S Rosi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
    Karim Belarbi
    Brain and Spinal Injury Center, University of California, San Francisco, California, USA
    J Neuroinflammation 9:23. 2012
  2. ncbi Trauma-induced alterations in cognition and Arc expression are reduced by previous exposure to 56Fe irradiation
    Susanna Rosi
    Brain and Spinal Injury Center, University of California, San Francisco, California 94110, USA
    Hippocampus 22:544-54. 2012
  3. ncbi Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat
    S Rosi
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 142:1303-15. 2006
  4. ncbi Cranial irradiation alters the behaviorally induced immediate-early gene arc (activity-regulated cytoskeleton-associated protein)
    Susanna Rosi
    Brain and Spinal Injury Center, Department of Physical Therapy and Rehabilitation Sciences, University of California, San Francisco, San Francisco, California 94110, USA
    Cancer Res 68:9763-70. 2008
  5. ncbi Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine
    S Rosi
    Brain and Spinal Injury Center, University of California, San Francisco, CA, USA
    Brain 132:2464-77. 2009
  6. ncbi Neuroinflammation and the plasticity-related immediate-early gene Arc
    Susanna Rosi
    Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA 94110, USA
    Brain Behav Immun 25:S39-49. 2011
  7. ncbi Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation
    Y Marchalant
    Arizona Research Laboratories, Division of Neural Systems Memory and Aging, University of Arizona, Tucson, AZ, USA
    Neuroscience 144:1516-22. 2007
  8. ncbi Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease
    S Rosi
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 134:671-6. 2005
  9. ncbi The toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease
    G L Wenk
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 121:719-29. 2003

Research Grants

  1. Brain Irradiation Affects Neuronal Function
    Susanna Rosi; Fiscal Year: 2010

Collaborators

Detail Information

Publications9

  1. ncbi TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
    Karim Belarbi
    Brain and Spinal Injury Center, University of California, San Francisco, California, USA
    J Neuroinflammation 9:23. 2012
    ..Our study was aimed to evaluate the therapeutic potential of a novel analog of thalidomide, 3,6'-dithiothalidomide (DT), an agent with anti-TNF-α activity, in a model of chronic neuroinflammation...
  2. ncbi Trauma-induced alterations in cognition and Arc expression are reduced by previous exposure to 56Fe irradiation
    Susanna Rosi
    Brain and Spinal Injury Center, University of California, San Francisco, California 94110, USA
    Hippocampus 22:544-54. 2012
    ..e., irradiation) induces tolerance to a subsequent and potentially more damaging insult (trauma)...
  3. ncbi Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat
    S Rosi
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 142:1303-15. 2006
    ..Combined, these findings suggest that low, therapeutically relevant doses of memantine delivered early in the development of neuroinflammation-influenced diseases may confer neural and cognitive protection...
  4. ncbi Cranial irradiation alters the behaviorally induced immediate-early gene arc (activity-regulated cytoskeleton-associated protein)
    Susanna Rosi
    Brain and Spinal Injury Center, Department of Physical Therapy and Rehabilitation Sciences, University of California, San Francisco, San Francisco, California 94110, USA
    Cancer Res 68:9763-70. 2008
    ..These findings are the first to show that local brain irradiation initiates changes in hippocampal neurons that disrupt the activity patterns (Arc expression) associated with neuroplasticity and memory...
  5. ncbi Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine
    S Rosi
    Brain and Spinal Injury Center, University of California, San Francisco, CA, USA
    Brain 132:2464-77. 2009
    ....
  6. ncbi Neuroinflammation and the plasticity-related immediate-early gene Arc
    Susanna Rosi
    Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA 94110, USA
    Brain Behav Immun 25:S39-49. 2011
    ..This review discusses the use of Arc expression during activation of the innate immune system as a valid marker of altered plasticity and a predictor of cognitive dysfunction...
  7. ncbi Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation
    Y Marchalant
    Arizona Research Laboratories, Division of Neural Systems Memory and Aging, University of Arizona, Tucson, AZ, USA
    Neuroscience 144:1516-22. 2007
    ....
  8. ncbi Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease
    S Rosi
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 134:671-6. 2005
    ..The present study suggests that DAPTA and other CCR5 antagonists may attenuate critical aspects of the neuroinflammation associated with Alzheimer's disease...
  9. ncbi The toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease
    G L Wenk
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 121:719-29. 2003
    ..The results suggest that noradrenergic cell loss in Alzheimer's disease does not augment the consequences of the chronic neuroinflammation and does not enhance neurodegeneration of forebrain cholinergic neurons...

Research Grants2

  1. Brain Irradiation Affects Neuronal Function
    Susanna Rosi; Fiscal Year: 2010
    ..These types of data are currently unavailable and are essential for determining the risks of specific central nervous system related effects and for the development of potential strategies to manage radiation-mediated brain injury. ..