Steven Roth

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi Visual loss in a prone-positioned spine surgery patient with the head on a foam headrest and goggles covering the eyes: an old complication with a new mechanism
    Steven Roth
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
    Anesth Analg 104:1185-7, tables of contents. 2007
  2. ncbi Mitochondrial potassium ATP channels and retinal ischemic preconditioning
    Steven Roth
    Department of Anesthesia and Critical Care, University of Chicago, Illinois 60637, USA
    Invest Ophthalmol Vis Sci 47:2114-24. 2006
  3. ncbi Perioperative visual loss: what do we know, what can we do?
    S Roth
    Department of Anaesthesia and Critical Care, University of Chicago, 5841 South Maryland Avenue, Box MC 4028, Chicago, IL 60637, USA
    Br J Anaesth 103:i31-40. 2009
  4. ncbi Protein kinase C subtypes and retinal ischemic preconditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Exp Eye Res 87:300-11. 2008
  5. ncbi Mitogen-activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, The University of Chicago, USA
    Exp Eye Res 93:340-9. 2011
  6. ncbi Involvement of erythropoietin in retinal ischemic preconditioning
    John C Dreixler
    Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
    Anesthesiology 110:774-80. 2009
  7. ncbi Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL, USA
    Exp Eye Res 89:782-90. 2009
  8. ncbi Delayed post-ischemic conditioning significantly improves the outcome after retinal ischemia
    John C Dreixler
    Department of Anesthesia and Critical Care, The University of Chicago, IL, USA
    Exp Eye Res 92:521-7. 2011
  9. ncbi Post-ischemic conditioning in the rat retina is dependent upon ischemia duration and is not additive with ischemic pre-conditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
    Exp Eye Res 91:844-52. 2010
  10. ncbi The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Exp Eye Res 88:512-21. 2009

Research Grants

  1. The Role of Adenosine in Retinal Ischemia
    Steven Roth; Fiscal Year: 2010
  2. The Role of Adenosine in Retinal Ischemia
    Steven Roth; Fiscal Year: 2007
  3. The Role of Adenosine in Retinal Ischemia
    Steven Roth; Fiscal Year: 2004
  4. ADENOSINE AND RETINAL ISCHEMIA
    Steven Roth; Fiscal Year: 2001
  5. The Role of Adenosine in Retinal Ischemia
    Steven Roth; Fiscal Year: 2009

Collaborators

Detail Information

Publications24

  1. ncbi Visual loss in a prone-positioned spine surgery patient with the head on a foam headrest and goggles covering the eyes: an old complication with a new mechanism
    Steven Roth
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
    Anesth Analg 104:1185-7, tables of contents. 2007
    ..A patient developed central retinal artery occlusion during surgery in the prone position with eye protectors placed over his eyes. We discuss the potential hazards of using such a device (the Dupaco Opti-Gard) in this setting...
  2. ncbi Mitochondrial potassium ATP channels and retinal ischemic preconditioning
    Steven Roth
    Department of Anesthesia and Critical Care, University of Chicago, Illinois 60637, USA
    Invest Ophthalmol Vis Sci 47:2114-24. 2006
    ..To examine the mechanisms of ischemic preconditioning (IPC) related to the opening of mitochondrial KATP (mKATP) channels in the retina...
  3. ncbi Perioperative visual loss: what do we know, what can we do?
    S Roth
    Department of Anaesthesia and Critical Care, University of Chicago, 5841 South Maryland Avenue, Box MC 4028, Chicago, IL 60637, USA
    Br J Anaesth 103:i31-40. 2009
    ..This review updates readers on the incidence, suspected risk factors, diagnosis, and treatment of POVL due to these conditions...
  4. ncbi Protein kinase C subtypes and retinal ischemic preconditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Exp Eye Res 87:300-11. 2008
    ..In summary, our experiments have shown that both PKC-delta and -epsilon subtypes are involved in the cellular signaling that results in neuroprotection from IPC and that both are downstream of the opening of mKATP channels...
  5. ncbi Mitogen-activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, The University of Chicago, USA
    Exp Eye Res 93:340-9. 2011
    ..The results suggest the involvement of dual-specificity phosphatase MKP-1 in IPC and that MKP-1 is involved in IPC by regulating levels of activated MAPK p38...
  6. ncbi Involvement of erythropoietin in retinal ischemic preconditioning
    John C Dreixler
    Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
    Anesthesiology 110:774-80. 2009
    ..The purpose of this study was to examine the role of erythropoietin in retinal ischemic preconditioning (IPC)...
  7. ncbi Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL, USA
    Exp Eye Res 89:782-90. 2009
    ..Specific inhibition of p38alpha suggests that this MAPK is involved in the protective effects of IPC, and that p38 is downstream of mitochondrial KATP channels, but not adenosine receptors, in this neuroprotection...
  8. ncbi Delayed post-ischemic conditioning significantly improves the outcome after retinal ischemia
    John C Dreixler
    Department of Anesthesia and Critical Care, The University of Chicago, IL, USA
    Exp Eye Res 92:521-7. 2011
    ..Compared to earlier studies, the present work demonstrates for the first time the novel ability of a significantly delayed ischemic stimulus to provide robust neuroprotection in the retina following ischemia...
  9. ncbi Post-ischemic conditioning in the rat retina is dependent upon ischemia duration and is not additive with ischemic pre-conditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
    Exp Eye Res 91:844-52. 2010
    ..Post-C has considerable promise for clinical translation to eye diseases that cause blindness by ischemia...
  10. ncbi The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Exp Eye Res 88:512-21. 2009
    ..Akt is downstream of adenosine A1 and A2a receptors and mKATP channel opening. The results indicate the presence in the retina of robust and redundant endogenous neuroprotection based upon subtypes of Akt...
  11. ncbi Mitogen-activated protein kinases and retinal ischemia
    Steven Roth
    Department of Anesthesia and Critical Care, University of Chicago, 5841 South Maryland, Box MC 4028, Chicago, IL 60637, USA
    Invest Ophthalmol Vis Sci 44:5383-95. 2003
    ..We hypothesized that MAPKs are differentially expressed and have distinct functions after retinal ischemia...
  12. ncbi Protein kinase B (Akt) and mitogen-activated protein kinase p38α in retinal ischemic post-conditioning
    John C Dreixler
    Department of Anesthesia and Critical Care, University of Chicago Medical Center, 5841 South Maryland Avenue, Box MC 4028, Chicago, IL 60637, USA
    J Mol Neurosci 45:309-20. 2011
    ..In conclusion, both p38 and Akt are essential components of the neuroprotection induced by post-ischemic conditioning in the retina...
  13. ncbi In-hospital complications and mortality after elective spinal fusion surgery in the united states: a study of the nationwide inpatient sample from 2001 to 2005
    Yang Shen
    Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    J Neurosurg Anesthesiol 21:21-30. 2009
    ..The majority of complications were operative, pulmonary, cardiovascular, or genito-urinary. Patient risk correlated with the number and nature of coexisting morbidities...
  14. ncbi Ischemic optic neuropathy following spine surgery
    Vivien T-G Ho
    Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosurg Anesthesiol 17:38-44. 2005
    ..The etiology of postoperative ION remains incompletely understood. Potential strategies to avoid this complication are discussed...
  15. ncbi Ischemic preconditioning attenuates apoptotic cell death in the rat retina
    Cheng Zhang
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, Illinois 60637, USA
    Invest Ophthalmol Vis Sci 43:3059-66. 2002
    ..CONCLUSIONS: IPC protects against ischemic injury, in part, by diminishing apoptosis-related gene expression and by altering protein phosphorylation...
  16. ncbi What will anesthesiologists be anesthetizing? Trends in neurosurgical procedure usage
    Andrew B Hughey
    Pritzker School of Medicine of the University of Chicago, Chicago, IL, USA
    Anesth Analg 110:1686-97. 2010
    ..To anticipate future changes to the practice of neuroanesthesia, we examined the nationwide trends in frequently performed operative neurosurgery...
  17. ncbi Endogenous neuroprotection in the retina
    Steven Roth
    Department of Anesthesia and Critical Care, University of Chicago, 5841 South Maryland, MC4028, Chicago, IL 60637, USA
    Brain Res Bull 62:461-6. 2004
    ..In addition, IPC prevents hypoperfusion following severe ischemia. Further study of the IPC phenomenon could lead to an enhanced understanding of the mechanisms of ischemic damage and its prevention in the retina...
  18. ncbi The prevalence of perioperative visual loss in the United States: a 10-year study from 1996 to 2005 of spinal, orthopedic, cardiac, and general surgery
    Yang Shen
    Pritzker School of Medicine, The Universityof Chicago, Chicago, Illinois 60637, USA
    Anesth Analg 109:1534-45. 2009
    ..We used the Nationwide Inpatient Sample to estimate the rate of POVL in the United States among the eight most common nonocular surgeries...
  19. ncbi Fulminant liver failure after radical prostatectomy in the hyperlordotic position
    Avery Tung
    Department of Anesthesia and Critical Care and Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Anesth Analg 103:986-8. 2006
    ..We describe a case of fulminant hepatic failure after radical retropubic prostatectomy performed in the hyperlordotic position...
  20. ncbi Operating table failure: another hazard of spine surgery
    Martin H Dauber
    Department of Anesthesia and Critical Care, University of Chicago, 5841 South Box MC 4028, Chicago, IL 60637, USA
    Anesth Analg 108:904-5. 2009
    ..The table design renders it difficult to easily identify when it is locked, and therefore a patient may be prone to falling off the table...
  21. ncbi Retinal preconditioning and the induction of heat-shock protein 27
    Yan Li
    Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Invest Ophthalmol Vis Sci 44:1299-304. 2003
    ..This increase in expression of Hsp27 occurs in both neuronal and non-neuronal retinal cells, and appears to be one component of the neuroprotective events induced by ischemic preconditioning in the retina...
  22. ncbi Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury
    Anna K Junk
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:10659-64. 2002
    ..These results further establish EPO as a neuroprotective agent in acute neuronal ischemic injury...
  23. ncbi Causes of elevated intraocular pressure during prone spine surgery
    Lorri A Lee
    Anesthesiology 97:759; author reply 760. 2002
  24. ncbi Multifactorial etiology of postoperative vision loss
    Jonathan L Benumof
    Anesthesiology 96:1531-2; author reply 1532-3. 2002

Research Grants17

  1. The Role of Adenosine in Retinal Ischemia
    Steven Roth; Fiscal Year: 2010
    ..Our experiments will definitively examine major mechanisms of IPC and should bring us closer to understanding molecular events underlying this robust, intriguing, and clinically relevant neuroprotection. ..
  2. The Role of Adenosine in Retinal Ischemia
    Steven Roth; Fiscal Year: 2007
    ..Our experiments will definitively examine major mechanisms of IPC and should bring us closer to understanding molecular events underlying this robust, intriguing, and clinically relevant neuroprotection. ..
  3. The Role of Adenosine in Retinal Ischemia
    Steven Roth; Fiscal Year: 2004
    ..The powerful effects of endogenous neuroprotection suggest that these experiments could lead directly to clinically useful treatments for retinal ischemic diseases. ..
  4. ADENOSINE AND RETINAL ISCHEMIA
    Steven Roth; Fiscal Year: 2001
    ..These studies are relevant to acute disease states such as retinal arterial occlusion, or to chronic diseases that also result in ischemia, such as diabetic retinopathy. ..
  5. The Role of Adenosine in Retinal Ischemia
    Steven Roth; Fiscal Year: 2009
    ....