Alan Lee Rothman

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Cellular immunology of sequential dengue virus infection and its role in disease pathogenesis
    Alan L Rothman
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Curr Top Microbiol Immunol 338:83-98. 2010
  2. ncbi T lymphocyte responses to heterologous secondary dengue virus infections
    Alan L Rothman
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Ann N Y Acad Sci 1171:E36-41. 2009
  3. ncbi Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C
    Alan Lee Rothman
    Center for Infectious Disease and Vaccine Research and Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 41:617-25. 2005
  4. ncbi Dengue: defining protective versus pathologic immunity
    Alan L Rothman
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 113:946-51. 2004
  5. ncbi Induction of T lymphocyte responses to dengue virus by a candidate tetravalent live attenuated dengue virus vaccine
    A L Rothman
    Center for Infectious Disease and Vaccine Research, Rm S5 326, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Vaccine 19:4694-9. 2001
  6. ncbi Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity
    S Green
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA Sharone
    J Infect Dis 179:755-62. 1999
  7. ncbi Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever
    S Green
    Center for Infectious Disease, University of Massachusetts, Worcester, MA, USA
    J Infect Dis 180:1429-35. 1999
  8. ncbi T cell receptor Vbeta gene usage in Thai children with dengue virus infection
    S J Gagnon
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester 01655, USA
    Am J Trop Med Hyg 64:41-8. 2001
  9. ncbi Analysis of plasma viral RNA levels during acute dengue virus infection using quantitative competitor reverse transcription-polymerase chain reaction
    T M Sudiro
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester 01655, USA
    J Med Virol 63:29-34. 2001
  10. ncbi MIP-1 alpha and MIP-1 beta induction by dengue virus
    T A Spain-Santana
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Med Virol 65:324-30. 2001

Research Grants

  1. PATHOGENESIS OF SEVERE DENGUE INFECTIONS IN VENEZUELA
    Alan Rothman; Fiscal Year: 2004
  2. VIRUS INFECTIONS: PATHOGENESIS AND HOST IMMUNE RESPONSES
    Alan Rothman; Fiscal Year: 2007
  3. Automated point-of-care PCR for hemorrhagic fever diagnosis
    Alan Rothman; Fiscal Year: 2007

Detail Information

Publications10

  1. ncbi Cellular immunology of sequential dengue virus infection and its role in disease pathogenesis
    Alan L Rothman
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Curr Top Microbiol Immunol 338:83-98. 2010
    ..Application of these techniques and principles to animal models and to clinical trials may advance the development of novel therapeutics and protective vaccines...
  2. ncbi T lymphocyte responses to heterologous secondary dengue virus infections
    Alan L Rothman
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Ann N Y Acad Sci 1171:E36-41. 2009
    ..Investigations are underway to identify the immunologic profiles associated with increased or decreased risk for severe disease...
  3. ncbi Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C
    Alan Lee Rothman
    Center for Infectious Disease and Vaccine Research and Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 41:617-25. 2005
    ....
  4. ncbi Dengue: defining protective versus pathologic immunity
    Alan L Rothman
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 113:946-51. 2004
    ..A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses...
  5. ncbi Induction of T lymphocyte responses to dengue virus by a candidate tetravalent live attenuated dengue virus vaccine
    A L Rothman
    Center for Infectious Disease and Vaccine Research, Rm S5 326, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Vaccine 19:4694-9. 2001
    ..This candidate vaccine is immunogenic for both CD4+ and CD8+ T lymphocytes. However, T cell responses to the four DV serotypes were not equivalent, suggesting that the vaccine could be further optimized...
  6. ncbi Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity
    S Green
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA Sharone
    J Infect Dis 179:755-62. 1999
    ..05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted...
  7. ncbi Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever
    S Green
    Center for Infectious Disease, University of Massachusetts, Worcester, MA, USA
    J Infect Dis 180:1429-35. 1999
    ..These data directly demonstrate that cellular immune activation is present early in acute dengue and is related to disease severity...
  8. ncbi T cell receptor Vbeta gene usage in Thai children with dengue virus infection
    S J Gagnon
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester 01655, USA
    Am J Trop Med Hyg 64:41-8. 2001
    ..These data suggest that the differences in T cell activation in DHF and DF are quantitative rather than qualitative and that T cells are activated by conventional antigen(s) and not a viral superantigen...
  9. ncbi Analysis of plasma viral RNA levels during acute dengue virus infection using quantitative competitor reverse transcription-polymerase chain reaction
    T M Sudiro
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester 01655, USA
    J Med Virol 63:29-34. 2001
    ..We conclude that this quantitative RT-PCR method will be valuable for further studies of natural DV infections...
  10. ncbi MIP-1 alpha and MIP-1 beta induction by dengue virus
    T A Spain-Santana
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Med Virol 65:324-30. 2001
    ..It is hypothesized that these chemokines may have roles in the immunopathology of dengue infections and may contribute to fever and bone marrow suppression observed in patients with DV infections...

Research Grants6

  1. PATHOGENESIS OF SEVERE DENGUE INFECTIONS IN VENEZUELA
    Alan Rothman; Fiscal Year: 2004
    ..The results may also identify key pathophysiologic mechanisms that can be targeted for novel approaches to the treatment of adults with denaue infections. ..
  2. VIRUS INFECTIONS: PATHOGENESIS AND HOST IMMUNE RESPONSES
    Alan Rothman; Fiscal Year: 2007
    ....
  3. Automated point-of-care PCR for hemorrhagic fever diagnosis
    Alan Rothman; Fiscal Year: 2007
    ..Assay validation will focus initially on a commercially viable assay for detecting dengue virus and be extended to detection of other viruses. ..