Research Topics
| Robert E RosenthalSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrestRobert E Rosenthal
Program in Trauma, Department of Surgery, University of Maryland, Baltimore, USA
Stroke 34:1311-6. 2003....- Delayed therapy of experimental global cerebral ischemia with acetyl-L-carnitine in dogsRobert E Rosenthal
Program in Trauma, Department of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
Neurosci Lett 378:82-7. 2005..A 30-min delay in ALCAR administration following ROSC from 10 min CA impairs the ability of this drug to promote neurologic recovery despite apparent normalization of brain lactate levels... - Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal deathViktoria Vereczki
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Cereb Blood Flow Metab 26:821-35. 2006..Moreover, these findings indicate the need for clinical trials comparing the effects of different ventilatory oxygen levels on neurologic outcome after cardiac arrest... - Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolismErica M Richards
Program in Neuroscience, The Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA
Stroke 38:1578-84. 2007..Using a clinically relevant canine cardiac arrest model, in this study we tested the hypothesis that hyperoxic reperfusion decreases hippocampal glucose metabolism and glutamate synthesis... - Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal deathJulie L Hazelton
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurotrauma 27:753-62. 2010.... - Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stressErica Martin
Department of Anesthesiology, University of Maryland School of Medicine, 684 W. Baltimore Street, Baltimore, MD 21201, USA
J Neurosci Res 79:240-7. 2005.... - Postischemic oxidative stress promotes mitochondrial metabolic failure in neurons and astrocytesGary Fiskum
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Ann N Y Acad Sci 1147:129-38. 2008..These results support the hypothesis that release and or consumption of mitochondrial NAD(H) is at least partially responsible for respiratory inhibition, particularly in neurons... - Oximetry-guided reoxygenation improves neurological outcome after experimental cardiac arrestIrina S Balan
Departments of Anesthesiology, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD, USA
Stroke 37:3008-13. 2006..Clinical trials of controlled normoxia after CA/restoration of spontaneous circulation should strongly be considered... - Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activityErica M Richards
Department of Anesthesiology, University of Maryland, Baltimore, MD 21201, USA
Free Radic Biol Med 40:1960-70. 2006..These results support the hypothesis that oxidative stress contributes to loss of hippocampal PDHC activity during cerebral ischemia and reperfusion and suggest that PDHC is a target of peroxynitrite... - Oxygen: could there be too much of a good thing?Robert E Rosenthal
Program in Trauma, The R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Hosp Med 66:76-7. 2005 - Protection against ischemic brain injury by inhibition of mitochondrial oxidative stressGary Fiskum
Department of Anesthesiology, University of Maryland School of Medicine, 685 W Baltimore St, MSTF 5 34, Baltimore, Maryland 21201, USA
J Bioenerg Biomembr 36:347-52. 2004.... - The effect of hyperbaric oxygen therapy on composite graft survivalEdward N Li
Division of Plastic and Reconstructive Surgery, University of Maryland Medical Systems, Baltimore, MD, USA
Ann Plast Surg 53:141-5. 2004..8 +/- 15.7% compared with a survival rate of 51.31 +/- 38.5% for the control group (n = 8; P = 0.0478). There was no such benefit in smaller grafts. HBO could prove clinically useful for larger composite grafts... - Ultrasound-diagnosed cardiac tamponade after blunt abdominal trauma-treated with emergent thoracotomyJay Menaker
R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Emerg Med 32:99-103. 2007.... - Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitationMaryla Krajewska
The Burnham Institute, La Jolla, CA 92037, USA
Exp Neurol 189:261-79. 2004.... - Mechanisms of ischemic neuroprotection by acetyl-L-carnitineSantina A Zanelli
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville 22908, USA
Ann N Y Acad Sci 1053:153-61. 2005.... - Neuroprotective effects of hyperbaric oxygen treatment in experimental focal cerebral ischemia are associated with reduced brain leukocyte myeloperoxidase activityMilena Miljkovic-Lolic
Department of Medicine, St Joseph Medical Center, Towson, MD, USA
Brain Res 971:90-4. 2003..25). CONCLUSION: These data confirm the neuroprotective effects of HBO in cerebral ischemia and suggest that the mechanism of this action may involve inhibition of PMN infiltration in the injured brain...