Affiliation: University of Pennsylvania
- Retroviruses 2004: review of the 2004 Cold Spring Harbor Retroviruses ConferenceEric O Freed
HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Bg 535 Rm 108, Frederick, MD 21702 1201, USA
Retrovirology 1:25. 2004..While the most striking developments this year involved post-entry events and assembly/release, significant progress was made towards elucidating a number of aspects of the retroviral replication cycle...
- MMTV infectious cycle and the contribution of virus-encoded proteins to transformation of mammary tissueSusan R Ross
Department of Microbiology Abramson Family Cancer Center, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 1914, USA
J Mammary Gland Biol Neoplasia 13:299-307. 2008..The envelope protein may also participate in transformation. Although there have been several reports of a similar virus in human breast cancer, the existence of a human MTV has not been definitely established...
- Novel common integration sites targeted by mouse mammary tumor virus insertion in mammary tumors have oncogenic activityHyoung H Kim
Department of Microbiology Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 6:e27425. 2011..As Tcf7l2, Antxr1/Tem8, and Arhgap18 have been associated with human breast and other cancers, these data demonstrate that MMTV-induced insertional mutation remains an important means for identifying genes involved in breast cancer...
- Mouse mammary tumor virus molecular biology and oncogenesisSusan R Ross
Department of Microbiology and Abramson Cancer Center, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Viruses 2:2000-12. 2010..Thus, mammary tumor induction is a by-product of the infection cycle. A number of important oncogenes have been discovered by carrying out MMTV integration site analysis, some of which may play a role in human breast cancer...
- An immunoreceptor tyrosine activation motif in the mouse mammary tumor virus envelope protein plays a role in virus-induced mammary tumorsSusan R Ross
University of Pennsylvania, 313BRBII III, 421 Curie Blvd, Philadelphia, PA 19104, USA
J Virol 80:9000-8. 2006..Taken together, these studies indicate that the MMTV Env protein participates in mammary epithelial cell transformation in vivo and that this requires a functional ITAM in the envelope protein...
- Mouse mammary tumor virus and its interaction with the immune systemS R Ross
Department of Microbiology, University of Pennsylvania, Philadelphia 19104 6142, USA
Immunol Res 17:209-16. 1998..Thus, this virus has evolved to take maximum advantage of its host's biology...
- Junin virus infects mouse cells and induces innate immune responsesChristian D Cuevas
Department of Microbiology and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Virol 85:11058-68. 2011....
- A novel membrane protein is a mouse mammary tumor virus receptorT V Golovkina
Department of Microbiology Cancer Center, University of Pennsylvania, Philadelphia 19104 6142, USA
J Virol 72:3066-71. 1998..The MTVR sequence clone is unique, shows no homology to known membrane proteins, and is transcribed in many tissues...
- Interleukin-4 up-regulates mouse mammary tumor virus expression yet is not required for in vivo virus spreadJ Czarneski
Department of Microbiology, Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6142, USA
J Virol 75:11886-90. 2001..In spite of this, mammary tumor incidence was decreased in STAT6 null mice...
- Mouse transferrin receptor 1 is the cell entry receptor for mouse mammary tumor virusSusan R Ross
Department of Microbiology and Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 99:12386-90. 2002....
- A novel block to mouse mammary tumor virus infection of lymphocytes in B10.BR miceChioma M Okeoma
Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Virol 82:1314-22. 2008....
- Critical role of dendritic cells in mouse mammary tumor virus in vivo infectionMaria Cecilia Courreges
Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, 313 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104 6142, USA
J Virol 81:3769-77. 2007..Finally, we demonstrate that targeted ablation of dendritic cells in vivo dramatically attenuated MMTV infection. These data indicate that MMTV infection of dendritic cells is critical to initial propagation of the virus in vivo...
- Murine retroviruses activate B cells via interaction with toll-like receptor 4John C Rassa
Department of Microbiology Cancer Center, University of Pennsylvania, Philadelphia, PA 19104 6142, USA
Proc Natl Acad Sci U S A 99:2281-6. 2002..These results identify retroviral proteins that interact with a mammalian toll receptor and show that direct activation by such viruses may initiate in vivo infection pathways...
- Viral immunoreceptor-associated tyrosine-based activation motifs: potential players in oncogenesisShannon M Grande
Department of Pathology and Laboratory Medicine and Abramson Family Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Future Oncol 2:301-10. 2006..As expression of proteins bearing this motif is normally restricted to hematopoietic cells, recent work highlighting the consequences of ITAM expression in epithelial cells suggests it may play a role in solid tumor formation...
- Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infectionEnxiu Wang
Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, Rm 313 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
J Biol Chem 281:10243-9. 2006..Thus, MMTV has apparently evolved to enter cells independently of the iron status of the host...
- Presence of mouse mammary tumor virus specifically alters the body odor of miceKunio Yamazaki
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 99:5612-5. 2002..These observations, together with the prospect of artificial human odor discrimination, may aid in the search for early human diagnostics...
- Toll-like receptor 4-dependent activation of dendritic cells by a retrovirusDalia Burzyn
Division Medicina Experimental, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina
J Virol 78:576-84. 2004..Thus, retroviral signaling through TLRs plays a critical role in dendritic-cell participation during infection...
- Identification of the receptor binding domain of the mouse mammary tumor virus envelope proteinYuanming Zhang
Department of Microbiology and Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA
J Virol 77:10468-78. 2003..This suggests that, in contrast to other murine retroviruses, binding to its receptor may result in few or no changes in MMTV envelope protein conformation...
- Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytesJennifer Czarneski
Department of Microbiology, University of Pennsylvania, Philadelphia, USA
Eur J Immunol 32:945-56. 2002..These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection...
- Sodium-dependent myo-inositol transporter 1 is a cellular receptor for Mus cervicolor M813 murine leukemia virusSibyll Hein
Department of Cell and Virus Genetics, Heinrich Pette Institute for Experimental ImmunologyVirology, D 20251 Hamburg, Germany
J Virol 77:5926-32. 2003..Characterization of SMIT1 orthologues in different species identified several amino acid variations within two extracellular loops that may restrict susceptibility to M813 infection...
- Mouse mammary tumor virus and the immune systemJennifer Czarneski
Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunol Res 27:469-80. 2003..Thus, MMTV utilizes the immune system to establish infection while simultaneously avoiding immune responses...
- Interleukin-12 inhibits angiogenesis and growth of transplanted but not in situ mouse mammary tumor virus-induced mammary carcinomasJames C Lee
Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Cancer Res 62:747-55. 2002..These results point to significant differences between the vasculature of transplanted and autochthonous murine tumors and indicate that their susceptibility to antivascular therapy may differ substantially...
- Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infectionGabriel Cabrera
Instituto de Leucemia Experimental Consejo Nacional de Investigaciones Científicas y Técnicas, Division Medicina Experimental, Academia Nacional de Medicina, Pacheco de Melo 3081 1425, Buenos Aires, Argentina
J Virol 82:7422-31. 2008..Thus, our results indicated that T(reg) cells play an important and complex role during MMTV infection...
- Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenavirusesSheli R Radoshitzky
Department of Microbiology and Molecular Genetics and New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Proc Natl Acad Sci U S A 105:2664-9. 2008....
- Lack of immunological or molecular evidence for a role of mouse mammary tumor retrovirus in primary biliary cirrhosisCarlo Selmi
Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, 95616, USA
Gastroenterology 127:493-501. 2004..Recent observations, including a pilot clinical trial, have suggested that a human mouse mammary tumor virus (MMTV) causes primary biliary cirrhosis (PBC). We attempted to confirm such data...
- APOBEC3 inhibits mouse mammary tumour virus replication in vivoChioma M Okeoma
Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6142, USA
Nature 445:927-30. 2007..Last, A3(-/-) mice were more susceptible to MMTV infection, because virus spread was more rapid and extensive than in their wild-type littermates...
- MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional cultureElad Katz
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Exp Med 201:431-9. 2005..Therefore, these data suggest a heretofore unappreciated potential mechanism for the initiation of breast cancer and identify MMTV Env and ITAM-containing proteins in human breast tumors as probable oncoproteins...
- Characterization of the MMTV ReceptorSusan Ross; Fiscal Year: 2006..Together, these two approaches will allow us to better understand how viruses utilize the biology of their host for propagation and how MMTV specifically induces breast cancer in mice. ..
- Genetics of Susceptibility to MMTV-Induced Mammary TumorSusan Ross; Fiscal Year: 2006..The results obtained from these studies will greatly increase our understanding of the genetic mechanisms which viruses use to infect their hosts and how genetic resistance to such viruses in the hosts occurs. ..
- Retroviral interactions with toll-like receptorsSusan Ross; Fiscal Year: 2006..The work proposed here represents the first characterization of viral PAMPs as well as the first structural studies of the extracellular domains of TLR2 and TLR4. ..
- Role of ITAM repeats in virus-induced breast cancerSusan R Ross; Fiscal Year: 2010..These studies are of potential importance in developing new treatment paradigms for breast and other cancers, especially those associated with viruses that encode proteins that activate ITAM-mediated signaling. ..