Research Topics
| C M RousseauSummaryAffiliation: University of Washington Country: USA Publications
| Collaborators
|
Detail Information
Publications
CCR5del32 in perinatal HIV-1 infectionC M Rousseau
Division of Medical Genetics, University of Washington, Seattle 98195 7720, USA
J Acquir Immune Defic Syndr Hum Retrovirol 16:239-42. 1997..016) was lower than in Catalan children (0.041). No evidence for a dominant protective effect of CCR5del32 for HIV-1 transmission or disease progression was found in these cohorts...- Long terminal repeat and nef gene variants of human immunodeficiency virus type 1 in perinatally infected long-term survivors and rapid progressorsC Rousseau
Division of Medical Genetics, University of Washington, Seattle 98195 7720, USA
AIDS Res Hum Retroviruses 13:1611-23. 1997..Mutations of the SP1-III site in a rapid progressor (RP056) indicate that this site is not necessary for rapid disease progression... - Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomesChristine M Rousseau
Department of Microbiology, University of Washington, Seattle, WA 98195 8070, USA
J Virol Methods 136:118-25. 2006..The methods are readily adaptable to other HIV-1 subtypes, and provide materials for viral functional analyses and population-based molecular epidemiology studies that include analysis of viral genome chimerization... 
HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral loadChristine M Rousseau
Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
J Virol 82:6434-46. 2008....- Racial differences in the evaluation and treatment of hepatitis C among veterans: a retrospective cohort studyChristine M Rousseau
Northwest Health Services Research and Development Center of Excellence and the Northwest Hepatitis C Resource Center, VA Puget Sound Health Care System, Seattle, WA, USA
Am J Public Health 98:846-52. 2008..We examined the association between race and hepatitis C virus (HCV) evaluation and treatment of veterans in the Northwest Network of the Department of Veterans Affairs (VA)... - Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infectionsChristine M Rousseau
Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
J Virol 81:4492-500. 2007..Thus, intrasubtype recombinants are common within the subtype C epidemic and these impact analyses of HIV-1 evolution... - Association of levels of HIV-1-infected breast milk cells and risk of mother-to-child transmissionChristine M Rousseau
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA
J Infect Dis 190:1880-8. 2004..09; P=.03) and breast milk (HR, 1.01; P=1.00). This suggests that infected BMCs may play a more important role in transmission of HIV via breast-feeding than does cell-free virus... - Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal diseaseChristine M Rousseau
Department of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109 1024, USA
J Infect Dis 187:741-7. 2003..3-3.0; P<.001). These results indicate that the risk of infant infection from breast-feeding is influenced by breast-milk virus load, which is highest early after delivery... - Subtype C Is associated with increased vaginal shedding of HIV-1Grace C John-Stewart
Department of Medicine, University of Washington, Seattle, 98104, USA
J Infect Dis 192:492-6. 2005..4-8.8]; P = .006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [95% CI, 1.1-8.6]; P = .03). These observations suggest that HIV-1 subtype influences mucosal shedding of HIV-1... - Rare HLA drive additional HIV evolution compared to more frequent allelesChristine M Rousseau
Department of Microbiology, University of Washington, Seattle, Washington 98103, USA
AIDS Res Hum Retroviruses 25:297-303. 2009..05), suggesting that rare HLA alleles provide a disproportionate force driving viral evolution compared to common alleles, likely due to the loss of preexisting escape variants during early stages postinfection... - Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loadsMorgane Rolland
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA
PLoS ONE 3:e1424. 2008..e., the intrinsic ability to present fewer, more or specific viral epitopes, could affect clinical markers of disease progression... - Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopesIsobella Honeyborne
Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
J Virol 81:3667-72. 2007..These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia... - Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertypeAlasdair Leslie
Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
J Immunol 177:4699-708. 2006..These findings are of relevance to vaccine approaches that seek to exploit HLA supertypes to overcome the problem of HLA diversity...