Robert C Rostomily

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Clinical utility of somatostatin receptor scintigraphic imaging (octreoscan) in esthesioneuroblastoma: a case study and survey of somatostatin receptor subtype expression
    Robert C Rostomily
    Department of Neurological Surgery, University of Washington School of Medicine, Mailstop 356470 Room RR 744, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Head Neck 28:305-12. 2006
  2. pmc Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion
    Robert C Rostomily
    Department of Neurological Surgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Proteome Res 9:2610-8. 2010
  3. pmc Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy
    Andrei M Mikheev
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA 98195, USA
    Aging Cell 11:1027-35. 2012
  4. ncbi request reprint [F-18]-fluorodeoxyglucose positron emission tomography for targeting radiation dose escalation for patients with glioblastoma multiforme: clinical outcomes and patterns of failure
    James G Douglas
    Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA 98195 6043, USA
    Int J Radiat Oncol Biol Phys 64:886-91. 2006
  5. pmc Increased re-entry into cell cycle mitigates age-related neurogenic decline in the murine subventricular zone
    Elizabeth A Stoll
    Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98195 8056, USA
    Stem Cells 29:2005-17. 2011
  6. pmc TWIST1 promotes invasion through mesenchymal change in human glioblastoma
    Svetlana A Mikheeva
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Cancer 9:194. 2010
  7. pmc Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism
    Elizabeth A Stoll
    Neurobiology and Behavior Program, University of Washington, Seattle, Washington 98109, USA
    J Biol Chem 286:38592-601. 2011
  8. doi request reprint Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology
    Wootack Rhee
    Department of Neurological Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 6470, USA
    Glia 57:510-23. 2009
  9. ncbi request reprint Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, 1959 N E Pacific Street, Seattle, WA 98195 6470, USA
    Clin Cancer Res 10:7875-83. 2004
  10. pmc Geropotency: Increased malignant potential of aging neural progenitors
    Andrei M Mikheev
    Department of Neurological Surgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195
    Aging (Albany NY) 4:854-5. 2012

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Clinical utility of somatostatin receptor scintigraphic imaging (octreoscan) in esthesioneuroblastoma: a case study and survey of somatostatin receptor subtype expression
    Robert C Rostomily
    Department of Neurological Surgery, University of Washington School of Medicine, Mailstop 356470 Room RR 744, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Head Neck 28:305-12. 2006
    ..To better define the general relevance of this imaging technique in this setting, we analyzed SSTR subtype expression in a panel of ENB tumors...
  2. pmc Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion
    Robert C Rostomily
    Department of Neurological Surgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Proteome Res 9:2610-8. 2010
    ..Future analysis of larger patient samples are warranted to further refine biomarker panels to predict biological behavior and assist in the identification of deleted gene products that define the 1p/19q phenotype...
  3. pmc Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy
    Andrei M Mikheev
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA 98195, USA
    Aging Cell 11:1027-35. 2012
    ....
  4. ncbi request reprint [F-18]-fluorodeoxyglucose positron emission tomography for targeting radiation dose escalation for patients with glioblastoma multiforme: clinical outcomes and patterns of failure
    James G Douglas
    Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA 98195 6043, USA
    Int J Radiat Oncol Biol Phys 64:886-91. 2006
    ..Based on these premises, we initiated a prospective study of FDG-PET for the treatment planning of radiation dose escalation for the treatment of glioblastoma multiforme...
  5. pmc Increased re-entry into cell cycle mitigates age-related neurogenic decline in the murine subventricular zone
    Elizabeth A Stoll
    Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98195 8056, USA
    Stem Cells 29:2005-17. 2011
    ..Together, these data surprisingly suggest that progenitor cells remaining in the aged SVZ are highly proliferative...
  6. pmc TWIST1 promotes invasion through mesenchymal change in human glioblastoma
    Svetlana A Mikheeva
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA 98195, USA
    Mol Cancer 9:194. 2010
    ..We previously showed that the bHLH transcription factor TWIST1 which orchestrates carcinoma metastasis through an epithelial mesenchymal transition (EMT) is upregulated in GBM and promotes invasion of the SF767 GBM cell line in vitro...
  7. pmc Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism
    Elizabeth A Stoll
    Neurobiology and Behavior Program, University of Washington, Seattle, Washington 98109, USA
    J Biol Chem 286:38592-601. 2011
    ..These results demonstrate that aging NPCs display an altered metabolic phenotype, characterized by a coordinated shift in protein expression, subcellular structure, and metabolic physiology...
  8. doi request reprint Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology
    Wootack Rhee
    Department of Neurological Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195 6470, USA
    Glia 57:510-23. 2009
    ....
  9. ncbi request reprint Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, 1959 N E Pacific Street, Seattle, WA 98195 6470, USA
    Clin Cancer Res 10:7875-83. 2004
    ..Clin Cancer Res 2002;8:3008.). Here we examine the association of glioma Ap endo activity with clinical response after alkylating agent-based chemotherapy or after radiotherapy...
  10. pmc Geropotency: Increased malignant potential of aging neural progenitors
    Andrei M Mikheev
    Department of Neurological Surgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195
    Aging (Albany NY) 4:854-5. 2012
    ....
  11. pmc A syngeneic glioma model to assess the impact of neural progenitor target cell age on tumor malignancy
    Andrei M Mikheev
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, 98195, USA
    Aging Cell 8:499-501. 2009
    ....
  12. ncbi request reprint Regional hypoxia in glioblastoma multiforme quantified with [18F]fluoromisonidazole positron emission tomography before radiotherapy: correlation with time to progression and survival
    Alexander M Spence
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    Clin Cancer Res 14:2623-30. 2008
    ....
  13. pmc TWIST is expressed in human gliomas and promotes invasion
    Maria C Elias
    Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA
    Neoplasia 7:824-37. 2005
    ..TWIST was also expressed in embryonic and fetal human brain, and in neurons, but not glia, of mature brain, indicating that, in gliomas, TWIST may promote the functions also critical for CNS development or normal neuronal physiology...
  14. pmc Fast bound pool fraction imaging of the in vivo rat brain: association with myelin content and validation in the C6 glioma model
    Hunter R Underhill
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Neuroimage 54:2052-65. 2011
    ..The rapid, whole-brain acquisition of the bound pool fraction may provide a reliable method for detection of glioma invasion in both GM and WM during animal and human imaging...
  15. ncbi request reprint Phase II study of concurrent continuous Temozolomide (TMZ) and Tamoxifen (TMX) for recurrent malignant astrocytic gliomas
    Alexander M Spence
    Departments of Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Neurooncol 70:91-5. 2004
    ..The aim of this study was to assess the frequency of response and toxicity in adults with recurrent anaplastic astrocytoma (AA) or glioblastoma multiforme (GM) treated with concurrent continuous TMZ and TMX...
  16. ncbi request reprint Volumetric analysis of 18F-FDG PET in glioblastoma multiforme: prognostic information and possible role in definition of target volumes in radiation dose escalation
    Kevin S Tralins
    Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA
    J Nucl Med 43:1667-73. 2002
    ..On the basis of these premises, we initiated a pilot study to investigate the use of (18)F-FDG PET for the guidance of radiation dose escalation in the treatment of GBM...
  17. ncbi request reprint On-line flow cytometry for real-time surgical guidance
    Ali H Mesiwala
    Department of Neurological Surgery, University of Washington, Seattle, Washington, USA
    Neurosurgery 55:551-60; discussion 560-1. 2004
    ..For the purposes of establishing feasibility, we used measurement of deoxyribonucleic acid (DNA) content as the end point for analysis...
  18. ncbi request reprint Resection of glioblastoma
    Daniel L Silbergeld
    J Neurosurg 96:809; author reply 810. 2002

Research Grants3

  1. THE ROLE OF BHLH GENES IN GLIOGENESIS AND GLIOMA BIOLOGY
    Robert Rostomily; Fiscal Year: 2004
    ..abstract_text> ..
  2. Modeling gliomagenesis with aging glial progenitor cells and hosts
    Robert Rostomily; Fiscal Year: 2007
    ....