MICHAEL GLENN ROSS

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth-restricted offspring
    Thomas R Magee
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Am J Obstet Gynecol 199:271.e1-5. 2008
  2. doi request reprint Developmental programming of offspring obesity, adipogenesis, and appetite
    Michael G Ross
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, USA
    Clin Obstet Gynecol 56:529-36. 2013
  3. pmc Peroxisome proliferator-activated receptor gamma modulation and lipogenic response in adipocytes of small-for-gestational age offspring
    Jennifer K Yee
    Department of Pediatrics, Division of Endocrinology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1000 West Carson Street, Harbor Box 446, Torrance, CA 90509, USA
    Nutr Metab (Lond) 9:62. 2012
  4. doi request reprint Correlation of arterial fetal base deficit and lactate changes with severity of variable heart rate decelerations in the near-term ovine fetus
    Michael G Ross
    Department of Obstetrics and Gynecology, LA BioMed at Harbor UCLA Medical Center, Torrance, CA, USA
    Am J Obstet Gynecol 208:285.e1-6. 2013
  5. pmc Altered placental development in undernourished rats: role of maternal glucocorticoids
    Louiza Belkacemi
    Department of Obstetrics and Gynecology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Reprod Biol Endocrinol 9:105. 2011
  6. pmc Organ-specific alterations in fatty acid de novo synthesis and desaturation in a rat model of programmed obesity
    Jennifer K Yee
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Bldg RB 1, Harbor Box 446, Torrance, CA 90502, USA
    Lipids Health Dis 10:72. 2011
  7. pmc Adult sequelae of intrauterine growth restriction
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Semin Perinatol 32:213-8. 2008
  8. ncbi request reprint Maternal plasma hypertonicity is accentuated in the postterm rat
    Subhashini J Ladella
    Perinatal Research Laboratories, The Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles and Harbor UCLA Medical Center, 1000 W Carson Street, Torrance, CA 90509, USA
    Am J Obstet Gynecol 189:1439-44. 2003
  9. ncbi request reprint Impact of FDA advisory on reported vacuum-assisted delivery and morbidity
    M G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California, USA
    J Matern Fetal Med 9:321-6. 2000
  10. ncbi request reprint Objective cervical portio length measurements: consistency and efficacy of screening for a short cervix
    Michael G Ross
    San Diego Perinatal Center and Sharp Mary Birch Hospital for Women, San Diego, California, USA
    J Reprod Med 52:385-9. 2007

Collaborators

Detail Information

Publications83

  1. pmc Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth-restricted offspring
    Thomas R Magee
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Am J Obstet Gynecol 199:271.e1-5. 2008
    ..We hypothesized that IUGR-induced inhibition of hepatic peroxisome proliferator-activated receptors (PPARs) is associated with an increased inflammatory response...
  2. doi request reprint Developmental programming of offspring obesity, adipogenesis, and appetite
    Michael G Ross
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, USA
    Clin Obstet Gynecol 56:529-36. 2013
    ..Future strategies for the prevention and therapy of obesity must address programming effects of the early life environment. ..
  3. pmc Peroxisome proliferator-activated receptor gamma modulation and lipogenic response in adipocytes of small-for-gestational age offspring
    Jennifer K Yee
    Department of Pediatrics, Division of Endocrinology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, 1000 West Carson Street, Harbor Box 446, Torrance, CA 90509, USA
    Nutr Metab (Lond) 9:62. 2012
    ..abstract:..
  4. doi request reprint Correlation of arterial fetal base deficit and lactate changes with severity of variable heart rate decelerations in the near-term ovine fetus
    Michael G Ross
    Department of Obstetrics and Gynecology, LA BioMed at Harbor UCLA Medical Center, Torrance, CA, USA
    Am J Obstet Gynecol 208:285.e1-6. 2013
    ..Recent guidelines classify variable decelerations without detail as to degree of depth. We hypothesized that variable deceleration severity is highly correlated with fetal base deficit accumulation...
  5. pmc Altered placental development in undernourished rats: role of maternal glucocorticoids
    Louiza Belkacemi
    Department of Obstetrics and Gynecology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Reprod Biol Endocrinol 9:105. 2011
    ....
  6. pmc Organ-specific alterations in fatty acid de novo synthesis and desaturation in a rat model of programmed obesity
    Jennifer K Yee
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Bldg RB 1, Harbor Box 446, Torrance, CA 90502, USA
    Lipids Health Dis 10:72. 2011
    ....
  7. pmc Adult sequelae of intrauterine growth restriction
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Semin Perinatol 32:213-8. 2008
    ..In some animal models, aspects of fetal programming can be reversed postnatally; however, at the present time, the best strategy for avoiding the adult consequences of fetal growth restriction is prevention...
  8. ncbi request reprint Maternal plasma hypertonicity is accentuated in the postterm rat
    Subhashini J Ladella
    Perinatal Research Laboratories, The Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles and Harbor UCLA Medical Center, 1000 W Carson Street, Torrance, CA 90509, USA
    Am J Obstet Gynecol 189:1439-44. 2003
    ..We sought to determine whether the relative maternal plasma hypertonicity continues in the postterm period...
  9. ncbi request reprint Impact of FDA advisory on reported vacuum-assisted delivery and morbidity
    M G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California, USA
    J Matern Fetal Med 9:321-6. 2000
    ..We compared FDA reports of vacuum delivery adverse events prior to and following the advisory...
  10. ncbi request reprint Objective cervical portio length measurements: consistency and efficacy of screening for a short cervix
    Michael G Ross
    San Diego Perinatal Center and Sharp Mary Birch Hospital for Women, San Diego, California, USA
    J Reprod Med 52:385-9. 2007
    ..To determine the consistency of 4-quadrant cervical portio length measurements with an objective cervical measuring device and to identify patients who may benefit from transvaginal ultrasound...
  11. ncbi request reprint Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Curr Alzheimer Res 4:213-7. 2007
    ..These findings suggest that potential risk factors for the development of Alzheimer's disease may be present as early as newborn life...
  12. ncbi request reprint Cervical neck dislocation associated with the Zavanelli maneuver
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Obstet Gynecol 108:737-8. 2006
    ..Reports of the Zavanelli maneuver have been remarkably optimistic despite the challenges of the procedure...
  13. ncbi request reprint Prenatal programming of hypernatremia and hypertension in neonatal lambs
    Michael G Ross
    Department of Obstetrics and Gynecology, University of California, Los Angeles, Harbor UCLA Medical Center, 1000 W Carson St, Box 3, Torrance, CA 90509, USA
    Am J Physiol Regul Integr Comp Physiol 288:R97-103. 2005
    ..In utero hypertonicity and perhaps maternal nutrient stress may program offspring osmoregulation and systemic arterial hypertension...
  14. ncbi request reprint Gestational programming: population survival effects of drought and famine during pregnancy
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, 1000 W Carson St, Box 3, Torrance, CA 90509, USA
    Am J Physiol Regul Integr Comp Physiol 288:R25-33. 2005
    ..Importantly, these results suggest that programming effects may be either potentiated or prevented by interventions during the neonatal period...
  15. ncbi request reprint Programmed syndrome of hypernatremic hypertension in ovine twin lambs
    Michael G Ross
    Department of Obstetrics and Gynecology, Box 3, Harbor UCLA Medical Center, 1000 W Carson St, Torrance, CA 90509 2910, USA
    Am J Obstet Gynecol 192:1196-204. 2005
    ..Because the sheep pregnancy consists of singleton and twin litters, we sought to determine the impact of ovine twin gestation and twin nursing on the cardiovascular and renal function of the offspring...
  16. doi request reprint Prediction of preterm birth: nonsonographic cervical methods
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Semin Perinatol 33:312-6. 2009
    ....
  17. ncbi request reprint Gastric emptying cycles in the human fetus
    Masakatsu Sase
    Department of Reproductive, Pediatric, and Infection Science, Division of Medicine for Maternal and Child Health, Yamaguchi University School of Medicine, Japan
    Am J Obstet Gynecol 193:1000-4. 2005
    ..We sought to determine the patterns of human fetal gastric emptying cycles across gestation...
  18. ncbi request reprint National Institute of Child Health and Development Conference summary: amniotic fluid biology--basic and clinical aspects
    M G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California, 90509 2910, USA
    J Matern Fetal Med 10:2-19. 2001
    ..Further, various clinical AF therapies remain largely experimental and their optimization and utilization need exploration. This report is a condensation of the views presented by the conference participants...
  19. doi request reprint Labor and fetal heart rate decelerations: relation to fetal metabolic acidosis
    Michael G Ross
    Department of Obstetrics and Gynecology, Geffen School of Medicine at UCLA, Los Angeles Harbor UCLA Medical Center, Torrance, California, USA
    Clin Obstet Gynecol 54:74-82. 2011
    ..The knowledge of normal changes in fetal metabolic acidosis during labor together with changes in association with fetal heart rate decelerations, can aid in the interpretation and management of fetal heart rate tracings...
  20. ncbi request reprint Unopposed orexic pathways in the developing fetus
    Michael G Ross
    University of California, Los Angeles, Harbor UCLA Medical Center, 1000 West, Carson Street, Box 3, Torrance, CA 90509, USA
    Physiol Behav 79:79-88. 2003
    ..Thus, dysfunctional appetite, and perhaps obesity, may result from maternal environmental influences during critical stages of development...
  21. ncbi request reprint Use of umbilical artery base excess: algorithm for the timing of hypoxic injury
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor University of California Los Angeles Medical Center, Torrance, 90509, USA
    Am J Obstet Gynecol 187:1-9. 2002
    ....
  22. ncbi request reprint Effect of oral sucrose on ingestive behavior in the near-term ovine fetus
    Mostafa A El-Haddad
    Perinatal Research Laboratories, Harbor UCLA Medical Center, University of California Los Angeles School of Medicine, 1124 W Carson Street, RB 1, Torrance, CA 90502, USA
    Am J Obstet Gynecol 187:898-901. 2002
    ..In the adult, sweet taste stimulates and potentiates ingestive behavior. We sought to determine whether oropharyngeal sucrose exposure stimulates ingestive behavior in the near-term ovine fetus...
  23. ncbi request reprint Chronic in utero plasma hyperosmolality alters hypothalamic arginine vasopressin synthesis and pituitary arginine vasopressin content in newborn lambs
    Bernice A Ramirez
    Department of Obstetrics and Gynecology, Harbor UCLA Research and Education Institute, School of Medicine, University of California, Los Angeles, Torrance, 90502, USA
    Am J Obstet Gynecol 187:191-6. 2002
    ....
  24. ncbi request reprint Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Torrance, CA, USA
    Am J Physiol Regul Integr Comp Physiol 288:R91-6. 2005
    ..Thus the degree of newborn nutrient enhancement and timing of IUGR newborn catch-up growth may determine the programming of orexigenic hormones and offspring obesity...
  25. doi request reprint Early undernutrition attenuates the inflammatory response in adult rat offspring
    Mina Desai
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, 90502, USA
    J Matern Fetal Neonatal Med 22:571-5. 2009
    ..We determined the impact of maternal food restriction during gestation and lactation or lactation alone on basal inflammation and lipopolysaccharide (LPS)-stimulated cytokine induction in adult female offspring...
  26. ncbi request reprint Neuronal NO modulates spontaneous and ANG II-stimulated fetal swallowing behavior in the near-term ovine fetus
    Mostafa A El-Haddad
    Perinatal Research Laboratories, Harbor University of California at Los Angeles Medical Center, University of California at Los Angeles School of Medicine, Torrance, California 90902, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1521-7. 2002
    ..0 +/- 0.04 swallows/min; P = 0.001). We speculate that the suppressive dipsogenic effects of central NPLA indicate that spontaneous and ANG II- stimulated fetal swallowing is dependent on central nNOS activity...
  27. ncbi request reprint Programming of hypertonicity in neonatal lambs: resetting of the threshold for vasopressin secretion
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Harbor UCLA Medical Center, Torrance 90502, USA
    Endocrinology 144:4332-7. 2003
    ..We postulate that the nutritional stress associated with twins (as well as dehydration-induced anorexia) contributes to increased plasma sodium levels, whereas the increased plasma osmolality is due to in utero hypertonicity...
  28. pmc Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth
    Darran N Tosh
    David Geffen School of Medicine at University of California Los Angeles, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Los Angeles, California, USA
    Am J Physiol Gastrointest Liver Physiol 299:G1023-9. 2010
    ..Modulation of the rate of IUGR newborn catch-up growth may thus protect against IGF1 epigenetic modifications and, consequently, obesity and associated metabolic abnormalities...
  29. ncbi request reprint Corticotropin-releasing factor inhibition of sheep fetal colonic contractility: mechanisms to prevent meconium passage in utero
    Jayaraman Lakshmanan
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA, USA
    Am J Obstet Gynecol 196:357.e1-7. 2007
    ..In humans, fetal in utero meconium (MEC) passage rarely occurs before term gestation. We hypothesized the existence of inhibitory mechanism(s) preventing colonic motility and MEC passage prior to term...
  30. ncbi request reprint Nutrient restriction in utero induces remodeling of the vascular extracellular matrix in rat offspring
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Reprod Sci 14:73-80. 2007
    ..By 2 months of life, the compositions of both vessel types are consistent with stiff vessels, a contributing factor to hypertension...
  31. ncbi request reprint Gender-specific orexigenic and anorexigenic mechanisms in rats
    Dave A Gayle
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA and Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance CA 90502, United States
    Life Sci 79:1531-6. 2006
    ....
  32. ncbi request reprint Maternal LPS induces cytokines in the amniotic fluid and corticotropin releasing hormone in the fetal rat brain
    Dave A Gayle
    Department of Obstetrics and Gynecology, Harbor University of California Los Angleles Medical Center and Research and Education Institute, Torrance, CA 90502, USA
    Am J Physiol Regul Integr Comp Physiol 286:R1024-9. 2004
    ..These findings suggest that maternal infections may lead to an unbalanced inflammatory reaction in the fetal environment that activates the fetal stress axis...
  33. ncbi request reprint Placental and fetal membrane Nephrin and Neph1 gene expression: response to inflammation
    Marie H Beall
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
    J Soc Gynecol Investig 12:298-302. 2005
    ..We sought to investigate whether nephrin and Neph1 were expressed in placenta and fetal membranes, and whether inflammation modified the expression...
  34. ncbi request reprint Protective effect of prenatal water restriction on offspring cardiovascular homeostasis in response to hemorrhage
    Mina Desai
    Dept of Obstetrics and Gynecology, LABioMed at Harbor UCLA Medical Center, 1124 West Carson St Box 446, RB 1 Bldg, Torrance, CA 90502, USA
    Am J Physiol Heart Circ Physiol 288:H2659-65. 2005
    ..Despite potential long-term adverse effects of systemic hypertension, these results suggest a protective effect of prenatal water restriction on offspring cardiovascular homeostasis during blood volume reduction...
  35. ncbi request reprint A randomized controlled trial of prophylactic maneuvers to reduce head-to-body delivery time in patients at risk for shoulder dystocia
    Marie H Beall
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, David Geffen School of Medicine at the University of California, Los Angeles, Torrance 90509, USA
    Obstet Gynecol 102:31-5. 2003
    ..To assess whether prophylactic use of the McRoberts maneuver and suprapubic pressure decreased the head-to-body time, as a proxy for shoulder dystocia, in at-risk patients...
  36. ncbi request reprint Adult obesity as a consequence of in utero programming
    Marie H Beall
    Department of Obstetrics and Gynecology, Geffen School of Medicine at the University of California, Los Angeles, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Clin Obstet Gynecol 47:957-66; discussion 980-1. 2004
  37. ncbi request reprint Central angiotensin II AT1 receptors mediate fetal swallowing and pressor responses in the near-term ovine fetus
    Mostafa A El-Haddad
    David Geffen UCLA Medical School, Research and Educational Institute, Harbor UCLA Medical Center, 1124 W Carson St, RB 1, Torrance, CA 90502, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1014-20. 2005
    ..These data demonstrate that in the near-term ovine fetus, AT1 receptor but not AT2 receptors accessible via CSF contribute to dipsogenic and pressor responses...
  38. ncbi request reprint Programmed hyperphagia due to reduced anorexigenic mechanisms in intrauterine growth-restricted offspring
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Torrance, California 90502, USA
    Reprod Sci 14:329-37. 2007
    ..This reduced anorexigenic function, together with normal or perhaps enhanced orexigenic function, contributes to the development of programmed obesity in IUGR rat offspring...
  39. ncbi request reprint Meconium passage in utero: mechanisms, consequences, and management
    Sureshbabu N Ahanya
    Department of Ob Gyn, Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, California 90509, USA
    Obstet Gynecol Surv 60:45-56; quiz 73-4. 2005
    ..This article reviews aspects of meconium passage in utero, its consequences, and management...
  40. pmc Central insulin sensitivity in male and female juvenile rats
    Erin Keen-Rhinehart
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Horm Behav 56:275-80. 2009
    ..The anorexigenic responsiveness of both genders suggests a potential pharmacologic approach to childhood obesity...
  41. ncbi request reprint Gender-specific programmed hepatic lipid dysregulation in intrauterine growth-restricted offspring
    Gyu Yeon Choi
    Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, CA, USA
    Am J Obstet Gynecol 196:477.e1-7. 2007
    ..Because lipid homeostasis is regulated by the liver, we hypothesized that hepatic structure and lipid content in intrauterine growth restriction would reflect a primary lipid dysfunction...
  42. pmc Enhanced nephrogenesis in offspring of water-restricted rat dams
    Roy Mansano
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Obstet Gynecol 196:480.e1-6. 2007
    ..Maternal water restriction (WR) may induce offspring plasma hypertonicity and enhanced vasopressin secretory responses. We determined effects of pregnancy WR on offspring body composition, renal morphology, and blood pressure...
  43. ncbi request reprint Maternal undernutrition inhibits angiogenesis in the offspring: a potential mechanism of programmed hypertension
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor University of California at Los Angeles Medical Center, 1000 W Carson St, Torrance, CA 90502, USA
    Am J Physiol Regul Integr Comp Physiol 293:R745-53. 2007
    ....
  44. pmc The timing of nutrient restriction during rat pregnancy/lactation alters metabolic syndrome phenotype
    Mina Desai
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
    Am J Obstet Gynecol 196:555.e1-7. 2007
    ..We investigated the impact of rapid versus delayed catch-up growth of IUGR offspring on glucose and lipid profiles...
  45. ncbi request reprint N-acetyl-cysteine suppresses amniotic fluid and placenta inflammatory cytokine responses to lipopolysaccharide in rats
    Ron Beloosesky
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute, Torrance, CA, USA
    Am J Obstet Gynecol 194:268-73. 2006
    ....
  46. ncbi request reprint Cardiovascular regulation and expressions of NO synthase-tyrosine hydroxylase in nucleus tractus solitarius of ovine fetus
    Sheng Xing Ma
    Department of Obstetrics and Gynecology, Harbor University of California Los Angles Medical Center, UCLA Medical School, Torrance, 90502, USA
    Am J Physiol Heart Circ Physiol 284:H1057-63. 2003
    ..The results suggest that during birth, there is upregulation of NADPHd/nNOS in the noradrenergic neurons of mNTS resulting in a centrally mediated reduction of fetal arterial blood pressure...
  47. ncbi request reprint N-methyl-D-aspartate glutamate receptor mediates spontaneous and angiotensin II-stimulated ovine fetal swallowing
    Mostafa A El-Haddad
    Perinatal Research Laboratories, Harbor UCLA Medical Center, School of Medicine, Los Angeles, California, USA
    J Soc Gynecol Investig 12:504-9. 2005
    ..The aim of present study was to determine the role of central NMDA receptors in the modulation of fetal swallowing activity...
  48. ncbi request reprint Expression of aquaporin 9 in human chorioamniotic membranes and placenta
    Shengbiao Wang
    Harbor UCLA Medical Center, 1000 W Carson St, Box 3, Torrance, CA 90502, USA
    Am J Obstet Gynecol 191:2160-7. 2004
    ..To investigate the molecular mechanism of intramembranous pathway of amniotic fluid regulation, we sought to determine whether AQP9 is expressed, and the cellular localization of AQP9 expression in human fetal membranes...
  49. ncbi request reprint Gender specificity of programmed plasma hypertonicity and hemoconcentration in adult offspring of water-restricted rat dams
    Mina Desai
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, LABiomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance 90502, USA
    J Soc Gynecol Investig 12:409-15. 2005
    ..We studied the impact of maternal water-restriction during rat pregnancy on newborn plasma composition, and determined the persistence of plasma composition alterations in adult offspring...
  50. ncbi request reprint Ontogeny of gastric emptying patterns in the human fetus
    Masakatsu Sase
    Division of Medicine for Maternal and Child Health, Department of Reproductive, Pediatric and Infection Science, Yamaguchi University School of Medicine, Yamaguchi, Japan
    J Matern Fetal Neonatal Med 17:213-7. 2005
    ..We speculated that fetal gastric emptying must be functional early in gestation to prevent rapid increases in AF. We sought to determine the human fetal ontogenic pattern of gastric emptying...
  51. ncbi request reprint Persistent sucrose stimulation of ovine fetal ingestion: lack of adaptation responses
    Mostafa A El-Haddad
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, California, USA
    J Matern Fetal Neonatal Med 18:123-7. 2005
    ..We sought to determine if prolonged oral sucrose infusion to the near term ovine fetus will evoke adaptation, as manifested by reduced swallowing stimulation...
  52. ncbi request reprint Maternal DDAVP-induced hyponatremia preserves fetal urine flow during acute fetal hemorrhage
    Mina Desai
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, Harbor University of California Los Angeles Medical Center, Torrance, CA 90502, USA
    Am J Physiol Regul Integr Comp Physiol 285:R373-9. 2003
    ..These results suggest that under conditions of acute fetal stress of hemorrhage, maternal DDAVP may preserve fetal urine flow and amniotic fluid volume...
  53. ncbi request reprint Fetal ST segment heart rate analysis in labor: improvement of intervention criteria using interpolated base deficit
    Roy Z Mansano
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California 90509, USA
    J Matern Fetal Neonatal Med 20:47-52. 2007
    ..We sought to determine if FHR ST segment analysis recommends intervention at appropriate levels of fetal acidosis...
  54. ncbi request reprint Fetal gastrointestinal motility in a rabbit model of gastroschisis
    Noboru Oyachi
    Division of Pediatric Surgery, UCLA Medical Center, Los Angeles, CA, USA
    J Pediatr Surg 39:366-70. 2004
    ..Using a fetal rabbit model, the authors assessed in vivo and in vitro GI motility in preterm GS fetuses...
  55. ncbi request reprint Elevated plasma corticotrophin release factor levels and in utero meconium passage
    Jayaraman Lakshmanan
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Pediatr Res 61:176-9. 2007
    ..In view of the known action of CRF in adult colonic motility, these results suggest that hypoxic stress-mediated MEC passage in term fetal rats is mediated by a CRF dependent pathway...
  56. ncbi request reprint Mechanisms of meconium passage: cholinergic stimulation of electromechanical coordination in the fetal colon
    Reinaldo Acosta
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, USA
    J Soc Gynecol Investig 12:169-73. 2005
    ..We assessed the effect of bethanechol, a cholinergic prokinetic agent, on colonic muscle muscular contractile and electromyogram (EMG) activity in the near-term ovine fetus...
  57. doi request reprint Maternal undernutrition influences placental-fetal development
    Louiza Belkacemi
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, and David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Biol Reprod 83:325-31. 2010
    ..This review associates fetal growth with maternal nutrition during pregnancy, placental growth and vascular development, and placental nutrient transport...
  58. pmc Effect of maternal food restriction on fetal rat lung lipid differentiation program
    Ahmet Karadag
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Pediatr Pulmonol 44:635-44. 2009
    ..We conclude that MFR alters fetal lung lipid differentiation programming and lung morphometry by affecting specific epithelial-mesenchymal signaling pathways, offering the possibility for specific interventions to overcome these effects...
  59. ncbi request reprint Cloning and cellular expression of aquaporin 9 in ovine fetal membranes
    Shengbiao Wang
    Department of Obstetrics and Gynecology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Am J Obstet Gynecol 193:841-8. 2005
    ..As AF dynamics continued to be explored primarily in the ovine model, we sought to clone and characterize the expression of ovine AQP9 in fetal membranes...
  60. ncbi request reprint Neuropeptide Y administered into cerebral ventricles stimulates sucrose ingestion in the near-term ovine fetus
    Mostafa A El-Haddad
    Perinatal Research Laboratories, Harbor UCLA Medical Center, University of California, Los Angeles School of Medicine, Torrance 90502, USA
    Am J Obstet Gynecol 189:949-52. 2003
    ..Because NPY may exert a preferential role in mediating adult carbohydrate intake, we sought to determine the effect of central NPY on near-term fetal carbohydrate ingestion...
  61. ncbi request reprint Prenatal nicotine increases testosterone levels in the fetus and female offspring
    Lynne M Smith
    Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles, School of Medicine, USA
    Nicotine Tob Res 5:369-74. 2003
    ....
  62. ncbi request reprint Development of ovine fetal ileal motility: role of muscarinic receptor subtypes
    Noboru Oyachi
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance 90509 2910, USA
    Am J Obstet Gynecol 189:953-7. 2003
    ..In view of the limited knowledge of fetal GI motility development, and the primary role of the muscarinic system in adult GI motility, we examined the development of GI muscarinic receptor subtypes associated with ileal motility...
  63. ncbi request reprint Clinician bias in fundal height measurement
    Andrea Jelks
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California, USA
    Obstet Gynecol 110:892-9. 2007
    ..To establish whether the degree of clinician bias in fundal height measurement is affected by patient body mass index (BMI) or provider experience...
  64. ncbi request reprint Programmed metabolic syndrome: prenatal undernutrition and postweaning overnutrition
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California, Los Angeles 90502, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2306-14. 2007
    ..Sex and offspring phenotype-associated effects of high-fat diet indicate differing pathophysiologic mechanisms that require specific therapeutic approaches...
  65. ncbi request reprint Maternal steroid enhancement of fetal rabbit gastrointestinal motility
    Masakatsu Sase
    Division of Pediatric Surgery, University of California, Los Angeles UCLA Medical Center, Los Angeles, CA, USA
    J Obstet Gynaecol Res 31:263-7. 2005
    ..The purpose of the present study was to determine the potential maturational effects of maternal dexamethasone administration on fetal upper gastrointestinal motility...
  66. ncbi request reprint In utero undernutrition in rats induces increased vascular smooth muscle content in the offspring
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Obstet Gynecol 196:486.e1-8. 2007
    ..We hypothesized that undernutrition in utero alters the structure of conduit and resistance vessels early in development...
  67. ncbi request reprint Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture
    Shengbiao Wang
    Department of Obstetrics and Gynecology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Soc Gynecol Investig 13:181-5. 2006
    ....
  68. ncbi request reprint Permanent reduction in heart and kidney organ growth in offspring of undernourished rat dams
    Mina Desai
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles, CA, USA
    Am J Obstet Gynecol 193:1224-32. 2005
    ..Maternal undernutrition affects fetal growth and development. We investigated whether maternal food restriction during pregnancy and/or lactation permanently alters organ growth among adult offspring...
  69. doi request reprint AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells
    Louiza Belkacemi
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90502, USA
    Life Sci 82:1272-80. 2008
    ..Thus, modulation of AQP1 expression by maternal hormones may regulate invasion and fetal-placental-amnion water homeostasis during gestation...
  70. ncbi request reprint Growth discordance in twins
    Michael G Ross
    Am J Obstet Gynecol 189:897; author reply 897-8. 2003
  71. ncbi request reprint Discordant fetal growth patterns in monochorionic twin pregnancies described by simple algebraic relations
    Asli Umur
    Laser Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Fetal Diagn Ther 18:301-8. 2003
    ....
  72. ncbi request reprint Vacuum assisted delivery in Ecuador for prolonged second stage of labor: maternal-neonatal outcome
    Xavier Chang
    Labor Unit, Enrique C Sotomayor Obstetrics and Gynecology Hospital, Guayaquil, Ecuador
    J Matern Fetal Neonatal Med 20:381-4. 2007
    ..The associated increases in maternal morbidity and healthcare costs indicate the need for alternative strategies. Operative vaginal delivery is minimally utilized in Ecuador, as neither vacuum nor forceps have been available...
  73. ncbi request reprint Meconium aspiration syndrome--more than intrapartum meconium
    Michael G Ross
    N Engl J Med 353:946-8. 2005
  74. ncbi request reprint Modeling a hydropic recipient twin in twin-twin transfusion syndrome
    Jeroen P H M van den Wijngaard
    Laser Center, Academic Medical Center, Univ of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 288:R799-814. 2005
    ..The model may allow an assessment of the efficacy of current therapeutic interventions for TTTS cases that include a hydropic recipient twin...
  75. ncbi request reprint Fetal monitoring and labor accelerations
    Michael G Ross
    J Matern Fetal Neonatal Med 19:445; author reply 445-6. 2006
  76. ncbi request reprint Maternal N-acetylcysteine suppresses fetal inflammatory cytokine responses to maternal lipopolysaccharide
    Ron Beloosesky
    Department of Obstetrics and Gynecology, Rambam Medical Center, Israel
    Am J Obstet Gynecol 195:1053-7. 2006
    ..Because cytokine actions may be mediated by oxidative stress, we determined whether N-acetylcysteine, an antioxidant, can blunt fetal inflammatory responses to maternal lipopolysaccharide...
  77. ncbi request reprint Haemodynamic resistance model of monochorionic twin pregnancies complicated by acardiac twinning
    Asli Umur
    Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Phys Med Biol 49:N205-13. 2004
    ..In conclusion, the haemodynamic analysis may contribute to an increased knowledge of the pathophysiologic consequences of an acardiac body mass for the pump twin...
  78. ncbi request reprint Gestational programming of offspring obesity/hypertension
    Donald A Novak
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Matern Fetal Neonatal Med 19:591-9. 2006
    ..We will review recent data regarding these associations and the pathophysiologic mechanisms underlying them in humans as well as in animal models...
  79. ncbi request reprint Modelling the influence of amnionicity on the severity of twin-twin transfusion syndrome in monochorionic twin pregnancies
    Jeroen P H M van den Wijngaard
    Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Phys Med Biol 49:N57-64. 2004
    ..Based on these results we expect the clinical disruption of the amnion septum in diamniotic-monochorionic TTTS pregnancies to have only minimal benefits...
  80. doi request reprint Estimation of birth weight by two-dimensional ultrasonography
    Michael G Ross
    Obstet Gynecol 111:1215, author reply 1215. 2008
  81. ncbi request reprint Problems with intrapartum fetal heart rate monitoring interpretation and patient management
    Michael G Ross
    Obstet Gynecol 101:1355-6. 2003
  82. ncbi request reprint Base excess during cord occlusion
    Michael G Ross
    Am J Obstet Gynecol 189:1811-2; author reply 1812. 2003
  83. ncbi request reprint Prolonged prenatal hypernatremia alters neuroendocrine and electrolyte homeostasis in neonatal sheep
    Shengbiao Wang
    Department of Molecular Genetics, Nichols Institute, Quest Diagnostics Inc, San Juan Capistrano, CA 92690, USA
    Exp Biol Med (Maywood) 228:41-5. 2003
    ....

Research Grants46

  1. Mechanisms of Programmed Gestational Hyperphagia
    MICHAEL GLENN ROSS; Fiscal Year: 2010
    ..These studies will provide important new information elucidating mechanisms for programming of orexigenic-mediated ingestive behavior, and provide a model to determine strategies for the prevention of child and adult obesity. ..
  2. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    ..The goal of this project is to determine critical efficacy and fetal safety issues central to maternal DDAVP treatment, prior to widespread clinical use in human pregnancies with oligohydramnios. ..
  3. LEPTIN & NEUROPEPTIDE-Y ALTERS FETAL SWALLOWING ACTIVITY
    Michael Ross; Fiscal Year: 2002
    ..In addition, these studies represent a model to examine the development and function of neuronal pathways and mechanisms which regulate fetal physiology. ..
  4. PREVENTION AND TREATMENT OF HUMAN OLIGOHYDRAMNIOS
    Michael Ross; Fiscal Year: 2001
    ..e., failure to reset osmolality threshold). This proposal will aid in the development of markers of prediction and therapeutic approaches to the prevention and treatment of human oligohydramnios. ..
  5. FETAL SWALLOWING--CENTRAL DIPSOGENIC MECHANISMS
    Michael Ross; Fiscal Year: 2002
    ....
  6. Fetal Swallowing: Central Dipsogenic Mechanisms
    Michael Ross; Fiscal Year: 2007
    ..Furthermore, these studies represent a model to examine the development and function of neuronal pathways and mechanisms regulating fetal physiology. ..
  7. Fetal Membrane AQP Expression/Amniotic Fluid Regulation
    Michael Ross; Fiscal Year: 2004
    ..Our objective is to determine the regulatory mechanisms of fetal membrane AQP expression and delineate the role of AQPs in AF homeostasis. ..
  8. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2000
    ..The goal of this project is to identify safe and effective treatments which can reliably alter AF volume in cases of poly- or oligohydramnios. ..
  9. MATERNAL DEHYDRATION--FETAL & AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 1992
    ..Studies of dehydration and rehydration of the ovine model represent a promising approach to understanding maternal-fetal water dynamics, while addressing a potentially critical problem in perinatal medicine...
  10. FETAL SWALLOWING--ONTOGENY AND REGULATION
    Michael Ross; Fiscal Year: 1993
    ..The ovine model offers the opportunity to study, in a precocial species, the ontogeny of "thirst" physiology, an important but relatively unexplored area of perinatal physiology...
  11. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 1999
    ..The goal of this project is to determine critical efficacy and fetal safety issues central to maternal DDAVP treatment, prior to widespread clinical use in human pregnancies with oligohydramnios. ..