Randal Ross

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Early expression of smooth-pursuit eye movement abnormalities in children of schizophrenic parents
    R G Ross
    University of Colorado Health Sciences Center, Denver, USA
    J Am Acad Child Adolesc Psychiatry 35:941-9. 1996
  2. pmc The stability of inhibitory and working memory deficits in children and adolescents who are children of parents with schizophrenia
    Randal G Ross
    Department of Psychiatry, University of Colorado at Denver, Denver, CO 80262, USA
    Schizophr Bull 34:47-51. 2008
  3. ncbi High rates of comorbidity are found in childhood-onset schizophrenia
    Randal G Ross
    University of Colorado at Denver and Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Schizophr Res 88:90-5. 2006
  4. ncbi Psychotic and manic-like symptoms during stimulant treatment of attention deficit hyperactivity disorder
    Randal G Ross
    Department of Psychiatry, Box C268 31, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Psychiatry 163:1149-52. 2006
  5. ncbi Saccadic eye movement task identifies cognitive deficits in children with schizophrenia, but not in unaffected child relatives
    Randal G Ross
    University of Colorado Health Sciences Center, CO, USA
    J Child Psychol Psychiatry 46:1354-62. 2005
  6. ncbi Creating school-age versions of semistructured interviews for the prodrome to schizophrenia: lessons from case reviews
    Randal G Ross
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, USA
    Schizophr Bull 29:729-35. 2003
  7. ncbi A 1-year open-label trial of olanzapine in school-age children with schizophrenia
    Randal G Ross
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Child Adolesc Psychopharmacol 13:301-9. 2003
  8. ncbi Early expression of a pathophysiological feature of schizophrenia: saccadic intrusions into smooth-pursuit eye movements in school-age children vulnerable to schizophrenia
    Randal G Ross
    Department of Psychiatry of the Denver Veterans Administration Medical Center and the University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Am Acad Child Adolesc Psychiatry 42:468-76. 2003
  9. ncbi Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes
    Randal G Ross
    Department of Psychiatry, Denver Veterans Administration Medical Center, Colorado, USA
    Psychophysiology 39:809-19. 2002
  10. ncbi Which duration of postsaccadic slowing identifies anticipatory saccades during smooth pursuit eye movements?
    R G Ross
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, USA
    Psychophysiology 38:325-33. 2001

Detail Information

Publications38

  1. ncbi Early expression of smooth-pursuit eye movement abnormalities in children of schizophrenic parents
    R G Ross
    University of Colorado Health Sciences Center, Denver, USA
    J Am Acad Child Adolesc Psychiatry 35:941-9. 1996
    ..This study compares SPEM in children of schizophrenic parents with normally developing control children to assess whether SPEM abnormalities are also present in a subset of at-risk children...
  2. pmc The stability of inhibitory and working memory deficits in children and adolescents who are children of parents with schizophrenia
    Randal G Ross
    Department of Psychiatry, University of Colorado at Denver, Denver, CO 80262, USA
    Schizophr Bull 34:47-51. 2008
    ..As etiologically driven strategies are developed for the cognitive deficits of schizophrenia, expansion of these treatments to relatives who share the cognitive but not the psychotic symptoms may be worth exploring...
  3. ncbi High rates of comorbidity are found in childhood-onset schizophrenia
    Randal G Ross
    University of Colorado at Denver and Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Schizophr Res 88:90-5. 2006
    ..Thus, there has been an increasing effort to identify and treat comorbid symptoms. This report extends that work by examining comorbidity in children and young adolescents with childhood-onset schizophrenia...
  4. ncbi Psychotic and manic-like symptoms during stimulant treatment of attention deficit hyperactivity disorder
    Randal G Ross
    Department of Psychiatry, Box C268 31, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Psychiatry 163:1149-52. 2006
  5. ncbi Saccadic eye movement task identifies cognitive deficits in children with schizophrenia, but not in unaffected child relatives
    Randal G Ross
    University of Colorado Health Sciences Center, CO, USA
    J Child Psychol Psychiatry 46:1354-62. 2005
    ..It is unknown whether school-age children, either with psychosis or as relatives of a schizophrenic proband, can be included...
  6. ncbi Creating school-age versions of semistructured interviews for the prodrome to schizophrenia: lessons from case reviews
    Randal G Ross
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, USA
    Schizophr Bull 29:729-35. 2003
    ..The inclusion of both Caregiver and Child report sections and the addition of concrete, detailed examples of clear-conscience, non-stress-related subthreshold psychotic symptoms are likely to be necessary...
  7. ncbi A 1-year open-label trial of olanzapine in school-age children with schizophrenia
    Randal G Ross
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Child Adolesc Psychopharmacol 13:301-9. 2003
    ..To determine the response of children with childhood-onset schizophrenia to a 1-year prospective, open-label trial of olanzapine...
  8. ncbi Early expression of a pathophysiological feature of schizophrenia: saccadic intrusions into smooth-pursuit eye movements in school-age children vulnerable to schizophrenia
    Randal G Ross
    Department of Psychiatry of the Denver Veterans Administration Medical Center and the University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Am Acad Child Adolesc Psychiatry 42:468-76. 2003
    ..This report describes early deficits in a putative genetic endophenotype, saccadic intrusions into smooth-pursuit eye movements (SPEM)...
  9. ncbi Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes
    Randal G Ross
    Department of Psychiatry, Denver Veterans Administration Medical Center, Colorado, USA
    Psychophysiology 39:809-19. 2002
    ..Relatives of childhood-onset and adult-onset probands had similar impairments. Gain and frequency of leading saccades may be genetic endophenotypes in childhood-onset and adult-onset schizophrenia...
  10. ncbi Which duration of postsaccadic slowing identifies anticipatory saccades during smooth pursuit eye movements?
    R G Ross
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, USA
    Psychophysiology 38:325-33. 2001
    ..54), and maintained a similar effect size across a broad age range. Leading saccades with a limited duration postsaccadic slowing criteria are a possible marker of genetic risk for schizophrenia...
  11. ncbi Diagnosis and treatment of psychiatric disorders in children with a schizophrenic parent
    R G Ross
    Denver Veterans Administration Medical Center, Research Services 151, 1055 Clermont Street, Denver, CO 80220, USA
    Schizophr Res 50:121-9. 2001
    ..The effectiveness and appropriateness of standard treatments remain unstudied in children-with-a-schizophrenic-parent...
  12. ncbi Eye movement task measures inhibition and spatial working memory in adults with schizophrenia, ADHD, and a normal comparison group
    R G Ross
    Psychiatry Service, Denver Veterans Administration Medical Center, Denver, CO 80220, USA
    Psychiatry Res 95:35-42. 2000
    ..The results are consistent with the hypothesis that working memory is a primary deficit in schizophrenia, but secondary to the inhibitory deficit in ADHD...
  13. ncbi Amplitude criteria and anticipatory saccades during smooth pursuit eye movements in schizophrenia
    R G Ross
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, USA
    Psychophysiology 36:464-8. 1999
    ..The separation of anticipatory saccades into leading saccades (anticipatory saccades with amplitude 1-4 degrees) and large anticipatory saccades (amplitude > 4 degrees) deserves further exploration...
  14. ncbi Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia
    R G Ross
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver Veterans Administration Medical Center, USA
    Am J Med Genet 88:188-99. 1999
    ..This physiological evidence suggests that childhood-onset schizophrenia may be associated with increased genetic loading because of contributions of genetic risk from both parents...
  15. ncbi Familial transmission of two independent saccadic abnormalities in schizophrenia
    R G Ross
    University of Colorado Health Sciences Center, Department of Psychiatry, Denver 80262, USA
    Schizophr Res 30:59-70. 1998
    ..However, a second familial factor related to the maintenance or manipulation of spatial information may also contribute to the genetic risk of the full clinical disorder...
  16. ncbi Varied effects of atypical neuroleptics on P50 auditory gating in schizophrenia patients
    Lawrence E Adler
    Box C268 26, Psychiatry, University of Colorado Health Science Ctr, 4200 East 9th Ave, Denver, CO 80262, USA
    Am J Psychiatry 161:1822-8. 2004
    ..This study sought to determine whether other atypical neuroleptics improve P50 ratios...
  17. pmc Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia
    Sarah H Stephens
    Department of Psychiatry, University of Colorado at Denver, United States
    Schizophr Res 109:102-12. 2009
    ..CHRNA7 was selected as the best candidate gene in the region for a well-documented endophenotype of schizophrenia, the P50 sensory processing deficit, by genetic linkage and biochemical studies...
  18. pmc Early biomarkers of psychosis
    Robert Freedman
    Department of Psychiatry C 268 71, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Dialogues Clin Neurosci 7:17-29. 2005
    ..Examples are given from work on the role of the alpha(T)nicotinic receptor and its gene CHRNA7 on chromosome 15 in the neurobiology and genetic transmission of schizophrenia...
  19. ncbi Physiology of schizophrenia, bipolar disorder, and schizoaffective disorder
    Laura F Martin
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Am J Psychiatry 164:1900-6. 2007
    ..A second aim was to determine whether subjects with schizoaffective disorder, bipolar type, were neurophysiologically more similar to subjects with schizophrenia or subjects with bipolar disorder...
  20. ncbi Story stem responses of preschoolers with mood disturbances
    Carol Beresford
    Department of Psychiatry, University of Colorado at Denver, Denver, CO 80262, USA
    Attach Hum Dev 9:255-70. 2007
    ....
  21. ncbi Use of the ADOS and ADI-R in children with psychosis: importance of clinical judgment
    Judith A Reaven
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Aurora 80045, USA
    Clin Child Psychol Psychiatry 13:81-94. 2008
    ..Issues concerning overlap of symptom presentation and implications for research and clinical use of these assessment tools are discussed...
  22. ncbi Neuropsychological deficits in children associated with increased familial risk for schizophrenia
    Deana B Davalos
    Department of Psychiatry, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Schizophr Res 67:123-30. 2004
    ..However, inhibition also appeared to be a cognitive process that significantly differentiated the groups. The possibility of a developmental expression of neurocognitive deficits is discussed...
  23. ncbi Neurobiology of smooth pursuit eye movement deficits in schizophrenia: an fMRI study
    Jason R Tregellas
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Psychiatry 161:315-21. 2004
    ..The investigators used functional magnetic resonance imaging (fMRI) to compare brain hemodynamic response during a smooth pursuit eye movement task in patients with schizophrenia and healthy comparison subjects...
  24. ncbi Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia
    Sherry Leonard
    Department of Psychiatry, Campus Box C 268 71, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262, USA
    Arch Gen Psychiatry 59:1085-96. 2002
    ..This study presents DNA sequence analysis of the core promoter region for CHRNA7 in schizophrenic and control subjects...
  25. ncbi Input dysfunction, schizotypy, and genetic models of schizophrenia
    Robert Freedman
    Department of Psychiatry and Pharmacology, University of Colorado Health Sciences Center, Campus Box C 268 71, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Schizophr Res 54:25-32. 2002
    ..Thus, as predicted by Venables, the substrates of schizotypy and schizophrenia may arise from variants in normal brain function...
  26. ncbi Differential effects of cigarette smoking on performance of a smooth pursuit and a saccadic eye movement task in schizophrenia
    Ann Olincy
    Department of Psychiatry, University of Colorado Health Sciences Center, 4200 E 9th Ave, Box C 268 71, Denver, CO 80262, USA
    Psychiatry Res 117:223-36. 2003
    ..However, premature saccades and large anticipatory saccades, although measures of inhibitory dysfunction in schizophrenia, appear to be unrelated to the nicotinic system...
  27. ncbi Early postnatal development of sensory gating
    Michael A Kisley
    Schizophrenia Research Center, Denver Veteran s Affairs Medical Center, Colorado, USA
    Neuroreport 14:693-7. 2003
    ..Nevertheless, these results demonstrate that the neural circuits underlying sensory gating are functional very early in postnatal development...
  28. ncbi Effects of interval duration on temporal processing in schizophrenia
    Deana B Davalos
    Denver VA Medical Center, University of Colorado Health Sciences Center, Denver, CO, USA
    Brain Cogn 52:295-301. 2003
    ....
  29. ncbi Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects
    Judith Gault
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet B Neuropsychiatr Genet 123:39-49. 2003
    ..Twenty-one variants were found in the exons, but non-synonymous changes were rare. Although the expression of CHRNA7 is decreased in schizophrenia, the general structure of the remaining receptors is likely to be normal...
  30. doi Reliability of P50 auditory sensory gating measures in infants during active sleep
    Sharon K Hunter
    Department of Psychiatry, University of Colorado at Denver and the Health Sciences Center, Denver, Colorado 80262, USA
    Neuroreport 19:79-82. 2008
    ..The results suggest that auditory sensory gating can be reliably measured during active sleep in young infants and might be a useful tool in the study of neurodevelopmental disorders...
  31. ncbi Eye movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probands
    Dianne L Koczat
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Autism Dev Disord 32:513-8. 2002
    ..These deficits deserve further evaluation as a potential endophenotypic marker for genetic risk for autism...
  32. ncbi Childhood-onset schizophrenia: premorbid and prodromal diagnostic and treatment histories
    John L Schaeffer
    Department of Psychiatry, Denver Veterans Administration Medical Center, CO 80262, USA
    J Am Acad Child Adolesc Psychiatry 41:538-45. 2002
    ..This study reviews the premorbid and prodromal diagnostic and treatment histories for childhood-onset schizophrenia, to assess whether early identification and treatment is possible in this school-age group...
  33. pmc Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia
    Randal G Ross
    Department of Psychiatry, University of Colorado Denver, Aurora, CO, USA
    J Child Psychol Psychiatry 51:535-49. 2010
    ..Therapeutic implications, including perinatal dietary choline supplementation, are discussed...
  34. pmc Regulation of a novel alphaN-catenin splice variant in schizophrenic smokers
    Sharon Mexal
    Institute for Behavioral Genetics, Boulder, Colorado, USA
    Am J Med Genet B Neuropsychiatr Genet 147:759-68. 2008
    ..The recent evolutionary divergence of this gene, as well as the differences in gene expression in postmortem brain of schizophrenic non-smokers, supports the role of alphaN-catenin III as a novel disease susceptibility gene...
  35. ncbi Brain activation during smooth-pursuit eye movements
    Jody Tanabe
    Department of Radiology, University of Colorado Health Sciences Center, Denver, 80262, USA
    Neuroimage 17:1315-24. 2002
    ..In addition, session-dependent changes in activation were greater in some regions than others and may indicate areas of brain, such as the supplementary eye fields, that are sensitive to attentional modulation of eye movements...
  36. ncbi Mismatch negativity in detection of interval duration deviation in schizophrenia
    Deana B Davalos
    Denver VA Medical Center, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box C268 71, Denver, CO 80262, USA
    Neuroreport 14:1283-6. 2003
    ..Results suggest that behavioral difficulties on time processing tasks in schizophrenia may reflect a physiological deficit in temporal perception in this population rather than simply more general difficulties in attention or motivation...
  37. pmc Assessing disordered thoughts in preschoolers with dysregulated mood
    Amanda K Hutchison
    Department of Psychiatry, University of Colorado Denver, School of Medicine, Anschutz Medical Campus, Campus Box F546, P O Box 6508, Aurora, CO 80045, USA
    Child Psychiatry Hum Dev 41:479-89. 2010
    ..This preschool expression of dysregulated mood appears similar to and possibly continuous with school-age and adult versions of bipolar disorder...
  38. doi New findings on antipsychotic use in children and adolescents with schizophrenia spectrum disorders
    Randal G Ross
    Am J Psychiatry 165:1369-72. 2008

Research Grants18

  1. Training Medical Students to Become Child Psychiatrists
    Randal Ross; Fiscal Year: 2007
    ..This program would help abate the national shortage of skilled child psychiatry researchers. ..
  2. Childhood Physiology and Risk for Schizophrenia
    Randal Ross; Fiscal Year: 2007
    ..Clarification of this methodology may lead to a novel prenatal intervention strategy designed to decrease risk for adolescent and adult onset of psychosis. ..
  3. Abnormal Eye Movement in Schizophrenia: Genome-Wide Scan
    Randal Ross; Fiscal Year: 2007
    ..Linkage in both groups will assessed using methods capable of detecting genetic effects on quantitative traits. ..
  4. Childhood Physiology and Risk for Schizophrenia
    Randal Ross; Fiscal Year: 2006
    ..Clarification of this methodology may lead to a novel prenatal intervention strategy designed to decrease risk for adolescent and adult onset of psychosis. ..
  5. Abnormal Eye Movement in Schizophrenia: Genome-Wide Scan
    Randal Ross; Fiscal Year: 2006
    ..Linkage in both groups will assessed using methods capable of detecting genetic effects on quantitative traits. ..
  6. Childhood Physiology and Risk for Schizophrenia
    Randal Ross; Fiscal Year: 2005
    ..Clarification of this methodology may lead to a novel prenatal intervention strategy designed to decrease risk for adolescent and adult onset of psychosis. ..
  7. Abnormal Eye Movement in Schizophrenia: Genome-Wide Scan
    Randal Ross; Fiscal Year: 2005
    ..Linkage in both groups will assessed using methods capable of detecting genetic effects on quantitative traits. ..
  8. Perinatal Vulnerability to Psychosis
    Randal Ross; Fiscal Year: 2004
    ....
  9. Childhood Physiology and Risk for Schizophrenia
    Randal Ross; Fiscal Year: 2004
    ..Clarification of this methodology may lead to a novel prenatal intervention strategy designed to decrease risk for adolescent and adult onset of psychosis. ..
  10. Abnormal Eye Movement in Schizophrenia: Genome-Wide Scan
    Randal Ross; Fiscal Year: 2004
    ..Linkage in both groups will assessed using methods capable of detecting genetic effects on quantitative traits. ..
  11. SMOOTH PURSUIT EYE MOVEMENTS--CHILDREN OF SCHIZOPHRENICS
    Randal Ross; Fiscal Year: 2001
    ..SPEM testing, behavioral and symptom evaluations, and peer adjustment assessments will be repeated 2 years after entry into the study. This will help differentiate these possibilities (aim #4 of this proposal). ..
  12. SMOOTH PURSUIT EYE MOVEMENTS--CHILDREN OF SCHIZOPHRENICS
    Randal Ross; Fiscal Year: 2000
    ..SPEM testing, behavioral and symptom evaluations, and peer adjustment assessments will be repeated 2 years after entry into the study. This will help differentiate these possibilities (aim #4 of this proposal). ..
  13. SMOOTH PURSUIT EYE MOVEMENTS--CHILDREN OF SCHIZOPHRENICS
    Randal Ross; Fiscal Year: 1999
    ..SPEM testing, behavioral and symptom evaluations, and peer adjustment assessments will be repeated 2 years after entry into the study. This will help differentiate these possibilities (aim #4 of this proposal). ..