Research Topics
Genomes and Genes | Louis A RosenthalSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine hostLouis A Rosenthal
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
PLoS ONE 7:e32061. 2012..This novel murine model of picornaviral airway infection and inflammation should be useful for defining mechanisms of HRV pathogenesis in humans...
Attenuated innate mechanisms of interferon-gamma production in rats susceptible to postviral airway dysfunctionLouis A Rosenthal
Morris Institute for Respiratory Research, University of Wisconsin Medical School, Madison, WI 53792, USA
Am J Respir Cell Mol Biol 30:702-9. 2004..Attenuation of innate IFN-gamma-producing responses to SeV in BN weanlings may be a critical factor in their susceptibility to postbronchiolitis chronic airway dysfunction...- Animal models of virus-induced chronic airway diseaseLouis A Rosenthal
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 948 CSC 9988, Madison, WI 53792, USA
Immunol Allergy Clin North Am 30:497-511, vi. 2010..Investigation of these rodent models should complement the research from pediatric cohort studies and begin to bring us closer to understanding the role of viral respiratory tract infections in the inception of childhood asthma... - Viral respiratory tract infections and asthma: the course aheadLouis A Rosenthal
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
J Allergy Clin Immunol 125:1212-7. 2010.... - A rat model of picornavirus-induced airway infection and inflammationLouis A Rosenthal
Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA
Virol J 6:122. 2009.... - Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of lifeJames E Gern
Department of Pediatrics, University of Wisconsin Hospital, 600 Highland Avenue, Madison, WI 53792, USA
J Allergy Clin Immunol 117:72-8. 2006..CONCLUSION: In children with a family history of allergies and/or asthma, mononuclear cell phytohemagglutinin-induced IL-13 and virus-induced IFN-gamma responses at birth are indicative of the risk for wheezing in the first year of life... - Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosisZhong Jian Shen
Waisman Center for Developmental Disabilities, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
J Clin Invest 118:479-90. 2008..These data suggest that pharmacologic suppression of Pin1 may be a novel therapeutic option to prevent airway fibrosis in individuals with chronic asthma... - Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunctionRonald L Sorkness
Morris Institute for Respiratory Research, Department of Medicine, School of Pharmacy, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
J Allergy Clin Immunol 110:607-9. 2002..The persistent increase in IL-13 suggests instead that the strain-related variability in virus-associated airway pathology might be determined by the host response to infection rather than by the intensity or duration of infection... - Altered allergen-induced eosinophil trafficking and physiological dysfunction in airways with preexisting virus-induced injuryRonald L Sorkness
School of Pharmacy, Department of Medicine, University of Wisconsin at Madison, 777 Highland Ave, Madison, WI 53705, USA
Am J Physiol Lung Cell Mol Physiol 292:L85-91. 2007.... - Viral infections, cytokine dysregulation and the origins of childhood asthma and allergic diseasesSamuel L Friedlander
Department of Medicine, Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison, WI, USA
Pediatr Infect Dis J 24:S170-6, discussion S174-5. 2005..The origins of asthma and allergic disease begin in early life for many individuals. It is vital to understand the factors and/or events leading to their development... 
Effects of a DNA vaccine in an animal model of Alternaria alternata sensitivityHiram Sanchez
Allergy Section, William S Middleton Memorial VA Hospital, Madison, WI, USA Department of Medicine, University of Wisconsin, Madison, WI, USA
Rev Iberoam Micol 26:121-8. 2009....- Effects of viral respiratory infections on lung development and childhood asthmaJames E Gern
Department of Pediatrics, University of Wisconsin Madison, 600 Highland Avenue, Madison, WI 53792 9988, USA
J Allergy Clin Immunol 115:668-74; quiz 675. 2005..Greater understanding of the effects of viral infections on lung development and growth in early childhood might lead to the discovery of additional strategies for the prevention of recurrent wheezing and chronic asthma... - Pin1 protein regulates Smad protein signaling and pulmonary fibrosisZhong Jian Shen
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
J Biol Chem 287:23294-305. 2012..Therefore, Pin1 is essential for normal Smad6 function and ECM production in response to injury or TGF-β and thus may be an attractive therapeutic target to prevent excess scarring in diverse lung diseases... - Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of lifeChristopher C Copenhaver
Department of Pediatrics, University of Wisconsin Hospital, Madison, WI 53792 9988, USA
Am J Respir Crit Care Med 170:175-80. 2004..Conversely, the frequency of viral infections in infancy can influence IFN-gamma responses... - A critical role for Pin1 in allergic pulmonary eosinophilia in ratsStephane Esnault
Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
J Allergy Clin Immunol 120:1082-8. 2007..We recently showed that in vitro Pin1 regulated eosinophil production of and response to GM-CSF... - Systemic and pulmonary effects of fluticasone administered through a metered-dose inhaler in ratsRonald L Sorkness
Morris Institute for Respiratory Research and the School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
J Allergy Clin Immunol 114:1027-32. 2004..Metered-dose inhalers (MDIs) are convenient, simple, inexpensive, and reproducible devices for administering aerosolized drugs through the pulmonary route, but methods have not been available for use of these devices in small animals... - Effects of dog ownership and genotype on immune development and atopy in infancyJames E Gern
Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis, USA
J Allergy Clin Immunol 113:307-14. 2004..These findings suggest that postnatal exposure to dogs can influence immune development in a genotype-specific fashion and thereby attenuate the development of atopy in at-risk children... - Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of lifeWilliam A Neaville
Department of Pediatrics, University of Wisconsin-Madison, USA
J Allergy Clin Immunol 112:740-6. 2003.... - Thymic stromal lymphopoietin expression in allergic pulmonary inflammation is Pin1-dependentStephane Esnault
J Allergy Clin Immunol 121:1289-90. 2008
Research Grants
- Immunomodulatory Mechanisms of Sublingual ImmunotherapyLouis Rosenthal; Fiscal Year: 2006..To investigate this controversial therapy, these studies will use a novel rat model to compare the efficacy of high vs. low doses of allergen drops and to elucidate mechanisms of sublingual immunotherapy. ..