Robert Roubey

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Mechanisms of autoantibody-mediated thrombosis
    R A Roubey
    Division of Rheumatology and Immunology, University of North Carolina at Chapel Hill, 27599 7280, USA
    Lupus 7:S114-9. 1998
  2. ncbi request reprint Tissue factor pathway and the antiphospholipid syndrome
    R A Roubey
    Division of Rheumatology and Immunology, The University ofNorth Carolina, Chapel Hill, NC 27599 7280, USA
    J Autoimmun 15:217-20. 2000
  3. ncbi request reprint Update on antiphospholipid antibodies
    R A Roubey
    Division of Rheumatology and Immunology, University of North Carolina at Chapel Hill, 27599 7280, USA
    Curr Opin Rheumatol 12:374-8. 2000
  4. ncbi request reprint Treatment of the antiphospholipid syndrome
    Robert A S Roubey
    Division of Rheumatology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7280, USA
    Curr Opin Rheumatol 14:238-42. 2002
  5. doi request reprint Risky business: the interpretation, use, and abuse of antiphospholipid antibody tests in clinical practice
    R A S Roubey
    Thurston Arthritis Research Center and Division of Rheumatology, Allergy, and Immunology, The University of North Carolina at Chapel Hill, NC 27599 7280, USA
    Lupus 19:440-5. 2010
  6. ncbi request reprint Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep
    Hong Zhou
    Division of Rheumatology and Immunology, CB 7280, Rm 3330 Thurston Bldg, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7280, USA
    Blood 104:2353-8. 2004
  7. doi request reprint Use of rituximab in the antiphospholipid syndrome
    Deepak Kumar
    Department of Medicine and Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Rheumatol Rep 12:40-4. 2010
  8. doi request reprint Development of an inhaled endotoxin challenge protocol for characterizing evoked cell surface phenotype and genomic responses of airway cells in allergic individuals
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ann Allergy Asthma Immunol 100:206-15. 2008
  9. ncbi request reprint Mechanisms of autoantibody-induced monocyte tissue factor expression
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, CB 7280, Rm 3330 Thurston Building, Chapel Hill, NC 27599 7280, USA
    Thromb Res 114:391-6. 2004
  10. ncbi request reprint Anti-beta 2-glycoprotein I antibodies do not increase TF activity by de-encryption
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 816A Brinkhous Bullitt Building, CB 7525, Chapel Hill, NC 27599 7525, USA
    Thromb Res 114:67-71. 2004

Research Grants

  1. AUTOIMMUNE MECHANISMS OF THROMBOSIS
    Robert Roubey; Fiscal Year: 2004

Detail Information

Publications18

  1. ncbi request reprint Mechanisms of autoantibody-mediated thrombosis
    R A Roubey
    Division of Rheumatology and Immunology, University of North Carolina at Chapel Hill, 27599 7280, USA
    Lupus 7:S114-9. 1998
    ..In light of these findings, previous reports implicating various mechanisms of autoantibody-mediated thrombosis are being re-evaluated...
  2. ncbi request reprint Tissue factor pathway and the antiphospholipid syndrome
    R A Roubey
    Division of Rheumatology and Immunology, The University ofNorth Carolina, Chapel Hill, NC 27599 7280, USA
    J Autoimmun 15:217-20. 2000
    ..Anti-beta 2-glycoprotein I autoantibodies have been specifically implicated in the antibody-mediated enhancement of tissue factor activity...
  3. ncbi request reprint Update on antiphospholipid antibodies
    R A Roubey
    Division of Rheumatology and Immunology, University of North Carolina at Chapel Hill, 27599 7280, USA
    Curr Opin Rheumatol 12:374-8. 2000
    ..Clinical research in APS will also benefit from the development of preliminary classification criteria...
  4. ncbi request reprint Treatment of the antiphospholipid syndrome
    Robert A S Roubey
    Division of Rheumatology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7280, USA
    Curr Opin Rheumatol 14:238-42. 2002
    ....
  5. doi request reprint Risky business: the interpretation, use, and abuse of antiphospholipid antibody tests in clinical practice
    R A S Roubey
    Thurston Arthritis Research Center and Division of Rheumatology, Allergy, and Immunology, The University of North Carolina at Chapel Hill, NC 27599 7280, USA
    Lupus 19:440-5. 2010
    ..Thus, the presence of LA indicates a high titer of aPL and this, rather than the intrinsic functional characteristics of LA antibodies, may explain the high risk of clinical manifestations associated with LA...
  6. ncbi request reprint Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep
    Hong Zhou
    Division of Rheumatology and Immunology, CB 7280, Rm 3330 Thurston Bldg, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7280, USA
    Blood 104:2353-8. 2004
    ..Pharmacologic agents that block monocyte TF activity may be a novel therapeutic approach in APS...
  7. doi request reprint Use of rituximab in the antiphospholipid syndrome
    Deepak Kumar
    Department of Medicine and Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Rheumatol Rep 12:40-4. 2010
    ..Antiphospholipid antibodies levels were significantly decreased in ten of 12 cases. Controlled clinical trials are needed to determine if rituximab is effective in the antiphospholipid syndrome...
  8. doi request reprint Development of an inhaled endotoxin challenge protocol for characterizing evoked cell surface phenotype and genomic responses of airway cells in allergic individuals
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ann Allergy Asthma Immunol 100:206-15. 2008
    ..Inhaled endotoxin protocols have been used to evaluate airway cell surface phenotypes associated with antigen presentation and innate immunity in healthy volunteers, but not in allergic volunteers...
  9. ncbi request reprint Mechanisms of autoantibody-induced monocyte tissue factor expression
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, CB 7280, Rm 3330 Thurston Building, Chapel Hill, NC 27599 7280, USA
    Thromb Res 114:391-6. 2004
    ....
  10. ncbi request reprint Anti-beta 2-glycoprotein I antibodies do not increase TF activity by de-encryption
    Alisa S Wolberg
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 816A Brinkhous Bullitt Building, CB 7525, Chapel Hill, NC 27599 7525, USA
    Thromb Res 114:67-71. 2004
  11. doi request reprint Pulmonary manifestations of the antiphospholipid antibody syndrome
    H James Ford
    University of North Carolina, Chapel Hill, NC 27599, USA
    Clin Chest Med 31:537-45. 2010
    ..In this article the authors review these manifestations, as well as less common findings including acute respiratory distress syndrome, alveolar hemorrhage, and pulmonary capillaritis...
  12. ncbi request reprint Annexin A2: better left alone
    Alisa S Wolberg
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Blood 105:1845-6. 2005
    ..Zhang and McCrae demonstrate that APLA/b2GPI-mediated endothelial cell activation occurs via dimerization of annexin A2 molecules on the cell surface...
  13. doi request reprint Venous thrombosis in the antiphospholipid syndrome
    Mary Katherine Farmer-Boatwright
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, and Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7280, USA
    Arterioscler Thromb Vasc Biol 29:321-5. 2009
    ..Low-dose aspirin is typically recommended for primary prevention of thrombosis in asymptomatic patients with moderate to high levels of antiphospholipid antibodies, although strong supporting data are lacking...
  14. ncbi request reprint Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individuals
    John C Lay
    J Allergy Clin Immunol 120:719-22. 2007
  15. ncbi request reprint Warfarin and the antiphospholipid syndrome: does one size fit all?
    Raj S Kasthuri
    Arthritis Rheum 57:1346-7. 2007
  16. ncbi request reprint Antiphospholipid antibodies: immunological aspects
    Robert A S Roubey
    Clin Immunol 112:127-8. 2004
  17. ncbi request reprint New approaches to prevention of thrombosis in the antiphospholipid syndrome: hopes, trials, and tribulations
    Robert A S Roubey
    Arthritis Rheum 48:3004-8. 2003
  18. pmc Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase
    Philip L Cohen
    Department of Medicine, Division of Rheumatology, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Exp Med 196:135-40. 2002
    ..These mice should be an excellent model for studying the role of apoptotic debris as an immunogenic stimulus for systemic autoimmunity...

Research Grants4

  1. AUTOIMMUNE MECHANISMS OF THROMBOSIS
    Robert Roubey; Fiscal Year: 2004
    ..These data will be useful in focusing future research efforts on specific pathways of antibody-mediated monocyte activation and hypercoagulability and in designing new therapeutic strategies...