Genomes and Genes
M D Rossman
Affiliation: University of Pennsylvania
- Is chronic beryllium disease sarcoidosis of known etiology?Milton D Rossman
Pulmonary, Allergy and Critical Care Division, Hospital of the University of Pennsylvania, University of Pennsylvania Health System, Philadelphia, PA 19104 6160, USA
Sarcoidosis Vasc Diffuse Lung Dis 20:104-9. 2003..Similarities and differences between these two disorders are reviewed and lessons for both sarcoidosis and chronic beryllium disease are discussed...
- Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69Massimo Amicosante
Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
Respir Res 6:94. 2005..However, no genetic associations have been found between BH affected subjects not carrying the HLA-DPGlu69 susceptibility marker...
- Chronic beryllium disease: diagnosis and managementM D Rossman
Pulmonary and Critical Care Division, Hospital of the University of Pennsylvania, Philadelphia 19104 4283, USA
Environ Health Perspect 104:945-7. 1996..Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease...
- Lesson learned from ACCESS (A Case Controlled Etiologic Study of Sarcoidosis)Milton D Rossman
Pulmonary, Allergy, and Critical Care Division, Department of Medicine, Hospital of University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Proc Am Thorac Soc 4:453-6. 2007..No single cause of sarcoidosis was identified. The results of this study are reviewed and possible lessons learned are discussed...
- HLA and environmental interactions in sarcoidosisM D Rossman
Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
Sarcoidosis Vasc Diffuse Lung Dis 25:125-32. 2008..Future studies in defined phenotypes of sarcoidosis may be necessary to define environmental and genetic associations with sarcoidosis...
- HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whitesMilton D Rossman
Pulmonary, Allergy and Critical Care Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA
Am J Hum Genet 73:720-35. 2003..These studies confirm a genetic predisposition for sarcoidosis and present evidence for the allelic variation at the HLA-DRB1 locus as a major contributor...
- Human leukocyte antigen Class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivityMilton D Rossman
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Respir Crit Care Med 165:788-94. 2002..In addition, HLA amino acid epitopes on HLA-DRB1 and -DQB1, in concert with or independently of HLA-DPB1-E69, may be associated with progression to CBD...
- Genome-wide search for sarcoidosis susceptibility genes in African AmericansM C Iannuzzi
Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Genes Immun 6:509-18. 2005..Fine mapping of the linked regions, particularly on chromosome 5q, should help to refine linkage signals and guide further sarcoidosis candidate gene investigation...
- Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung diseaseMary Elizabeth Kreider
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Ann Thorac Surg 83:1140-4. 2007..To shed light on the risk-benefit ratio for this recommendation, we examined the morbidity and mortality associated with video-assisted thoracoscopic surgical (VATS) lung biopsy in a group of outpatients...
- Relationship of environmental exposures to the clinical phenotype of sarcoidosisMary Elizabeth Kreider
Division of Pulmonary and Critical Care, University of Pennsylvania School of Medicine, 826 Gates Building, 3400 Spruce St, Philadelphia, PA 19104, USA
Chest 128:207-15. 2005..We examined the relationship between environmental and occupational exposures, and the clinical phenotype of sarcoidosis...
- Recent chronic beryllium disease in residents surrounding a beryllium facilityLisa A Maier
Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 177:1012-7. 2008..Further surveillance was not performed in these communities, and additional cases have not been reported...
- Pulmonary and psychosocial findings at enrollment in the ACCESS studyHenry Yeager
Pulmonary, Critical Care, and Sleep Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
Sarcoidosis Vasc Diffuse Lung Dis 22:147-53. 2005..To assess lung involvement and the association of demographic and psychosocial factors with respiratory health in 736 persons with sarcoidosis at enrollment in A Case Control Etiologic Study of Sarcoidosis (ACCESS)...
- Chronic beryllium disease: a hypersensitivity disorderM D Rossman
Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, USA
Appl Occup Environ Hyg 16:615-8. 2001..The understanding that CBD is a hypersensitivity disorder has had important implications for the diagnosis, screening, and environmental control precautions necessary for its prevention...
- Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosisB Li
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Immunol 161:1558-67. 1998..AICD of gamma delta T cells, therefore, provides an explanation for the loss of Mtb-reactive T cells during mycobacterial infection...
- Flow cytometric test for beryllium sensitivityTatyana N Milovanova
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Cytometry B Clin Cytom 60:23-30. 2004..It offers the added specificity of enabling phenotypic description of the responding cell type and may prove to be easier to standardize for clinical use...
- A double-blinded, randomized, placebo-controlled trial of infliximab in subjects with active pulmonary sarcoidosisMilton D Rossman
Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Sarcoidosis Vasc Diffuse Lung Dis 23:201-8. 2006..CONCLUSIONS: Infliximab may improve VC in patients with active PS resistant to steroids. Larger scale, longer term studies will be needed to assess both safety and efficacy...
- Process-related risk of beryllium sensitization and disease in a copper-beryllium alloy facilityChristine R Schuler
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Am J Ind Med 47:195-205. 2005..At a copper-beryllium alloy strip and wire finishing facility we performed a cross-sectional survey to examine prevalences of beryllium sensitization and CBD, and relationships between sensitization and CBD and work areas/processes...
- Two year prognosis of sarcoidosis: the ACCESS experienceMarc A Judson
Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
Sarcoidosis Vasc Diffuse Lung Dis 20:204-11. 2003..Several factors associated with improved or worse outcome over two years were identified...
- Comparison of sarcoidosis phenotypes among affected African-American siblingsMarc A Judson
Division of Pulmonary and Critical Care Medicine CSB 812, Medical University of South Carolina, Charleston, SC 29425, USA
Chest 130:855-62. 2006..To test the hypothesis that sibling pairs, who share genes and environmental exposures, might have similar phenotypic expressions of sarcoidosis beyond what would be expected by chance alone...
- A sarcoidosis genetic linkage consortium: the sarcoidosis genetic analysis (SAGA) studyBenjamin A Rybicki
Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI 48202, USA
Sarcoidosis Vasc Diffuse Lung Dis 22:115-22. 2005..In the United States of America, African Americans have a higher sarcoidosis incidence and suffer greater morbidity than Caucasians...
- A case control etiologic study of sarcoidosis: environmental and occupational risk factorsLee S Newman
National Jewish Medical and Research Center and Univresity of Colorado Health Scienes Center, Denver, CO 80206, USA
Am J Respir Crit Care Med 170:1324-30. 2004..65, CI 0.51-0.82). The study did not identify a single, predominant cause of sarcoidosis. We identified several exposures associated with sarcoidosis risk, including insecticides, agricultural employment, and microbial bioaerosols...
- The spectrum of biopsy sites for the diagnosis of sarcoidosisAlvin S Teirstein
Mount Sinai Medical Center, New York, NY 10029, USA
Sarcoidosis Vasc Diffuse Lung Dis 22:139-46. 2005..Clinicians must decide which site offers the best chance of achieving a diagnostic biopsy with the least patient risk and discomfort...