Research Topics
| Barry W RowSummaryAffiliation: University of Louisville Country: USA Publications
Research Grants
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Detail Information
Publications
Intermittent hypoxia and cognitive function: implications from chronic animal modelsBarry W Row
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
Adv Exp Med Biol 618:51-67. 2007..Improved understanding of the determinants of IH-related susceptibility may help explain the phenotypic variance in OSAS-associated morbidities, and enable improved therapeutic approaches in the future...- Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficitsBarry W Row
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
J Neurochem 89:189-96. 2004..Collectively, these findings indicate that inflammatory signaling and neurobehavioral impairments induced by IH are mediated through PAF receptors... - Nitric oxide synthase and intermittent hypoxia-induced spatial learning deficits in the ratRichard C Li
Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Neurobiol Dis 17:44-53. 2004..We conclude that IH is associated with a time-dependent induction of iNOS and that the increased expression of iNOS may play a critical role in the early pathophysiological events leading to IH-mediated neurobehavioral deficits... 
Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxiaIsabel C Burckhardt
Kosair Children s Hospital Research Institute, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA
Am J Respir Crit Care Med 177:1135-41. 2008..We hypothesized that green tea catechin polyphenols (GTPs) may attenuate IH-induced neurobehavioral deficits by reducing IH-induced NADPH oxidase expression, lipid peroxidation, and inflammation...- Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesisDavid Gozal
Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, 570 South Preston St, Louisville, KY 40202 USA
Eur J Neurosci 18:2335-42. 2003.... - Increased susceptibility to intermittent hypoxia in aging rats: changes in proteasomal activity, neuronal apoptosis and spatial functionDavid Gozal
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA
J Neurochem 86:1545-52. 2003.... - Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficitsLeila Kheirandish
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, KY 40202, USA
Sleep 28:1412-7. 2005.... - Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brainRichard C Li
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, KY 40202, USA
Brain Res 1096:173-9. 2006..Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain... - Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleepBarry W Row
Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Behav Brain Res 177:308-14. 2007..However, compensatory mechanisms may also be activated in other brain regions, and may provide potential therapeutic targets for the cognitive impairments associated with SDB... - Spatial pre-training attenuates hippocampal impairments in rats exposed to intermittent hypoxiaBarry W Row
Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Baxter Biomedical Research Building, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
Neurosci Lett 339:67-71. 2003..Further, IH-induced decreases in CREB phosphorylation were attenuated by pre-training. We conclude that prior exposure to the water maze behavioral requirements attenuates the behavioral deficits occurring after IH exposure... - Anatomical changes in selected cardio-respiratory brainstem nuclei following early post-natal chronic intermittent hypoxiaStephen R Reeves
Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville School of Medicine, KY 40202, USA
Neurosci Lett 402:233-7. 2006..Thus, CIH-associated cardio-respiratory metaplasticity is accompanied by substantial structural changes within both the nTS and Namb... - Impaired spatial learning and hyperactivity in developing rats exposed to intermittent hypoxiaBarry W Row
Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville, Louisville, Kentucky 40202, USA
Pediatr Res 52:449-53. 2002..We postulate that this novel experimental model may allow for future exploration of mechanisms underlying the neurobehavioral deficits of children with OSA... - Respiratory effects of gestational intermittent hypoxia in the developing ratDavid Gozal
Kosair Children s Hospital Research Institute, University of Louisville, 570 S Preston Street, Ste 321, Louisville, KY 40202, USA
Am J Respir Crit Care Med 167:1540-7. 2003..We conclude that gestational intermittent hypoxia elicits long-lasting alterations in the control of breathing. We postulate that such IH-induced respiratory plasticity may create selective vulnerability to hypoxia during development... - Behavioral and anatomical abnormalities in a sodium iodate-induced model of retinal pigment epithelium degenerationVolker Enzmann
Department of Ophthalmology and Visual Sciences, University of Louisville, 301 E Muhammad Ali Blvd, Louisville, KY 40202, USA
Exp Eye Res 82:441-8. 2006..As such, it should be useful in the assessment of rescue or mitigating effects of retinal or stem cell transplantation on visual function... - Post-training administration of corticotropin-releasing hormone (CRH) enhances retention of a spatial memory through a noradrenergic mechanism in male ratsBarry W Row
Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville, Louisville, KY 40202, USA
Neurobiol Learn Mem 89:370-8. 2008..1, 1.0 microg). Results indicate that post-training administration of CRH enhanced spatial memory as measured in a water maze, and this effect was mediated, at least partly, by a noradrenergic mechanism... - Intermittent hypoxia during development induces long-term alterations in spatial working memory, monoamines, and dendritic branching in rat frontal cortexLeila Kheirandish
Department of Pediatrics, Kosair Children's Hospital Research Institute, Louisville, KY 40202, USA
Pediatr Res 58:594-9. 2005..In conclusion, exposure to IH during a critical developmental period is associated with long-term alterations in frontal cortical dopaminergic pathways that may underlie gender differences in neurobehavioral deficits... - Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the ratBarry W Row
Kosair Children's Hospital Research Institute, University of Louisville, Baxter Biomedical Research Building, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA
Am J Respir Crit Care Med 167:1548-53. 2003..Collectively, these findings indicate that the IH exposure is associated with increased oxidative stress, which is likely to play an important role in the behavioral impairments observed in a rodent model of sleep-disordered breathing... - Consequences of snoring and sleep disordered breathing in childrenDavid Gozal
Division of Sleep Medicine, Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville, Baxter Biomedical Research Building, Suite 321, 571 S. Preston Street, Louisville, KY 40202, USA
Pediatr Pulmonol Suppl 26:166-8. 2004 - Cyclooxygenase 2 and intermittent hypoxia-induced spatial deficits in the ratRichard C Li
Kosair Children's Hospital Research Institute, 570 South Preston Street, Suite 321, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA
Am J Respir Crit Care Med 168:469-75. 2003..We conclude that IH induces upregulation and activation of COX-2 in rat cortex and that COX-2 may play a role in IH-mediated neurobehavioral deficits... - Intermittent hypoxia and behavior: is dopamine to blame?Barry W Row
Sleep 28:165-7. 2005
Research Grants
- Stress & Memory Following Postnatal Intermittent HypoxiaBARRY ROW; Fiscal Year: 2004..More importantly, these experiments will provide information on the long-term consequences of exposure to CIH during development and generate the foundation for clinical studies of OSAS in children. ..