Randy Rosier

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
    Robert A Mooney
    Department of Pathology and Laboratory Medicine, Box 626, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R198. 2011
  2. pmc The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids
    Valentine B Andela
    Department of Orthopaedics and The James P, Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, New York, 14642, USA
    Mol Cancer 3:8. 2004
  3. ncbi request reprint Continuing competency in orthopaedics: the future of recertification
    Randy N Rosier
    Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, University of Rochester, Rochester, NY 14642, USA
    Clin Orthop Relat Res 449:72-5. 2006
  4. ncbi request reprint Institutional barriers to the orthopaedic clinician-scientist
    Randy N Rosier
    Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, University of Rochester, Rochester, NY 14642, USA
    Clin Orthop Relat Res 449:159-64. 2006
  5. ncbi request reprint Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis
    Hicham Drissi
    The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, United States
    Mol Aspects Med 26:169-79. 2005
  6. ncbi request reprint Smad6 is induced by BMP-2 and modulates chondrocyte differentiation
    Xeufeng Li
    Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    J Orthop Res 21:908-13. 2003
  7. ncbi request reprint Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists
    Valentine B Andela
    The James P Wilmot Cancer Center and the Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue Box 665 Rochester, NY 14642, USA
    FEBS Lett 579:1765-9. 2005
  8. ncbi request reprint PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling
    Tian Fang Li
    Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Exp Cell Res 300:159-69. 2004
  9. pmc Teriparatide (1-34 human PTH) regulation of osterix during fracture repair
    Lee A Kaback
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Cell Biochem 105:219-26. 2008
  10. ncbi request reprint Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB
    Roman A Eliseev
    Musculo Skeletal Research Unit, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 279:46748-54. 2004

Research Grants

Collaborators

Detail Information

Publications48

  1. pmc High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
    Robert A Mooney
    Department of Pathology and Laboratory Medicine, Box 626, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Res Ther 13:R198. 2011
    ..This study was undertaken to establish a causal relation between the HF diet and accelerated OA progression in a mouse model and to determine the relative roles of weight gain and metabolic dysregulation in this progression...
  2. pmc The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids
    Valentine B Andela
    Department of Orthopaedics and The James P, Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue Box 665, Rochester, New York, 14642, USA
    Mol Cancer 3:8. 2004
    ....
  3. ncbi request reprint Continuing competency in orthopaedics: the future of recertification
    Randy N Rosier
    Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, University of Rochester, Rochester, NY 14642, USA
    Clin Orthop Relat Res 449:72-5. 2006
    ..Case list reviews, with a focus on patient safety measures, will also be a new addition to the process...
  4. ncbi request reprint Institutional barriers to the orthopaedic clinician-scientist
    Randy N Rosier
    Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, University of Rochester, Rochester, NY 14642, USA
    Clin Orthop Relat Res 449:159-64. 2006
    ....
  5. ncbi request reprint Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis
    Hicham Drissi
    The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, United States
    Mol Aspects Med 26:169-79. 2005
    ..Thus, unraveling the molecular interplay between various factors that regulate chondrocyte maturation during OA occurrence and progression is the main focus of ongoing efforts...
  6. ncbi request reprint Smad6 is induced by BMP-2 and modulates chondrocyte differentiation
    Xeufeng Li
    Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    J Orthop Res 21:908-13. 2003
    ..Additional studies are required to determine the extent to which this pathway participates in pathologic processes involving cartilage...
  7. ncbi request reprint Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists
    Valentine B Andela
    The James P Wilmot Cancer Center and the Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue Box 665 Rochester, NY 14642, USA
    FEBS Lett 579:1765-9. 2005
    ..These findings, suggest that inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists...
  8. ncbi request reprint PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling
    Tian Fang Li
    Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Exp Cell Res 300:159-69. 2004
    ..These observations demonstrate potent prostaglandin regulatory effects on chondrocyte maturation and show a role for both PKA and PKC signaling in PGE2 regulatory events...
  9. pmc Teriparatide (1-34 human PTH) regulation of osterix during fracture repair
    Lee A Kaback
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Cell Biochem 105:219-26. 2008
    ..Collectively, these data suggest a mechanism for teriparatide mediated fracture healing possibly via Osx induction in MSCs...
  10. ncbi request reprint Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB
    Roman A Eliseev
    Musculo Skeletal Research Unit, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 279:46748-54. 2004
    ..We, therefore, conclude that diazoxide-mediated preconditioning against apoptosis involves activation of the pro-survival transcription factors CREB and NFkappaB...
  11. ncbi request reprint Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway
    Tian Fang Li
    Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Exp Cell Res 299:128-36. 2004
    ..Overall, our results demonstrate that PTHrP downregulates Runx2 expression primarily through the PKA signaling pathway...
  12. ncbi request reprint Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation
    Xinping Zhang
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Bone 34:809-17. 2004
    ....
  13. ncbi request reprint Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone
    Andrew H Gordon
    Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA
    Cancer Res 65:3209-17. 2005
    ..These findings imply that NF-kappaB and its associated genes may be relevant therapeutic targets in osteolytic tumor burden...
  14. ncbi request reprint Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase
    Roman A Eliseev
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cell Biochem 96:1262-73. 2005
    ..Our study brings new insight into the mechanisms underlying radiation-induced apoptosis of osteosarcoma, and may lead to development of new therapeutic strategies against osteosarcoma...
  15. ncbi request reprint Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB
    Roman A Eliseev
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Cell Res 312:40-50. 2006
    ..We therefore conclude that in osteosarcoma Saos2 cells, NFkappaB represses BMP/Smad signaling and BMP2-induced differentiation through Smad7...
  16. pmc Quantification of massive allograft healing with dynamic contrast enhanced-MRI and cone beam-CT: a pilot study
    Nicole Ehrhart
    Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA
    Clin Orthop Relat Res 466:1897-904. 2008
    ....
  17. ncbi request reprint A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival
    Valentine B Andela
    The James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    FEBS Lett 579:6814-20. 2005
    ..Accordingly, mI-kappaB-Line 1 cells are markedly sensitized to pharmacologic inhibition of beta-oxidative respiration. These findings are indicative of compensatory changes that could undermine anti-cancer therapies targeting NF-kappaB...
  18. pmc Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation
    Tian Fang Li
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Bone Miner Res 21:4-16. 2006
    ..Smad2 or Smad3 overexpression and BMP blockade abrogate accelerated maturation in Smad3-/- chondrocytes. BMP signaling is increased in TGF-beta deficiency and is required for accelerated chondrocyte maturation...
  19. ncbi request reprint Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition
    Roman A Eliseev
    Musculoskeletal Research Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States roman
    Neurobiol Aging 28:1532-42. 2007
    ..This may be a protection mechanism that raises the threshold of brain tissue against injuries...
  20. ncbi request reprint Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae
    Tzong Jen Sheu
    Department of Orthopedics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Bone Miner Res 17:915-22. 2002
    ..The clone 5 peptide shows a high homology to glypican 4 (GPC4), a proteoglycan attachment receptor found in a number of cell types...
  21. pmc Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin
    Qiuqian Wu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Bone Miner Res 23:552-63. 2008
    ..The mechanism underlying Smurf2-mediated morphological changes during embryonic development may provide new mechanistic insights and potential targets for prevention and treatment of human osteoarthritis...
  22. pmc Regulation of embryonic endochondral ossification by Smurf2
    Qiuqian Wu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 26:704-12. 2008
    ....
  23. ncbi request reprint Molecular biology in orthopaedics: the advent of molecular orthopaedics
    Christopher H Evans
    Center for Molecular Orthopaedics, Harvard Medical School, 221 Long wood Avenue, BLI 152, Boston, MA 02115, USA
    J Bone Joint Surg Am 87:2550-64. 2005
    ..Both surgical and nonsurgical decisions will increasingly accommodate molecular criteria...
  24. ncbi request reprint 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes
    Michael J Zuscik
    Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Cell Biochem 92:316-31. 2004
    ....
  25. ncbi request reprint CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter
    Andreia M Ionescu
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
    J Cell Physiol 198:428-40. 2004
    ....
  26. ncbi request reprint A role for the BMP antagonist chordin in endochondral ossification
    Donghui Zhang
    Department of Orthopedics, School of Medicine and Dentistry, University of Rochester, New York, USA
    J Bone Miner Res 17:293-300. 2002
    ..In summary, these findings strongly support a role for chordin as a negative regulator of endochondral ossification...
  27. ncbi request reprint Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors
    Christopher R Good
    Department of Orthopaedics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Surg Oncol 79:174-9. 2002
    ..This report examines osteolytic bone tumor expression of receptor activator of nuclear factor B-ligand (RANK-L), a cytokine that is arguably the most critical regulator of osteoclast differentiation and activation...
  28. ncbi request reprint Growth plate chondrocyte maturation is regulated by basal intracellular calcium
    Michael J Zuscik
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Exp Cell Res 276:310-9. 2002
    ..These findings underscore the importance of cellular Ca(2+) in GPC function and suggest that PTHrP action in the growth plate is at least partially regulated by changes in basal [Ca(2+)](i)...
  29. pmc Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, New York 14642, USA
    J Clin Invest 109:1405-15. 2002
    ..These results provide a model whereby COX-2 regulates the induction of cbfa1 and osterix to mediate normal skeletal repair...
  30. ncbi request reprint Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes
    Michael J Zuscik
    Center for Muscluskeletal Research, School of Medicine and Dentistry, University of Rochester, NY 14642, USA
    J Orthop Res 20:811-8. 2002
    ....
  31. ncbi request reprint Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB
    Valentine B Andela
    Center for Musculoskeletal Research, University of Rochester Medical Center, NY 14620, USA
    Biochem Biophys Res Commun 297:237-41. 2002
    ..These results point to the negative regulation of osteoblast differentiation by NFkappaB, with implications in the pathogenesis and progression of osteosarcomas...
  32. ncbi request reprint Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A
    Michael J Zuscik
    Department of Orthopaedics, School of Medicine and Dentistry, University of Rochester, NY 14642, USA
    J Orthop Res 20:1079-90. 2002
    ..These data demonstrate that although activation of PKC or Ca2+ signals is not required, the cylic AMP-dependent A kinase is required for PTHrP to regulate key hallmarks of GPC phenotype...
  33. ncbi request reprint A phage display technique identifies a novel regulator of cell differentiation
    Tzong Jen Sheu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 278:438-43. 2003
    ..We hypothesize that binding to TRAP may be one mechanism by which the full osteoblast phenotype is expressed during the process of bone remodeling...
  34. ncbi request reprint Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes
    Dhruv B Pateder
    Department of Orthopaedic Surgery, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Radiat Res 157:62-8. 2002
    ....
  35. ncbi request reprint Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes
    M Hicham Drissi
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Cell Biochem 90:1287-98. 2003
    ..Factors or signals that alter either of these transcription factors regulate the rate of chondrocyte differentiation...
  36. ncbi request reprint ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development
    Donghui Zhang
    Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 18:1593-604. 2003
    ..The findings suggest that BMP signaling modulates the Ihh/PTHrP signaling pathway that regulates the rate of chondrocyte differentiation...
  37. ncbi request reprint ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation
    Andreia M Ionescu
    Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Exp Cell Res 288:198-207. 2003
    ..Thus, ATF-2 regulates chondrocyte maturation as a direct target of TGF-beta signaling while CREB regulates differentiation by targeting genes independent of the individual signaling effects of TGF-beta or BMP-2...
  38. ncbi request reprint Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB
    Valentine B Andela
    Center for Musculoskeletal Research, University of Rochester Medical Center, 575 Elmwood Avenue, 1 7534, Rochester, NY 14642, USA
    Cancer Lett 194:37-43. 2003
    ..Our results are consistent with the putative role of retinoids and cAMP in the malignant reversion of tumor cells and illustrative of the binary nature of transcriptional programs that modulate malignant progression...
  39. ncbi request reprint Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5
    Xuefeng Li
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Endocrinology 144:2514-23. 2003
    ..These findings demonstrate that RA induces the expression of BMP-signaling molecules and enhances BMP effects in chondrocytes...
  40. pmc Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction
    Mei Zhu
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 58:2053-64. 2008
    ..To determine the role of beta-catenin signaling in articular chondrocyte function, we generated Col2a1-ICAT-transgenic mice to inhibit beta-catenin signaling in chondrocytes...
  41. ncbi request reprint In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis
    Lisa M Childs
    Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
    J Bone Miner Res 17:192-9. 2002
    ..These studies indicate that osteoclast depletion via RANK blockade is an effective method to prevent and reverse wear debris-induced osteolysis without jeopardizing osteogenesis...
  42. pmc The association between environmental lead exposure and bone density in children
    James R Campbell
    Department of Pediatrics, University of Rochester Medical Center, and Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
    Environ Health Perspect 112:1200-3. 2004
    ..Accelerated maturation of bone may ultimately result in a lower peak BMD being achieved in young adulthood, thus predisposing to osteoporosis in later life. Future studies need to investigate this proposed model...
  43. ncbi request reprint COX-1 and COX-2 expression in osteoid osteomas
    David V Mungo
    Department of Orthopaedics, Medical Center, University of Rochester, NY 14642, USA
    J Orthop Res 20:159-62. 2002
    ..These findings suggest that the newly selective COX-2 inhibitors could be used to more safely treat osteoid osteomas...
  44. ncbi request reprint The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles
    Alexander Soloviev
    Center for Musculoskeletal Research, The University of Rochester School of Medicine, NY 14642, USA
    J Orthop Res 20:714-22. 2002
    ..TNFalpha induction appears to be mediated, at least in part, through NFkappaB binding to the kappaB2a site of the TNFalpha promoter...
  45. ncbi request reprint Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis
    J Jeffrey Goater
    Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester Medical Center, NY 14642, USA
    J Orthop Res 20:169-73. 2002
    ..This increased osteoclastogenesis was completely inhibited by the FLS-OPG, as osteoclast numbers in the calvaria of these animals were similar to that seen in the SHAM controls...
  46. ncbi request reprint Altered negative regulation of transforming growth factor beta signaling in scleroderma: potential involvement of SMURF2 in disease
    Michael J Zuscik
    Arthritis Rheum 48:1779-80. 2003
  47. ncbi request reprint American Board of Orthopaedic Surgery Practice of the Orthopaedic Surgeon: Part-II, certification examination case mix
    William E Garrett
    Duke University Medical Center, Box 3338, Durham, NC 27710, USA
    J Bone Joint Surg Am 88:660-7. 2006
  48. pmc Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency
    Jonathan J Carmouche
    Center for Musculoskeletal Research, University of Rochester Medical Center, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 113:749-55. 2005
    ..We conclude that Pb delays fracture healing at environmentally relevant doses and induces fibrous nonunions at higher doses by inhibiting the progression of endochondral ossification...

Research Grants12

  1. ACTIVATION OF CHONDROCYTE MATURATION IN OSTEOARTHRITIS
    Randy Rosier; Fiscal Year: 2007
    ..Finally, the expression of Smurf1 and Smurf2 in human normal and OA cartilage will be examined. These studies should provide a comprehensive picture of the function of Smurfs in regulating normal and OA cartilage phenotype. ..
  2. ACTIVATION OF CHONDROCYTE MATURATION IN OSTEOARTHRITIS
    Randy Rosier; Fiscal Year: 2002
    ..Thus, this proposal will examine the inter-relationships between BMPs, PTHrP and their coordinate role in the regulation of chondrocyte maturation during endochondral ossification. ..