Research Topics
| Brian RossSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision makingAlexander Lin
Rudi Schulte Research Institute, Santa Barbara, California 93105, USA
NeuroRx 2:197-214. 2005..Additional efficacy studies could extend the range of this capability...- Noninvasive imaging of apoptosis and its application in cancer therapeuticsJulia M Coppola
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Clin Cancer Res 14:2492-501. 2008..Noninvasive imaging of apoptosis facilitates optimization of therapeutic protocols regarding dosing and schedule and enables identification of efficacious combination therapies... - Novel molecular imaging platform for monitoring oncological kinasesShyam Nyati
Department of Radiation Oncology, University of Michigan, Ann Arbor MI 48109 USA
Cancer Cell Int 10:23. 2010..Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions... 
Magnetic resonance imaging in cancer researchB D Ross
Department of Radiology, University of Michigan Medical School, 1150 West Medical Center Drive, Medical Sciences Research Building III, Room 9303, Ann Arbor 48109 0648, USA
Eur J Cancer 38:2147-56. 2002..These examples provide an overview of areas in which imaging of animal tumour models can contribute towards improving the evaluation of experimental therapeutic agents...- Evaluation of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on the 9L rat brain tumor model using MRIBrian D Ross
Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, MI 48109, USA
NMR Biomed 16:67-76. 2003.... - The parametric response map is an imaging biomarker for early cancer treatment outcomeCraig J Galban
Departments of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, USA
Nat Med 15:572-6. 2009..Even when accounting for baseline rCBV, which is prognostic, PRM(rCBV) proved more predictive of overall survival... - Functional diffusion map as an early imaging biomarker for high-grade glioma: correlation with conventional radiologic response and overall survivalDaniel A Hamstra
University of Michigan, B2A209 UH 1500 East Medical Center Dr, Ann Arbor, MI 48109 0030, USA
J Clin Oncol 26:3387-94. 2008..Diffusion magnetic resonance imaging (MRI) using a functional diffusion map (fDM) may provide an earlier measure to predict patient survival... - The functional diffusion map: an imaging biomarker for the early prediction of cancer treatment outcomeBradford A Moffat
Center for Molecular Imaging, Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109-0648, USA
Neoplasia 8:259-67. 2006..Therefore, The fDM imaging biomarker for early prediction of treatment efficacy can be used in the drug development process... - Therapeutic efficacy of DTI-015 using diffusion magnetic resonance imaging as an early surrogate markerDaniel E Hall
University of Michigan, Center for Molecular Imaging and Department of Radiology, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0648, USA
Clin Cancer Res 10:7852-9. 2004.... - Inhibition of vascular endothelial growth factor (VEGF)-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-DBradford A Moffat
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan 48109 0503, USA
Clin Cancer Res 12:1525-32. 2006..The aim of this study was to evaluate the effect of VEGF-A expression on tumor growth, perfusion, and chemotherapeutic efficacy in orthotopic 9L gliosarcomas... - Evaluation of treatment-associated inflammatory response on diffusion-weighted magnetic resonance imaging and 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography imaging biomarkersCraig J Galban
Center for Molecular Imaging and Departments of Radiology, University of Michigan, School of Medicine, Ann Arbor, Michigan 48109 0220, USA
Clin Cancer Res 16:1542-52. 2010.... - Molecular imaging of Akt kinase activityLimin Zhang
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
Nat Med 13:1114-9. 2007..The results provide unique insights into the pharmacokinetics and pharmacodynamics of agents that modulate Akt activity, revealing the usefulness of this reporter for rapid dose and schedule optimization in the drug development process... - Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomasThomas C Kwee
Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
J Magn Reson Imaging 31:531-7. 2010..To compare apparent diffusion coefficients (ADCs) with distributed diffusion coefficients (DDCs) in high-grade gliomas... - Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapyKuei C Lee
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Biomedical Sciences Research Building, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Clin Cancer Res 13:443-50. 2007..In this study, we evaluate the feasibility of using diffusion magnetic resonance imaging (MRI) as a reliable and quantitative measure for the early assessment of response in a breast cancer model... - Survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT [corrected]Yue Cao
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
Int J Radiat Oncol Biol Phys 64:876-85. 2006..To determine whether cerebral blood volume (CBV) and cerebral blood flow can predict the response of high-grade gliomas to radiotherapy (RT) by taking into account spatial heterogeneity and temporal changes in perfusion... - Diffusion MRI: a new strategy for assessment of cancer therapeutic efficacyThomas L Chenevert
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0030, USA
Mol Imaging 1:336-43. 2002.... - A review of the past, present, and future directions of neoplasiaAlnawaz Rehemtulla
University of Michigan Medical Center, Ann Arbor, MI 48109-0582, USA
Neoplasia 7:1039-46. 2005 - Sodium and proton diffusion MRI as biomarkers for early therapeutic response in subcutaneous tumorsVictor D Schepkin
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109 0503, USA
Magn Reson Imaging 24:273-8. 2006..The results of this study support the continued clinical testing of diffusion MRI for evaluation of early tumor treatment response and demonstrate the complementary insights of sodium MRI for oncology applications... - Dynamic imaging of emerging resistance during cancer therapyKuei C Lee
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Cancer Res 66:4687-92. 2006..Overall, this study highlights the ability of diffusion MRI to provide sensitive dynamic assessment of therapy-induced response, allowing early opportunities for optimization of therapeutic protocols... - A methodology for registration of a histological slide and in vivo MRI volume based on optimizing mutual informationCharles R Meyer
University of Michigan, Ann Arbor, USA
Mol Imaging 5:16-23. 2006..Overall, this approach provides a robust method for coregistration of in vivo images with histological sections and will have broad applications in the field of functional and molecular imaging... - Diffusion imaging: insight to cell status and cytoarchitectureThomas L Chenevert
Department of Radiology, University of Michigan Health Systems, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
Neuroimaging Clin N Am 16:619-32, viii-ix. 2006..Similarly, therapeutic intervention that alters these properties may be monitored for efficacy via diffusion MR imaging. This article outlines basic technical concepts and applications of diffusion imaging with an emphasis on oncology... - Diffusion magnetic resonance imaging: a biomarker for treatment response in oncologyDaniel A Hamstra
Department of Radiation Oncology, The Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
J Clin Oncol 25:4104-9. 2007..This review highlights the development of this technique and the state of current clinical understanding of its utility... - Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor--a pharmacokinetic studyDaniel A Hamstra
The Department of Radiation, The University of Michigan Medical Center, Ann Arbor, MI 48109-0648, USA
J Neurooncol 73:225-38. 2005.... - Radiation-induced changes in normal-appearing white matter in patients with cerebral tumors: a diffusion tensor imaging studyVijaya Nagesh
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109 0100, USA
Int J Radiat Oncol Biol Phys 70:1002-10. 2008..To quantify the radiation-induced changes in normal-appearing white matter before, during, and after radiotherapy (RT) in cerebral tumor patients... 
Pharmacokinetic analysis and phase 1 study of MRX-1024 in patients treated with radiation therapy with or without cisplatinum for head and neck cancerDaniel A Hamstra
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 5010, USA
Clin Cancer Res 16:2666-76. 2010..A previous study reported radiation protection from mucosal injury with D-methionine (D-met) in preclinical evaluation; therefore, the pharmacokinetics, safety, and utility of D-met were evaluated clinically...- Parametric response map as an imaging biomarker to distinguish progression from pseudoprogression in high-grade gliomaChristina Tsien
Department of Radiation Oncology, University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
J Clin Oncol 28:2293-9. 2010..To assess whether a new method of quantifying therapy-associated hemodynamic alterations may help to distinguish pseudoprogression from true progression in patients with high-grade glioma... - A transgenic mouse for imaging caspase-dependent apoptosis within the skinDivya Khanna
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
J Invest Dermatol 130:1797-806. 2010..This reporter and transgenic mouse could serve as a unique tool for the study of apoptosis in living cells and animals, especially in the context of skin biology... - Diffusion imaging for therapy response assessment of brain tumorThomas L Chenevert
Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Neuroimaging Clin N Am 19:559-71. 2009..Diffusion tensor imaging and its derivative maps of diffusion anisotropy allow assessment of tumor compression or destruction of adjacent normal tissue anisotropy and may aid to assess tumor infiltration and aid presurgical planning... - Evaluation of D-methionine as a novel oral radiation protector for prevention of mucositisSaleha B Vuyyuri
Departments of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
Clin Cancer Res 14:2161-70. 2008..D-Methionine (D-Met), the dextro-isomer of the common amino acid l-methionine, has been documented to protect normal tissues from a diverse array of oxidative insults... - Voxel-by-voxel functional diffusion mapping for early evaluation of breast cancer treatmentBing Ma
Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
Inf Process Med Imaging 21:276-87. 2009..Comparison of the experimental results with pathology shows that ADC changes can be used to evaluate early response of breast cancer treatment... - Bioluminescence detection of cells having stabilized p53 in response to a genotoxic eventAlnawaz Rehemtulla
Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor 48109, USA
Mol Imaging 3:63-8. 2004..It could also be used to study p53 stabilization as a result of inactivating p53 mutations. Such studies will further our understanding of p53's role as the "guardian of the genome" and its function in tumorigenesis... - Radiosynthesis and evaluation of 5-[125I]iodoindol-3-yl-beta-D-galactopyranoside as a beta-galactosidase imaging radioligandMarcian E Van Dort
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
Mol Imaging 7:187-97. 2008.... - Sodium magnetic resonance imaging of chemotherapeutic response in a rat gliomaVictor D Schepkin
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Kresge II Research Building, R3028, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Magn Reson Med 53:85-92. 2005..This study demonstrates the possibility of Na MRI to function as a biomarker for monitoring early tumor treatment and validates the use of monitoring changes in diffusion MRI values for assessing tumor cellularity... - Continuous arterial spin labeling using a train of adiabatic inversion pulsesBradford A Moffat
Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA
J Magn Reson Imaging 21:290-6. 2005.... - The extent and severity of vascular leakage as evidence of tumor aggressiveness in high-grade gliomasYue Cao
Departments of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
Cancer Res 66:8912-7. 2006..In contrast, survival depends chiefly on the volume of aggressive tumor at the time of presentation... - Predicting outcome of patients with high-grade gliomas after radiotherapy using quantitative analysis of T1-weighted magnetic resonance imagingChristina Tsien
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
Int J Radiat Oncol Biol Phys 67:1476-83. 2007.... - Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapyYong Eun Lee Koo
University of Michigan, Michigan 48109, USA
Appl Opt 46:1924-30. 2007.... - Intravoxel water diffusion heterogeneity imaging of human high-grade gliomasThomas C Kwee
Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
NMR Biomed 23:179-87. 2010..The observed negative correlation between tumor alpha and tumor DDC requires further investigation... - Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade gliomaDaniel A Hamstra
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109-0648, USA
Proc Natl Acad Sci U S A 102:16759-64. 2005..Further evaluation of this technique is warranted to determine whether it may be useful in the individualization of treatment or evaluation of the response in clinical protocols... - An imaging biomarker of early treatment response in prostate cancer that has metastasized to the boneKuei C Lee
Department of Radiology, and Center for Molecular Imaging, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Cancer Res 67:3524-8. 2007..Validation of fDM results was accomplished by histologic analysis of excised tissue. Results from this study show the capability of fDM as a biomarker for detection of bone cancer treatment efficacy, thus warranting clinical evaluation... - Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumorsBeata Chertok
Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109 1065, USA
Biomaterials 29:487-96. 2008..Hence, these nanoparticles appear to be a promising vehicle for glioma-targeted drug delivery... - Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor responseBradford A Moffat
Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 102:5524-9. 2005..Overall, fDM analysis provided an early biomarker for predicting treatment response in brain tumor patients... - Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of gliomaPatrick McConville
MIR Preclinical Services, Inc, Ann Arbor, Michigan, USA
Clin Cancer Res 13:2897-904. 2007..The nestin tv-a (Ntv-a) genetically engineered mouse spontaneously develops glioma when infected with ALV-A expressing platelet-derived growth factor, resulting in autocrine platelet-derived growth factor signaling... - A feasibility study evaluating the functional diffusion map as a predictive imaging biomarker for detection of treatment response in a patient with metastatic prostate cancer to the boneKuei C Lee
Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Neoplasia 9:1003-11. 2007..Thus, the fDM imaging biomarker may provide a quantifiable therapeutic endpoint to assess response in patients with metastatic bone cancer... - Noninvasive molecular imaging sheds light on the synergy between 5-fluorouracil and TRAIL/Apo2L for cancer therapyKuei C Lee
Department of Biological Chemistry, The University of Michigan Medical Center, Ann Arbor, MI 48109 0582, USA
Clin Cancer Res 13:1839-46. 2007.... - A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRIBradford A Moffat
University of Michigan, Ann Arbor, USA
Mol Imaging 2:324-32. 2003..The flexible formulation of these nanoparticles suggests that future modifications could be accomplished allowing for their use as a targeted molecular imaging contrast agent and/or therapeutic platform for multiple indications... - Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFPWilliam H Perman
Department of Radiology, Saint Louis University School of Medicine, PO Box 15250, St Louis, Mo 63110 0250, USA
Magn Reson Imaging 28:459-65. 2010..The goal of this work was to develop a fast 3D chemical shift imaging technique for the noninvasive measurement of hyperpolarized (13)C-labeled substrates and metabolic products at low concentration... - Molecular imaging of N-linked glycosylation suggests glycan biosynthesis is a novel target for cancer therapyJoseph N Contessa
Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan, USA
Clin Cancer Res 16:3205-14. 2010..We therefore investigated the feasibility of blocking NLG in vivo to reduce overexpression of RTKs... - Noninvasive real-time imaging of apoptosisBharathi Laxman
Center for Molecular Imaging, University of Michigan Medical School, 1150 West Medical Center Drive, Medical Sciences Research Building III, Room 9303, Ann Arbor, MI 48109-0648, USA
Proc Natl Acad Sci U S A 99:16551-5. 2002.... - Vascular targeted nanoparticles for imaging and treatment of brain tumorsG Ramachandra Reddy
Molecular Therapeutics, Inc, Ann Arbor, MI 48109, USA
Clin Cancer Res 12:6677-86. 2006..CONCLUSIONS: This study reveals the versatility and efficacy of the multifunctional nanoparticle for the targeted detection and treatment of cancer... - Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imagingDaniel A Hamstra
Department of Radiation Oncology, University of Michigan Medical Center, 1331 East Ann Street, Ann Arbor, MI 48109, USA
Cancer Res 66:7482-9. 2006..In addition, the kinetics of oscillations were altered by pretreatment with radiation-modifying agents. These results show the use of this mouse model in enhancing our understanding of the transcriptional role of p53 in vivo... - Quantitative characterization of hemodynamic properties and vasculature dysfunction of high-grade gliomasVijaya Nagesh
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
NMR Biomed 20:566-77. 2007..Progressive abnormalities in vasculature and hemodynamic characteristics of the vascular bed were delineated, with significant disorder in the tumor but mild abnormality in peritumoral tissue... - Enhancing Akt imaging through targeted reporter expressionLimin Zhang
Department of Radiation Oncology, Center for Molecular Imaging, University of Michigan, Ann Arbor, MI 48109, USA
Mol Imaging 7:168-74. 2008..Based on these results, we propose that the membrane-associated Akt reporter may be better suited for identification of novel compounds that modulate the Akt pathway by high-throughput screening... - Synthesis and characterization of silica-embedded iron oxide nanoparticles for magnetic resonance imagingFei Yan
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA
J Nanosci Nanotechnol 4:72-6. 2004..The design of the nanoparticle is universal and flexible and allows for facile addition or interchange of its active components (i.e., MRI contrast agents and targeting moiety) with photodynamic dyes... - Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancerMahaveer S Bhojani
Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 0648, USA
Cell Cycle 4:1478-81. 2005..These results suggest that levels of p-FADD may be used as a prognostic biomarker for predicting survival of lung cancer patients... - Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomasGuoan Chen
Departments of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 102:12507-12. 2005.... - A small-molecule furin inhibitor inhibits cancer cell motility and invasivenessJulia M Coppola
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neoplasia 10:363-70. 2008..Additionally, this molecule inhibited proMT1-MMP processing, complete MMP-2 maturation, and invasiveness of human fibrosarcoma cells (HT1080)... - Evaluation of cancer therapy using diffusion magnetic resonance imagingBrian D Ross
University of Michigan Medical School, Ann Arbor, Michigan 48109-0648, USA
Mol Cancer Ther 2:581-7. 2003..This article provides an overview of the use of diffusion magnetic resonance imaging as a surrogate marker for quantitating treatment responsiveness in both preclinical and clinical studies... - Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small moleculesTomoko Komiyama
Departments of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0606, USA
J Biol Chem 284:15729-38. 2009.... - Imaging of proteolytic activity using a conditional cell surface receptorMahaveer Swaroop Bhojani
University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Mol Imaging 5:129-37. 2006..This methodology may provide for a multimodal noninvasive real-time imaging of apoptosis and a new opportunity for high-throughput screening of cell-death-modulating therapeutic agents... - Brain cancer diagnosis and therapy with nanoplatformsYong-Eun Lee Koo
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
Adv Drug Deliv Rev 58:1556-77. 2006..The advantages of nanoparticle-based delivery and the types of nanoparticle systems under investigation are described, as well as their applications... - Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activityJulia M Coppola
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Anal Biochem 364:19-29. 2007..In conclusion, we describe a customizable noninvasive technology for real-time assessment of Golgi protease activity used to identify inhibitors of furin and BACE... - Development of a syngeneic rat brain tumor model expressing EGFRvIII and its use for molecular targeting studies with monoclonal antibody L8A4Weilian Yang
Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
Clin Cancer Res 11:341-50. 2005..CONCLUSIONS: Based on these data, we have concluded that the F98(npEGFRvIII) glioma should be a valuable animal model for therapy studies focusing on molecular targeting of EGFRvIII by receptor specific mAbs... - Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistanceVictor D Schepkin
National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA
NMR Biomed 19:1035-42. 2006..Overall, these experiments demonstrate the sensitivity and applicability of sodium and diffusion MRI as tools for dynamic assessment of tumor response to therapy... - Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neuronsHoon Ryu
Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 23:3597-606. 2003..Taken together, these results establish Sp1 and Sp3 as oxidative stress-induced transcription factors in cortical neurons that positively regulate neuronal survival... - It's not just about anatomy: in vivo bioluminescence imaging as an eyepiece into biologyChristopher H Contag
Departments of Pediatrics, Radiology, and Microbiology and Immunology, Stanford University Medical Center, Stanford University, Stanford, California 94305 5308, USA
J Magn Reson Imaging 16:378-87. 2002.... - Molecular imaging of gene expression and efficacy following adenoviral-mediated brain tumor gene therapyAlnawaz Rehemtulla
University of Michigan School of Medicine, USA
Mol Imaging 1:43-55. 2002.... - The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapiesDaniel A Hamstra
Department of Radiation Oncology, The University of Michigan Medical Center, Ann Arbor 48109 0582, USA
Mol Ther 10:916-28. 2004.... - Towards hyperpolarized (13)C-succinate imaging of brain cancerPratip Bhattacharya
MR Unit, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
J Magn Reson 186:150-5. 2007..These ex vivo results indicate that hyperpolarized (13)C sodium succinate may become a useful tool for rapid in vivo identification of brain tumors, providing novel biomarkers in (13)C MR spectral-spatial images... - Impact of evidence-based medicine on magnetic resonance spectroscopyAlexander P Lin
Rudi Schulte Research Institute, Santa Barbara, CA 93130, USA
NMR Biomed 19:476-83. 2006..Based on the conclusions of the EBM assessments, strategies are suggested that involve all entities responsible for spectroscopy including the scientists' role in ensuring the future for clinical spectroscopy... - Kinetics of glial glutamine efflux and the mechanism of neuronal uptake studied in vivo in mildly hyperammonemic rat brainKeiko Kanamori
Magnetic Resonance Spectroscopy Laboratory, Huntington Medical Research Institutes, Pasadena, California 91105, USA
J Neurochem 99:1103-13. 2006..The results strongly suggest that SAT is the predominant mediator of neuronal GLN(ECF) uptake in adult rat brain in vivo... - Reduced glutamate neurotransmission in patients with Alzheimer's disease -- an in vivo (13)C magnetic resonance spectroscopy studyAlexander P Lin
Clinical Spectroscopy Unit, Huntington Medical Research Institutes, 660 S Fair Oaks Avenue, Pasadena, CA 91105, USA
MAGMA 16:29-42. 2003..73-0.95; P<0.05-0.01), suggesting that impairment of GNT may be a contributing factor in the cognitive impairment characteristic of AD... - In vivo characterization of fatty acids in human adipose tissue using natural abundance 1H decoupled 13C MRS at 1.5 T: clinical applications to dietary therapyJong Hee Hwang
Huntington Medical Research Institutes, Pasadena, CA, USA
NMR Biomed 16:160-7. 2003..Since the examination is rapid, robust and noninvasive, opportunities arise for large clinical trials of preventive or therapeutic diets to be performed with (13)C MRS on a clinical MR scanner...
Research Grants
- Image Biomarker Development for TreatmentEfficacy of Prostate Cancer to the BoneBrian Ross; Fiscal Year: 2009..In addition, imaging biomarkers for early assessment of treatment response will be evaluated and validated leading to individualization of treatment for bone cancer patients. ..
- 7.0T/210 Imaging SystemBrian Ross; Fiscal Year: 2005..This proposal provides documentation of our need, past contributions to small animal imaging, organizational and training competence, and institutional commitment. ..
- Brain Tumor Therapeutic Efficacy by Quantitative MRBrian Ross; Fiscal Year: 2006..The Biostatistical Core D provides statistical support to all projects. ..
- Michigan Small Animal Imaging Resource (MSAIR)Brian Ross; Fiscal Year: 2007..Moreover, the MSAIR has become a central, diverse and dynamic resource facility wherein exchange of techniques and ideas can occur, which fosters productive interdisciplinary collaborations in cancer research. ..
- In Vivo Imaging NeoplasiaBrian Ross; Fiscal Year: 2007..abstract_text> ..
- Brain Tumor Therapeutic Efficacy of Quantitative MRBrian Ross; Fiscal Year: 2007..Overall management of the program project will be accomplished by the administrative core (Core A) ..
- Image Biomarker Development for TreatmentEfficacy of Prostate Cancer to the BoneBrian D Ross; Fiscal Year: 2010..In addition, imaging biomarkers for early assessment of treatment response will be evaluated and validated leading to individualization of treatment for bone cancer patients. ..