Brian Ross

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making
    Alexander Lin
    Rudi Schulte Research Institute, Santa Barbara, California 93105, USA
    NeuroRx 2:197-214. 2005
  2. pmc Noninvasive imaging of apoptosis and its application in cancer therapeutics
    Julia M Coppola
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 14:2492-501. 2008
  3. pmc Novel molecular imaging platform for monitoring oncological kinases
    Shyam Nyati
    Department of Radiation Oncology, University of Michigan, Ann Arbor MI 48109 USA
    Cancer Cell Int 10:23. 2010
  4. ncbi request reprint Magnetic resonance imaging in cancer research
    B D Ross
    Department of Radiology, University of Michigan Medical School, 1150 West Medical Center Drive, Medical Sciences Research Building III, Room 9303, Ann Arbor 48109 0648, USA
    Eur J Cancer 38:2147-56. 2002
  5. ncbi request reprint Evaluation of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on the 9L rat brain tumor model using MRI
    Brian D Ross
    Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, MI 48109, USA
    NMR Biomed 16:67-76. 2003
  6. pmc The parametric response map is an imaging biomarker for early cancer treatment outcome
    Craig J Galban
    Departments of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, USA
    Nat Med 15:572-6. 2009
  7. pmc Functional diffusion map as an early imaging biomarker for high-grade glioma: correlation with conventional radiologic response and overall survival
    Daniel A Hamstra
    University of Michigan, B2A209 UH 1500 East Medical Center Dr, Ann Arbor, MI 48109 0030, USA
    J Clin Oncol 26:3387-94. 2008
  8. pmc The functional diffusion map: an imaging biomarker for the early prediction of cancer treatment outcome
    Bradford A Moffat
    Center for Molecular Imaging, Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0648, USA
    Neoplasia 8:259-67. 2006
  9. ncbi request reprint Therapeutic efficacy of DTI-015 using diffusion magnetic resonance imaging as an early surrogate marker
    Daniel E Hall
    University of Michigan, Center for Molecular Imaging and Department of Radiology, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0648, USA
    Clin Cancer Res 10:7852-9. 2004
  10. ncbi request reprint Inhibition of vascular endothelial growth factor (VEGF)-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-D
    Bradford A Moffat
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan 48109 0503, USA
    Clin Cancer Res 12:1525-32. 2006

Collaborators

Detail Information

Publications73

  1. pmc Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making
    Alexander Lin
    Rudi Schulte Research Institute, Santa Barbara, California 93105, USA
    NeuroRx 2:197-214. 2005
    ..Additional efficacy studies could extend the range of this capability...
  2. pmc Noninvasive imaging of apoptosis and its application in cancer therapeutics
    Julia M Coppola
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 14:2492-501. 2008
    ..Noninvasive imaging of apoptosis facilitates optimization of therapeutic protocols regarding dosing and schedule and enables identification of efficacious combination therapies...
  3. pmc Novel molecular imaging platform for monitoring oncological kinases
    Shyam Nyati
    Department of Radiation Oncology, University of Michigan, Ann Arbor MI 48109 USA
    Cancer Cell Int 10:23. 2010
    ..Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions...
  4. ncbi request reprint Magnetic resonance imaging in cancer research
    B D Ross
    Department of Radiology, University of Michigan Medical School, 1150 West Medical Center Drive, Medical Sciences Research Building III, Room 9303, Ann Arbor 48109 0648, USA
    Eur J Cancer 38:2147-56. 2002
    ..These examples provide an overview of areas in which imaging of animal tumour models can contribute towards improving the evaluation of experimental therapeutic agents...
  5. ncbi request reprint Evaluation of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on the 9L rat brain tumor model using MRI
    Brian D Ross
    Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, MI 48109, USA
    NMR Biomed 16:67-76. 2003
    ....
  6. pmc The parametric response map is an imaging biomarker for early cancer treatment outcome
    Craig J Galban
    Departments of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, USA
    Nat Med 15:572-6. 2009
    ..Even when accounting for baseline rCBV, which is prognostic, PRM(rCBV) proved more predictive of overall survival...
  7. pmc Functional diffusion map as an early imaging biomarker for high-grade glioma: correlation with conventional radiologic response and overall survival
    Daniel A Hamstra
    University of Michigan, B2A209 UH 1500 East Medical Center Dr, Ann Arbor, MI 48109 0030, USA
    J Clin Oncol 26:3387-94. 2008
    ..Diffusion magnetic resonance imaging (MRI) using a functional diffusion map (fDM) may provide an earlier measure to predict patient survival...
  8. pmc The functional diffusion map: an imaging biomarker for the early prediction of cancer treatment outcome
    Bradford A Moffat
    Center for Molecular Imaging, Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0648, USA
    Neoplasia 8:259-67. 2006
    ..Therefore, The fDM imaging biomarker for early prediction of treatment efficacy can be used in the drug development process...
  9. ncbi request reprint Therapeutic efficacy of DTI-015 using diffusion magnetic resonance imaging as an early surrogate marker
    Daniel E Hall
    University of Michigan, Center for Molecular Imaging and Department of Radiology, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0648, USA
    Clin Cancer Res 10:7852-9. 2004
    ....
  10. ncbi request reprint Inhibition of vascular endothelial growth factor (VEGF)-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-D
    Bradford A Moffat
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan 48109 0503, USA
    Clin Cancer Res 12:1525-32. 2006
    ..The aim of this study was to evaluate the effect of VEGF-A expression on tumor growth, perfusion, and chemotherapeutic efficacy in orthotopic 9L gliosarcomas...
  11. pmc Evaluation of treatment-associated inflammatory response on diffusion-weighted magnetic resonance imaging and 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography imaging biomarkers
    Craig J Galban
    Center for Molecular Imaging and Departments of Radiology, University of Michigan, School of Medicine, Ann Arbor, Michigan 48109 0220, USA
    Clin Cancer Res 16:1542-52. 2010
    ....
  12. ncbi request reprint Molecular imaging of Akt kinase activity
    Limin Zhang
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Med 13:1114-9. 2007
    ..The results provide unique insights into the pharmacokinetics and pharmacodynamics of agents that modulate Akt activity, revealing the usefulness of this reporter for rapid dose and schedule optimization in the drug development process...
  13. pmc Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas
    Thomas C Kwee
    Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Magn Reson Imaging 31:531-7. 2010
    ..To compare apparent diffusion coefficients (ADCs) with distributed diffusion coefficients (DDCs) in high-grade gliomas...
  14. ncbi request reprint Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapy
    Kuei C Lee
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Biomedical Sciences Research Building, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Clin Cancer Res 13:443-50. 2007
    ..In this study, we evaluate the feasibility of using diffusion magnetic resonance imaging (MRI) as a reliable and quantitative measure for the early assessment of response in a breast cancer model...
  15. ncbi request reprint Survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT [corrected]
    Yue Cao
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 64:876-85. 2006
    ..To determine whether cerebral blood volume (CBV) and cerebral blood flow can predict the response of high-grade gliomas to radiotherapy (RT) by taking into account spatial heterogeneity and temporal changes in perfusion...
  16. ncbi request reprint Diffusion MRI: a new strategy for assessment of cancer therapeutic efficacy
    Thomas L Chenevert
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0030, USA
    Mol Imaging 1:336-43. 2002
    ....
  17. pmc A review of the past, present, and future directions of neoplasia
    Alnawaz Rehemtulla
    University of Michigan Medical Center, Ann Arbor, MI 48109 0582, USA
    Neoplasia 7:1039-46. 2005
  18. pmc Sodium and proton diffusion MRI as biomarkers for early therapeutic response in subcutaneous tumors
    Victor D Schepkin
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109 0503, USA
    Magn Reson Imaging 24:273-8. 2006
    ..The results of this study support the continued clinical testing of diffusion MRI for evaluation of early tumor treatment response and demonstrate the complementary insights of sodium MRI for oncology applications...
  19. ncbi request reprint Dynamic imaging of emerging resistance during cancer therapy
    Kuei C Lee
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 66:4687-92. 2006
    ..Overall, this study highlights the ability of diffusion MRI to provide sensitive dynamic assessment of therapy-induced response, allowing early opportunities for optimization of therapeutic protocols...
  20. pmc A methodology for registration of a histological slide and in vivo MRI volume based on optimizing mutual information
    Charles R Meyer
    University of Michigan, Ann Arbor, USA
    Mol Imaging 5:16-23. 2006
    ..Overall, this approach provides a robust method for coregistration of in vivo images with histological sections and will have broad applications in the field of functional and molecular imaging...
  21. ncbi request reprint Diffusion imaging: insight to cell status and cytoarchitecture
    Thomas L Chenevert
    Department of Radiology, University of Michigan Health Systems, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuroimaging Clin N Am 16:619-32, viii-ix. 2006
    ..Similarly, therapeutic intervention that alters these properties may be monitored for efficacy via diffusion MR imaging. This article outlines basic technical concepts and applications of diffusion imaging with an emphasis on oncology...
  22. ncbi request reprint Diffusion magnetic resonance imaging: a biomarker for treatment response in oncology
    Daniel A Hamstra
    Department of Radiation Oncology, The Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
    J Clin Oncol 25:4104-9. 2007
    ..This review highlights the development of this technique and the state of current clinical understanding of its utility...
  23. ncbi request reprint Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor--a pharmacokinetic study
    Daniel A Hamstra
    The Department of Radiation, The University of Michigan Medical Center, Ann Arbor, MI 48109 0648, USA
    J Neurooncol 73:225-38. 2005
    ....
  24. pmc Radiation-induced changes in normal-appearing white matter in patients with cerebral tumors: a diffusion tensor imaging study
    Vijaya Nagesh
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109 0100, USA
    Int J Radiat Oncol Biol Phys 70:1002-10. 2008
    ..To quantify the radiation-induced changes in normal-appearing white matter before, during, and after radiotherapy (RT) in cerebral tumor patients...
  25. doi request reprint Pharmacokinetic analysis and phase 1 study of MRX-1024 in patients treated with radiation therapy with or without cisplatinum for head and neck cancer
    Daniel A Hamstra
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 5010, USA
    Clin Cancer Res 16:2666-76. 2010
    ..A previous study reported radiation protection from mucosal injury with D-methionine (D-met) in preclinical evaluation; therefore, the pharmacokinetics, safety, and utility of D-met were evaluated clinically...
  26. pmc Parametric response map as an imaging biomarker to distinguish progression from pseudoprogression in high-grade glioma
    Christina Tsien
    Department of Radiation Oncology, University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    J Clin Oncol 28:2293-9. 2010
    ..To assess whether a new method of quantifying therapy-associated hemodynamic alterations may help to distinguish pseudoprogression from true progression in patients with high-grade glioma...
  27. pmc A transgenic mouse for imaging caspase-dependent apoptosis within the skin
    Divya Khanna
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    J Invest Dermatol 130:1797-806. 2010
    ..This reporter and transgenic mouse could serve as a unique tool for the study of apoptosis in living cells and animals, especially in the context of skin biology...
  28. doi request reprint Diffusion imaging for therapy response assessment of brain tumor
    Thomas L Chenevert
    Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Neuroimaging Clin N Am 19:559-71. 2009
    ..Diffusion tensor imaging and its derivative maps of diffusion anisotropy allow assessment of tumor compression or destruction of adjacent normal tissue anisotropy and may aid to assess tumor infiltration and aid presurgical planning...
  29. doi request reprint Evaluation of D-methionine as a novel oral radiation protector for prevention of mucositis
    Saleha B Vuyyuri
    Departments of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
    Clin Cancer Res 14:2161-70. 2008
    ..D-Methionine (D-Met), the dextro-isomer of the common amino acid l-methionine, has been documented to protect normal tissues from a diverse array of oxidative insults...
  30. pmc Voxel-by-voxel functional diffusion mapping for early evaluation of breast cancer treatment
    Bing Ma
    Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
    Inf Process Med Imaging 21:276-87. 2009
    ..Comparison of the experimental results with pathology shows that ADC changes can be used to evaluate early response of breast cancer treatment...
  31. ncbi request reprint Bioluminescence detection of cells having stabilized p53 in response to a genotoxic event
    Alnawaz Rehemtulla
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor 48109, USA
    Mol Imaging 3:63-8. 2004
    ..It could also be used to study p53 stabilization as a result of inactivating p53 mutations. Such studies will further our understanding of p53's role as the "guardian of the genome" and its function in tumorigenesis...
  32. pmc Radiosynthesis and evaluation of 5-[125I]iodoindol-3-yl-beta-D-galactopyranoside as a beta-galactosidase imaging radioligand
    Marcian E Van Dort
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Mol Imaging 7:187-97. 2008
    ....
  33. pmc Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma
    Victor D Schepkin
    Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Kresge II Research Building, R3028, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Magn Reson Med 53:85-92. 2005
    ..This study demonstrates the possibility of Na MRI to function as a biomarker for monitoring early tumor treatment and validates the use of monitoring changes in diffusion MRI values for assessing tumor cellularity...
  34. ncbi request reprint Continuous arterial spin labeling using a train of adiabatic inversion pulses
    Bradford A Moffat
    Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA
    J Magn Reson Imaging 21:290-6. 2005
    ....
  35. ncbi request reprint The extent and severity of vascular leakage as evidence of tumor aggressiveness in high-grade gliomas
    Yue Cao
    Departments of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Cancer Res 66:8912-7. 2006
    ..In contrast, survival depends chiefly on the volume of aggressive tumor at the time of presentation...
  36. ncbi request reprint Predicting outcome of patients with high-grade gliomas after radiotherapy using quantitative analysis of T1-weighted magnetic resonance imaging
    Christina Tsien
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 67:1476-83. 2007
    ....
  37. ncbi request reprint Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy
    Yong Eun Lee Koo
    University of Michigan, Michigan 48109, USA
    Appl Opt 46:1924-30. 2007
    ....
  38. doi request reprint Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas
    Thomas C Kwee
    Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    NMR Biomed 23:179-87. 2010
    ..The observed negative correlation between tumor alpha and tumor DDC requires further investigation...
  39. pmc Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade glioma
    Daniel A Hamstra
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109 0648, USA
    Proc Natl Acad Sci U S A 102:16759-64. 2005
    ..Further evaluation of this technique is warranted to determine whether it may be useful in the individualization of treatment or evaluation of the response in clinical protocols...
  40. ncbi request reprint An imaging biomarker of early treatment response in prostate cancer that has metastasized to the bone
    Kuei C Lee
    Department of Radiology, and Center for Molecular Imaging, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Cancer Res 67:3524-8. 2007
    ..Validation of fDM results was accomplished by histologic analysis of excised tissue. Results from this study show the capability of fDM as a biomarker for detection of bone cancer treatment efficacy, thus warranting clinical evaluation...
  41. pmc Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors
    Beata Chertok
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109 1065, USA
    Biomaterials 29:487-96. 2008
    ..Hence, these nanoparticles appear to be a promising vehicle for glioma-targeted drug delivery...
  42. pmc Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response
    Bradford A Moffat
    Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:5524-9. 2005
    ..Overall, fDM analysis provided an early biomarker for predicting treatment response in brain tumor patients...
  43. ncbi request reprint Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma
    Patrick McConville
    MIR Preclinical Services, Inc, Ann Arbor, Michigan, USA
    Clin Cancer Res 13:2897-904. 2007
    ..The nestin tv-a (Ntv-a) genetically engineered mouse spontaneously develops glioma when infected with ALV-A expressing platelet-derived growth factor, resulting in autocrine platelet-derived growth factor signaling...
  44. pmc A feasibility study evaluating the functional diffusion map as a predictive imaging biomarker for detection of treatment response in a patient with metastatic prostate cancer to the bone
    Kuei C Lee
    Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Neoplasia 9:1003-11. 2007
    ..Thus, the fDM imaging biomarker may provide a quantifiable therapeutic endpoint to assess response in patients with metastatic bone cancer...
  45. ncbi request reprint Noninvasive molecular imaging sheds light on the synergy between 5-fluorouracil and TRAIL/Apo2L for cancer therapy
    Kuei C Lee
    Department of Biological Chemistry, The University of Michigan Medical Center, Ann Arbor, MI 48109 0582, USA
    Clin Cancer Res 13:1839-46. 2007
    ....
  46. ncbi request reprint A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI
    Bradford A Moffat
    University of Michigan, Ann Arbor, USA
    Mol Imaging 2:324-32. 2003
    ..The flexible formulation of these nanoparticles suggests that future modifications could be accomplished allowing for their use as a targeted molecular imaging contrast agent and/or therapeutic platform for multiple indications...
  47. pmc Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP
    William H Perman
    Department of Radiology, Saint Louis University School of Medicine, PO Box 15250, St Louis, Mo 63110 0250, USA
    Magn Reson Imaging 28:459-65. 2010
    ..The goal of this work was to develop a fast 3D chemical shift imaging technique for the noninvasive measurement of hyperpolarized (13)C-labeled substrates and metabolic products at low concentration...
  48. pmc Molecular imaging of N-linked glycosylation suggests glycan biosynthesis is a novel target for cancer therapy
    Joseph N Contessa
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan, USA
    Clin Cancer Res 16:3205-14. 2010
    ..We therefore investigated the feasibility of blocking NLG in vivo to reduce overexpression of RTKs...
  49. pmc Noninvasive real-time imaging of apoptosis
    Bharathi Laxman
    Center for Molecular Imaging, University of Michigan Medical School, 1150 West Medical Center Drive, Medical Sciences Research Building III, Room 9303, Ann Arbor, MI 48109 0648, USA
    Proc Natl Acad Sci U S A 99:16551-5. 2002
    ....
  50. ncbi request reprint Vascular targeted nanoparticles for imaging and treatment of brain tumors
    G Ramachandra Reddy
    Molecular Therapeutics, Inc, Ann Arbor, MI 48109, USA
    Clin Cancer Res 12:6677-86. 2006
    ..The ability to directly target a therapeutic agent to a tumor site would minimize systemic drug exposure, thus providing the potential for increasing the therapeutic index...
  51. ncbi request reprint Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging
    Daniel A Hamstra
    Department of Radiation Oncology, University of Michigan Medical Center, 1331 East Ann Street, Ann Arbor, MI 48109, USA
    Cancer Res 66:7482-9. 2006
    ..In addition, the kinetics of oscillations were altered by pretreatment with radiation-modifying agents. These results show the use of this mouse model in enhancing our understanding of the transcriptional role of p53 in vivo...
  52. ncbi request reprint Quantitative characterization of hemodynamic properties and vasculature dysfunction of high-grade gliomas
    Vijaya Nagesh
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    NMR Biomed 20:566-77. 2007
    ..Progressive abnormalities in vasculature and hemodynamic characteristics of the vascular bed were delineated, with significant disorder in the tumor but mild abnormality in peritumoral tissue...
  53. pmc Enhancing Akt imaging through targeted reporter expression
    Limin Zhang
    Department of Radiation Oncology, Center for Molecular Imaging, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Imaging 7:168-74. 2008
    ..Based on these results, we propose that the membrane-associated Akt reporter may be better suited for identification of novel compounds that modulate the Akt pathway by high-throughput screening...
  54. ncbi request reprint Synthesis and characterization of silica-embedded iron oxide nanoparticles for magnetic resonance imaging
    Fei Yan
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109 1055, USA
    J Nanosci Nanotechnol 4:72-6. 2004
    ..The design of the nanoparticle is universal and flexible and allows for facile addition or interchange of its active components (i.e., MRI contrast agents and targeting moiety) with photodynamic dyes...
  55. ncbi request reprint Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer
    Mahaveer S Bhojani
    Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 0648, USA
    Cell Cycle 4:1478-81. 2005
    ..These results suggest that levels of p-FADD may be used as a prognostic biomarker for predicting survival of lung cancer patients...
  56. pmc Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Departments of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:12507-12. 2005
    ....
  57. pmc A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness
    Julia M Coppola
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 10:363-70. 2008
    ..Additionally, this molecule inhibited proMT1-MMP processing, complete MMP-2 maturation, and invasiveness of human fibrosarcoma cells (HT1080)...
  58. ncbi request reprint Evaluation of cancer therapy using diffusion magnetic resonance imaging
    Brian D Ross
    University of Michigan Medical School, Ann Arbor, Michigan 48109 0648, USA
    Mol Cancer Ther 2:581-7. 2003
    ..This article provides an overview of the use of diffusion magnetic resonance imaging as a surrogate marker for quantitating treatment responsiveness in both preclinical and clinical studies...
  59. pmc Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules
    Tomoko Komiyama
    Departments of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 284:15729-38. 2009
    ....
  60. ncbi request reprint Imaging of proteolytic activity using a conditional cell surface receptor
    Mahaveer Swaroop Bhojani
    University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Mol Imaging 5:129-37. 2006
    ..This methodology may provide for a multimodal noninvasive real-time imaging of apoptosis and a new opportunity for high-throughput screening of cell-death-modulating therapeutic agents...
  61. ncbi request reprint Brain cancer diagnosis and therapy with nanoplatforms
    Yong Eun Lee Koo
    Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Adv Drug Deliv Rev 58:1556-77. 2006
    ..The advantages of nanoparticle-based delivery and the types of nanoparticle systems under investigation are described, as well as their applications...
  62. pmc Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity
    Julia M Coppola
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Anal Biochem 364:19-29. 2007
    ..In conclusion, we describe a customizable noninvasive technology for real-time assessment of Golgi protease activity used to identify inhibitors of furin and BACE...
  63. ncbi request reprint Development of a syngeneic rat brain tumor model expressing EGFRvIII and its use for molecular targeting studies with monoclonal antibody L8A4
    Weilian Yang
    Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
    Clin Cancer Res 11:341-50. 2005
    ..t., and convection enhanced delivery to brain tumor-bearing rats...
  64. pmc Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance
    Victor D Schepkin
    National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA
    NMR Biomed 19:1035-42. 2006
    ..Overall, these experiments demonstrate the sensitivity and applicability of sodium and diffusion MRI as tools for dynamic assessment of tumor response to therapy...
  65. ncbi request reprint Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons
    Hoon Ryu
    Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:3597-606. 2003
    ..Taken together, these results establish Sp1 and Sp3 as oxidative stress-induced transcription factors in cortical neurons that positively regulate neuronal survival...
  66. ncbi request reprint It's not just about anatomy: in vivo bioluminescence imaging as an eyepiece into biology
    Christopher H Contag
    Departments of Pediatrics, Radiology, and Microbiology and Immunology, Stanford University Medical Center, Stanford University, Stanford, California 94305 5308, USA
    J Magn Reson Imaging 16:378-87. 2002
    ....
  67. ncbi request reprint Molecular imaging of gene expression and efficacy following adenoviral-mediated brain tumor gene therapy
    Alnawaz Rehemtulla
    University of Michigan School of Medicine, USA
    Mol Imaging 1:43-55. 2002
    ....
  68. ncbi request reprint The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies
    Daniel A Hamstra
    Department of Radiation Oncology, The University of Michigan Medical Center, Ann Arbor 48109 0582, USA
    Mol Ther 10:916-28. 2004
    ....
  69. pmc Towards hyperpolarized (13)C-succinate imaging of brain cancer
    Pratip Bhattacharya
    MR Unit, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    J Magn Reson 186:150-5. 2007
    ..These ex vivo results indicate that hyperpolarized (13)C sodium succinate may become a useful tool for rapid in vivo identification of brain tumors, providing novel biomarkers in (13)C MR spectral-spatial images...
  70. ncbi request reprint Impact of evidence-based medicine on magnetic resonance spectroscopy
    Alexander P Lin
    Rudi Schulte Research Institute, Santa Barbara, CA 93130, USA
    NMR Biomed 19:476-83. 2006
    ..Based on the conclusions of the EBM assessments, strategies are suggested that involve all entities responsible for spectroscopy including the scientists' role in ensuring the future for clinical spectroscopy...
  71. ncbi request reprint Kinetics of glial glutamine efflux and the mechanism of neuronal uptake studied in vivo in mildly hyperammonemic rat brain
    Keiko Kanamori
    Magnetic Resonance Spectroscopy Laboratory, Huntington Medical Research Institutes, Pasadena, California 91105, USA
    J Neurochem 99:1103-13. 2006
    ..The results strongly suggest that SAT is the predominant mediator of neuronal GLN(ECF) uptake in adult rat brain in vivo...
  72. ncbi request reprint Reduced glutamate neurotransmission in patients with Alzheimer's disease -- an in vivo (13)C magnetic resonance spectroscopy study
    Alexander P Lin
    Clinical Spectroscopy Unit, Huntington Medical Research Institutes, 660 S Fair Oaks Avenue, Pasadena, CA 91105, USA
    MAGMA 16:29-42. 2003
    ..73-0.95; P<0.05-0.01), suggesting that impairment of GNT may be a contributing factor in the cognitive impairment characteristic of AD...
  73. ncbi request reprint In vivo characterization of fatty acids in human adipose tissue using natural abundance 1H decoupled 13C MRS at 1.5 T: clinical applications to dietary therapy
    Jong Hee Hwang
    Huntington Medical Research Institutes, Pasadena, CA, USA
    NMR Biomed 16:160-7. 2003
    ..Since the examination is rapid, robust and noninvasive, opportunities arise for large clinical trials of preventive or therapeutic diets to be performed with (13)C MRS on a clinical MR scanner...

Research Grants11

  1. Image Biomarker Development for TreatmentEfficacy of Prostate Cancer to the Bone
    Brian Ross; Fiscal Year: 2009
    ..In addition, imaging biomarkers for early assessment of treatment response will be evaluated and validated leading to individualization of treatment for bone cancer patients. ..
  2. 7.0T/210 Imaging System
    Brian Ross; Fiscal Year: 2005
    ..This proposal provides documentation of our need, past contributions to small animal imaging, organizational and training competence, and institutional commitment. ..
  3. Brain Tumor Therapeutic Efficacy by Quantitative MR
    Brian Ross; Fiscal Year: 2006
    ..The Biostatistical Core D provides statistical support to all projects. ..
  4. Michigan Small Animal Imaging Resource (MSAIR)
    Brian Ross; Fiscal Year: 2007
    ..Moreover, the MSAIR has become a central, diverse and dynamic resource facility wherein exchange of techniques and ideas can occur, which fosters productive interdisciplinary collaborations in cancer research. ..
  5. In Vivo Imaging Neoplasia
    Brian Ross; Fiscal Year: 2007
    ..abstract_text> ..
  6. Brain Tumor Therapeutic Efficacy of Quantitative MR
    Brian Ross; Fiscal Year: 2007
    ..Overall management of the program project will be accomplished by the administrative core (Core A) ..
  7. Image Biomarker Development for TreatmentEfficacy of Prostate Cancer to the Bone
    Brian D Ross; Fiscal Year: 2010
    ..In addition, imaging biomarkers for early assessment of treatment response will be evaluated and validated leading to individualization of treatment for bone cancer patients. ..