David Rowitch

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Developmental genetics of vertebrate glial-cell specification
    David H Rowitch
    Howard Hughes Medical Institute, University of California, San Francisco, USA
    Nature 468:214-22. 2010
  2. pmc Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
    Louis Chesler
    Department of Neurology, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Res 66:8139-46. 2006
  3. pmc Neurocritical care for neonates
    Hannah C Glass
    Department of Neurology, University of California, Box 0663, 521 Parnassus Avenue, C 215, San Francisco, CA 94143 0663, USA
    Neurocrit Care 12:421-9. 2010
  4. pmc Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain
    Magdalena A Petryniak
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158 2611, USA
    Neuron 55:417-33. 2007
  5. ncbi request reprint Origin of oligodendrocytes in the subventricular zone of the adult brain
    Benedicte Menn
    Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7907-18. 2006
  6. pmc OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms
    José Javier Otero
    Division of Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143, USA
    J Neurooncol 104:423-38. 2011
  7. doi request reprint Overcoming remyelination failure in multiple sclerosis and other myelin disorders
    Stephen P J Fancy
    Department of Pediatrics, Eli and Edyth Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Exp Neurol 225:18-23. 2010
  8. pmc Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination
    Emily P Harrington
    Department of Pediatrics, University of California at San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 68:703-16. 2010

Research Grants

  1. Cellular and Genetic Origins of Astrocytes
    David H Rowitch; Fiscal Year: 2010
  2. OLIGODENDROCYTE LINEAGE GENE FUNCTION IN THE CNS
    David Rowitch; Fiscal Year: 2009
  3. Mechanisms of hedge-hog induced neuroproliferation
    David Rowitch; Fiscal Year: 2007
  4. OLIGODENDROCYTE LINEAGE GENE FUNCTION IN THE CNS
    David Rowitch; Fiscal Year: 2003
  5. OLIGODENDROCYTE LINEAGE GENE FUNCTION IN THE CNS
    David H Rowitch; Fiscal Year: 2010

Collaborators

Detail Information

Publications8

  1. doi request reprint Developmental genetics of vertebrate glial-cell specification
    David H Rowitch
    Howard Hughes Medical Institute, University of California, San Francisco, USA
    Nature 468:214-22. 2010
    ..Gaining insight into the developmental genetics of macroglia has great potential to improve our understanding of a variety of neurological disorders in humans...
  2. pmc Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
    Louis Chesler
    Department of Neurology, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Res 66:8139-46. 2006
    ....
  3. pmc Neurocritical care for neonates
    Hannah C Glass
    Department of Neurology, University of California, Box 0663, 521 Parnassus Avenue, C 215, San Francisco, CA 94143 0663, USA
    Neurocrit Care 12:421-9. 2010
    ..To describe the concept, implementation, patient characteristics, and preliminary outcomes of a Neonatal Neurocritical Care Service (NNCS) recently established at the University of California, San Francisco...
  4. pmc Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain
    Magdalena A Petryniak
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158 2611, USA
    Neuron 55:417-33. 2007
    ..Our results identify another role for Dlx genes as modulators of neuron versus oligodendrocyte development in the ventral embryonic forebrain...
  5. ncbi request reprint Origin of oligodendrocytes in the subventricular zone of the adult brain
    Benedicte Menn
    Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7907-18. 2006
    ..Our work identifies SVZ type B cells as progenitors of oligodendrocytes in normal and injured adult brain...
  6. pmc OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms
    José Javier Otero
    Division of Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143, USA
    J Neurooncol 104:423-38. 2011
    ....
  7. doi request reprint Overcoming remyelination failure in multiple sclerosis and other myelin disorders
    Stephen P J Fancy
    Department of Pediatrics, Eli and Edyth Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Exp Neurol 225:18-23. 2010
    ....
  8. pmc Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination
    Emily P Harrington
    Department of Pediatrics, University of California at San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 68:703-16. 2010
    ....

Research Grants17

  1. Cellular and Genetic Origins of Astrocytes
    David H Rowitch; Fiscal Year: 2010
    ....
  2. OLIGODENDROCYTE LINEAGE GENE FUNCTION IN THE CNS
    David Rowitch; Fiscal Year: 2009
    ..Identification of regulatory factors for glial progenitor cell specification and differentiation will have practical overtones for the therapy of glial-based diseases such as multiple sclerosis and malignant glioma. ..
  3. Mechanisms of hedge-hog induced neuroproliferation
    David Rowitch; Fiscal Year: 2007
    ..Thus, elucidation of novel intra- and intercellular interactions of Hedgehog signaling during CNS development could provide clues for therapeutic intervention in human tumors. ..
  4. OLIGODENDROCYTE LINEAGE GENE FUNCTION IN THE CNS
    David Rowitch; Fiscal Year: 2003
    ..In particular, the work may shed light on the molecular phenotype of glial tumors and point to possible new therapies. ..
  5. OLIGODENDROCYTE LINEAGE GENE FUNCTION IN THE CNS
    David H Rowitch; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The proposed work may shed light on molecular mechanisms that regulate neural progenitors in malignant gliomas, spinal cord injury and demyelinating diseases. ..