Research Topics
Species | M D RothSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cellsS M Kiertscher
Division of Pulmonary Medicine, Comprehensive Cancer Center, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
J Immunol 164:1269-76. 2000..Supernatants collected from nonmalignant cell sources had no effect on DC maturation. The altered maturation and early apoptosis of monocyte-derived DC may represent another mechanism by which tumors evade immune detection...- Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinolTheodore Sarafian
Division of Pulmonary and Critical Care, Department of Medicine, 14 184 Warren Hall, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Toxicol Lett 158:95-107. 2005..THC, delivered as a component of marijuana smoke, may induce a profile of gene expression that contributes to the pulmonary pathology associated with marijuana use... - Adenoviral-encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of alpha(v)beta3 integrinsAiri Harui
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, USA
J Leukoc Biol 79:1271-8. 2006..These results suggest that a limited subset of DC expressing high levels of alpha(v)beta3 integrins is preferentially transduced by Ad vectors and activates CD8+ T cell responses against Ad-encoded antigens... 
Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung diseaseMichael D Roth
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
Arthritis Rheum 63:2797-808. 2011..To identify baseline characteristics of patients with scleroderma-related interstitial lung disease (SSc-ILD) that could serve as predictors of the most favorable response to 12-month treatment with oral cyclophosphamide (CYC)...
Eosinophil and T cell markers predict functional decline in COPD patientsJEANINE M D'ARMIENTO
Department of Medicine, Columbia University, New York, NY, USA
Respir Res 10:113. 2009..We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease...- Reconstitution of huPBL-NSG mice with donor-matched dendritic cells enables antigen-specific T-cell activationAiri Harui
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
J Neuroimmune Pharmacol 6:148-57. 2011.... - Helper-dependent adenoviral vectors efficiently express transgenes in human dendritic cells but still stimulate antiviral immune responsesMichael D Roth
Pulmonary and Critical Care Medicine, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Immunol 169:4651-6. 2002..We conclude that Hd-AdV vectors can be used to obtain higher transgene expression in human DCs but that they still evoke a vector-related immune response similar to that generated by E1-AdV... - Effects of delta-9-tetrahydrocannabinol on human immune function and host defenseMichael D Roth
Division of Pulmonary and Critical Care Medicine and Hematology Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Chem Phys Lipids 121:229-39. 2002..Macrophage function is restored by treatment with interferon-gamma, a type 1 cytokine. Habitual exposure to THC appears capable of impacting on human cell-mediated immunity and host defense... - Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytesMichael D Roth
Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
J Infect Dis 185:701-5. 2002..This report describes a model for evaluating HIV cofactors and supports cocaine's role in the development and progression of AIDS... - Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinolM D Roth
Division of Pulmonary and Critical Care Medicine, Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
Am J Respir Cell Mol Biol 24:339-44. 2001..This complex regulation of CYP1A1 by marijuana smoke and the Delta(9)-THC that it contains has implications for the role of marijuana as a cancer risk factor... - Granulocyte macrophage colony-stimulating factor and interleukin 4 enhance the number and antigen-presenting activity of circulating CD14+ and CD83+ cells in cancer patientsM D Roth
Division of Pulmonary and Critical Care Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles School of Medicine, 90095 1690, USA
Cancer Res 60:1934-41. 2000..Clinically significant and sustained tumor regression was observed in one patient. Systemic therapy with GM-CSF and IL-4 may provide a mechanism for increasing the number and function of APCs in patients with cancer... - Interferon-alpha and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cellsR L Paquette
Department of Medicine, The University of California at Los Angeles, 90095 1678, USA
J Leukoc Biol 64:358-67. 1998..These results demonstrate an important role for IFN-alpha in the generation of DCs with potent antigen-presenting capabilities from peripheral blood monocytes... - Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID modelMichael D Roth
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1678, USA
J Leukoc Biol 78:1198-203. 2005..Our results suggest that systemic exposure to cocaine can enhance HIV infection in vivo by activating sigma-1 receptors and by modulating the expression of HIV coreceptors... - Airway inflammation in young marijuana and tobacco smokersM D Roth
Department of Medicine, and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
Am J Respir Crit Care Med 157:928-37. 1998..We conclude that regular smoking of marijuana by young adults is associated with significant airway inflammation that is similar in frequency, type, and magnitude to that observed in the lungs of tobacco smokers... - Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cellsMichael Yuan
Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA
J Neuroimmunol 133:124-31. 2002..The CB2 receptor antagonist, SR144528, abrogated the majority of these effects. We conclude that cannabinoids have the potential to regulate the activation and balance of human Th1/Th2 cells by a CB2 receptor-dependent pathway... - Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouseMichael D Roth
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA
Life Sci 77:1711-22. 2005..These results suggest that exposure to THC in vivo can suppress immune function, increase HIV coreceptor expression, and act as a cofactor to significantly enhance HIV replication... - Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung diseaseCharlie Strange
Division of Pulmonary and Critical Care Medicine, MUSC, 96 Jonathan Lucas Street, 812 CSB, Charleston, SC 29425, USA
Am J Respir Crit Care Med 177:91-8. 2008..The presence of inflammatory cells on bronchoalveolar lavage is often used to predict disease activity and the need for therapy in systemic sclerosis-associated interstitial lung disease... - Correlation of the degree of dyspnea with health-related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: results from the Scleroderma Lung StudyDinesh Khanna
David Geffen School of Medicine, University of California, Los Angeles, USA
Arthritis Rheum 52:592-600. 2005.... - Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokersMichael D Roth
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Neuroimmunol 147:82-6. 2004..These findings confirm a significant role for NO as an antibacterial effector molecule used by normal human AM and suggest that this host defense mechanism is suppressed by habitual exposure to inhaled marijuana or crack cocaine in vivo... - Recruitment strategies for a lung cancer chemoprevention trial involving ex-smokersSteve H Kye
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1690, USA
Contemp Clin Trials 30:464-72. 2009..Our results suggest that advertising on news radio is a highly effective recruitment method for successful accrual of ex-smokers into lung cancer chemoprevention trials... - Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectorsAiri Harui
Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles CA 90095-1690, USA
J Immunol Methods 312:94-104. 2006.... - Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosisT A Sarafian
Department of Medicine, Division of Pulmonary and Critical Care, UCLA School of Medicine, Room 37 131, Center for Health Sciences, Los Angeles, California 90095 1690, USA
Toxicol Appl Pharmacol 174:264-72. 2001..This shift may affect both the carcinogenic and immunologic consequences of marijuana smoke exposure... - Feasibility of retinoids for the treatment of emphysema studyMichael D Roth
Division of Pulmonary and Critical Care, University of California, Los Angeles, CA 90095 1690, USA
Chest 130:1334-45. 2006..Retinoids promote alveolar septation in the developing lung and stimulate alveolar repair in some animal models of emphysema... - Phase I trial of granulocyte macrophage-colony stimulating factor and interleukin-4 as a combined immunotherapy for patients with cancerBarbara J Gitlitz
Division of Hematology/Oncology, Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, USA
J Immunother (1997) 26:171-8. 2003..Systemic GM-CSF plus IL-4 provides a mechanism for increasing the number and function of APC in cancer patients. Future clinical applications of this strategy are numerous and include the potential as a strong vaccine adjuvant... - Treatment of scleroderma-interstitial lung disease with cyclophosphamide is associated with less progressive fibrosis on serial thoracic high-resolution CT scan than placebo: findings from the scleroderma lung studyJonathan Goldin
Department of Radiologic Sciences, David Geffen School of Medicine, School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA
Chest 136:1333-40. 2009..This study examined thoracic high-resolution CT (HRCT) scans obtained during the SLS for treatment-associated changes over time... - Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironmentLinda M Liau
Division of Neurosurgery, Department of Surgery, The Brain Research Institute, David Geffen School of Medicine at University of California at Los Angeles, University of California Los Angeles, Los Angeles, California 90095, USA
Clin Cancer Res 11:5515-25. 2005..As a next step in vaccine development, a phase I clinical trial was established to evaluate this strategy for its feasibility, safety, and induction of systemic and intracranial T-cell responses in patients with glioblastoma multiforme... - Celecoxib decreases Ki-67 proliferative index in active smokersJenny T Mao
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1690, USA
Clin Cancer Res 12:314-20. 2006..We hypothesized that treatment with oral Celecoxib, a selective COX-2 inhibitor, would favorably alter the biomarkers of lung cancer risk as measured by the Ki-67 proliferative labeling index (Ki-67 LI)... - Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivoTheodore A Sarafian
Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Am J Physiol Lung Cell Mol Physiol 290:L1202-9. 2006..These results suggest that inhalation of marijuana smoke has deleterious effects on airway epithelial cell energetics that may contribute to the adverse pulmonary consequences of marijuana smoking... - Cyclophosphamide versus placebo in scleroderma lung diseaseDonald P Tashkin
University of California at Los Angeles, Los Angeles, USA
N Engl J Med 354:2655-66. 2006.... - Scleroderma lung study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosisPhilip J Clements
Divisions of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Ann Rheum Dis 66:1641-7. 2007..This report examines the differences at baseline and over 12 months between patients with limited versus diffuse cutaneous SSc who participated in the Scleroderma Lung Study... - High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung diseaseJonathan G Goldin
David Geffen School of Medicine at UCLA, Department of Radiology, Los Angeles, CA 90095 1721, USA
Chest 134:358-67. 2008..The frequency, nature, and progression of interstitial lung disease seen on high-resolution CT (HRCT) scans in patients with diffuse SSc (dcSSc) compared with those with limited SSc (lcSSc) has not been well characterized... - Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung diseaseDonald P Tashkin
Department of Medicine, David Geffen School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
Am J Respir Crit Care Med 176:1026-34. 2007..Although treatment-related benefits in pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year of therapy, the duration of benefit beyond 1 year was unclear... - Clarifying CB2 receptor-dependent and independent effects of THC on human lung epithelial cellsTheodore Sarafian
Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 CHS, Los Angeles, CA 90095, USA
Toxicol Appl Pharmacol 231:282-90. 2008..We conclude that airway epithelial cells are sensitive to both CB2R-dependent and independent effects mediated by THC... - Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4Saroj K Basak
Division of Pulmonary and Critical Care, Department of Medicine, UCLA School of Medicine, Los Angeles 90095 1690, USA
Blood 99:2869-79. 2002..We conclude that systemic therapy with the combination of rGM-CSF/rIL-4 provides a new approach for generating DCs in vivo... - Evidence of chronic damage to the pulmonary microcirculation in habitual users of alkaloidal ("crack") cocaineGayle Cocita Baldwin
Division of Hematology, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
Chest 121:1231-8. 2002..To evaluate BAL cells obtained from habitual users of alkaloidal ("crack") cocaine alone or in combination with tobacco, for evidence of cocaine-associated alveolar injury... - A pilot study of all-trans-retinoic acid for the treatment of human emphysemaJenny T Mao
Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 99095-1690, USA
Am J Respir Crit Care Med 165:718-23. 2002..We conclude that ATRA is well tolerated in patients with emphysema, and trials evaluating higher doses, longer treatment, or different dosing schedules are feasible... - Synergistic cytotoxicity of Delta(9)-tetrahydrocannabinol and butylated hydroxyanisoleTheodore A Sarafian
Department of Medicine, Division of Pulmonary and Critical Care, Rm 37 131 Center for Health Sciences, University of California, Los Angeles 90095, USA
Toxicol Lett 133:171-9. 2002..The combination was synergistic in this respect, reducing ATP levels to <15% of control. Exposure to marijuana smoke in conjunction with BHA, a common food additive, may promote deleterious health effects in the lung... - Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energeticsTheodore A Sarafian
Department of Medicine, Division of Pulmonary and Critical Care, Center for Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
Am J Physiol Lung Cell Mol Physiol 284:L298-306. 2003..These results suggest that exposure of the bronchopulmonary epithelium to THC may have important health and physiological consequences... - Impairment of antimicrobial activity and nitric oxide production in alveolar macrophages from smokers of marijuana and cocaineAngela Hanchi Shay
Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Infect Dis 187:700-4. 2003..These results confirm that NO plays a significant role as an effector molecule used by normal human AMs, but this capacity is suppressed in AMs from MS and CS because of a lack of intrinsic cytokine priming... - Granulocyte/macrophage-colony stimulating factor and interleukin-4 expand and activate type-1 dendritic cells (DC1) when administered in vivo to cancer patientsSylvia M Kiertscher
Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
Int J Cancer 107:256-61. 2003..These effects correlate with antigen-presenting activity, providing a mechanism by which systemic GM-CSF and IL-4 might stimulate anti-tumor immunity in vivo... - All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysemaJenny T Mao
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Chest 124:1724-32. 2003..This study was designed to evaluate the impact of all-trans retinoic acid (ATRA) on the balance of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with emphysema... - Celecoxib modulates the capacity for prostaglandin E2 and interleukin-10 production in alveolar macrophages from active smokersJenny T Mao
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1690, USA
Clin Cancer Res 9:5835-41. 2003..We hypothesized that treatment with oral celecoxib, a selective COX-2 inhibitor, would favorably alter biomarkers of lung cancer risk. This study evaluated the feasibility of COX-2 inhibition as a form of chemoprevention for lung cancer... - Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharideJenny T Mao
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1690, USA
Clin Cancer Res 10:6872-8. 2004.... - Cocaine modulates cytokine and enhances tumor growth through sigma receptorsBrian Gardner
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
J Neuroimmunol 147:95-8. 2004..We conclude that sigma(1) receptor ligands, including cocaine, augment tumor growth via a cytokine-dependent, receptor-mediated mechanism that involves regulation of T helper 1/T helper 2 cytokine balance... - Regional differences in bronchoalveolar lavage and thoracic high-resolution computed tomography results in dyspneic patients with systemic sclerosisPhilip J Clements
Department of Medicine, University of California, Los Angeles, 90095, USA
Arthritis Rheum 50:1909-17. 2004..This study was undertaken to investigate the utility of high-resolution computed tomography (HRCT) of the chest, in comparison with bronchoalveolar lavage (BAL), in the diagnosis of alveolitis in these patients... - Modifying adenoviral vectors for use as gene-based cancer vaccinesSaroj K Basak
Pulmonary and Critical Care Medicine and the Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1690, USA
Viral Immunol 17:182-96. 2004..There is every reason to believe that safer and more effective forms of AdV-based vaccines can be developed and applied to patient therapy... - Vaccination with helper-dependent adenovirus enhances the generation of transgene-specific CTLA Harui
Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA
Gene Ther 11:1617-26. 2004..We conclude that HD-AdV stimulates superior transgene-specific immune responses when compared to a FG-AdV, and that immunization with a DC-based vaccine maintains this efficacy while limiting antiviral reactivity... - Respiratory and immunologic consequences of marijuana smokingDonald P Tashkin
Deportment of Medicine, UCLA School of Medicine, 90095-1690, USA
J Clin Pharmacol 42:71S-81S. 2002..Additional well designed epidemiological and immune monitoring studies are required to determine the potential causal relationship between marijuana use and the development of respiratory infection and/or cancer... - Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2C J Hertz
Division of Dermatology and Pulmonary Medicine, Department of Microbiology and Immunology, and Molecular Biology Institute, University of California School of Medicine, Los Angeles, CA 90095, USA
J Immunol 166:2444-50. 2001..These results demonstrate that lipopeptides can stimulate DC maturation via TLR2, providing a mechanism by which products of bacteria can participate in the initiation of an immune response... - Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteinsKouki Morizono
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, BSRB 173, Charles E Young Dr South, Los Angeles, CA 90095, USA
J Virol 84:6923-34. 2010..These results indicate that the strategy of redirecting viral vectors according to alterations of their N-glycan structures would enable the vectors to target specific cells types expressing particular types of lectins... - Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobaccoS H Barsky
Department of Pathology, University of California, Los Angeles, USA
J Natl Cancer Inst 90:1198-205. 1998.... - Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected menChun Chao
Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095 1772, USA
Drug Alcohol Depend 94:165-71. 2008..These results indicate that use of these substances does not adversely affect the numbers and percentages of circulating CD4 or CD8 T cells in either HIV-uninfected or -infected MSM... - Recreational drug use and risk of Kaposi's sarcoma in HIV- and HHV-8-coinfected homosexual menChun Chao
Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
AIDS Res Hum Retroviruses 25:149-56. 2009..46 (1.01-2.13)]. However, no clear dose-response relationship was observed. These findings do not support a biological association between use of these substances and KS development in HIV- and HHV-8-coinfected homosexual men... - Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokersLiang Nong
Department of Medical Microbiology and Immunology, MDC Box 10, 12901 Bruce Downs Blvd, University of South Florida, Tampa, FL 33612, USA
J Neuroimmunol 127:169-76. 2002..These studies suggest that marijuana smoking and immune activation can alter the basal levels of CB1 and CB2 in PBMCs... - Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patientsJosephia R Muindi
Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
J Clin Pharmacol 48:96-107. 2008..25). The authors conclude that intermittent therapy with high-dose ATRA produced the greatest ATRA exposure, but alternative approaches for limiting self-induced ATRA catabolism should be sought... - Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung studyDinesh Khanna
University of Cincinnati, Cincinnati, Ohio 45267 0563, USA
Arthritis Rheum 56:1676-84. 2007..To assess the impact of cyclophosphamide (CYC) on the health-related quality of life (HRQOL) of patients with scleroderma after 12 months of treatment... - Pharmacokinetics of a novel agent, R667, in patients with emphysemaYu Yuan Chiu
Hoffmann La Roche Inc, Pharma Development Medical Pharmacology, Nutley, NJ 07110, USA
Br J Clin Pharmacol 63:527-33. 2007..To evaluate the pharmacokinetics of R667, a novel emphysema agent, in patients with moderate to severe emphysema... - Pharmacology: marijuana and your heartMichael D Roth
Nature 434:708-9. 2005
Research Grants
- CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASEMichael Roth; Fiscal Year: 2009..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
- Adjuvant immunotherapy for non-small cell lung cancerMichael Roth; Fiscal Year: 2005..abstract_text> ..
- Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral ImmunityMichael Roth; Fiscal Year: 2007..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies. ..
- CYTOKINES AS PREDICTORS OF DISEASE PROGRESSION IN SCLERODERMA LUNG DISEASEMichael Roth; Fiscal Year: 2007..It will also allow us to develop biologic markers and predictors of disease progression and to determine which patients would benefit most from treatment with cytotoxic therapy. ..
- Vector-based Generation of Monoclonal Antibodies against the CB2 ReceptorMichael Roth; Fiscal Year: 2007..This work has the capacity to significantly accelerate cannabinoid research. ..
- COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSEMichael Roth; Fiscal Year: 2006..abstract_text> ..
- Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral ImmunityMichael D Roth; Fiscal Year: 2010..These findings will help define the interrelationships between MJ abuse and opportunistic infections and provide insight into the appropriate design/use of future HIV and HBV vaccine strategies. ..