M D Roth

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells
    S M Kiertscher
    Division of Pulmonary Medicine, Comprehensive Cancer Center, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 164:1269-76. 2000
  2. ncbi request reprint Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol
    Theodore Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, 14 184 Warren Hall, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Toxicol Lett 158:95-107. 2005
  3. ncbi request reprint Adenoviral-encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of alpha(v)beta3 integrins
    Airi Harui
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    J Leukoc Biol 79:1271-8. 2006
  4. pmc Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung disease
    Michael D Roth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Arthritis Rheum 63:2797-808. 2011
  5. pmc Eosinophil and T cell markers predict functional decline in COPD patients
    JEANINE M D'ARMIENTO
    Department of Medicine, Columbia University, New York, NY, USA
    Respir Res 10:113. 2009
  6. pmc Reconstitution of huPBL-NSG mice with donor-matched dendritic cells enables antigen-specific T-cell activation
    Airi Harui
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    J Neuroimmune Pharmacol 6:148-57. 2011
  7. ncbi request reprint Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol
    M D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
    Am J Respir Cell Mol Biol 24:339-44. 2001
  8. ncbi request reprint Effects of delta-9-tetrahydrocannabinol on human immune function and host defense
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine and Hematology Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Chem Phys Lipids 121:229-39. 2002
  9. ncbi request reprint Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    J Infect Dis 185:701-5. 2002
  10. ncbi request reprint Helper-dependent adenoviral vectors efficiently express transgenes in human dendritic cells but still stimulate antiviral immune responses
    Michael D Roth
    Pulmonary and Critical Care Medicine, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 169:4651-6. 2002

Detail Information

Publications59

  1. ncbi request reprint Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells
    S M Kiertscher
    Division of Pulmonary Medicine, Comprehensive Cancer Center, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 164:1269-76. 2000
    ..Supernatants collected from nonmalignant cell sources had no effect on DC maturation. The altered maturation and early apoptosis of monocyte-derived DC may represent another mechanism by which tumors evade immune detection...
  2. ncbi request reprint Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol
    Theodore Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, 14 184 Warren Hall, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Toxicol Lett 158:95-107. 2005
    ..THC, delivered as a component of marijuana smoke, may induce a profile of gene expression that contributes to the pulmonary pathology associated with marijuana use...
  3. ncbi request reprint Adenoviral-encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of alpha(v)beta3 integrins
    Airi Harui
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    J Leukoc Biol 79:1271-8. 2006
    ..These results suggest that a limited subset of DC expressing high levels of alpha(v)beta3 integrins is preferentially transduced by Ad vectors and activates CD8+ T cell responses against Ad-encoded antigens...
  4. pmc Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung disease
    Michael D Roth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Arthritis Rheum 63:2797-808. 2011
    ..To identify baseline characteristics of patients with scleroderma-related interstitial lung disease (SSc-ILD) that could serve as predictors of the most favorable response to 12-month treatment with oral cyclophosphamide (CYC)...
  5. pmc Eosinophil and T cell markers predict functional decline in COPD patients
    JEANINE M D'ARMIENTO
    Department of Medicine, Columbia University, New York, NY, USA
    Respir Res 10:113. 2009
    ..We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease...
  6. pmc Reconstitution of huPBL-NSG mice with donor-matched dendritic cells enables antigen-specific T-cell activation
    Airi Harui
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    J Neuroimmune Pharmacol 6:148-57. 2011
    ....
  7. ncbi request reprint Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol
    M D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
    Am J Respir Cell Mol Biol 24:339-44. 2001
    ..This complex regulation of CYP1A1 by marijuana smoke and the Delta(9)-THC that it contains has implications for the role of marijuana as a cancer risk factor...
  8. ncbi request reprint Effects of delta-9-tetrahydrocannabinol on human immune function and host defense
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine and Hematology Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Chem Phys Lipids 121:229-39. 2002
    ..Macrophage function is restored by treatment with interferon-gamma, a type 1 cytokine. Habitual exposure to THC appears capable of impacting on human cell-mediated immunity and host defense...
  9. ncbi request reprint Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    J Infect Dis 185:701-5. 2002
    ..This report describes a model for evaluating HIV cofactors and supports cocaine's role in the development and progression of AIDS...
  10. ncbi request reprint Helper-dependent adenoviral vectors efficiently express transgenes in human dendritic cells but still stimulate antiviral immune responses
    Michael D Roth
    Pulmonary and Critical Care Medicine, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 169:4651-6. 2002
    ..We conclude that Hd-AdV vectors can be used to obtain higher transgene expression in human DCs but that they still evoke a vector-related immune response similar to that generated by E1-AdV...
  11. ncbi request reprint Granulocyte macrophage colony-stimulating factor and interleukin 4 enhance the number and antigen-presenting activity of circulating CD14+ and CD83+ cells in cancer patients
    M D Roth
    Division of Pulmonary and Critical Care Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles School of Medicine, 90095 1690, USA
    Cancer Res 60:1934-41. 2000
    ..Clinically significant and sustained tumor regression was observed in one patient. Systemic therapy with GM-CSF and IL-4 may provide a mechanism for increasing the number and function of APCs in patients with cancer...
  12. ncbi request reprint Interferon-alpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells
    R L Paquette
    Department of Medicine, The University of California at Los Angeles, 90095 1678, USA
    J Leukoc Biol 64:358-67. 1998
    ..These results demonstrate an important role for IFN-alpha in the generation of DCs with potent antigen-presenting capabilities from peripheral blood monocytes...
  13. ncbi request reprint Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model
    Michael D Roth
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1678, USA
    J Leukoc Biol 78:1198-203. 2005
    ..Our results suggest that systemic exposure to cocaine can enhance HIV infection in vivo by activating sigma-1 receptors and by modulating the expression of HIV coreceptors...
  14. ncbi request reprint Airway inflammation in young marijuana and tobacco smokers
    M D Roth
    Department of Medicine, and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
    Am J Respir Crit Care Med 157:928-37. 1998
    ..We conclude that regular smoking of marijuana by young adults is associated with significant airway inflammation that is similar in frequency, type, and magnitude to that observed in the lungs of tobacco smokers...
  15. ncbi request reprint Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells
    Michael Yuan
    Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
    J Neuroimmunol 133:124-31. 2002
    ..The CB2 receptor antagonist, SR144528, abrogated the majority of these effects. We conclude that cannabinoids have the potential to regulate the activation and balance of human Th1/Th2 cells by a CB2 receptor-dependent pathway...
  16. ncbi request reprint Correlation of the degree of dyspnea with health-related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: results from the Scleroderma Lung Study
    Dinesh Khanna
    David Geffen School of Medicine, University of California, Los Angeles, USA
    Arthritis Rheum 52:592-600. 2005
    ....
  17. ncbi request reprint Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokers
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Neuroimmunol 147:82-6. 2004
    ..These findings confirm a significant role for NO as an antibacterial effector molecule used by normal human AM and suggest that this host defense mechanism is suppressed by habitual exposure to inhaled marijuana or crack cocaine in vivo...
  18. ncbi request reprint Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouse
    Michael D Roth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Life Sci 77:1711-22. 2005
    ..These results suggest that exposure to THC in vivo can suppress immune function, increase HIV coreceptor expression, and act as a cofactor to significantly enhance HIV replication...
  19. pmc Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung disease
    Charlie Strange
    Division of Pulmonary and Critical Care Medicine, MUSC, 96 Jonathan Lucas Street, 812 CSB, Charleston, SC 29425, USA
    Am J Respir Crit Care Med 177:91-8. 2008
    ..The presence of inflammatory cells on bronchoalveolar lavage is often used to predict disease activity and the need for therapy in systemic sclerosis-associated interstitial lung disease...
  20. ncbi request reprint Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis
    T A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, UCLA School of Medicine, Room 37 131, Center for Health Sciences, Los Angeles, California 90095 1690, USA
    Toxicol Appl Pharmacol 174:264-72. 2001
    ..This shift may affect both the carcinogenic and immunologic consequences of marijuana smoke exposure...
  21. ncbi request reprint Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectors
    Airi Harui
    Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles CA 90095 1690, USA
    J Immunol Methods 312:94-104. 2006
    ....
  22. doi request reprint Recruitment strategies for a lung cancer chemoprevention trial involving ex-smokers
    Steve H Kye
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1690, USA
    Contemp Clin Trials 30:464-72. 2009
    ..Our results suggest that advertising on news radio is a highly effective recruitment method for successful accrual of ex-smokers into lung cancer chemoprevention trials...
  23. ncbi request reprint Phase I trial of granulocyte macrophage-colony stimulating factor and interleukin-4 as a combined immunotherapy for patients with cancer
    Barbara J Gitlitz
    Division of Hematology Oncology, Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, USA
    J Immunother 26:171-8. 2003
    ..Systemic GM-CSF plus IL-4 provides a mechanism for increasing the number and function of APC in cancer patients. Future clinical applications of this strategy are numerous and include the potential as a strong vaccine adjuvant...
  24. ncbi request reprint Feasibility of retinoids for the treatment of emphysema study
    Michael D Roth
    Division of Pulmonary and Critical Care, University of California, Los Angeles, CA 90095 1690, USA
    Chest 130:1334-45. 2006
    ..Retinoids promote alveolar septation in the developing lung and stimulate alveolar repair in some animal models of emphysema...
  25. pmc Treatment of scleroderma-interstitial lung disease with cyclophosphamide is associated with less progressive fibrosis on serial thoracic high-resolution CT scan than placebo: findings from the scleroderma lung study
    Jonathan Goldin
    Department of Radiologic Sciences, David Geffen School of Medicine, School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA
    Chest 136:1333-40. 2009
    ..This study examined thoracic high-resolution CT (HRCT) scans obtained during the SLS for treatment-associated changes over time...
  26. ncbi request reprint Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment
    Linda M Liau
    Division of Neurosurgery, Department of Surgery, The Brain Research Institute, David Geffen School of Medicine at University of California at Los Angeles, University of California Los Angeles, Los Angeles, California 90095, USA
    Clin Cancer Res 11:5515-25. 2005
    ..As a next step in vaccine development, a phase I clinical trial was established to evaluate this strategy for its feasibility, safety, and induction of systemic and intracranial T-cell responses in patients with glioblastoma multiforme...
  27. ncbi request reprint Celecoxib decreases Ki-67 proliferative index in active smokers
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1690, USA
    Clin Cancer Res 12:314-20. 2006
    ..We hypothesized that treatment with oral Celecoxib, a selective COX-2 inhibitor, would favorably alter the biomarkers of lung cancer risk as measured by the Ki-67 proliferative labeling index (Ki-67 LI)...
  28. ncbi request reprint Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo
    Theodore A Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1202-9. 2006
    ..These results suggest that inhalation of marijuana smoke has deleterious effects on airway epithelial cell energetics that may contribute to the adverse pulmonary consequences of marijuana smoking...
  29. pmc Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Am J Respir Crit Care Med 176:1026-34. 2007
    ..Although treatment-related benefits in pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year of therapy, the duration of benefit beyond 1 year was unclear...
  30. ncbi request reprint Cyclophosphamide versus placebo in scleroderma lung disease
    Donald P Tashkin
    University of California at Los Angeles, Los Angeles, USA
    N Engl J Med 354:2655-66. 2006
    ....
  31. ncbi request reprint High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease
    Jonathan G Goldin
    David Geffen School of Medicine at UCLA, Department of Radiology, Los Angeles, CA 90095 1721, USA
    Chest 134:358-67. 2008
    ..The frequency, nature, and progression of interstitial lung disease seen on high-resolution CT (HRCT) scans in patients with diffuse SSc (dcSSc) compared with those with limited SSc (lcSSc) has not been well characterized...
  32. pmc Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cells
    Theodore Sarafian
    Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 CHS, Los Angeles, CA 90095, USA
    Toxicol Appl Pharmacol 231:282-90. 2008
    ..We conclude that airway epithelial cells are sensitive to both CB2R-dependent and independent effects mediated by THC...
  33. pmc Scleroderma lung study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosis
    Philip J Clements
    Divisions of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Ann Rheum Dis 66:1641-7. 2007
    ..This report examines the differences at baseline and over 12 months between patients with limited versus diffuse cutaneous SSc who participated in the Scleroderma Lung Study...
  34. ncbi request reprint Synergistic cytotoxicity of Delta(9)-tetrahydrocannabinol and butylated hydroxyanisole
    Theodore A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, Rm 37 131 Center for Health Sciences, University of California, Los Angeles 90095, USA
    Toxicol Lett 133:171-9. 2002
    ..The combination was synergistic in this respect, reducing ATP levels to <15% of control. Exposure to marijuana smoke in conjunction with BHA, a common food additive, may promote deleterious health effects in the lung...
  35. ncbi request reprint Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4
    Saroj K Basak
    Division of Pulmonary and Critical Care, Department of Medicine, UCLA School of Medicine, Los Angeles 90095 1690, USA
    Blood 99:2869-79. 2002
    ..We conclude that systemic therapy with the combination of rGM-CSF/rIL-4 provides a new approach for generating DCs in vivo...
  36. ncbi request reprint Evidence of chronic damage to the pulmonary microcirculation in habitual users of alkaloidal ("crack") cocaine
    Gayle Cocita Baldwin
    Division of Hematology, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
    Chest 121:1231-8. 2002
    ..To evaluate BAL cells obtained from habitual users of alkaloidal ("crack") cocaine alone or in combination with tobacco, for evidence of cocaine-associated alveolar injury...
  37. ncbi request reprint Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energetics
    Theodore A Sarafian
    Department of Medicine, Division of Pulmonary and Critical Care, Center for Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Lung Cell Mol Physiol 284:L298-306. 2003
    ..These results suggest that exposure of the bronchopulmonary epithelium to THC may have important health and physiological consequences...
  38. ncbi request reprint A pilot study of all-trans-retinoic acid for the treatment of human emphysema
    Jenny T Mao
    Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 99095 1690, USA
    Am J Respir Crit Care Med 165:718-23. 2002
    ..We conclude that ATRA is well tolerated in patients with emphysema, and trials evaluating higher doses, longer treatment, or different dosing schedules are feasible...
  39. ncbi request reprint Impairment of antimicrobial activity and nitric oxide production in alveolar macrophages from smokers of marijuana and cocaine
    Angela Hanchi Shay
    Division of Hematology Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Infect Dis 187:700-4. 2003
    ..These results confirm that NO plays a significant role as an effector molecule used by normal human AMs, but this capacity is suppressed in AMs from MS and CS because of a lack of intrinsic cytokine priming...
  40. ncbi request reprint All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysema
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Chest 124:1724-32. 2003
    ..This study was designed to evaluate the impact of all-trans retinoic acid (ATRA) on the balance of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with emphysema...
  41. ncbi request reprint Celecoxib modulates the capacity for prostaglandin E2 and interleukin-10 production in alveolar macrophages from active smokers
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Clin Cancer Res 9:5835-41. 2003
    ..We hypothesized that treatment with oral celecoxib, a selective COX-2 inhibitor, would favorably alter biomarkers of lung cancer risk. This study evaluated the feasibility of COX-2 inhibition as a form of chemoprevention for lung cancer...
  42. ncbi request reprint Cocaine modulates cytokine and enhances tumor growth through sigma receptors
    Brian Gardner
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
    J Neuroimmunol 147:95-8. 2004
    ..We conclude that sigma(1) receptor ligands, including cocaine, augment tumor growth via a cytokine-dependent, receptor-mediated mechanism that involves regulation of T helper 1/T helper 2 cytokine balance...
  43. ncbi request reprint Regional differences in bronchoalveolar lavage and thoracic high-resolution computed tomography results in dyspneic patients with systemic sclerosis
    Philip J Clements
    Department of Medicine, University of California, Los Angeles, 90095, USA
    Arthritis Rheum 50:1909-17. 2004
    ..This study was undertaken to investigate the utility of high-resolution computed tomography (HRCT) of the chest, in comparison with bronchoalveolar lavage (BAL), in the diagnosis of alveolitis in these patients...
  44. ncbi request reprint Modifying adenoviral vectors for use as gene-based cancer vaccines
    Saroj K Basak
    Pulmonary and Critical Care Medicine and the Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
    Viral Immunol 17:182-96. 2004
    ..There is every reason to believe that safer and more effective forms of AdV-based vaccines can be developed and applied to patient therapy...
  45. ncbi request reprint Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide
    Jenny T Mao
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Clin Cancer Res 10:6872-8. 2004
    ....
  46. ncbi request reprint Granulocyte/macrophage-colony stimulating factor and interleukin-4 expand and activate type-1 dendritic cells (DC1) when administered in vivo to cancer patients
    Sylvia M Kiertscher
    Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
    Int J Cancer 107:256-61. 2003
    ..These effects correlate with antigen-presenting activity, providing a mechanism by which systemic GM-CSF and IL-4 might stimulate anti-tumor immunity in vivo...
  47. ncbi request reprint Vaccination with helper-dependent adenovirus enhances the generation of transgene-specific CTL
    A Harui
    Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
    Gene Ther 11:1617-26. 2004
    ..We conclude that HD-AdV stimulates superior transgene-specific immune responses when compared to a FG-AdV, and that immunization with a DC-based vaccine maintains this efficacy while limiting antiviral reactivity...
  48. ncbi request reprint Respiratory and immunologic consequences of marijuana smoking
    Donald P Tashkin
    Deportment of Medicine, UCLA School of Medicine, 90095 1690, USA
    J Clin Pharmacol 42:71S-81S. 2002
    ..Additional well designed epidemiological and immune monitoring studies are required to determine the potential causal relationship between marijuana use and the development of respiratory infection and/or cancer...
  49. ncbi request reprint Oxidative stress produced by marijuana smoke. An adverse effect enhanced by cannabinoids
    T A Sarafian
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 90095, USA
    Am J Respir Cell Mol Biol 20:1286-93. 1999
    ..We conclude that MJ smoke containing Delta9-THC is a potent source of cellular oxidative stress that could contribute significantly to cell injury and dysfunction in the lungs of smokers...
  50. ncbi request reprint Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2
    C J Hertz
    Division of Dermatology and Pulmonary Medicine, Department of Microbiology and Immunology, and Molecular Biology Institute, University of California School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 166:2444-50. 2001
    ..These results demonstrate that lipopeptides can stimulate DC maturation via TLR2, providing a mechanism by which products of bacteria can participate in the initiation of an immune response...
  51. pmc Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteins
    Kouki Morizono
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, BSRB 173, Charles E Young Dr South, Los Angeles, CA 90095, USA
    J Virol 84:6923-34. 2010
    ..These results indicate that the strategy of redirecting viral vectors according to alterations of their N-glycan structures would enable the vectors to target specific cells types expressing particular types of lectins...
  52. ncbi request reprint Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobacco
    S H Barsky
    Department of Pathology, University of California, Los Angeles, USA
    J Natl Cancer Inst 90:1198-205. 1998
    ....
  53. pmc Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men
    Chun Chao
    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095 1772, USA
    Drug Alcohol Depend 94:165-71. 2008
    ..These results indicate that use of these substances does not adversely affect the numbers and percentages of circulating CD4 or CD8 T cells in either HIV-uninfected or -infected MSM...
  54. pmc Recreational drug use and risk of Kaposi's sarcoma in HIV- and HHV-8-coinfected homosexual men
    Chun Chao
    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    AIDS Res Hum Retroviruses 25:149-56. 2009
    ..46 (1.01-2.13)]. However, no clear dose-response relationship was observed. These findings do not support a biological association between use of these substances and KS development in HIV- and HHV-8-coinfected homosexual men...
  55. ncbi request reprint Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patients
    Josephia R Muindi
    Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Pharmacol 48:96-107. 2008
    ..25). The authors conclude that intermittent therapy with high-dose ATRA produced the greatest ATRA exposure, but alternative approaches for limiting self-induced ATRA catabolism should be sought...
  56. ncbi request reprint Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers
    Liang Nong
    Department of Medical Microbiology and Immunology, MDC Box 10, 12901 Bruce Downs Blvd, University of South Florida, Tampa, FL 33612, USA
    J Neuroimmunol 127:169-76. 2002
    ..These studies suggest that marijuana smoking and immune activation can alter the basal levels of CB1 and CB2 in PBMCs...
  57. ncbi request reprint Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung study
    Dinesh Khanna
    University of Cincinnati, Cincinnati, Ohio 45267 0563, USA
    Arthritis Rheum 56:1676-84. 2007
    ..To assess the impact of cyclophosphamide (CYC) on the health-related quality of life (HRQOL) of patients with scleroderma after 12 months of treatment...
  58. pmc Pharmacokinetics of a novel agent, R667, in patients with emphysema
    Yu Yuan Chiu
    Hoffmann La Roche Inc, Pharma Development Medical Pharmacology, Nutley, NJ 07110, USA
    Br J Clin Pharmacol 63:527-33. 2007
    ..To evaluate the pharmacokinetics of R667, a novel emphysema agent, in patients with moderate to severe emphysema...
  59. ncbi request reprint Pharmacology: marijuana and your heart
    Michael D Roth
    Nature 434:708-9. 2005

Research Grants11

  1. CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASE
    Michael Roth; Fiscal Year: 2009
    ..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
  2. Vector-based Generation of Monoclonal Antibodies against the CB2 Receptor
    Michael Roth; Fiscal Year: 2007
    ..This work has the capacity to significantly accelerate cannabinoid research. [unreadable] [unreadable] [unreadable]..
  3. Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral Immunity
    Michael Roth; Fiscal Year: 2009
    ..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies. ..
  4. Adjuvant immunotherapy for non-small cell lung cancer
    Michael Roth; Fiscal Year: 2005
    ..abstract_text> ..
  5. EFFECTS OF MARIJUANA ON HIV AND VIRAL IMMUNITY
    Michael Roth; Fiscal Year: 2006
    ..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies. ..
  6. CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASE
    Michael Roth; Fiscal Year: 2008
    ..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
  7. Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral Immunity
    Michael Roth; Fiscal Year: 2008
    ..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies. ..
  8. Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral Immunity
    Michael Roth; Fiscal Year: 2007
    ..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies. ..
  9. CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASE
    Michael Roth; Fiscal Year: 2007
    ..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
  10. COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSE
    Michael Roth; Fiscal Year: 2006
    ..abstract_text> ..
  11. Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral Immunity
    Michael D Roth; Fiscal Year: 2010
    ..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies. ..