KEVIN AARON ROTH

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress
    Arindam P Ghosh
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e39586. 2012
  2. pmc The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cells
    Latika Kohli
    Departments of Pathology, University of Alabama at Birmingham, WP P210, 619 South 19th St, Birmingham, AL 35294 0017, USA
    Neuro Oncol 14:266-77. 2012
  3. pmc Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
    Liyan Qiao
    Department of Pathology, University of Alabama at Birmingham, USA
    Mol Brain 1:17. 2008
  4. pmc bcl-2/Adenovirus E1B 19-kd interacting protein 3 (BNIP3) regulates hypoxia-induced neural precursor cell death
    K C Walls
    Department of Pathology, University of Alabama at Birmingham, BirminghamAL 35294 0017, USA
    J Neuropathol Exp Neurol 68:1326-38. 2009
  5. ncbi Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 27:2081-90. 2007
  6. ncbi Molecular regulation of acute ethanol-induced neuron apoptosis
    Lisa Nowoslawski
    Department of Pathology, Division of Neuropathology University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neuropathol Exp Neurol 64:490-7. 2005
  7. ncbi p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis
    Ying Geng
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neuropathol Exp Neurol 66:66-74. 2007
  8. pmc Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis
    Ying Geng
    Department of Pathology, University of Alabama at Birmingham, USA
    J Histochem Cytochem 58:265-75. 2010
  9. pmc The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis
    Arindam P Ghosh
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Neuropathol Exp Neurol 68:747-56. 2009
  10. ncbi BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death
    Rizwan S Akhtar
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neurosci 26:7257-64. 2006

Research Grants

  1. BCL-X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2001
  2. Molecular Characterization of Neural Stem Cell Apoptosis
    Kevin Roth; Fiscal Year: 2009
  3. BCL-X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2009
  4. Multi-Modal Lysosomotropic Death Therapy for Malignant Peripheral Nerve Sheath Tu
    Kevin Roth; Fiscal Year: 2009
  5. Molecular Characterization of Neural Stem Cell Apoptosis
    KEVIN AARON ROTH; Fiscal Year: 2010
  6. BCL-X DEPENDENT NEUROPATHOLOGY
    KEVIN AARON ROTH; Fiscal Year: 2010
  7. BCL-X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2007
  8. Molecular Characterization of Neural Stem Cell Apoptosis
    Kevin Roth; Fiscal Year: 2006
  9. BCL X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2000
  10. BCL-X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2002

Collaborators

Detail Information

Publications38

  1. pmc CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress
    Arindam P Ghosh
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e39586. 2012
    ..In summary, CHOP regulates the expression of multiple pro-apoptotic BH3-only molecules through multiple mechanisms, making CHOP an important therapeutic target relevant to a number of neurodegenerative conditions...
  2. pmc The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cells
    Latika Kohli
    Departments of Pathology, University of Alabama at Birmingham, WP P210, 619 South 19th St, Birmingham, AL 35294 0017, USA
    Neuro Oncol 14:266-77. 2012
    ..We found that PD168393 and CQ in combination significantly increased cytotoxicity. We conclude that combinatorial therapies with erbB inhibitors and agents inducing lysosomal dysfunction may be an effective means of treating MPNSTs...
  3. pmc Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
    Liyan Qiao
    Department of Pathology, University of Alabama at Birmingham, USA
    Mol Brain 1:17. 2008
    ..Our data identify a conserved CD function in α-syn degradation and identify CD as a novel target for LB disease therapeutics...
  4. pmc bcl-2/Adenovirus E1B 19-kd interacting protein 3 (BNIP3) regulates hypoxia-induced neural precursor cell death
    K C Walls
    Department of Pathology, University of Alabama at Birmingham, BirminghamAL 35294 0017, USA
    J Neuropathol Exp Neurol 68:1326-38. 2009
    ..These studies demonstrate that hypoxia activates both caspase-dependent and -independent NPC death pathways that are critically regulated by multiple Bcl-2 family members...
  5. ncbi Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 27:2081-90. 2007
    ....
  6. ncbi Molecular regulation of acute ethanol-induced neuron apoptosis
    Lisa Nowoslawski
    Department of Pathology, Division of Neuropathology University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neuropathol Exp Neurol 64:490-7. 2005
    ..These studies indicate that ethanol activates an intrinsic apoptotic death program in neurons that is likely to contribute to the neuropathologic effects of human fetal alcohol exposure...
  7. ncbi p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis
    Ying Geng
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neuropathol Exp Neurol 66:66-74. 2007
    ..Thus, p53 has multiple death promoting mechanisms in cerebellar NPCs...
  8. pmc Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis
    Ying Geng
    Department of Pathology, University of Alabama at Birmingham, USA
    J Histochem Cytochem 58:265-75. 2010
    ..These observations suggest that cytoplasmic p53 can trigger transcription-independent NPC apoptosis through its potential interaction with NPM and activated Bax...
  9. pmc The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis
    Arindam P Ghosh
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Neuropathol Exp Neurol 68:747-56. 2009
    ..Collectively, these studies indicate a p53-independent, Bax- and Puma-dependent mechanism of neuronal apoptosis and identify Puma as a possible molecular target for inhibiting the effects of intrauterine ethanol exposure in humans...
  10. ncbi BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death
    Rizwan S Akhtar
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neurosci 26:7257-64. 2006
    ..Together, these experiments identify Noxa and Puma as important regulators of genotoxin-induced telencephalic NPC death...
  11. pmc Kainic acid induces early and transient autophagic stress in mouse hippocampus
    John J Shacka
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, SC 961, 1530 3rd Ave S, Birmingham, AL 35294 0017, USA
    Neurosci Lett 414:57-60. 2007
    ..Together these data indicate the transient induction of autophagic stress by KA which may serve to regulate excitotoxic death in mouse hippocampus...
  12. ncbi Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine
    Myoung Sun Roh
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Biol Psychiatry 57:278-86. 2005
    ....
  13. pmc Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3
    Tae Yeon Eom
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 282:22856-64. 2007
    ..Thus, NPCs are sensitive to loss of trophic factors and genotoxic stress, and inhibitors of GSK3 are capable of enhancing NPC survival...
  14. ncbi Caspase regulation of genotoxin-induced neural precursor cell death
    Cleta D'Sa
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    J Neurosci Res 74:435-45. 2003
    ..These studies suggest that caspase-9 activation is both necessary and sufficient for genotoxin-induced neural precursor cell reactive oxygen species generation and death...
  15. ncbi Tissue transglutaminase overexpression in the brain potentiates calcium-induced hippocampal damage
    Janusz Tucholski
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 35294, USA
    J Neurochem 97:582-94. 2006
    ....
  16. pmc Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice
    Rizwan S Akhtar
    Division of Neuropathology, Department of Pathology, University of Alabama Birmingham SC 961, 1530 3rd Avenue South, Birmingham, AL 35294 0017, USA
    J Histochem Cytochem 56:921-7. 2008
    ..Our work identifies Bim as an important regulator of bcl-x deficiency-induced cell death during hematopoiesis and testicular development...
  17. pmc Lithium prevents and ameliorates experimental autoimmune encephalomyelitis
    Patrizia De Sarno
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 181:338-45. 2008
    ....
  18. pmc Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats
    Dario Siniscalco
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, via S Maria di Costantinopoli 16, 80138 Napoli, Italy
    Pharmacol Res 57:223-33. 2008
    ....
  19. pmc Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death
    Violetta N Pivtoraiko
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Antioxid Redox Signal 11:481-96. 2009
    ....
  20. ncbi Bcl-2 family regulation of neuronal development and neurodegeneration
    Rizwan S Akhtar
    Division of Pediatric Neurology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochim Biophys Acta 1644:189-203. 2004
    ....
  21. pmc Lysosome dysfunction triggers Atg7-dependent neural apoptosis
    Ken C Walls
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 285:10497-507. 2010
    ..These findings indicate that Atg7- and Beclin1-induced autophagy plays a cytoprotective role during starvation but that Atg7 has a unique pro-apoptotic function in response to lysosome dysfunction...
  22. pmc Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction
    Violetta N Pivtoraiko
    Department of Pathology, Neuropathology Division, University of Alabama, Birmingham, AL, USA
    J Neurochem 114:1193-204. 2010
    ....
  23. pmc Differential activation of c-fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia
    Jayne M Ness
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Neurosci Res 86:1115-24. 2008
    ..The differential expression of c-Fos in HI-resistant hippocampal subpopulations vs. cleaved caspase-3 in dying neurons suggests a neuroprotective role for c-Fos expression in neonatal HI...
  24. ncbi The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy
    John J Shacka
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Front Biosci 13:718-36. 2008
    ..Potential therapies for AD and PD are also discussed that may promote survival by regulating the autophagy and lysosomal degradation pathway...
  25. ncbi Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons
    John J Shacka
    Department of Pathology, Division of Neuropathology, University of Alabama at Birmingham, SC961, 1530 3rd Ave South, Birmingham, AL 35294 0017, USA
    Mol Pharmacol 69:1125-36. 2006
    ....
  26. ncbi Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Int J Neuropsychopharmacol 10:7-19. 2007
    ..These findings may support the pharmacological mechanisms of atypical antipsychotics in the treatment of mood disorders...
  27. ncbi Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia
    Jayne M Ness
    Department of Pediatrics, University of Alabama at Birmingham, 35487, USA
    Brain Res 1099:150-9. 2006
    ..These results indicate that Bad and Bim are selectively involved in neuron death following neonatal HI and may be targets for therapeutic intervention...
  28. ncbi Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Autophagy 2:228-30. 2006
    ....
  29. ncbi Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain
    Ken C Walls
    Department of Cell Biology, Neuropathology Division, University of Alabama at Birmingham, Birmingham Alabama 35294 0017, USA
    Autophagy 3:222-9. 2007
    ..Together these observations indicate a pronounced decrease in pro-survival PI3-K signaling in CD-/- brain that may contribute to autophagic stress-induced and apoptotic neuropathology...
  30. ncbi Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Autophagy 3:474-6. 2007
    ..Herein, we review CD deficiency in the broader context of NCL and offer potential mechanisms for neuron death and neurodegeneration induced by CD deficiency...
  31. ncbi Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implications
    John J Shacka
    Division of Neuropathology, Dept of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Drug Targets CNS Neurol Disord 4:25-39. 2005
    ....
  32. ncbi Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14
    Stephen Crimmins
    Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 26:11423-31. 2006
    ....
  33. ncbi Hypertrophic neuropathies and malignant peripheral nerve sheath tumors in transgenic mice overexpressing glial growth factor beta3 in myelinating Schwann cells
    Richard P H Huijbregts
    Division of Neuropathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neurosci 23:7269-80. 2003
    ..Furthermore, overexpression of this NRG-1 isoform frequently induces neoplastic Schwann cell proliferation within PNS ganglia, suggesting that NRG-1 may contribute to human Schwann cell neoplasia...
  34. pmc Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent
    Ying Geng
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Neuro Oncol 12:473-81. 2010
    ....
  35. pmc Cathepsin deficiency as a model for neuronal ceroid lipofuscinoses
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, 35294 0017, USA
    Am J Pathol 167:1473-6. 2005
  36. pmc Autophagy: cerebral home cooking
    Latika Kohli
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Am J Pathol 176:1065-71. 2010
    ..This review summarizes the recent expansion of our understanding of the scope of this physiological process...
  37. ncbi Immunohistochemical detection with quantum dots
    Rizwan S Akhtar
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, AL, USA
    Methods Mol Biol 374:11-28. 2007
    ..QD conjugates expand the arsenal of the immunohistochemist and increase experimental flexibility in many applications...
  38. ncbi Combined tyramide signal amplification and quantum dots for sensitive and photostable immunofluorescence detection
    Jayne M Ness
    Division of Pediatric Neurology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Histochem Cytochem 51:981-7. 2003
    ..This simple method provides a sensitive and stable fluorescence immunohistochemical alternative to standard chromogen detection...

Research Grants22

  1. BCL-X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2001
    ..These experiments will yield significant new insights into the molecular pathways regulating neuronal cell death during development and neuropathological conditions. ..
  2. Molecular Characterization of Neural Stem Cell Apoptosis
    Kevin Roth; Fiscal Year: 2009
    ....
  3. BCL-X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2009
    ..In total, these studies will yield new insights into the molecular pathways regulating both physiological and pathological neuron death. ..
  4. Multi-Modal Lysosomotropic Death Therapy for Malignant Peripheral Nerve Sheath Tu
    Kevin Roth; Fiscal Year: 2009
    ..This application aims to define their mechanism of tumoricidal action and to test these lysosomotropic compounds in mouse models of MPNSTs. ..
  5. Molecular Characterization of Neural Stem Cell Apoptosis
    KEVIN AARON ROTH; Fiscal Year: 2010
    ....
  6. BCL-X DEPENDENT NEUROPATHOLOGY
    KEVIN AARON ROTH; Fiscal Year: 2010
    ..In total, these studies will yield new insights into the molecular pathways regulating both physiological and pathological neuron death. ..
  7. BCL-X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2007
    ..In total, these studies will yield new insights into the molecular pathways regulating both physiological and pathological neuron death. ..
  8. Molecular Characterization of Neural Stem Cell Apoptosis
    Kevin Roth; Fiscal Year: 2006
    ..These studies will define the key molecules regulating death in this important cell population and provide new insights into neural stem cell biology. ..
  9. BCL X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2000
    ..These experiments will yield significant new insights into the molecular pathways regulating neuronal cell death during development and neuropathological conditions. ..
  10. BCL-X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2002
    ..These experiments will yield significant new insights into the molecular pathways regulating neuronal cell death during development and neuropathological conditions. ..
  11. Molecular Characterization of Neural Stem Cell Apoptosis
    Kevin Roth; Fiscal Year: 2003
    ..These studies will define the key molecules regulating death in this important cell population and provide new insights into neural stem cell biology. ..
  12. BCL-X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2003
    ..These experiments will yield significant new insights into the molecular pathways regulating neuronal cell death during development and neuropathological conditions. ..
  13. BCL-X DEPENDENT NEUROPATHOLOGY
    Kevin Roth; Fiscal Year: 2004
    ..These experiments will yield significant new insights into the molecular pathways regulating neuronal cell death during development and neuropathological conditions. ..
  14. Multi-Modal Lysosomotropic Death Therapy for Malignant Peripheral Nerve Sheath Tu
    KEVIN AARON ROTH; Fiscal Year: 2010
    ..This application aims to define their mechanism of tumoricidal action and to test these lysosomotropic compounds in mouse models of MPNSTs. ..