Louis A Rosenthal

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
    PLoS ONE 7:e32061. 2012
  2. ncbi request reprint Attenuated innate mechanisms of interferon-gamma production in rats susceptible to postviral airway dysfunction
    Louis A Rosenthal
    Morris Institute for Respiratory Research, University of Wisconsin Medical School, Madison, WI 53792, USA
    Am J Respir Cell Mol Biol 30:702-9. 2004
  3. pmc Animal models of virus-induced chronic airway disease
    Louis A Rosenthal
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 948 CSC 9988, Madison, WI 53792, USA
    Immunol Allergy Clin North Am 30:497-511, vi. 2010
  4. pmc Viral respiratory tract infections and asthma: the course ahead
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Allergy Clin Immunol 125:1212-7. 2010
  5. pmc A rat model of picornavirus-induced airway infection and inflammation
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA
    Virol J 6:122. 2009
  6. pmc Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis
    Zhong Jian Shen
    Waisman Center for Developmental Disabilities, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    J Clin Invest 118:479-90. 2008
  7. ncbi request reprint Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunction
    Ronald L Sorkness
    Morris Institute for Respiratory Research, Department of Medicine, School of Pharmacy, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    J Allergy Clin Immunol 110:607-9. 2002
  8. ncbi request reprint Altered allergen-induced eosinophil trafficking and physiological dysfunction in airways with preexisting virus-induced injury
    Ronald L Sorkness
    School of Pharmacy, Department of Medicine, University of Wisconsin at Madison, 777 Highland Ave, Madison, WI 53705, USA
    Am J Physiol Lung Cell Mol Physiol 292:L85-91. 2007
  9. ncbi request reprint Effects of a DNA vaccine in an animal model of Alternaria alternata sensitivity
    Hiram Sanchez
    Allergy Section, William S Middleton Memorial VA Hospital, Madison, WI, USA Department of Medicine, University of Wisconsin, Madison, WI, USA
    Rev Iberoam Micol 26:121-8. 2009
  10. ncbi request reprint Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life
    James E Gern
    Department of Pediatrics, University of Wisconsin Hospital, 600 Highland Avenue, Madison, WI 53792, USA
    J Allergy Clin Immunol 117:72-8. 2006

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
    PLoS ONE 7:e32061. 2012
    ..This novel murine model of picornaviral airway infection and inflammation should be useful for defining mechanisms of HRV pathogenesis in humans...
  2. ncbi request reprint Attenuated innate mechanisms of interferon-gamma production in rats susceptible to postviral airway dysfunction
    Louis A Rosenthal
    Morris Institute for Respiratory Research, University of Wisconsin Medical School, Madison, WI 53792, USA
    Am J Respir Cell Mol Biol 30:702-9. 2004
    ..Attenuation of innate IFN-gamma-producing responses to SeV in BN weanlings may be a critical factor in their susceptibility to postbronchiolitis chronic airway dysfunction...
  3. pmc Animal models of virus-induced chronic airway disease
    Louis A Rosenthal
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 948 CSC 9988, Madison, WI 53792, USA
    Immunol Allergy Clin North Am 30:497-511, vi. 2010
    ..Investigation of these rodent models should complement the research from pediatric cohort studies and begin to bring us closer to understanding the role of viral respiratory tract infections in the inception of childhood asthma...
  4. pmc Viral respiratory tract infections and asthma: the course ahead
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Allergy Clin Immunol 125:1212-7. 2010
    ....
  5. pmc A rat model of picornavirus-induced airway infection and inflammation
    Louis A Rosenthal
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA
    Virol J 6:122. 2009
    ....
  6. pmc Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis
    Zhong Jian Shen
    Waisman Center for Developmental Disabilities, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    J Clin Invest 118:479-90. 2008
    ..These data suggest that pharmacologic suppression of Pin1 may be a novel therapeutic option to prevent airway fibrosis in individuals with chronic asthma...
  7. ncbi request reprint Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunction
    Ronald L Sorkness
    Morris Institute for Respiratory Research, Department of Medicine, School of Pharmacy, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    J Allergy Clin Immunol 110:607-9. 2002
    ..The persistent increase in IL-13 suggests instead that the strain-related variability in virus-associated airway pathology might be determined by the host response to infection rather than by the intensity or duration of infection...
  8. ncbi request reprint Altered allergen-induced eosinophil trafficking and physiological dysfunction in airways with preexisting virus-induced injury
    Ronald L Sorkness
    School of Pharmacy, Department of Medicine, University of Wisconsin at Madison, 777 Highland Ave, Madison, WI 53705, USA
    Am J Physiol Lung Cell Mol Physiol 292:L85-91. 2007
    ....
  9. ncbi request reprint Effects of a DNA vaccine in an animal model of Alternaria alternata sensitivity
    Hiram Sanchez
    Allergy Section, William S Middleton Memorial VA Hospital, Madison, WI, USA Department of Medicine, University of Wisconsin, Madison, WI, USA
    Rev Iberoam Micol 26:121-8. 2009
    ....
  10. ncbi request reprint Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life
    James E Gern
    Department of Pediatrics, University of Wisconsin Hospital, 600 Highland Avenue, Madison, WI 53792, USA
    J Allergy Clin Immunol 117:72-8. 2006
    ..Viral infections are the major cause of acute wheezing illnesses in childhood. Variations in immunologic responses at birth may be determinants of the risk of acquiring these illnesses...
  11. ncbi request reprint Viral infections, cytokine dysregulation and the origins of childhood asthma and allergic diseases
    Samuel L Friedlander
    Department of Medicine, Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison, WI, USA
    Pediatr Infect Dis J 24:S170-6, discussion S174-5. 2005
    ..The origins of asthma and allergic disease begin in early life for many individuals. It is vital to understand the factors and/or events leading to their development...
  12. ncbi request reprint Effects of viral respiratory infections on lung development and childhood asthma
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, 600 Highland Avenue, Madison, WI 53792 9988, USA
    J Allergy Clin Immunol 115:668-74; quiz 675. 2005
    ..Greater understanding of the effects of viral infections on lung development and growth in early childhood might lead to the discovery of additional strategies for the prevention of recurrent wheezing and chronic asthma...
  13. pmc Pin1 protein regulates Smad protein signaling and pulmonary fibrosis
    Zhong Jian Shen
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Biol Chem 287:23294-305. 2012
    ..Therefore, Pin1 is essential for normal Smad6 function and ECM production in response to injury or TGF-β and thus may be an attractive therapeutic target to prevent excess scarring in diverse lung diseases...
  14. ncbi request reprint Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life
    Christopher C Copenhaver
    Department of Pediatrics, University of Wisconsin Hospital, Madison, WI 53792 9988, USA
    Am J Respir Crit Care Med 170:175-80. 2004
    ..Conversely, the frequency of viral infections in infancy can influence IFN-gamma responses...
  15. ncbi request reprint A critical role for Pin1 in allergic pulmonary eosinophilia in rats
    Stephane Esnault
    Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Allergy Clin Immunol 120:1082-8. 2007
    ..We recently showed that in vitro Pin1 regulated eosinophil production of and response to GM-CSF...
  16. ncbi request reprint Systemic and pulmonary effects of fluticasone administered through a metered-dose inhaler in rats
    Ronald L Sorkness
    Morris Institute for Respiratory Research and the School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
    J Allergy Clin Immunol 114:1027-32. 2004
    ..Metered-dose inhalers (MDIs) are convenient, simple, inexpensive, and reproducible devices for administering aerosolized drugs through the pulmonary route, but methods have not been available for use of these devices in small animals...
  17. ncbi request reprint Effects of dog ownership and genotype on immune development and atopy in infancy
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, Madison, Wis, USA
    J Allergy Clin Immunol 113:307-14. 2004
    ..Exposure to furred pets might confer protection against the development of allergic sensitization through a mechanism that is incompletely understood...
  18. ncbi request reprint Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life
    William A Neaville
    Department of Pediatrics, University of Wisconsin Madison, USA
    J Allergy Clin Immunol 112:740-6. 2003
    ..Allergic diseases have been linked to abnormal patterns of immune development, and this has stimulated efforts to define the precise patterns of cytokine dysregulation that are associated with specific atopic phenotypes...
  19. doi request reprint Thymic stromal lymphopoietin expression in allergic pulmonary inflammation is Pin1-dependent
    Stephane Esnault
    J Allergy Clin Immunol 121:1289-90. 2008

Research Grants1

  1. Immunomodulatory Mechanisms of Sublingual Immunotherapy
    Louis Rosenthal; Fiscal Year: 2006
    ..To investigate this controversial therapy, these studies will use a novel rat model to compare the efficacy of high vs. low doses of allergen drops and to elucidate mechanisms of sublingual immunotherapy. ..