M E Ross

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Human brain malformations and their lessons for neuronal migration
    M E Ross
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Neurosci 24:1041-70. 2001
  2. ncbi request reprint Lissencephaly with cerebellar hypoplasia (LCH): a heterogeneous group of cortical malformations
    M E Ross
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuropediatrics 32:256-63. 2001
  3. pmc Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice
    C Iadecola
    Center for Clinical and Molecular Neurobiology, Department of Neurology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 98:1294-9. 2001
  4. ncbi request reprint Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation
    K Niwa
    Center for Clinical and Molecular Neurobiology, Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Circ Res 88:600-8. 2001
  5. ncbi request reprint Stellate neurons mediate functional hyperemia in the cerebellar molecular layer
    G Yang
    Center for Clinical and Molecular Neurobiology, Department of Neurology, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 20:6968-73. 2000
  6. ncbi request reprint Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice
    C Iadecola
    Center for Clinical and Molecular Neurobiology, Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 21:1436-41. 2001
  7. ncbi request reprint Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity
    E Araki
    Center for Clinical and Molecular Neurobiology, Department of Neurology, University of Minnesota, Minneapolis 55455, USA
    Stroke 32:2370-5. 2001
  8. ncbi request reprint Cerebellar histogenesis is disturbed in mice lacking cyclin D2
    J M Huard
    Laboratory of Molecular Neurobiology and Development, Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Development 126:1927-35. 1999
  9. ncbi request reprint Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia
    C Iadecola
    Department of Neurology, University of Minnesota Medical School Minneapolis 55455, USA
    Stroke 27:1373-80. 1996
  10. ncbi request reprint Gene-dosing effect and persistence of reduction in ischemic brain injury in mice lacking inducible nitric oxide synthase
    X Zhao
    Center for Clinical and Molecular Neurobiology, Departments of Neurology and Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Brain Res 872:215-8. 2000

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Human brain malformations and their lessons for neuronal migration
    M E Ross
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Neurosci 24:1041-70. 2001
    ..We do this from the perspective of human brain malformation syndromes, noting both what is now known of their genetic bases and what remains to be discovered...
  2. ncbi request reprint Lissencephaly with cerebellar hypoplasia (LCH): a heterogeneous group of cortical malformations
    M E Ross
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuropediatrics 32:256-63. 2001
    ....
  3. pmc Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice
    C Iadecola
    Center for Clinical and Molecular Neurobiology, Department of Neurology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 98:1294-9. 2001
    ..Thus, COX-2 is involved in pathogenic events occurring in both the early and late stages of cerebral ischemia and may be a valuable therapeutic target for treatment of human stroke...
  4. ncbi request reprint Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation
    K Niwa
    Center for Clinical and Molecular Neurobiology, Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Circ Res 88:600-8. 2001
    ..The data provide evidence for a critical role of COX-1 in maintaining resting vascular tone and in selected vasodilator responses of the cerebral microcirculation...
  5. ncbi request reprint Stellate neurons mediate functional hyperemia in the cerebellar molecular layer
    G Yang
    Center for Clinical and Molecular Neurobiology, Department of Neurology, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 20:6968-73. 2000
    ..The data provide evidence that stellate neurons are a critical link between neural activity and blood flow in the activated cerebellum and that NO is the principal effector of their vascular actions...
  6. ncbi request reprint Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice
    C Iadecola
    Center for Clinical and Molecular Neurobiology, Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 21:1436-41. 2001
    ..Thus, the vascular effects of COX-1 may contribute to maintain cerebral blood flow in the postischemic brain and, as such, play a protective role in ischemic brain injury...
  7. ncbi request reprint Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity
    E Araki
    Center for Clinical and Molecular Neurobiology, Department of Neurology, University of Minnesota, Minneapolis 55455, USA
    Stroke 32:2370-5. 2001
    ..The data support the hypothesis that COX-2, in addition to its role in glutamate excitotoxicity, participates in the cytotoxicity associated with inflammation...
  8. ncbi request reprint Cerebellar histogenesis is disturbed in mice lacking cyclin D2
    J M Huard
    Laboratory of Molecular Neurobiology and Development, Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Development 126:1927-35. 1999
    ..These results suggest that cyclin D2 is required in cerebellum not only for proliferation of the granule cell precursors but also for proper differentiation of granule and stellate interneurons...
  9. ncbi request reprint Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia
    C Iadecola
    Department of Neurology, University of Minnesota Medical School Minneapolis 55455, USA
    Stroke 27:1373-80. 1996
    ....
  10. ncbi request reprint Gene-dosing effect and persistence of reduction in ischemic brain injury in mice lacking inducible nitric oxide synthase
    X Zhao
    Center for Clinical and Molecular Neurobiology, Departments of Neurology and Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Brain Res 872:215-8. 2000
    ..We conclude that the reduction in ischemic damage conferred by iNOS deletion exhibits a gene-dosing effect and that the protection is long lasting...
  11. ncbi request reprint Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia
    C Iadecola
    Department of Neurology, University of Minnesota Medical School, Minneapolis 55455, USA
    Acta Neuropathol 98:9-14. 1999
    ..The data suggest that COX-2 up-regulation is also relevant to cerebral ischemia in humans and raise the possibility that COX-2 reaction products participate in the mechanisms of ischemic injury also in the human brain...
  12. ncbi request reprint Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex
    K Niwa
    Center for Clinical and Molecular Neurobiology, Departments of Neurology and Neuroscience, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Neurosci 20:763-70. 2000
    ..The findings provide evidence for a previously unrecognized role of COX-2 in the mechanisms coupling synaptic activity to neocortical blood flow and provide an insight into one of the functions of constitutive COX-2 in the CNS...
  13. pmc The transcription factor interferon regulatory factor 1 is expressed after cerebral ischemia and contributes to ischemic brain injury
    C Iadecola
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Exp Med 189:719-27. 1999
    ..Thus, IRF-1 is the first nuclear transacting factor demonstrated to contribute directly to cerebral ischemic damage and may be a novel therapeutic target in ischemic stroke...
  14. ncbi request reprint The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene
    M Nagayama
    Department of Neurology, University of Minnesota Medical School, Minneapolis, USA
    J Cereb Blood Flow Metab 19:1213-9. 1999
    ..Thus, COX-2 reaction products may be another mechanism by which iNOS-derived NO contributes to ischemic brain injury...
  15. ncbi request reprint Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein
    J G Gleeson
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Cell 92:63-72. 1998
    ..Doublecortin, along with the newly characterized mDab1, may define an Abl-dependent pathway regulating neuronal migration...
  16. ncbi request reprint Molecular pathology of cerebral ischemia: delayed gene expression and strategies for neuroprotection
    C Iadecola
    Department of Neurology, University of Minnesota Medical School, Minneapolis 55455, USA
    Ann N Y Acad Sci 835:203-17. 1997
    ..Inhibition of iNOS or COX-2 offers the prospect of treatments directed to the late stages of the damage. However, additional preclinical studies would be necessary before these new treatment strategies can be tested in human stroke...
  17. ncbi request reprint MN20, a D2 cyclin, is transiently expressed in selected neural populations during embryogenesis
    M E Ross
    Department of Neurology, University of Minnesota, Minneapolis 55455, USA
    J Neurosci 16:210-9. 1996
    ....
  18. ncbi request reprint Astrotactin (ASTN), a gene for glial-guided neuronal migration, maps to human chromosome 1q25.2
    J M Fink
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455, USA
    Genomics 40:202-5. 1997
  19. ncbi request reprint Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene
    C Iadecola
    Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 17:9157-64. 1997
    ..iNOS inhibition may provide a novel therapeutic strategy targeted specifically at the secondary progression of ischemic brain injury...
  20. ncbi request reprint MN20, a D2 cyclin found in brain, is implicated in neural differentiation
    M E Ross
    Department of Neurology, University of Minnesota, Minneapolis 55455
    J Neurosci 14:6384-91. 1994
    ....
  21. ncbi request reprint Expression of the adaptor protein BLNK/SLP-65 in childhood acute lymphoblastic leukemia
    C Imai
    Department of Hematology Oncology, St Jude Children s Research Hospital, North Lauderdale, Memphis, TN 38105 2794, USA
    Leukemia 18:922-5. 2004
    ..These results indicate that BLNK deficiency is a rare occurrence in childhood B-lineage ALL and is unlikely to be a common leukemogenic event as previously proposed...
  22. ncbi request reprint Mutation analysis of the DCX gene and genotype/phenotype correlation in subcortical band heterotopia
    N Matsumoto
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Eur J Hum Genet 9:5-12. 2001
    ..Maternal germline mosaicism was found in one family. Significant differences in genotype were found in relation to band thickness and familial vs sporadic status...
  23. ncbi request reprint Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit
    S S Tate
    J Biol Chem 252:6042-5. 1977
    ..The heavy subunits of the two enzymes are markedly different in both molecular weight and amino acid content; this may account for differences observed in acceptor amino acid specificity and in the magnitude of the maleate effect...
  24. ncbi request reprint LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformation
    D T Pilz
    Department of Human Genetics, University of Chicago, 924 East 57th Street, R113, Chicago, IL 60637, USA
    Hum Mol Genet 7:2029-37. 1998
    ..The distinct LIS patterns suggest that LIS1 and XLIS may be part of overlapping, but distinct, signaling pathways that promote neuronal migration...
  25. doi request reprint The molar tooth sign: a new Joubert syndrome and related cerebellar disorders classification system tested in Egyptian families
    M S Zaki
    Clinical Genetics Department, National Research Centre, Neuromotor Institute, Cairo, Egypt
    Neurology 70:556-65. 2008
    ..Each family could be classified into one of the four subtypes. This classification may thus be useful in the evaluation of patients with JSRD...