project. Particular emphasis will be placed on hippocampal assessments. ..