Research Topics
Species | M D RothSummaryAffiliation: University of California Country: USA Publications
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Publications
High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung diseaseJonathan G Goldin
David Geffen School of Medicine at UCLA, Department of Radiology, Los Angeles, CA 90095 1721, USA
Chest 134:358-67. 2008..The frequency, nature, and progression of interstitial lung disease seen on high-resolution CT (HRCT) scans in patients with diffuse SSc (dcSSc) compared with those with limited SSc (lcSSc) has not been well characterized...
Airway inflammation in young marijuana and tobacco smokersM D Roth
Department of Medicine, and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
Am J Respir Crit Care Med 157:928-37. 1998..We conclude that regular smoking of marijuana by young adults is associated with significant airway inflammation that is similar in frequency, type, and magnitude to that observed in the lungs of tobacco smokers...- Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobaccoS H Barsky
Department of Pathology, University of California, Los Angeles, USA
J Natl Cancer Inst 90:1198-205. 1998.... - Adenoviral-encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of alpha(v)beta3 integrinsAiri Harui
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, USA
J Leukoc Biol 79:1271-8. 2006..These results suggest that a limited subset of DC expressing high levels of alpha(v)beta3 integrins is preferentially transduced by Ad vectors and activates CD8+ T cell responses against Ad-encoded antigens... - Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivoTheodore A Sarafian
Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Am J Physiol Lung Cell Mol Physiol 290:L1202-9. 2006..These results suggest that inhalation of marijuana smoke has deleterious effects on airway epithelial cell energetics that may contribute to the adverse pulmonary consequences of marijuana smoking... - Celecoxib decreases Ki-67 proliferative index in active smokersJenny T Mao
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1690, USA
Clin Cancer Res 12:314-20. 2006..We hypothesized that treatment with oral Celecoxib, a selective COX-2 inhibitor, would favorably alter the biomarkers of lung cancer risk as measured by the Ki-67 proliferative labeling index (Ki-67 LI)... - Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID modelMichael D Roth
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1678, USA
J Leukoc Biol 78:1198-203. 2005..Our results suggest that systemic exposure to cocaine can enhance HIV infection in vivo by activating sigma-1 receptors and by modulating the expression of HIV coreceptors... - Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironmentLinda M Liau
Division of Neurosurgery, Department of Surgery, The Brain Research Institute, David Geffen School of Medicine at University of California at Los Angeles, University of California Los Angeles, Los Angeles, California 90095, USA
Clin Cancer Res 11:5515-25. 2005..As a next step in vaccine development, a phase I clinical trial was established to evaluate this strategy for its feasibility, safety, and induction of systemic and intracranial T-cell responses in patients with glioblastoma multiforme... - Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinolTheodore Sarafian
Division of Pulmonary and Critical Care, Department of Medicine, 14 184 Warren Hall, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Toxicol Lett 158:95-107. 2005..THC, delivered as a component of marijuana smoke, may induce a profile of gene expression that contributes to the pulmonary pathology associated with marijuana use... - Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouseMichael D Roth
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA
Life Sci 77:1711-22. 2005..These results suggest that exposure to THC in vivo can suppress immune function, increase HIV coreceptor expression, and act as a cofactor to significantly enhance HIV replication... - Correlation of the degree of dyspnea with health-related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: results from the Scleroderma Lung StudyDinesh Khanna
David Geffen School of Medicine, University of California, Los Angeles, USA
Arthritis Rheum 52:592-600. 2005.... - Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectorsAiri Harui
Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles CA 90095-1690, USA
J Immunol Methods 312:94-104. 2006.... - Cyclophosphamide versus placebo in scleroderma lung diseaseDonald P Tashkin
University of California at Los Angeles, Los Angeles, USA
N Engl J Med 354:2655-66. 2006.... - Feasibility of retinoids for the treatment of emphysema studyMichael D Roth
Division of Pulmonary and Critical Care, University of California, Los Angeles, CA 90095 1690, USA
Chest 130:1334-45. 2006..Retinoids promote alveolar septation in the developing lung and stimulate alveolar repair in some animal models of emphysema... 
Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cellsTheodore Sarafian
Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 CHS, Los Angeles, CA 90095, USA
Toxicol Appl Pharmacol 231:282-90. 2008..We conclude that airway epithelial cells are sensitive to both CB2R-dependent and independent effects mediated by THC...- Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patientsJosephia R Muindi
Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
J Clin Pharmacol 48:96-107. 2008..25). The authors conclude that intermittent therapy with high-dose ATRA produced the greatest ATRA exposure, but alternative approaches for limiting self-induced ATRA catabolism should be sought... - Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung diseaseCharlie Strange
Division of Pulmonary and Critical Care Medicine, MUSC, 96 Jonathan Lucas Street, 812 CSB, Charleston, SC 29425, USA
Am J Respir Crit Care Med 177:91-8. 2008..The presence of inflammatory cells on bronchoalveolar lavage is often used to predict disease activity and the need for therapy in systemic sclerosis-associated interstitial lung disease... - Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung diseaseDonald P Tashkin
Department of Medicine, David Geffen School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
Am J Respir Crit Care Med 176:1026-34. 2007..Although treatment-related benefits in pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year of therapy, the duration of benefit beyond 1 year was unclear... - Scleroderma lung study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosisPhilip J Clements
Divisions of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Ann Rheum Dis 66:1641-7. 2007..This report examines the differences at baseline and over 12 months between patients with limited versus diffuse cutaneous SSc who participated in the Scleroderma Lung Study... - Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung studyDinesh Khanna
University of Cincinnati, Cincinnati, Ohio 45267 0563, USA
Arthritis Rheum 56:1676-84. 2007..To assess the impact of cyclophosphamide (CYC) on the health-related quality of life (HRQOL) of patients with scleroderma after 12 months of treatment... - Pharmacokinetics of a novel agent, R667, in patients with emphysemaYu Yuan Chiu
Hoffmann La Roche Inc, Pharma Development Medical Pharmacology, Nutley, NJ 07110, USA
Br J Clin Pharmacol 63:527-33. 2007..To evaluate the pharmacokinetics of R667, a novel emphysema agent, in patients with moderate to severe emphysema... - Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharideJenny T Mao
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1690, USA
Clin Cancer Res 10:6872-8. 2004.... - Modifying adenoviral vectors for use as gene-based cancer vaccinesSaroj K Basak
Pulmonary and Critical Care Medicine and the Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1690, USA
Viral Immunol 17:182-96. 2004..There is every reason to believe that safer and more effective forms of AdV-based vaccines can be developed and applied to patient therapy... - Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cellsMichael Yuan
Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA
J Neuroimmunol 133:124-31. 2002..The CB2 receptor antagonist, SR144528, abrogated the majority of these effects. We conclude that cannabinoids have the potential to regulate the activation and balance of human Th1/Th2 cells by a CB2 receptor-dependent pathway... - Respiratory and immunologic consequences of marijuana smokingDonald P Tashkin
Deportment of Medicine, UCLA School of Medicine, 90095-1690, USA
J Clin Pharmacol 42:71S-81S. 2002..Additional well designed epidemiological and immune monitoring studies are required to determine the potential causal relationship between marijuana use and the development of respiratory infection and/or cancer... - Helper-dependent adenoviral vectors efficiently express transgenes in human dendritic cells but still stimulate antiviral immune responsesMichael D Roth
Pulmonary and Critical Care Medicine, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Immunol 169:4651-6. 2002..We conclude that Hd-AdV vectors can be used to obtain higher transgene expression in human DCs but that they still evoke a vector-related immune response similar to that generated by E1-AdV... - Synergistic cytotoxicity of Delta(9)-tetrahydrocannabinol and butylated hydroxyanisoleTheodore A Sarafian
Department of Medicine, Division of Pulmonary and Critical Care, Rm 37 131 Center for Health Sciences, University of California, Los Angeles 90095, USA
Toxicol Lett 133:171-9. 2002..The combination was synergistic in this respect, reducing ATP levels to <15% of control. Exposure to marijuana smoke in conjunction with BHA, a common food additive, may promote deleterious health effects in the lung... - Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokersLiang Nong
Department of Medical Microbiology and Immunology, MDC Box 10, 12901 Bruce Downs Blvd, University of South Florida, Tampa, FL 33612, USA
J Neuroimmunol 127:169-76. 2002..These studies suggest that marijuana smoking and immune activation can alter the basal levels of CB1 and CB2 in PBMCs... - Evidence of chronic damage to the pulmonary microcirculation in habitual users of alkaloidal ("crack") cocaineGayle Cocita Baldwin
Division of Hematology, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
Chest 121:1231-8. 2002..To evaluate BAL cells obtained from habitual users of alkaloidal ("crack") cocaine alone or in combination with tobacco, for evidence of cocaine-associated alveolar injury... - Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4Saroj K Basak
Division of Pulmonary and Critical Care, Department of Medicine, UCLA School of Medicine, Los Angeles 90095 1690, USA
Blood 99:2869-79. 2002..We conclude that systemic therapy with the combination of rGM-CSF/rIL-4 provides a new approach for generating DCs in vivo... - A pilot study of all-trans-retinoic acid for the treatment of human emphysemaJenny T Mao
Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 99095-1690, USA
Am J Respir Crit Care Med 165:718-23. 2002..We conclude that ATRA is well tolerated in patients with emphysema, and trials evaluating higher doses, longer treatment, or different dosing schedules are feasible... - Effects of delta-9-tetrahydrocannabinol on human immune function and host defenseMichael D Roth
Division of Pulmonary and Critical Care Medicine and Hematology Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Chem Phys Lipids 121:229-39. 2002..Macrophage function is restored by treatment with interferon-gamma, a type 1 cytokine. Habitual exposure to THC appears capable of impacting on human cell-mediated immunity and host defense... - Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energeticsTheodore A Sarafian
Department of Medicine, Division of Pulmonary and Critical Care, Center for Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
Am J Physiol Lung Cell Mol Physiol 284:L298-306. 2003..These results suggest that exposure of the bronchopulmonary epithelium to THC may have important health and physiological consequences... - Impairment of antimicrobial activity and nitric oxide production in alveolar macrophages from smokers of marijuana and cocaineAngela Hanchi Shay
Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Infect Dis 187:700-4. 2003..These results confirm that NO plays a significant role as an effector molecule used by normal human AMs, but this capacity is suppressed in AMs from MS and CS because of a lack of intrinsic cytokine priming... - Regional differences in bronchoalveolar lavage and thoracic high-resolution computed tomography results in dyspneic patients with systemic sclerosisPhilip J Clements
Department of Medicine, University of California, Los Angeles, 90095, USA
Arthritis Rheum 50:1909-17. 2004..This study was undertaken to investigate the utility of high-resolution computed tomography (HRCT) of the chest, in comparison with bronchoalveolar lavage (BAL), in the diagnosis of alveolitis in these patients... - Cocaine modulates cytokine and enhances tumor growth through sigma receptorsBrian Gardner
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
J Neuroimmunol 147:95-8. 2004..We conclude that sigma(1) receptor ligands, including cocaine, augment tumor growth via a cytokine-dependent, receptor-mediated mechanism that involves regulation of T helper 1/T helper 2 cytokine balance... - Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokersMichael D Roth
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Neuroimmunol 147:82-6. 2004..These findings confirm a significant role for NO as an antibacterial effector molecule used by normal human AM and suggest that this host defense mechanism is suppressed by habitual exposure to inhaled marijuana or crack cocaine in vivo... - Celecoxib modulates the capacity for prostaglandin E2 and interleukin-10 production in alveolar macrophages from active smokersJenny T Mao
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1690, USA
Clin Cancer Res 9:5835-41. 2003..We hypothesized that treatment with oral celecoxib, a selective COX-2 inhibitor, would favorably alter biomarkers of lung cancer risk. This study evaluated the feasibility of COX-2 inhibition as a form of chemoprevention for lung cancer... - All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysemaJenny T Mao
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Chest 124:1724-32. 2003..This study was designed to evaluate the impact of all-trans retinoic acid (ATRA) on the balance of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with emphysema... - Granulocyte/macrophage-colony stimulating factor and interleukin-4 expand and activate type-1 dendritic cells (DC1) when administered in vivo to cancer patientsSylvia M Kiertscher
Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
Int J Cancer 107:256-61. 2003..These effects correlate with antigen-presenting activity, providing a mechanism by which systemic GM-CSF and IL-4 might stimulate anti-tumor immunity in vivo... - Phase I trial of granulocyte macrophage-colony stimulating factor and interleukin-4 as a combined immunotherapy for patients with cancerBarbara J Gitlitz
Division of Hematology/Oncology, Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, USA
J Immunother (1997) 26:171-8. 2003..Systemic GM-CSF plus IL-4 provides a mechanism for increasing the number and function of APC in cancer patients. Future clinical applications of this strategy are numerous and include the potential as a strong vaccine adjuvant... - Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytesMichael D Roth
Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
J Infect Dis 185:701-5. 2002..This report describes a model for evaluating HIV cofactors and supports cocaine's role in the development and progression of AIDS... - Pharmacology: marijuana and your heartMichael D Roth
Nature 434:708-9. 2005 - Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected menChun Chao
Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095 1772, USA
Drug Alcohol Depend 94:165-71. 2008..These results indicate that use of these substances does not adversely affect the numbers and percentages of circulating CD4 or CD8 T cells in either HIV-uninfected or -infected MSM...