JULIE ANN ROSS

..Genetic determinants of susceptibility to IL are unknown. Recent genome-wide association studies for childhood acute lymphoblastic leukemia (ALL) have identified susceptibility loci at IKZF1, ARID5B, and CEBPE...

..Results from previous studies have been mixed, but some methylation differences have been observed...

..Translocations present in neonatal blood spots and the young age peak of diagnosis suggest that early-life factors are involved in childhood leukemia etiology...

..Little is known about the causes of adult leukemia. A few small studies have reported a reduced risk associated with regular use of nonsteroidal anti-inflammatory drugs (NSAID)...

..Because there are many biological activities attributed to the flavonoids, some of which could be beneficial or detrimental depending on specific circumstances, further studies in both the laboratory and with populations are warranted...

..We hypothesized that maternal consumption of dietary DNAt2 inhibitors during pregnancy would increase the risk of infant leukemia, particularly AML(MLL+)...

..6). Given the prevalence of overweight and obesity in the United States, the population attributable risk of AML due to obesity could approach 30%...

..The new Childhood Cancer Research Network in the Children's Oncology Group, when fully implemented, should make it less difficult in the future to recruit the large numbers of patients needed for such studies...

..Because children with Down syndrome (DS) experience a 20-fold higher risk of leukemia than the general population, the authors evaluated whether periconceptional vitamin supplementation reduced the risk of leukemia in children with DS...

..Since estrogen receptors are expressed on certain hematopoietic cells, it is possible that HRT use may also increase the risk of leukemia...

..To evaluate the relationship between neonatal oxygen supplementation (O2) and childhood cancer in the Collaborative Perinatal Project (CPP)...

..These results suggest that DBS analysis may identify infants of women who smoke throughout pregnancy...

..These results suggest that birth registries may be used to select controls for studies of rare childhood diseases on a national scale...

..Other variables of interest were not notably associated with infant leukemia regardless of MLL status. This investigation further supports the contention that molecularly defined subtypes of infant leukemia have separate etiologies...

..This review will focus on these factors in the treatment of childhood ALL...

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..These data, representing a larger series than any reported previously, suggest that GST genotype does not affect etiology or outcome of childhood ALL...

..These data suggest that some participants in WIC make a concerted effort to quit smoking when they find out they are pregnant, and are generally truthful when reporting their smoking habits during pregnancy...

..However, given that our study focused on older women from a defined geographical area, analyses of prospective studies in other populations are needed to confirm or refute these results...

..The objective of this study was to examine cancer incidence in this population, because it may indicate areas for targeted surveillance and intervention...

..We explored whether maternal medication use during pregnancy may be an important etiologic area for investigation in studies of infant leukemia...

..To the authors' knowledge, few studies to date have evaluated trends in pediatric GCTs. Results from these analyses may provide clues to the etiology of GCTs...

..However, several subsequent studies have suggested that long-term ERT could increase ovarian cancer risk...

..We examined whether maternal infections and health conditions during pregnancy were associated with acute leukemia in children with DS...

..The authors of this report evaluated incidence and survival trends by RMS demographic subgroups to inform future etiologic hypotheses...

..46, 95% CI 0.22-0.96). These sex and cancer site specific associations should be confirmed in additional studies as they may provide clues to the etiology of pediatric GCT...

..63 to 0.78 across these end points). Allergy history, which may reflect enhanced immunosurveillance, is associated with a reduced risk of colorectal cancer...

..Although many studies have investigated the association between anthropometry and ovarian cancer risk, results have been inconsistent...

..S. overall and among demographic subgroups, including Asian/Pacific Islanders and Hispanics, for whom to the authors' knowledge trends have not been previously examined...

..There is mixed evidence for associations between reproductive history or infertility and acute leukemia among children without DS...

..4% per year (95% CI: -2.7, -2.0; p < 0.001). The current low response rates for RDD indicate a substantial potential for selection bias and a need to seek alternative sources of controls...

..Previous epidemiologic studies have suggested that exposure to pesticides in utero and during early childhood may increase the risk for development of childhood cancer, including Wilms tumor, a childhood kidney tumor...

..Future research should include larger sample sizes as well as a full assessment of diet including vitamin supplementation to adequately examine the relation between nutritional status and childhood leukaemia...

..These data, representing the only data in pediatric AML, suggest that XPD genotype does not affect the etiology or outcome of childhood AML...

..5 (0.92-2.6); for weight, 1.9 (1.1-3.4); for waist circumference, 2.0 (1.1-3.5); and for hip circumference, 1.8 (1.0-3.0). CONCLUSION: Greater adiposity may increase the risk of multiple myeloma...

..33-4.26) to develop AML compared with women who lived in a city with a population of >10,000 people. These results provide evidence that women who live on farms or rural areas are at an increased risk of AML...

..93, 95% CI: 0.86-1.00). This study provides further support for a beneficial effect of flavonoid intake on lung cancer risk, especially among current and past smokers...

..The decreased ORs observed in this study may be due to recall bias assuming plausibly low values of sensitivity...

..Results for histologic subtypes were similar. Overall, fat, cholesterol and egg intakes were not associated with ovarian cancer risk. The positive association for saturated fat intake at very high intakes merits further investigation...

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..The authors compared frequencies of common genetic polymorphisms believed to influence risk of malignancy to determine whether frequencies in the Hmong are different from those in other Asian populations and in white Minnesotans...

..We investigated the association between breast-feeding and Wilms tumor, a childhood kidney tumor...

..0. This exploratory study suggests that household chemical exposure may play a role in the development of acute lymphoblastic leukemia in children with Down's syndrome...

..However, because future case-control studies will at least partially rely on questionnaire data, improvements including probing questions, better interview techniques, and validation studies are indicated...

..8, 95% CI 1.0-1.3) were associated with N-ras mutations. This study suggests that parental exposure to specific chemicals may be associated with distinct ras mutations in children who develop ALL...

..Although preliminary, the notable differences observed in leukemia risk between aspirin and nonaspirin NSAID use warrant further investigation...

..CONCLUSIONS: Although the current study confirmed some of the results noted in other populations, the observed overall decline in leukemia survival for blacks is surprising and warrants further investigation...

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..Fewer black children than expected had an available family marrow donor...

..These results suggest that consumption of the major carotenoids during adulthood does not play a major role in the incidence of ovarian cancer...

..The absence of an association should be encouraging for concerned parents of children with Down syndrome who undergo a series of diagnostic radiographs in the course of their standard care...

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..This study will utilize the unique resources available through the Children's Oncology Group, and include ascertainment of cases over a four-year period (Jan 1, 2003-Dec 31, 2006). ..

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..The significance of this proposal, specifically with respect-to the identification of possible prevention strategies for adult AML, has important public health implications. ..

..It is claimed that each case-control study has adequate statistical power to address the hypotheses being explored. ..

..The overall sample size includes 250 matched sets (2 controls per case), which will provide sufficient statistical power to address the hypothesis being investigated. ..

..We are proposing one of the largest epidemiological studies of MDS ever conducted, with the goal of being able to identify risk factors that could lead to prevention. ..