Affiliation: University of Tennessee
Country: USA


  1. Varanasi S, Rajasagi N, Jaggi U, Rouse B. Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions. Mucosal Immunol. 2018;11:1705-1715 pubmed publisher
    ..Thus, overall our results imply that IL-18 may participate in controlling the severity of SK and contribute to tissue repair by converting both Treg and effector T cells into those that produce Amphiregulin. ..
  2. Jaggi U, Varanasi S, Bhela S, Rouse B. On the role of retinoic acid in virus induced inflammatory response in cornea. Microbes Infect. 2018;20:337-345 pubmed publisher
    ..Since the therapy was effective when used both early and after the initiation of lesions, it may represent a valuable means of therapy when used alone or along with additional therapies. ..
  3. Bhela S, Mulik S, Giménez F, Reddy P, Richardson R, Varanasi S, et al. Role of miR-155 in the pathogenesis of herpetic stromal keratitis. Am J Pathol. 2015;185:1073-84 pubmed publisher
    ..In conclusion, our results indicate that miR-155 contributes to the pathogenesis of SK and represents a promising target to control SK severity. ..
  4. request reprint
    Rouse B, Kaistha S. A tale of 2 alpha-herpesviruses: lessons for vaccinologists. Clin Infect Dis. 2006;42:810-7 pubmed
  5. Rouse B, Sehrawat S. Immunity and immunopathology to viruses: what decides the outcome?. Nat Rev Immunol. 2010;10:514-26 pubmed publisher
  6. Varanasi S, Reddy P, Bhela S, Jaggi U, Giménez F, Rouse B. Azacytidine Treatment Inhibits the Progression of Herpes Stromal Keratitis by Enhancing Regulatory T Cell Function. J Virol. 2017;91: pubmed publisher
    ..Hence, therapy with Aza, which acts mainly by its effects on Treg, can be an effective means to control virus-induced inflammatory lesions. ..
  7. Bhela S, Rouse B. Are miRNAs critical determinants in herpes simplex virus pathogenesis?. Microbes Infect. 2018;20:461-465 pubmed publisher
    ..In this review we discuss the function of both host and viral miRNAs in regulating herpes simplex virus pathogenesis and also discuss the prospect of using miRNAs as biomarkers and therapeutic tools. ..
  8. Rajasagi N, Rouse B. Application of our understanding of pathogenesis of herpetic stromal keratitis for novel therapy. Microbes Infect. 2018;20:526-530 pubmed publisher
    ..In this review, we highlight the essential events involved in SK pathogenesis which can be targeted for improved therapy. We also examine some approaches which can be combined with the current treatments to effectively control SK. ..
  9. Sharma S, Rajasagi N, Veiga Parga T, Rouse B. Herpes virus entry mediator (HVEM) modulates proliferation and activation of regulatory T cells following HSV-1 infection. Microbes Infect. 2014;16:648-60 pubmed publisher
    ..Our results indicate that HVEM regulates Treg responses, and its modulation could represent a useful approach to control HSV induced corneal immunopathology. ..

More Information


  1. Giménez F, Bhela S, Dogra P, Harvey L, Varanasi S, Jaggi U, et al. The inflammasome NLRP3 plays a protective role against a viral immunopathological lesion. J Leukoc Biol. 2016;99:647-57 pubmed publisher
    ..In conclusion, our results indicate that NLRP3 has a regulatory and beneficial role in herpetic stromal keratitis pathogenesis. ..
  2. Rajasagi N, Rouse B. IL-2 complex treatment amplifies CD8+ T cell mediated immunity following herpes simplex virus-1 infection. Microbes Infect. 2016;18:735-746 pubmed publisher
    ..Taken, together, these studies demonstrate that IL-2 complex therapy can be useful to boost protection against a cutaneous virus infection. ..
  3. Rajasagi N, Bhela S, Varanasi S, Rouse B. Frontline Science: Aspirin-triggered resolvin D1 controls herpes simplex virus-induced corneal immunopathology. J Leukoc Biol. 2017;102:1159-1171 pubmed publisher
    ..These findings demonstrate that AT-RvD1 treatment could represent a useful strategy for the management of virus-induced immunopathological lesions. ..
  4. Bhela S, Varanasi S, Jaggi U, Sloan S, Rajasagi N, Rouse B. The Plasticity and Stability of Regulatory T Cells during Viral-Induced Inflammatory Lesions. J Immunol. 2017;199:1342-1352 pubmed publisher
    ..Our results demonstrate that CD25lo Treg and iTreg instability occurs during a viral immunoinflammatory lesion and that its control may help to avoid lesion chronicity. ..
  5. Varanasi S, Donohoe D, Jaggi U, Rouse B. Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects. J Immunol. 2017;199:1748-1761 pubmed publisher
  6. Varanasi S, Rouse B. How host metabolism impacts on virus pathogenesis. Curr Opin Virol. 2017;28:37-42 pubmed publisher
    ..The case is also made for metabolic profiling as a potential tool to predict the outcome of a virus infection and to guide therapies that enhance host resistance...