Genomes and Genes
D M Rothwarf
Affiliation: University of California
- The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleusD M Rothwarf
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, CA 92093 0636, USA
Sci STKE 1999:RE1. 1999....
- The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activationE Zandi
Department of Pharmacology, University of California at San Diego, La Jolla 92093 0636, USA
Cell 91:243-52. 1997..While the interactions between IKKalpha and IKKbeta may be mediated through their leucine zipper motifs, their helix-loop-helix motifs may be involved in interactions with essential regulatory subunits...
- IKK-gamma is an essential regulatory subunit of the IkappaB kinase complexD M Rothwarf
Department of Pharmacology, University of California San Diego, La Jolla 92093 0636, USA
Nature 395:297-300. 1998..IKK-gamma interacts preferentially with IKK-beta and is required for the activation of the IKK complex. An IKK-gamma carboxy-terminal truncation mutant that still binds IKK-beta blocks the activation of IKK and NF-kappaB...
- A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaBJ A DiDonato
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, La Jolla 92093 0636, USA
Nature 388:548-54. 1997..A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-kappaB activation...