EDWARD ROSLONIEC

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. pmc Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice
    Yoshihiko Sakurai
    Department of Medicine, University of Tennessee, 956 Court Avenue, Memphis, TN 38163, USA
    Arthritis Res Ther 8:R150. 2006
  2. ncbi HLA-DR1 (DRB1*0101) and DR4 (DRB1*0401) use the same anchor residues for binding an immunodominant peptide derived from human type II collagen
    Edward F Rosloniec
    Veterans Affairs Medical Center, Research Service 151, 1030 Jefferson Avenue, Memphis, TN 38104, USA
    J Immunol 168:253-9. 2002
  3. ncbi Second-generation peptidomimetic inhibitors of antigen presentation effectively treat autoimmune diseases in HLA-DR-transgenic mouse models
    Edward F Rosloniec
    Research Service, Veterans Affairs Medical Center, Memphis, TN 38104, USA
    J Autoimmun 27:182-95. 2006
  4. pmc Paradoxical roles of IFN-gamma in models of Th1-mediated autoimmunity
    Edward F Rosloniec
    VA Medical Center, Research Service 151, Memphis, Tennessee, USA
    Arthritis Res 4:333-6. 2002
  5. ncbi Collagen-induced arthritis mediated by HLA-DR1 (*0101) and HLA-DR4 (*0401)
    Edward F Rosloniec
    Veterans Affairs Medical Center and the Department of Medicine, University of Tennessee, Memphis, Tennessee 38104, USA
    Am J Med Sci 327:169-79. 2004
  6. ncbi Ex vivo characterization of the autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of type II collagen-specific cells and their presence in arthritic joints
    Kary A Latham
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 174:3978-85. 2005
  7. pmc Molecular characterization of an arthritogenic collagen peptide interacting with I-Ar
    Yoshihiko Sakurai
    Department of Medicine, University of Tennessee, Memphis, TN 38163, USA
    Immunology 117:136-42. 2006
  8. ncbi Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice
    Linda K Myers
    University of Tennessee, Memphis, USA
    Arthritis Rheum 46:3369-77. 2002
  9. ncbi Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis
    Kary A Latham
    Veterans Affairs Medical Center, Memphis, TN 38104, USA
    J Immunol 171:5820-7. 2003
  10. ncbi Immunopathogenesis of collagen arthritis
    David D Brand
    Veterans Affairs Medical Center, Research Service 151, 130 Jefferson Avenue, Memphis, TN 38104, USA
    Springer Semin Immunopathol 25:3-18. 2003

Research Grants

  1. MECHANISMS OF AUTOIMMUNE ARTHRITIS
    EDWARD ROSLONIEC; Fiscal Year: 2001

Collaborators

Detail Information

Publications22

  1. pmc Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice
    Yoshihiko Sakurai
    Department of Medicine, University of Tennessee, 956 Court Avenue, Memphis, TN 38163, USA
    Arthritis Res Ther 8:R150. 2006
    ..These experiments represent the first description of an analog peptide of CII recognized by T cells in the context of HLA-DR4 that can suppress autoimmune arthritis...
  2. ncbi HLA-DR1 (DRB1*0101) and DR4 (DRB1*0401) use the same anchor residues for binding an immunodominant peptide derived from human type II collagen
    Edward F Rosloniec
    Veterans Affairs Medical Center, Research Service 151, 1030 Jefferson Avenue, Memphis, TN 38104, USA
    J Immunol 168:253-9. 2002
    ....
  3. ncbi Second-generation peptidomimetic inhibitors of antigen presentation effectively treat autoimmune diseases in HLA-DR-transgenic mouse models
    Edward F Rosloniec
    Research Service, Veterans Affairs Medical Center, Memphis, TN 38104, USA
    J Autoimmun 27:182-95. 2006
    ..Selected compounds of this series are shown to inhibit antigen presentation in vivo, as well as effectively treat collagen induced arthritis and experimental autoimmune encephalomyelitis in HLA-DR transgenic mouse models...
  4. pmc Paradoxical roles of IFN-gamma in models of Th1-mediated autoimmunity
    Edward F Rosloniec
    VA Medical Center, Research Service 151, Memphis, Tennessee, USA
    Arthritis Res 4:333-6. 2002
    ....
  5. ncbi Collagen-induced arthritis mediated by HLA-DR1 (*0101) and HLA-DR4 (*0401)
    Edward F Rosloniec
    Veterans Affairs Medical Center and the Department of Medicine, University of Tennessee, Memphis, Tennessee 38104, USA
    Am J Med Sci 327:169-79. 2004
    ..In all, these studies demonstrate that DR1 and DR4 are capable of binding peptides derived from human type II collagen (hCII) and support the hypothesis that autoimmune responses to hCII play a role in the pathogenesis of RA...
  6. ncbi Ex vivo characterization of the autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of type II collagen-specific cells and their presence in arthritic joints
    Kary A Latham
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 174:3978-85. 2005
    ....
  7. pmc Molecular characterization of an arthritogenic collagen peptide interacting with I-Ar
    Yoshihiko Sakurai
    Department of Medicine, University of Tennessee, Memphis, TN 38163, USA
    Immunology 117:136-42. 2006
    ..Identification of the molecular interactions involved in T-cell recognition of CII should lead to antigen-specific means of inhibiting autoimmune arthritis...
  8. ncbi Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice
    Linda K Myers
    University of Tennessee, Memphis, USA
    Arthritis Rheum 46:3369-77. 2002
    ..To identify peptides capable of altering the immune response to type II collagen (CII) in the context of HLA-DR...
  9. ncbi Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis
    Kary A Latham
    Veterans Affairs Medical Center, Memphis, TN 38104, USA
    J Immunol 171:5820-7. 2003
    ....
  10. ncbi Immunopathogenesis of collagen arthritis
    David D Brand
    Veterans Affairs Medical Center, Research Service 151, 130 Jefferson Avenue, Memphis, TN 38104, USA
    Springer Semin Immunopathol 25:3-18. 2003
    ..In recent years, the pathogenesis of this model has been studied extensively and the CIA model is proving to be a valuable asset for the design of new immunotherapeutics for the potential treatment of RA and other autoimmune diseases...
  11. doi An autoantigen-specific, highly restricted T cell repertoire infiltrates the arthritic joints of mice in an HLA-DR1 humanized mouse model of autoimmune arthritis
    Zhaohui Qian
    Veterans Affairs Medical Center, Memphis, TN 38104, USA
    J Immunol 185:110-8. 2010
    ..In addition, this model may be very useful for studying the function in situ and the mechanism by which autoimmune T cells are recruited to the site of inflammation...
  12. ncbi T cell immunity to type II collagen in the biobreeding rat: the identification and characterization of RT1u-restricted T cell epitopes on alpha 1(II)
    Michael A Cremer
    Research Service of Veterans Affairs Medical Center, Memphis, TN 38104, USA
    J Immunol 173:1795-801. 2004
    ..This motif is similar to one recognized by collagen-induced arthritis-susceptible HLA-DR1- and HLA-DR4-transgenic mice...
  13. pmc MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis
    Jianya Huan
    Neuroimmunology Research, Veterans Affairs Medical Center, Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland 97201, USA
    J Immunol 180:1249-57. 2008
    ..This is the first report demonstrating effective prevention of joint inflammation and clinical signs of CIA with an I-Aq-derived RTL, thus supporting the possible clinical use of this approach for treating rheumatoid arthritis in humans...
  14. ncbi Collagen-induced arthritis
    David D Brand
    Research Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Nat Protoc 2:1269-75. 2007
    ..The total time for the preparation of reagents and the immunization of ten mice is about 1.5 h...
  15. ncbi Detection of early changes in autoimmune T cell phenotype and function following intravenous administration of type II collagen in a TCR-transgenic model
    David D Brand
    Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA
    J Immunol 168:490-8. 2002
    ....
  16. ncbi The mouse model of collagen-induced arthritis
    David D Brand
    Department of Medicine, University of Tennessee Health Sciences Center, Memphis, USA
    Methods Mol Med 102:295-312. 2004
    ....
  17. ncbi Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen
    Edward F Rosloniec
    Veterans Affairs Medical Center, Memphis, TN 38104, USA
    J Immunol 177:3884-92. 2006
    ..Comparison of the DR1-CII structure to a DR1-hemagglutinin peptide structure revealed that the binding of these two peptides generates significantly different interfaces for the interaction with their respective Ag-specific TCRs...
  18. ncbi An analog peptide that suppresses collagen-induced arthritis
    Linda K Myers
    Department of Pediatrics and Medicine, University of Tennessee, and from the Research Service of the Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Am J Med Sci 327:212-6. 2004
    ..An analog peptide of CII recognized by T cells in the context of a human major histocompatibility complex molecule should have therapeutic significance for autoimmune arthritis...
  19. ncbi T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usage
    Xiaowen He
    Research Service, Memphis Veterans Affairs Medical Center, and University of Tennessee, 38104, USA
    Arthritis Rheum 50:1996-2004. 2004
    ..To determine the T cell receptor (TCR) structure recognizing type II collagen (CII) in HLA-DR-transgenic mice, and to examine the role of T cells with certain V(beta)-chains in collagen-induced arthritis (CIA)...
  20. doi Collagen-induced arthritis
    Edward F Rosloniec
    Veterans Affairs Medical Center, and University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Curr Protoc Immunol . 2010
    ....
  21. ncbi Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen
    Michael T Falta
    University of Colorado Health Sciences Center, and National Jewish Medical and Research Center, Denver, Colorado 80262, USA
    Arthritis Rheum 52:1885-96. 2005
    ..We undertook this study to better understand the parameters for specific binding of this tetramer...
  22. ncbi A single-chain class II MHC-IgG3 fusion protein inhibits autoimmune arthritis by induction of antigen-specific hyporesponsiveness
    Li Zuo
    Division of Rheumatology, Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Immunol 168:2554-9. 2002
    ..Such fusion proteins may be useful to study novel therapeutic approaches for T cell-mediated autoimmune diseases...

Research Grants4

  1. MECHANISMS OF AUTOIMMUNE ARTHRITIS
    EDWARD ROSLONIEC; Fiscal Year: 2001
    ..These recombinant DR molecules will be tested for their ability to alter T-cell responses to hCII in vitro, and prevent the development of autoimmune arthritis in the DR transgenic mice. ..