M D Roth

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease
    Jonathan G Goldin
    David Geffen School of Medicine at UCLA, Department of Radiology, Los Angeles, CA 90095 1721, USA
    Chest 134:358-67. 2008
  2. ncbi request reprint Airway inflammation in young marijuana and tobacco smokers
    M D Roth
    Department of Medicine, and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
    Am J Respir Crit Care Med 157:928-37. 1998
  3. ncbi request reprint Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobacco
    S H Barsky
    Department of Pathology, University of California, Los Angeles, USA
    J Natl Cancer Inst 90:1198-205. 1998
  4. ncbi request reprint Adenoviral-encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of alpha(v)beta3 integrins
    Airi Harui
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    J Leukoc Biol 79:1271-8. 2006
  5. ncbi request reprint Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo
    Theodore A Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1202-9. 2006
  6. ncbi request reprint Celecoxib decreases Ki-67 proliferative index in active smokers
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1690, USA
    Clin Cancer Res 12:314-20. 2006
  7. ncbi request reprint Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model
    Michael D Roth
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
    J Leukoc Biol 78:1198-203. 2005
  8. ncbi request reprint Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment
    Linda M Liau
    Division of Neurosurgery, Department of Surgery, The Brain Research Institute, David Geffen School of Medicine at University of California at Los Angeles, University of California Los Angeles, Los Angeles, California 90095, USA
    Clin Cancer Res 11:5515-25. 2005
  9. ncbi request reprint Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol
    Theodore Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, 14 184 Warren Hall, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Toxicol Lett 158:95-107. 2005
  10. ncbi request reprint Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouse
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Life Sci 77:1711-22. 2005

Detail Information

Publications44

  1. doi request reprint High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease
    Jonathan G Goldin
    David Geffen School of Medicine at UCLA, Department of Radiology, Los Angeles, CA 90095 1721, USA
    Chest 134:358-67. 2008
    ..The frequency, nature, and progression of interstitial lung disease seen on high-resolution CT (HRCT) scans in patients with diffuse SSc (dcSSc) compared with those with limited SSc (lcSSc) has not been well characterized...
  2. ncbi request reprint Airway inflammation in young marijuana and tobacco smokers
    M D Roth
    Department of Medicine, and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
    Am J Respir Crit Care Med 157:928-37. 1998
    ..We conclude that regular smoking of marijuana by young adults is associated with significant airway inflammation that is similar in frequency, type, and magnitude to that observed in the lungs of tobacco smokers...
  3. ncbi request reprint Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobacco
    S H Barsky
    Department of Pathology, University of California, Los Angeles, USA
    J Natl Cancer Inst 90:1198-205. 1998
    ....
  4. ncbi request reprint Adenoviral-encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of alpha(v)beta3 integrins
    Airi Harui
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    J Leukoc Biol 79:1271-8. 2006
    ..These results suggest that a limited subset of DC expressing high levels of alpha(v)beta3 integrins is preferentially transduced by Ad vectors and activates CD8+ T cell responses against Ad-encoded antigens...
  5. ncbi request reprint Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo
    Theodore A Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1202-9. 2006
    ..These results suggest that inhalation of marijuana smoke has deleterious effects on airway epithelial cell energetics that may contribute to the adverse pulmonary consequences of marijuana smoking...
  6. ncbi request reprint Celecoxib decreases Ki-67 proliferative index in active smokers
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1690, USA
    Clin Cancer Res 12:314-20. 2006
    ..We hypothesized that treatment with oral Celecoxib, a selective COX-2 inhibitor, would favorably alter the biomarkers of lung cancer risk as measured by the Ki-67 proliferative labeling index (Ki-67 LI)...
  7. ncbi request reprint Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model
    Michael D Roth
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
    J Leukoc Biol 78:1198-203. 2005
    ..Our results suggest that systemic exposure to cocaine can enhance HIV infection in vivo by activating sigma-1 receptors and by modulating the expression of HIV coreceptors...
  8. ncbi request reprint Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment
    Linda M Liau
    Division of Neurosurgery, Department of Surgery, The Brain Research Institute, David Geffen School of Medicine at University of California at Los Angeles, University of California Los Angeles, Los Angeles, California 90095, USA
    Clin Cancer Res 11:5515-25. 2005
    ..As a next step in vaccine development, a phase I clinical trial was established to evaluate this strategy for its feasibility, safety, and induction of systemic and intracranial T-cell responses in patients with glioblastoma multiforme...
  9. ncbi request reprint Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol
    Theodore Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, 14 184 Warren Hall, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Toxicol Lett 158:95-107. 2005
    ..THC, delivered as a component of marijuana smoke, may induce a profile of gene expression that contributes to the pulmonary pathology associated with marijuana use...
  10. ncbi request reprint Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouse
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Life Sci 77:1711-22. 2005
    ..These results suggest that exposure to THC in vivo can suppress immune function, increase HIV coreceptor expression, and act as a cofactor to significantly enhance HIV replication...
  11. ncbi request reprint Correlation of the degree of dyspnea with health-related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: results from the Scleroderma Lung Study
    Dinesh Khanna
    David Geffen School of Medicine, University of California, Los Angeles, USA
    Arthritis Rheum 52:592-600. 2005
    ....
  12. ncbi request reprint Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectors
    Airi Harui
    Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles CA 90095 1690, USA
    J Immunol Methods 312:94-104. 2006
    ....
  13. ncbi request reprint Cyclophosphamide versus placebo in scleroderma lung disease
    Donald P Tashkin
    University of California at Los Angeles, Los Angeles, USA
    N Engl J Med 354:2655-66. 2006
    ....
  14. ncbi request reprint Feasibility of retinoids for the treatment of emphysema study
    Michael D Roth
    Division of Pulmonary and Critical Care, University of California, Los Angeles, CA 90095 1690, USA
    Chest 130:1334-45. 2006
    ..Retinoids promote alveolar septation in the developing lung and stimulate alveolar repair in some animal models of emphysema...
  15. pmc Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cells
    Theodore Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 CHS, Los Angeles, CA 90095, USA
    Toxicol Appl Pharmacol 231:282-90. 2008
    ..We conclude that airway epithelial cells are sensitive to both CB2R-dependent and independent effects mediated by THC...
  16. ncbi request reprint Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patients
    Josephia R Muindi
    Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Pharmacol 48:96-107. 2008
    ..25). The authors conclude that intermittent therapy with high-dose ATRA produced the greatest ATRA exposure, but alternative approaches for limiting self-induced ATRA catabolism should be sought...
  17. pmc Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung disease
    Charlie Strange
    Division of Pulmonary and Critical Care Medicine, MUSC, 96 Jonathan Lucas Street, 812 CSB, Charleston, SC 29425, USA
    Am J Respir Crit Care Med 177:91-8. 2008
    ..The presence of inflammatory cells on bronchoalveolar lavage is often used to predict disease activity and the need for therapy in systemic sclerosis-associated interstitial lung disease...
  18. pmc Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Am J Respir Crit Care Med 176:1026-34. 2007
    ..Although treatment-related benefits in pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year of therapy, the duration of benefit beyond 1 year was unclear...
  19. pmc Scleroderma lung study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosis
    Philip J Clements
    Divisions of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Ann Rheum Dis 66:1641-7. 2007
    ..This report examines the differences at baseline and over 12 months between patients with limited versus diffuse cutaneous SSc who participated in the Scleroderma Lung Study...
  20. ncbi request reprint Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung study
    Dinesh Khanna
    University of Cincinnati, Cincinnati, Ohio 45267 0563, USA
    Arthritis Rheum 56:1676-84. 2007
    ..To assess the impact of cyclophosphamide (CYC) on the health-related quality of life (HRQOL) of patients with scleroderma after 12 months of treatment...
  21. pmc Pharmacokinetics of a novel agent, R667, in patients with emphysema
    Yu Yuan Chiu
    Hoffmann La Roche Inc, Pharma Development Medical Pharmacology, Nutley, NJ 07110, USA
    Br J Clin Pharmacol 63:527-33. 2007
    ..To evaluate the pharmacokinetics of R667, a novel emphysema agent, in patients with moderate to severe emphysema...
  22. ncbi request reprint Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Clin Cancer Res 10:6872-8. 2004
    ....
  23. ncbi request reprint Modifying adenoviral vectors for use as gene-based cancer vaccines
    Saroj K Basak
    Pulmonary and Critical Care Medicine and the Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
    Viral Immunol 17:182-96. 2004
    ..There is every reason to believe that safer and more effective forms of AdV-based vaccines can be developed and applied to patient therapy...
  24. ncbi request reprint Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells
    Michael Yuan
    Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
    J Neuroimmunol 133:124-31. 2002
    ..The CB2 receptor antagonist, SR144528, abrogated the majority of these effects. We conclude that cannabinoids have the potential to regulate the activation and balance of human Th1/Th2 cells by a CB2 receptor-dependent pathway...
  25. ncbi request reprint Respiratory and immunologic consequences of marijuana smoking
    Donald P Tashkin
    Deportment of Medicine, UCLA School of Medicine, 90095 1690, USA
    J Clin Pharmacol 42:71S-81S. 2002
    ..Additional well designed epidemiological and immune monitoring studies are required to determine the potential causal relationship between marijuana use and the development of respiratory infection and/or cancer...
  26. ncbi request reprint Helper-dependent adenoviral vectors efficiently express transgenes in human dendritic cells but still stimulate antiviral immune responses
    Michael D Roth
    Pulmonary and Critical Care Medicine, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 169:4651-6. 2002
    ..We conclude that Hd-AdV vectors can be used to obtain higher transgene expression in human DCs but that they still evoke a vector-related immune response similar to that generated by E1-AdV...
  27. ncbi request reprint Synergistic cytotoxicity of Delta(9)-tetrahydrocannabinol and butylated hydroxyanisole
    Theodore A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, Rm 37 131 Center for Health Sciences, University of California, Los Angeles 90095, USA
    Toxicol Lett 133:171-9. 2002
    ..The combination was synergistic in this respect, reducing ATP levels to <15% of control. Exposure to marijuana smoke in conjunction with BHA, a common food additive, may promote deleterious health effects in the lung...
  28. ncbi request reprint Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers
    Liang Nong
    Department of Medical Microbiology and Immunology, MDC Box 10, 12901 Bruce Downs Blvd, University of South Florida, Tampa, FL 33612, USA
    J Neuroimmunol 127:169-76. 2002
    ..These studies suggest that marijuana smoking and immune activation can alter the basal levels of CB1 and CB2 in PBMCs...
  29. ncbi request reprint Evidence of chronic damage to the pulmonary microcirculation in habitual users of alkaloidal ("crack") cocaine
    Gayle Cocita Baldwin
    Division of Hematology, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    Chest 121:1231-8. 2002
    ..To evaluate BAL cells obtained from habitual users of alkaloidal ("crack") cocaine alone or in combination with tobacco, for evidence of cocaine-associated alveolar injury...
  30. ncbi request reprint Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4
    Saroj K Basak
    Division of Pulmonary and Critical Care, Department of Medicine, UCLA School of Medicine, Los Angeles 90095 1690, USA
    Blood 99:2869-79. 2002
    ..We conclude that systemic therapy with the combination of rGM-CSF/rIL-4 provides a new approach for generating DCs in vivo...
  31. ncbi request reprint A pilot study of all-trans-retinoic acid for the treatment of human emphysema
    Jenny T Mao
    Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 99095 1690, USA
    Am J Respir Crit Care Med 165:718-23. 2002
    ..We conclude that ATRA is well tolerated in patients with emphysema, and trials evaluating higher doses, longer treatment, or different dosing schedules are feasible...
  32. ncbi request reprint Effects of delta-9-tetrahydrocannabinol on human immune function and host defense
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine and Hematology Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Chem Phys Lipids 121:229-39. 2002
    ..Macrophage function is restored by treatment with interferon-gamma, a type 1 cytokine. Habitual exposure to THC appears capable of impacting on human cell-mediated immunity and host defense...
  33. ncbi request reprint Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energetics
    Theodore A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, Center for Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Lung Cell Mol Physiol 284:L298-306. 2003
    ..These results suggest that exposure of the bronchopulmonary epithelium to THC may have important health and physiological consequences...
  34. ncbi request reprint Impairment of antimicrobial activity and nitric oxide production in alveolar macrophages from smokers of marijuana and cocaine
    Angela Hanchi Shay
    Division of Hematology Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Infect Dis 187:700-4. 2003
    ..These results confirm that NO plays a significant role as an effector molecule used by normal human AMs, but this capacity is suppressed in AMs from MS and CS because of a lack of intrinsic cytokine priming...
  35. ncbi request reprint Regional differences in bronchoalveolar lavage and thoracic high-resolution computed tomography results in dyspneic patients with systemic sclerosis
    Philip J Clements
    Department of Medicine, University of California, Los Angeles, 90095, USA
    Arthritis Rheum 50:1909-17. 2004
    ..This study was undertaken to investigate the utility of high-resolution computed tomography (HRCT) of the chest, in comparison with bronchoalveolar lavage (BAL), in the diagnosis of alveolitis in these patients...
  36. ncbi request reprint Cocaine modulates cytokine and enhances tumor growth through sigma receptors
    Brian Gardner
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
    J Neuroimmunol 147:95-8. 2004
    ..We conclude that sigma(1) receptor ligands, including cocaine, augment tumor growth via a cytokine-dependent, receptor-mediated mechanism that involves regulation of T helper 1/T helper 2 cytokine balance...
  37. ncbi request reprint Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokers
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Neuroimmunol 147:82-6. 2004
    ..These findings confirm a significant role for NO as an antibacterial effector molecule used by normal human AM and suggest that this host defense mechanism is suppressed by habitual exposure to inhaled marijuana or crack cocaine in vivo...
  38. ncbi request reprint Celecoxib modulates the capacity for prostaglandin E2 and interleukin-10 production in alveolar macrophages from active smokers
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Clin Cancer Res 9:5835-41. 2003
    ..We hypothesized that treatment with oral celecoxib, a selective COX-2 inhibitor, would favorably alter biomarkers of lung cancer risk. This study evaluated the feasibility of COX-2 inhibition as a form of chemoprevention for lung cancer...
  39. ncbi request reprint All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysema
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Chest 124:1724-32. 2003
    ..This study was designed to evaluate the impact of all-trans retinoic acid (ATRA) on the balance of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with emphysema...
  40. ncbi request reprint Granulocyte/macrophage-colony stimulating factor and interleukin-4 expand and activate type-1 dendritic cells (DC1) when administered in vivo to cancer patients
    Sylvia M Kiertscher
    Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
    Int J Cancer 107:256-61. 2003
    ..These effects correlate with antigen-presenting activity, providing a mechanism by which systemic GM-CSF and IL-4 might stimulate anti-tumor immunity in vivo...
  41. ncbi request reprint Phase I trial of granulocyte macrophage-colony stimulating factor and interleukin-4 as a combined immunotherapy for patients with cancer
    Barbara J Gitlitz
    Division of Hematology Oncology, Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, USA
    J Immunother 26:171-8. 2003
    ..Systemic GM-CSF plus IL-4 provides a mechanism for increasing the number and function of APC in cancer patients. Future clinical applications of this strategy are numerous and include the potential as a strong vaccine adjuvant...
  42. ncbi request reprint Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    J Infect Dis 185:701-5. 2002
    ..This report describes a model for evaluating HIV cofactors and supports cocaine's role in the development and progression of AIDS...
  43. ncbi request reprint Pharmacology: marijuana and your heart
    Michael D Roth
    Nature 434:708-9. 2005
  44. pmc Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men
    Chun Chao
    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095 1772, USA
    Drug Alcohol Depend 94:165-71. 2008
    ..These results indicate that use of these substances does not adversely affect the numbers and percentages of circulating CD4 or CD8 T cells in either HIV-uninfected or -infected MSM...