Michael Rowbotham

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Treatment response in antidepressant-naïve postherpetic neuralgia patients: double-blind, randomized trial
    Michael C Rowbotham
    UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, School of Medicine, San Francisco, California 94115, USA
    J Pain 6:741-6. 2005
  2. ncbi Is fibromyalgia a neuropathic pain syndrome?
    Michael C Rowbotham
    University of California San Francisco Pain Clinical Research Center, San Francisco, California 94115, USA
    J Rheumatol Suppl 75:38-40. 2005
  3. ncbi Mechanisms of neuropathic pain and their implications for the design of clinical trials
    Michael C Rowbotham
    The UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, California, USA
    Neurology 65:S66-73. 2005
  4. ncbi Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study
    Michael C Rowbotham
    UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, CA, USA
    Pain 110:697-706. 2004
  5. ncbi Pilot tolerability and effectiveness study of levetiracetam for postherpetic neuralgia
    Michael C Rowbotham
    UCSF Pain Clinical Research Center, Department of Neurology, School of Medicine, University of California San Francisco, CA 94115, USA
    Neurology 61:866-7. 2003
  6. ncbi Pharmacologic management of complex regional pain syndrome
    Michael C Rowbotham
    UCSF Pain Clinical Research Center, Departments of Neurology and Anesthesia, University of California, San Francisco, School of Medicine, USA
    Clin J Pain 22:425-9. 2006
  7. ncbi Natural history of pain following herpes zoster
    Hans Gustav Thyregod
    UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, CA 94115, USA
    Pain 128:148-56. 2007
  8. ncbi Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers
    Adam R Frymoyer
    UCSF Pain Clinical Research Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94115, USA
    J Pain 8:19-25. 2007
  9. ncbi How effective is long-term opioid therapy for chronic noncancer pain?
    Michael C Rowbotham
    Department of Neurology, UCSF Pain Clinical Research Center, University of California, School of Medicine, San Francisco, CA 94115, USA
    Clin J Pain 23:300-2. 2007
  10. ncbi Relief of post-herpetic neuralgia by surgical removal of painful skin: 5 years later
    Karin Lottrup Petersen
    UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, CA 94115, USA
    Pain 131:214-8. 2007

Research Grants

  1. PAIN & NEURAL DYSFUNCTION FROM ACUTE HERPES ZOSTER
    Michael Rowbotham; Fiscal Year: 2002
  2. CHRONIC NEUROPATHIC PAIN MECHANISMS AND MANAGEMENT
    Michael Rowbotham; Fiscal Year: 2004

Detail Information

Publications22

  1. ncbi Treatment response in antidepressant-naïve postherpetic neuralgia patients: double-blind, randomized trial
    Michael C Rowbotham
    UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, School of Medicine, San Francisco, California 94115, USA
    J Pain 6:741-6. 2005
    ..All 3 drugs reduced PHN pain, with desipramine providing satisfactory relief in 80% of those treated...
  2. ncbi Is fibromyalgia a neuropathic pain syndrome?
    Michael C Rowbotham
    University of California San Francisco Pain Clinical Research Center, San Francisco, California 94115, USA
    J Rheumatol Suppl 75:38-40. 2005
    ....
  3. ncbi Mechanisms of neuropathic pain and their implications for the design of clinical trials
    Michael C Rowbotham
    The UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, California, USA
    Neurology 65:S66-73. 2005
    ..Examples of study designs and potential solutions are presented...
  4. ncbi Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study
    Michael C Rowbotham
    UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, CA, USA
    Pain 110:697-706. 2004
    ..Venlafaxine ER appears effective and safe in relieving pain associated with diabetic neuropathy. NNT values for higher dose venlafaxine ER are comparable to those of tricyclic antidepressants and the anticonvulsant gabapentin...
  5. ncbi Pilot tolerability and effectiveness study of levetiracetam for postherpetic neuralgia
    Michael C Rowbotham
    UCSF Pain Clinical Research Center, Department of Neurology, School of Medicine, University of California San Francisco, CA 94115, USA
    Neurology 61:866-7. 2003
  6. ncbi Pharmacologic management of complex regional pain syndrome
    Michael C Rowbotham
    UCSF Pain Clinical Research Center, Departments of Neurology and Anesthesia, University of California, San Francisco, School of Medicine, USA
    Clin J Pain 22:425-9. 2006
    ..In summary, treatment of CRPS has received insufficient study and remains largely empirical...
  7. ncbi Natural history of pain following herpes zoster
    Hans Gustav Thyregod
    UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, CA 94115, USA
    Pain 128:148-56. 2007
    ..Defining PHN as average daily pain >0/100 at 6 months after rash onset appears to substantially overestimate the number of HZ patients negatively impacted by ongoing pain and disability...
  8. ncbi Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers
    Adam R Frymoyer
    UCSF Pain Clinical Research Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94115, USA
    J Pain 8:19-25. 2007
    ..Human experimental models of pain and neuronal sensitization, which are responsive to oral opioids, allow efficient study of opioid combination analgesics and simplify the process for determining the optimal dose and/or dose ratio...
  9. ncbi How effective is long-term opioid therapy for chronic noncancer pain?
    Michael C Rowbotham
    Department of Neurology, UCSF Pain Clinical Research Center, University of California, School of Medicine, San Francisco, CA 94115, USA
    Clin J Pain 23:300-2. 2007
  10. ncbi Relief of post-herpetic neuralgia by surgical removal of painful skin: 5 years later
    Karin Lottrup Petersen
    UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, CA 94115, USA
    Pain 131:214-8. 2007
    ..Pain topography and characteristics are different from pre-surgery and may relate to the pathophysiology of PHN. Skin resection cannot be recommended as a treatment for PHN...
  11. ncbi Changes in morphine analgesia and side effects during daily subcutaneous administration in healthy volunteers
    Karin Lottrup Petersen
    Department of Neurology, UCSF Pain Clinical Research Center, University of San Francisco, CA, USA
    Pain 137:395-404. 2008
    ..As 4 days is the threshold for demonstrating analgesic tolerance to twice-daily morphine in animal models, a longer period of opioid exposure in healthy volunteers might be needed to detect analgesic tolerance...
  12. ncbi Relief of post-herpetic neuralgia by surgical removal of painful skin
    Karin L Petersen
    Department of Neurology, UCSF Pain Clinical Research Center, University of California San Francisco, 1701 Divisadero Street, Suite 480, San Francisco, CA 94115, USA
    Pain 98:119-26. 2002
    ..The results may explain the anatomical basis of the capsaicin-response test and have implications for our understanding of clinical mechanisms underlying PHN pain...
  13. ncbi Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studies
    Daniel K Kajdasz
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Clin Ther 29:2536-46. 2007
    ....
  14. ncbi Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial
    Leslie J Crofford
    University of Michigan, Ann Arbor, USA
    Arthritis Rheum 52:1264-73. 2005
    ..FMS affects an estimated 2% of the population, predominantly women. This trial was designed to evaluate the efficacy and safety of pregabalin, a novel alpha(2)-delta ligand, for treatment of symptoms associated with FMS...
  15. ncbi Complex regional pain syndrome-like symptoms during herpes zoster
    James D Berry
    UCSF Pain Clinical Research Center, University of California, San Francisco 94115, USA
    Pain 110:e1-12. 2004
    ..Prospective randomized controlled studies are needed to determine which subjects are most likely to benefit and when treatment should begin...
  16. ncbi Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Meedicine and Dentistry, Rochester, NY 14642
    Arch Neurol 60:1524-34. 2003
    ..Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach...
  17. ncbi A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization
    Karin L Petersen
    Pain Clinical Research Center and Department of Neurology, University of California, San Francisco, CA 94115, USA
    J Pain 4:400-6. 2003
    ....
  18. ncbi Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization
    Jesper Dirks
    Laboratory of Pain Physiology, Department of Anesthesiology and Intensive Care Medicine, Herlev University Hospital, Herlev, Denmark
    Anesthesiology 97:102-7. 2002
    ..The aim of the present study was to link data from animal models and clinical trials for chronic pain by investigating the effect of gabapentin on acute nociception and experimentally induced cutaneous hyperalgesia in healthy volunteers...
  19. ncbi Oral opioid therapy for chronic peripheral and central neuropathic pain
    Michael C Rowbotham
    Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, School of Medicine, San Francisco, USA
    N Engl J Med 348:1223-32. 2003
    ..Although opioids are commonly used to treat chronic neuropathic pain, there are limited data to guide their use. Few controlled trials have been performed, and many types of neuropathic pain remain unstudied...
  20. ncbi The lidocaine patch 5% effectively treats all neuropathic pain qualities: results of a randomized, double-blind, vehicle-controlled, 3-week efficacy study with use of the neuropathic pain scale
    Bradley S Galer
    Pain Clinical Research, University of Washington Multidisciplinary Pain Center, Seattle Washington, USA
    Clin J Pain 18:297-301. 2002
    ..Several controlled clinical trials have demonstrated the efficacy and safety of the lidocaine patch 5% (LP) for the treatment of postherpetic neuralgia (PHN)...
  21. ncbi Recommendations for the management of herpes zoster
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
    Clin Infect Dis 44:S1-26. 2007
    ..Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ...
  22. ncbi Does pain change the brain?
    Frank Birklein
    Neurology 65:666-7. 2005

Research Grants5

  1. PAIN & NEURAL DYSFUNCTION FROM ACUTE HERPES ZOSTER
    Michael Rowbotham; Fiscal Year: 2002
    ..The importance of neural dysfunction and neuronal loss as risk factors for PHN will be compared to risk factors found in other studies. ..
  2. CHRONIC NEUROPATHIC PAIN MECHANISMS AND MANAGEMENT
    Michael Rowbotham; Fiscal Year: 2004
    DESCRIPTION (Adapted From The Applicant's Abstract): Michael Rowbotham, a clinical neurologist and clinical neuroscientist specializing in chronic pain, has an international reputation as a leader in patient-oriented research on ..