D M Rothwarf

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus
    D M Rothwarf
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, CA 92093 0636, USA
    Sci STKE 1999:RE1. 1999
  2. ncbi request reprint The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
    E Zandi
    Department of Pharmacology, University of California at San Diego, La Jolla 92093 0636, USA
    Cell 91:243-52. 1997
  3. ncbi request reprint IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
    D M Rothwarf
    Department of Pharmacology, University of California San Diego, La Jolla 92093 0636, USA
    Nature 395:297-300. 1998
  4. ncbi request reprint A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
    J A DiDonato
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, La Jolla 92093 0636, USA
    Nature 388:548-54. 1997

Collaborators

  • E Zandi
  • M Hayakawa
  • M Karin
  • J A DiDonato
  • M Delhase

Detail Information

Publications4

  1. ncbi request reprint The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus
    D M Rothwarf
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, CA 92093 0636, USA
    Sci STKE 1999:RE1. 1999
    ....
  2. ncbi request reprint The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
    E Zandi
    Department of Pharmacology, University of California at San Diego, La Jolla 92093 0636, USA
    Cell 91:243-52. 1997
    ..While the interactions between IKKalpha and IKKbeta may be mediated through their leucine zipper motifs, their helix-loop-helix motifs may be involved in interactions with essential regulatory subunits...
  3. ncbi request reprint IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
    D M Rothwarf
    Department of Pharmacology, University of California San Diego, La Jolla 92093 0636, USA
    Nature 395:297-300. 1998
    ..IKK-gamma interacts preferentially with IKK-beta and is required for the activation of the IKK complex. An IKK-gamma carboxy-terminal truncation mutant that still binds IKK-beta blocks the activation of IKK and NF-kappaB...
  4. ncbi request reprint A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
    J A DiDonato
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, La Jolla 92093 0636, USA
    Nature 388:548-54. 1997
    ..A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-kappaB activation...